Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences最新文献_第9页

[Studies on the stability of ferrous ion in the feeds added iron lactate during storage]. [添加乳酸铁饲料贮存期间亚铁离子稳定性的研究]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1994-01-01

Y Takeda, H Ishiwata, T Yamada

引用次数: 0

[Official inspection estimated production of coal-tar dyes (including dye aluminum lakes) in 1993-1994]. [官方检查估计1993-1994年煤焦油染料(包括染料铝湖)的产量]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1994-01-01

S Ishimitsu, M Kimura, M Umemoto, S Tsuji, T Shibata, Y Ito

引用次数: 0

[Subchronic toxicity study of liquid paraffin in F344 rats]. [液体石蜡对F344大鼠亚慢性毒性研究]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1994-01-01

K Toyoda, T Kawanishi, C Uneyama, M Takahashi

引用次数: 0

[Studies on the identification of sulfadimidine in pork by high performance liquid chromatography with photodiode array detector and gas chromatograph-mass spectrometry]. [光电二极管阵列高效液相色谱-气相色谱-质谱联用技术鉴别猪肉中磺胺的研究]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1993-01-01

K Kamakura, M Hasegawa, S Koiguchi, M Miyata, K Okamoto, M Narita, Y Hirahara, T Yamana, Y Tonogai, Y Ito

引用次数: 0

[Elution of lead and cadmium from imported gold-decorated glassware]. [进口镀金玻璃器皿中铅和镉的洗脱]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1993-01-01

T Hosogai, S Ito, H Sakurai, Y Tada, Y Satou, Y Shiomi, M Takeda, H Ishiwata, T Sugita, T Yamada

引用次数: 0

[Evaluation of immunotoxicity tests using cyclosporin A-treated rats: the International Collaborative Immunotoxicity Study II (cyclosporin A)]. [使用环孢素A治疗的大鼠进行免疫毒性试验的评价:国际合作免疫毒性研究II(环孢素A)]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1993-01-01

T Ochiai, K Naito, O Murakami, K Ohno, K Sekita, T Furuya, Y Kurokawa, K Matsumoto, Y Saito, A Hachisuka

{"title":"[Evaluation of immunotoxicity tests using cyclosporin A-treated rats: the International Collaborative Immunotoxicity Study II (cyclosporin A)].","authors":"T Ochiai, K Naito, O Murakami, K Ohno, K Sekita, T Furuya, Y Kurokawa, K Matsumoto, Y Saito, A Hachisuka","doi":"","DOIUrl":"","url":null,"abstract":"Immunotoxicological effects of cyclosporin A (CsA) were studied by enhanced histopathological and functional tests in rats. Male F344 rats were orally administered with CsA in doses of 0, 2.5, 10, and 40 mg/kg/day for 28 successive days. Hematological examination revealed that the CsA treatment brought about a marked dose-dependent decrease in the number of WBCs, which was attributed to a decrease in the number of lymphocytes. In the femoral bone marrow, a significant reduction in the number of nucleated cells was observed, which was attributed to a decrease in the number of lymphocytes and erythroblasts. Histopathologically, diminution of thymic medullas, appearance of tangible body macrophages in thymic cortices, and calcification and basophilic changes in kidneys were observed in the middle and high dose groups. Immunohistological examination with anti-rat T lymphocyte antibody showed a decrease in the number of T cells at the periarterial lymphatic sheaths in the spleens. As for the functional tests, CsA treatment remarkably reduced the PFC number even in the low dose group. The Con A response of spleen cells was decreased in the middle and high dose groups. The STM response was reduced only in the high dose group. The NK activity was little affected. Thus, in the CsA-treated F344 rats, the enhanced histopathological and some functional tests which were proposed by ICICIS, were found to be useful to detect damages to the immune system.","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":" 111","pages":"91-9"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18917225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Scientific basis in the setting of residue limits for veterinary drugs in food of animal origin taking into account the presence of their metabolites]. [考虑到动物源性食品中兽药代谢产物的存在，制定兽药残留限量的科学依据]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1993-01-01

