Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences最新文献_第10页

[A 13-week toxicity study of simultaneous administration of cochineal and aluminum potassium sulfate in rats]. [大鼠同时给药胭脂虫和硫酸铝钾13周毒性研究]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1994-01-01

Y Kawasaki, T Umemura, K Sai, R Hasegawa, J Momma, M Saitoh, Y Matsushima, Y Nakaji, M Tsuda, Y Kurokawa

{"title":"[A 13-week toxicity study of simultaneous administration of cochineal and aluminum potassium sulfate in rats].","authors":"Y Kawasaki, T Umemura, K Sai, R Hasegawa, J Momma, M Saitoh, Y Matsushima, Y Nakaji, M Tsuda, Y Kurokawa","doi":"","DOIUrl":"","url":null,"abstract":"Cochineal (C), a scarlet material extracted from the powdered pregnant insect, Dactylopius Coceus Costa, is used as a color food additive in the form of aluminum lakes. A 13 week subchronic toxicity study was conducted to investigate the effects of simultaneous administration of C and aluminum potassium sulfate (A). Male and female Wistar rats (5-weeks-old, 15 rats/group) were given diets containing 0.75%A and 0.75%C (1.5%AC), 1.5%A and 1.5%C (3%AC), 3%C alone or 3%A alone. The following results were obtained. 1) No toxic symptoms or death occurred in any treated group. Body weight gain in male rats of the 3%A group decreased significantly. 2) Serum levels of phospholipids, triglycerides (TG) and total cholesterol in male rats and TG in female rats fed 3%C, 3%A or 3%AC were significantly decreased at the 13th week. The serum level of glutamate dehydrogenase (GIDH) in male rats treated with 1.5% or 3%AC was increased at the 4th week but no difference from control was observed at the 13th week. 3) No histopathological changes attributable to A and/or C administration were observed. In this 13-week oral toxicity study, no dose-dependent synergistic effects of simultaneous administration of C and A were found except for an increase in serum GIDH.","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19822590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[13-week subchronic oral toxicity study of isopropyl p-hydroxybenzoate in F344 rats]. [对羟基苯甲酸异丙酯对F344大鼠13周亚慢性口服毒性研究]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1994-01-01

H Onodera, K Mitsumori, K Yasuhara, T Shimo, N Kurokawa, M Takahashi

{"title":"[13-week subchronic oral toxicity study of isopropyl p-hydroxybenzoate in F344 rats].","authors":"H Onodera, K Mitsumori, K Yasuhara, T Shimo, N Kurokawa, M Takahashi","doi":"","DOIUrl":"","url":null,"abstract":"A 13-week subchronic oral toxicity study of isopropyl p-hydroxybenzoate was performed in both sexes of F344 rats. CRF-1 diet containing 0, 0.25, 1.25, 2.5 or 5% isopropyl p-hydroxybenzoate was fed to 5 randomly constituted groups of animals, each consisting of 10 males and 10 females, to determine appropriate dose levels for a subsequent 2-year carcinogenicity study. No animals died during the administration period. Significant suppression of body weight gain was observed in males of the 2.5% and 5% isopropyl p-hydroxybenzoate groups, and in females of the groups treated with 1.25% or above as compared with the control group. Serum biochemistry evaluations revealed increases in gamma-GTP and total cholesterol in male groups treated with 2.5% or more and increases in gamma-GTP, ALP and BUN in female groups treated with 1.25% or more, as compared to the controls. Histopathologically, centrilobular hepatocellular swelling was observed in males treated with 2.5% or more and in females of the 5% group. In the affected populations, hepatocytes filled with small vacuoles, possibly of lipid native, were sometimes found. An increased severity of intracytoplasmic eosinophilic globule formation in the renal proximal tubular epithelia of males of the 5% group was noted. Based on these results, a dietary concentration of 1% in males or 0.5% in females was concluded to be a suitable maximum tolerable dose (MTD) of this chemical for a 2-year carcinogenicity study in rats.","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19822594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The Thiamine Hydrochloride Reference Standard (Control 931) of the National Institute of Health Sciences]. 国家卫生科学研究所盐酸硫胺素参考标准(Control 931)。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1994-01-01

A Kitajima, K Yoshii, H Komatsu, S Ishimitsu, S Okada

引用次数: 0

[The Testosterone Propionate Reference Standard (Control 881) of the National Institute of Health Sciences]. [国家卫生科学研究所丙酸睾酮参考标准(对照品881)]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1994-01-01

S Ishimitsu, A Kitajima, K Yoshii, H Komatsu, S Okada

引用次数: 0

[The current trend of the Pharmacopoeia of Japan]. 【日本药典的当前趋势】。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1994-01-01

M Uchiyama

引用次数: 0

[Comparison of several fluorescence HPLC methods for fumonisin analysis]. 几种荧光高效液相色谱法分析伏马菌素的比较

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1994-01-01

H Akiyama, M Miyahara, M Toyoda, Y Saito

引用次数: 0

[Analysis of chemically synthesized peptides by liquid secondary ion mass spectrometry (LSIMS)]. [液相二次离子质谱法(LSIMS)分析化学合成肽]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1994-01-01

T Yagami, M Sato, A Nakamura

{"title":"[Analysis of chemically synthesized peptides by liquid secondary ion mass spectrometry (LSIMS)].","authors":"T Yagami, M Sato, A Nakamura","doi":"","DOIUrl":"","url":null,"abstract":"Liquid secondary ion mass spectrometry (LSIMS) was proven to have advantage for analysis of chemically synthesized peptides. The molecular weights of large peptides were determined accurately, without difficulty in spite of only small sample quantities (50 pmol-10 nmol). This approach was also useful in comparing actual isotopic cluster-distribution of protonated molecular-ion with that derived theoretically for ascertaining peptide integrity. Sometimes LSIMS spectra showed abundant fragment ions from which partial peptide sequences were determinable and unexpected synthetic product could be easily identified from informative fragment ions in LSIMS spectra. The analytical procedure combining LSIMS and high performance liquid chromatography (HPLC) was very beneficial for detecting impurities having slight structural differences. Moreover, LSIMS proved excellent for use in analysis of tyrosine-O-sulfate [Tyr(SO3H)] containing peptides. Constant neutral loss (80 amu) spectra, measured in view of the specific fragmentation (-SO3), showed the complete sequence of a Tyr(SO3H) containing peptide. These results document the usefulness of LSIMS for analysis of peptide samples where difficulty is encountered in evaluation by traditional analytical methods.","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19821876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The Dexamethasone Reference Standard (Control 931) of the National Institute of Health Sciences]. [国家卫生科学研究所地塞米松参比标准(Control 931)]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1994-01-01

A Kitajima, K Yoshii, H Komatsu, S Ishimitsu, S Okada

引用次数: 0

[Studies on the stability of ferrous ion in the feeds added iron lactate during storage]. [添加乳酸铁饲料贮存期间亚铁离子稳定性的研究]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1994-01-01

Y Takeda, H Ishiwata, T Yamada

引用次数: 0

[Official inspection estimated production of coal-tar dyes (including dye aluminum lakes) in 1993-1994]. [官方检查估计1993-1994年煤焦油染料(包括染料铝湖)的产量]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1994-01-01

S Ishimitsu, M Kimura, M Umemoto, S Tsuji, T Shibata, Y Ito

引用次数: 0