Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences最新文献

{"title":"[Studies on compensation in medicinal plants. Compensative effects in leaves of Papaver somniferum L. on photosynthetic and transpiration rates].","authors":"O Iida,&nbsp;Y Hatakeyama","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To investigate compensative effects in leaves of Papaver somniferum L., the relation between photosynthetic rate and light density and leaf temperature, and the influences on photosynthetic and transpiration rates of removal of the three upper leaves were examined under field conditions. The light saturation point in leaves of P. somniferum was about 900 micro molm-2sec-1 and the photosynthetic rate at the light saturation point was about 13.5 micro molm-2sec-1 between 23 and 28 degrees C in leaf temperature. The light compensation point in leaves was nearly 50 micro molm-2sec-1. The influence of leaf temperature on photosynthetic rate was significant, so that the latter showed a remarkable decrease when the leaf temperature was above 30 degrees C. When the three upper leaves were removed, the photosynthetic and transpiration rates in the 4th leaf tended to increase as compared with control level, although the increases were not significant.</p>","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19822595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Determination of organochlorine and organophosphorus pesticide levels in imported beef].","authors":"S Takatsuki,&nbsp;S Nemoto,&nbsp;R Matsuda,&nbsp;K Sasaki,&nbsp;Y Saito","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A simple and efficient cleanup method was established for capillary gas chromatographic determination of 12 organochlorine and 11 organophosphorus pesticides in beef. Extracted fat was subjected to silica gel dry column chromatography and further cleaned up by Florisil minicolumn chromatography for organochlorine pesticide analysis, while partitioning between n-hexane and acetonitrile of the extract and silica gel minicolumn chromatography were employed for the analysis of organophosphorus pesticides. Several samples (imported Australian beef) were analyzed by the proposed method. DDT was detected in 14 (0.01-0.10 ppm). BHC was found in 11 (0.003-0.031 ppm) and dieldrin was demonstrated in 2 (0.004 and 0.008 ppm). Heptachlors and the 11 organophosphorus pesticides investigated were not detected in any of the meat samples.</p>","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19822597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Elcatonin Reference Standard (Control 921) of National Institute of Health Sciences].","authors":"S Okada,&nbsp;C Yomota,&nbsp;M Ema,&nbsp;Y Ogawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The raw material of elcatonin was examined for preparation of the \"Elcatonin Reference Standard\". The candidate material was evaluated by a domestic collaborative study in which five laboratories participated. The biological activity was determined to be 11.3 Unit/Amp. against the International Elcatonin Reference Standard (Code 84/614), based on one hour hypocalcaemia rat bioassay. In spite of the differences in rat strain, sex, administration method, dosage and assay method for serum calcium etc., the separately obtained biological activities for the candidate agreed closely with each other (95% confidence limits 11.08-11.53 Unit/Amp.). The physico-chemical evaluation of the candidate material was also performed, by using HPLC and amino acid chromatography. Based on the above results, this raw material was authorized to be the Elcatonin Reference Standard of the National Institute of Health Sciences.</p>","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19823158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Important points and references for the description of hazard information in MSDS].","authors":"M Yamamoto,&nbsp;T Kaminuma","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The preparation of MSDS (material safety data sheets) began in Japan in April 1993 with the notice of three Ministries, the Ministry of Health and Welfare, the Ministry of International Trade and Industry and the Ministry of Labor. MSDS are designed to provide chemical information to protect human health and the environment from chemical hazards. Important points in describing hazard information in MSDS are explained as well as references which are useful for preparation of MSDS. Problems for further discussion are also pointed out.</p>","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19821880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Hazard information for the preparation of material safety data sheets (MSDS). Ethylenethiourea].","authors":"M Yamamoto,&nbsp;Y Aida","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Information on ethylenethiourea (ETU) was collected to estimate the amount of actual intake into the body. Useful information such as physical properties, toxicological data and environmental data was selected and described for the preparation of material safety data sheets (MSDS).</p>","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19821882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The Human Insulin Reference Standard (Control 921) of the National Institute of Health Sciences].","authors":"C Yomota,&nbsp;M Ema,&nbsp;Y Ogawa,&nbsp;S Okada","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Raw human insulin material was examined for preparation of the \"Human Insulin Reference Standard\". The candidate material was evaluated by a domestic collaborative study in which four laboratories participated. The biological activity was determined to be 26.0 Unit/mg against the International Human Insulin Reference Standard (Code 83/500), based on the rabbit blood-glucose method specified in the JP XII (1991). Because of the possibility of application as a chemical reference standard for assay by the HPLC method, a physico-chemical evaluation of the candidate material was also performed. The total desamide form, dimer and oligomer impurities were estimated to be about 1% by HPLC. Based on the above findings, this raw material was authorized as the Human Insulin Reference Standard of the National Institute of Health Sciences.</p>","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19821884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Estradiol Reference Standard (Control 931) of National Institute of Health Sciences].","authors":"A Kitajima,&nbsp;K Yoshii,&nbsp;H Komatsu,&nbsp;S Ishimitsu,&nbsp;S Okada","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The raw material for estradiol was examined for preparation of the \"National Institute of Health Sciences (NIHS) Estradiol Reference Standard (Control 931)\". Analytical data obtained were as follows: melting point, 179.0 degrees C; infrared spectrum, the same as that of the present NIHS Estradiol Reference Standard; optical rotation, -alpha-20D = +80.4 degrees; thin-layer chromatography, no impurity was detected; high-performance liquid chromatography (HPLC), a trace amount of two impurities were detected; loss on drying, 0.24%; assay, 100.4% by UV spectrophotometry and 101.2% by HPLC. Based on the above results, the raw material was authorized as the NIHS Estradiol Reference Standard (Control 931).