EFSA Journal最新文献

{"title":"Modification of the existing maximum residue levels for flupyradifurone and difluoroacetic acid (DFA) in tomatoes.","authors":"Giulia Bellisai, Giovanni Bernasconi, Irene Castellan, Monica Del Aguila, Lucien Ferreira, Renata Leuschner, Andrea Mioč, Marta Szot, Manuela Tiramani, Alessia Verani, Abdulshakur Isah","doi":"10.2903/j.efsa.2026.10361","DOIUrl":"10.2903/j.efsa.2026.10361","url":null,"abstract":"<p><p>In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Bayer AG submitted a request to the competent national authority in Greece to modify the existing maximum residue levels (MRLs) for flupyradifurone and its metabolite difluoroacetic acid (DFA) in tomatoes. The data submitted in support of the request were found to be sufficient to derive MRL proposals for flupyradifurone and DFA in the commodity under assessment. Adequate analytical methods for enforcement are available to control the residues of flupyradifurone and DFA in the plant commodity under consideration at the validated limits of quantification (LOQs) of 0.01 and 0.007 mg/kg, respectively. Based on the risk assessment results, EFSA concluded that the short-term and long-term intake of flupyradifurone and DFA residues resulting from the use of flupyradifurone according to the reported agricultural practices is unlikely to present a risk to consumer health.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 10","pages":"e10361"},"PeriodicalIF":3.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13647200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety evaluation of the food enzyme cyclomaltodextrin glucanotransferase from the genetically modified Escherichia coli K12 strain DSM 34230","authors":"EFSA Panel on Food Enzymes (FEZ),&nbsp;Holger Zorn,&nbsp;José Manuel Barat Baviera,&nbsp;Claudia Bolognesi,&nbsp;Francesco Catania,&nbsp;Gabriele Gadermaier,&nbsp;Ralf Greiner,&nbsp;Baltasar Mayo,&nbsp;Alicja Mortensen,&nbsp;Yrjö Henrik Roos,&nbsp;Marize L. M. Solano,&nbsp;Henk Van Loveren,&nbsp;Laurence Vernis,&nbsp;Cristina Andreoli,&nbsp;Andrea Terron,&nbsp;Andrey Yurkov,&nbsp;Magdalena Andryszkiewicz,&nbsp;Daniele Cavanna,&nbsp;Yi Liu,&nbsp;Amparo Quiles Chulia,&nbsp;Daniela Bassi,&nbsp;Verónica Briz,&nbsp;Elena Molian,&nbsp;Edgar Perez","doi":"10.2903/j.efsa.2026.10342","DOIUrl":"10.2903/j.efsa.2026.10342","url":null,"abstract":"<p>The food enzyme cyclomaltodextrin glucanotransferase (1,4-α-<span>d</span>-glucan 4-α-<span>d</span>-[1,4α-<span>d</span>-glucano]-transferase (cyclising); EC 2.4.1.19) is produced with the genetically modified strain <i>Escherichia coli</i> K12 DSM 34230 by Wacker Chemie AG. The genetic modifications do not give rise to safety concerns. The food enzyme was considered free from viable cells of the production organism, but not from recombinant DNA. It is intended to be used in the processing of sugars for the production of specialty carbohydrates (γ-cyclodextrins). Since residual amounts of food enzyme–total organic solids are removed during the production of γ-cyclodextrins, dietary exposure was not calculated and toxicological testing was not needed. A search for the homology of the amino acid sequence of the cyclomaltodextrin glucanotransferase to known allergens was made and matches with two respiratory allergens were found. The Panel considered that a risk of allergic reactions upon dietary exposure cannot be excluded, but that the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13647199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modification of the terms of the authorisation of ammonium chloride (AmoklorTM) for sows (Latochema Co Ltd)","authors":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP),&nbsp;Roberto Edoardo Villa,&nbsp;Giovanna Azimonti,&nbsp;Eleftherios Bonos,&nbsp;Henrik Christensen,&nbsp;Mojca Durjava,&nbsp;Birgit Dusemund,&nbsp;Ronette Gehring,&nbsp;Boet Glandorf,&nbsp;Maryline Kouba,&nbsp;Marta López-Alonso,&nbsp;Francesca Marcon,&nbsp;Giovanna Martelli,&nbsp;Carlo Nebbia,&nbsp;Alena Pechová,&nbsp;Miguel Prieto-Maradona,&nbsp;Katerina Theodoridou,&nbsp;Guido Rychen,&nbsp;Jaume Galobart,&nbsp;Jordi Ortuño,&nbsp;Maria Vittoria Vettori,&nbsp;Alberto Navarro-Villa,&nbsp;Eleni Gkimprixi","doi":"10.2903/j.efsa.2026.10356","DOIUrl":"10.2903/j.efsa.2026.10356","url":null,"abstract":"<p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of Ammonium chloride (Amoklor^TM) as zootechnical feed additive for sows. The additive is already authorised for its use in ruminants, cats and dogs, and in sows from the 9th to the 