</p>","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19823162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The Cyclandelate Reference Standard (Control 931) of the National Institute of Health Sciences].","authors":"A Kitajima,&nbsp;K Yoshii,&nbsp;H Komatsu,&nbsp;S Ishimitsu,&nbsp;S Okada","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Raw cyclandelate material was tested for preparation of the \"Cyclandelate Reference Standard (Control 931)\". Analytical data obtained were as follows: melting point, 57.4 degrees C; ultraviolet spectrum, lambdamax = 252.0, 258.1 and 264.1 nm and E 1cm 1% = 5.85 (252.0 nm), 6.95 (258.1 nm), 5.30 (264.1 nm), respectively; infrared spectrum, the same as that of the JP Cyclandelate Reference Standard; thin-layer chromatography, no impurities were detected up to 1000 micro g; high-performance liquid chromatography (HPLC), no impurities were detected; loss on drying, 0.03%; assay result, 101.4% by HPLC. Based on the above findings, the raw material was authorized as the JP Cyclandelate Reference Standard (Control 931).</p>","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19823164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[New regulation of tap water quality and exposure assessment].","authors":"M Ando","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recently, social concerns regarding tap water quality have increased, mainly because of the possible reduction in safety due to contamination of tap water by various chemicals and more frequent occurrence of the strange odors and tastes in as a result of resource water eutrophication. Consequently, the Ministry of Health and Welfare conducted a detailed two-year investigation of the Water Quality Standards of the Water Works Law by summoning an expert committee, and as a result, totally revised the Standards in December 1992. This was the first overall revision since 1958 when the Water Quality Standards were established, and an additional 21 items, including mainly hazardous chemicals including pesticides and chlorinated by-products, were newly added. Values and testing methods are now listed for 46 items, and the Law obliges every water supply to conduct periodical water testing for the necessary items almost every month with ad-hoc testing, as required of hydrants. Simultaneously, 26 monitoring items are listed in hazardous contaminants guidelines which should be checked, when necessary. The new Water Quality Standards and the guidelines were brought into force in December 1993, and the quality of all parts of the water supply is now tested in accordance. Risk assessment is a scientific process that includes some form of measurement as one of its central elements. In many cases, the measured parameter is the level of exposure to a hazard. Also, measurements are essential in establishing the quantitative relationship between exposure and response, and in determining natural baseline conditions in the environment. Exposure assessment is the process of measuring or estimating the intensity, frequency, and duration of human or other population exposures to risk agents. Exposures may occur in a variety of ways, such as through ingestion, dermal contact, or inhalation. For many risk assessments, exposure assessment is the most difficult task. The reason for this is that exposure assessment often depends on factors that are hard to estimate and for which there are few data. Critical information on the conditions of exposure is often lacking. To be comprehensive, an exposure assessment must describe the levels of exposure and all conditions that might be needed to assess the effects of such exposures, including their magnitude, duration, schedule, and route. This report presents the various problems covered in exposure assessment relevant to monitoring, testing, and methodology.</p>","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19823342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of a bacterial endotoxin test for parenteral drugs].","authors":"Y Ogawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The Limulus test, which has been adopted as the Test for Bacterial Endotoxins in the JP XII, can detect or quantitate endotoxins of Gram-negative bacterial origin using blood corpuscle extracts (Limulus amebocyte lysate, LAL) of horseshoe crabs (Limulus polyphemus, Tachypleus tridentatus, etc.). It may be conducted by the gel-clot or spectrophotometric (turbidimetric and colorimetric) techniques, the former being based on gel formation due to the activation of LAL by endotoxins. The turbidimetric technique is based on the LAL turbidity change during the gel formation and the colorimetric technique on activation of peptide hydrolytic enzymes in LAL. The Limulus test has been unofficially utilized as a simple and highly sensitive method for the determination of endotoxins in parenteral drugs in lieu of the in vivo Pyrogen Test using rabbits. For the Bacterial Endotoxins Test of the JP XII, the gel-clot technique alone was adopted, the technique being only allowed for Injection. Although most parenteral drugs show inhibition or enhancement in practice, this test can be most easily conducted by eliminating interfering effects through dilution of specimens by a factor not exceeding the maximum valid dilution (MVD) with water. Since MVD is dependent on the sensitivity of applied methodology, the turbidimetric and colorimetric techniques, which are more sensitive than the gel-clot technique, have a distinct advantage. The JP, as the leading Pharmacopoeia for the international harmonization of Bacterial Endotoxins Testing, has presented a \"Draft towards International Harmonization of Bacterial Endotoxins Test\", whose main purpose is the introduction of supplementary turbidimetric and colorimetric techniques. Under these circumstances the following subjects are discussed: (1) the proposal that, with a view towards international harmonization of the technical requirements of Pharmacopoeias, both the turbidimetric and colorimetic techniques should be included together with the gel-clot technique, (2) the differences in the testing principles and/or conditions prescribed in the current Bacterial Endotoxins Test of JP, USP and EP, and (3) the worldwide situation for Endotoxin Reference Standards.</p>","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19822398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}