11th week of gestion and from the 15th week of gestations until the first week of lactation. The aim of the current application is to modify the terms of the authorisation in sows to cover the entire gestation and the first week of lactation. The use of the additive ammonium chloride (Amoklor^TM) is safe for sows for the newly proposed conditions of use covering the complete gestation period and the first week of lactation, for consumers and for the environment. The additive is not irritant to skin nor a skin sensitiser, but it is considered irritant to eyes and a respiratory sensitiser. Exposure of users via eyes and respiratory tract is considered a risk. The Panel concludes that the additive is efficacious in reducing sows' urinary pH when administered to sows for the entire gestation period and the first week of lactation at the level of 5000 mg of ammonium chloride/kg complete feed.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13647194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peer review of the pesticide risk assessment for the active substance cyazofamid in light of confirmatory data submitted.","authors":"Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Mark Egsmose, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Mariano Lopez Romano, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Silvia Mazzega, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar-Bouza","doi":"10.2903/j.efsa.2026.10325","DOIUrl":"10.2903/j.efsa.2026.10325","url":null,"abstract":"<p><p>The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessment carried out by the competent authority of the rapporteur Member State, France, for the pesticide active substance cyazofamid are reported. The context of the peer review was that requested by the European Commission following the submission and evaluation of confirmatory information with regard to the endocrine disruption potential of cyazofamid for humans and wild mammals for the EATS modalities and for non-target organisms other than mammals. The conclusions were reached on the basis of the evaluation of the representative uses of cyazofamid as a fungicide on potatoes, tomatoes and cucurbits. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and/or literature in the dossier peer reviewed, are presented. Assessments not finalised, together with the missing information identified as being required by the regulatory framework, are listed.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 10","pages":"e10325"},"PeriodicalIF":3.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13647298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety evaluation of a food enzyme containing leucyl aminopeptidase and Xaa-Pro dipeptidyl-peptidase activities from the non-genetically modified Aspergillus sp. strain DAP 19-109","authors":"EFSA Panel on Food Enzymes (FEZ),&nbsp;Holger Zorn,&nbsp;José Manuel Barat Baviera,&nbsp;Claudia Bolognesi,&nbsp;Francesco Catania,&nbsp;Gabriele Gadermaier,&nbsp;Ralf Greiner,&nbsp;Baltasar Mayo,&nbsp;Alicja Mortensen,&nbsp;Yrjö Henrik Roos,&nbsp;Marize L. M. Solano,&nbsp;Henk Van Loveren,&nbsp;Laurence Vernis,&nbsp;Cristina Andreoli,&nbsp;Andrea Terron,&nbsp;Andrey Yurkov,&nbsp;Simone Lunardi,&nbsp;Magdalena Andryszkiewicz,&nbsp;Daniele Cavanna,&nbsp;Natalia Kovalkovicova,&nbsp;Yi Liu","doi":"10.2903/j.efsa.2026.10332","DOIUrl":"10.2903/j.efsa.2026.10332","url":null,"abstract":"<p>The food enzyme containing leucyl aminopeptidase (EC 3.4.11.1) and Xaa-Pro dipeptidyl-peptidase (EC 3.4.14.11) activities is produced with the non-genetically modified <i>Aspergillus</i> sp. strain DAP 19-109 by Shin Nihon Chemical Co., Ltd. The food enzyme was considered free from viable cells of the production organism. It is intended to be used in 14 food manufacturing processes. Since residual amounts of food enzyme–total organic solids (TOS) are removed in one process, dietary exposure was calculated for the remaining 13 food manufacturing processes. It was estimated to be up to 0.929 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 2310 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 2487. A search for the homology of the two amino acid sequences to known allergens was made and matches with three injected allergens were found. The Panel considered that a risk of allergic reactions upon dietary exposure to this food enzyme cannot be excluded, but that the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of guanidinoacetic acid (GAA) and a preparation of GAA (Creamino®) as feed additives for chickens for fattening and reared for breeding/laying, weaned piglets and pigs for fattening, for the renewal of their authorisation and its extension of use to suckling piglets (Alzchem Trostberg GmbH)","authors":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP),&nbsp;Roberto Edoardo Villa,&nbsp;Giovanna Azimonti,&nbsp;Eleftherios Bonos,&nbsp;Henrik Christensen,&nbsp;Mojca Durjava,&nbsp;Birgit Dusemund,&nbsp;Ronette Gehring,&nbsp;Boet Glandorf,&nbsp;Maryline Kouba,&nbsp;Marta López-Alonso,&nbsp;Francesca Marcon,&nbsp;Giovanna Martelli,&nbsp;Carlo Nebbia,&nbsp;Alena Pechová,&nbsp;Miguel Prieto-Maradona,&nbsp;Katerina Theodoridou,&nbsp;Nuria Duran,&nbsp;Jaume Galobart,&nbsp;Jordi Ortuño,&nbsp;Maria Vittoria Vettori,&nbsp;Alberto Navarro-Villa,&nbsp;Elena Abenza","doi":"10.2903/j.efsa.2026.10357","DOIUrl":"10.2903/j.efsa.2026.10357","url":null,"abstract":"<p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the feed additives guanidinoacetic acid (GAA) and a preparation of GAA (Creamino®) for chickens for fattening and reared for laying and breeding, weaned piglets and pigs for fattening for the renewal of their authorisation and their extension of use in feed for suckling pigs. The additives are already authorised for use in chickens for fattening and reared for laying and breeding, weaned piglets and pigs for fattening. The FEEDAP Panel concludes that the additives remain safe for the target species, consumers and environment and that the extension of the use to suckling piglets would not affect these conclusions. Regarding user safety, the additives were not considered irritant to skin or eyes and were not considered a potential skin sensitiser. There is no need for assessing the efficacy of the additives in the context of the renewal of the authorisation for chickens for fattening, chickens reared for laying and breeding, weaned piglets and pigs for fattening. The Panel concludes that the additives are efficacious in feed for suckling piglets at 600 mg/kg complete feed.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of a feed additive consisting of l-valine produced with Escherichia coli CCTCC M 2022134 for all animal species (Welding GmbH & Co. KG)","authors":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP),&nbsp;Roberto Edoardo Villa,&nbsp;Giovanna Azimonti,&nbsp;Eleftherios Bonos,&nbsp;Henrik Christensen,&nbsp;Mojca Durjava,&nbsp;Birgit Dusemund,&nbsp;Ronette Gehring,&nbsp;Boet Glandorf,&nbsp;Maryline Kouba,&nbsp;Marta López-Alonso,&nbsp;Francesca Marcon,&nbsp;Giovanna Martelli,&nbsp;Carlo Nebbia,&nbsp;Alena Pechová,&nbsp;Miguel Prieto-Maradona,&nbsp;Katerina Theodoridou,&nbsp;Lieve Herman,&nbsp;Montserrat Anguita,&nbsp;Matteo L. Innocenti,&nbsp;Elisa Pettenati,&nbsp;Jordi Tarrés-Call,&nbsp;Nicole Bozzi Cionci,&nbsp;Noelia Domínguez-Morueco,&nbsp;Alessandra Fontana,&nbsp;Sara Leston","doi":"10.2903/j.efsa.2026.10348","DOIUrl":"10.2903/j.efsa.2026.10348","url":null,"abstract":"<p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of <span>l</span>-valine produced with a genetically modified strain of <i>Escherichia coli</i> CCTCC M 2022134 as a nutritional additive for feed and water for drinking for all animal species. The <span>l</span>-valine manufactured by fermentation with <i>E. coli</i> CCTCC M 2022134 does not give rise to any safety concern regarding the genetic modifications of the production strain. No viable cells nor DNA of the production strain were detected in the final product. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded that the use of <span>l</span>-valine produced with <i>E. coli</i> CCTCC M 2022134 in feed is safe for the target species when supplemented in appropriate amounts to the diet according to the nutritional needs of the species. The FEEDAP Panel expressed concerns on the use of <span>l</span>-valine in water for drinking. The use in animal nutrition of <span>l</span>-valine produced by fermentation with <i>E. coli</i> CCTCC M 2022134 was considered safe for the consumers of products from animals receiving the additive, and for the environment. Regarding the safety for the user, the additive is considered irritant to the eyes and the respiratory tract. No conclusion can be made on its potential to be irritant to skin or dermal sensitiser. Exposure of users by inhalation or via the eyes is considered a risk. The additive is regarded as an effective source of the amino acid <span>l</span>-valine for all non-ruminant species. To be as efficacious in ruminants as in non-ruminants, it should be protected from ruminal degradation.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of maximum authorised levels of cobalt and molybdenum for the environment","authors":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP),&nbsp;Roberto Edoardo Villa,&nbsp;Giovanna Azimonti,&nbsp;Eleftherios Bonos,&nbsp;Henrik Christensen,&nbsp;Mojca Durjava,&nbsp;Birgit Dusemund,&nbsp;Ronette Gehring,&nbsp;Boet Glandorf,&nbsp;Maryline Kouba,&nbsp;Marta López-Alonso,&nbsp;Francesca Marcon,&nbsp;Giovanna Martelli,&nbsp;Carlo Nebbia,&nbsp;Alena Pechová,&nbsp;Miguel Prieto-Maradona,&nbsp;Katerina Theodoridou,&nbsp;Antonio Finizio,&nbsp;Thomas Poiger,&nbsp;Ivana Teodorovic,&nbsp;Jordi Tarrés-Call","doi":"10.2903/j.efsa.2026.10347","DOIUrl":"10.2903/j.efsa.2026.10347","url":null,"abstract":"<p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety for the environment of feed additives containing trace elements, namely cobalt, copper, iodine, manganese, molybdenum, selenium and zinc. In agreement with the European Commission, the present scientific opinion assesses only cobalt and molybdenum, as these are currently authorised exclusively for use in terrestrial food-producing animals. The safety for the environment of the remaining trace elements will be assessed in a subsequent scientific opinion. Based on the available evidence, the use of cobalt and molybdenum as nutritional additives in terrestrial food-producing animals at the respective current maximum authorised levels in complete feed is considered safe for the environment.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety evaluation of the food enzyme phospholipase A1 from the non-genetically modified Fusarium commune strain LFC","authors":"EFSA Panel on Food Enzymes (FEZ),&nbsp;Holger Zorn,&nbsp;José Manuel Barat Baviera,&nbsp;Claudia Bolognesi,&nbsp;Francesco Catania,&nbsp;Gabriele Gadermaier,&nbsp;Ralf Greiner,&nbsp;Baltasar Mayo,&nbsp;Alicja Mortensen,&nbsp;Yrjö Henrik Roos,&nbsp;Marize L. M. Solano,&nbsp;Henk Van Loveren,&nbsp;Laurence Vernis,&nbsp;Cristina Andreoli,&nbsp;Andrea Terron,&nbsp;Andrey Yurkov,&nbsp;Simone Lunardi,&nbsp;Magdalena Andryszkiewicz,&nbsp;Ana Criado,&nbsp;Yi Liu,&nbsp;Irene Bonino","doi":"10.2903/j.efsa.2026.10341","DOIUrl":"10.2903/j.efsa.2026.10341","url":null,"abstract":"<p>The food enzyme phospholipase A₁ (phosphatidylcholine 1-acylhydrolase; EC 3.1.1.32) is produced with the non-genetically modified <i>Fusarium commune</i> strain LFC by DSM Food Specialties B.V. The food enzyme was considered free from viable cells of the production organism. It is intended to be used in two food manufacturing processes. Dietary exposure was estimated to be up to 0.432 mg total organic solids (TOS)/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1124 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 2601. A search for the homology of the amino acid sequence of the phospholipase A₁ to known allergens was made and no match was found. The Panel considered that a risk of allergic reactions upon dietary exposure cannot be excluded, but that the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peer review of the pesticide risk assessment of the active substance <i>Helicoverpa armigera</i> nucleopolyhedrovirus BV-0003.","authors":"Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Mariano Lopez Romano, Jochem Louisse, Christopher Lythgo, Iris Mangas, Silvia Mazzega, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar-Bouza, Adriana Scattareggia Marchese","doi":"10.2903/j.efsa.2026.10359","DOIUrl":"10.2903/j.efsa.2026.10359","url":null,"abstract":"<p><p>The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State Estonia and the co-rapporteur Member State France, for the pesticide active substance <i>Helicoverpa armigera</i> nucleopolyhedrovirus BV-0003 and the considerations as regards the inclusion of the substance in Annex IV of Regulation (EC) No 396/2005 are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012, as amended by Commission Implementing Regulation (EU) No 2018/1659. The conclusions were reached on the basis of the evaluation of the representative professional and non-professional uses of <i>Helicoverpa armigera</i> nucleopolyhedrovirus BV-0003 as an insecticide on maize, sweet corn and tomato. The reliable end points, appropriate for use in regulatory risk assessment are presented. Missing information identified as being required by the regulatory framework is listed.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 10","pages":"e10359"},"PeriodicalIF":3.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}