K Mitsumori

{"title":"[Scientific basis in the setting of residue limits for veterinary drugs in food of animal origin taking into account the presence of their metabolites].","authors":"K Mitsumori","doi":"","DOIUrl":"","url":null,"abstract":"Maximum residue level (MRL) for veterinary drugs in food of animal origin has been proposed by FAO/WHO, as a new evaluation procedure taking into account the presence of metabolites for the regulation of veterinary drug residues. The MRL is the maximum concentration of residue resulting from the use of a veterinary drug that is recommended to be legally permitted as acceptable in a food. It is established from the Acceptable Daily Intake (ADI) obtained from the data of toxicological studies, the residue concentration of the drug when used according to good practice in the use of veterinary drugs, and the lowest level consistent with the practical analytical methods available for routine residue analysis. Among the veterinary drugs, some chemicals contain a large amount of bound residues that are neither extractable from tissues by the analytical method identical with that used in parent chemicals. Especially, the bioavailable residues which are probably absorbed when the food is ingested are of great toxicological concern. In this case, the FAO/WHO recommends that the MRL can be established after the calculation of daily intake of residues of toxicological concern by the addition of both the extractable and bioavailable bound residues.","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":" 111","pages":"148-9"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18919240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Dermatological evaluation of a flame retardant, hexabromocyclododecane (HBCD) on guinea pig by using the primary irritation, sensitization, phototoxicity and photosensitization of skin]. [六溴环十二烷(HBCD)阻燃剂对豚鼠皮肤的主要刺激、致敏、光毒性和光敏的皮肤学评价]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1993-01-01

J Momma, M Kaniwa, H Sekiguchi, K Ohno, Y Kawasaki, M Tsuda, A Nakamura, Y Kurokawa

{"title":"[Dermatological evaluation of a flame retardant, hexabromocyclododecane (HBCD) on guinea pig by using the primary irritation, sensitization, phototoxicity and photosensitization of skin].","authors":"J Momma, M Kaniwa, H Sekiguchi, K Ohno, Y Kawasaki, M Tsuda, A Nakamura, Y Kurokawa","doi":"","DOIUrl":"","url":null,"abstract":"As one of the projects in the safety evaluation of chemical constituents in common house-hold products, effects of hexabromocyclododecane (HBCD) were evaluated by primary skin irritation, skin sensitization, phototoxicity and photosensitization using guinea pigs. Primary skin irritation was not observed in HBCD emulsified in distilled water by the Draize test method. Skin sensitization test was carried out according to the maximization test method of Magnusson and Kligman. For this test, HBCD was dissolved in olive oil to give 5, 0.5 and 0.05%. When induction of sensitization occurred, challenged doses of 0.005, 0.05, 0.5 and 5% of HBCD (dissolved in acetone) were applied to its respective sensitized groups. The results showed that the induction dose of greater than 0.5% and the challenge dose of greater than 0.05% elicited a positive response. The increase in the concentration of induction and challenge doses did not further increase the percentage of positive response or the intensity of skin response. Phototoxicity test was carried out with 0, 0.5 and 5% of HBCD dissolved in acetone. Phototoxicity was not observed at all HBCD concentration tested. Photosensitization test was performed according to the Sato's adjuvant-strip method. The skin sensitization and challenge reaction doses were 5 and 0.5% and 0 and 0.5% HBCD (dissolved in acetone), respectively, and no positive reaction was observed. It is clear from the foregoing results that HBCD is a mild skin allergen.","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":" 111","pages":"18-24"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18919242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Studies on the identification of psychotropic substances. IX. Preparation and various analytical data of reference standard of new psychotropic substances, N-ethyl methylenedioxyamphetamine, N-hydroxy methylenedioxyamphetamine, mecloqualone, 4-methylaminorex, phendimetrazine and phenmetrazine]. 精神药物鉴定研究。9精神药物新物质n -乙基亚甲二氧苯丙胺、n -羟基亚甲二氧苯丙胺、甲氯喹酮、4-甲基氨基苯胺、苯地美trazine、苯美trazine参考标准的制备及各项分析数据

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1993-01-01

M Shimamine, K Takahashi, Y Nakahara

引用次数: 0

[Colorimetric determination of the total protein eluted from latex gloves]. 【乳胶手套洗脱总蛋白的比色法测定】。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1993-01-01

T Yagami, M Sato, A Nakamura

{"title":"[Colorimetric determination of the total protein eluted from latex gloves].","authors":"T Yagami, M Sato, A Nakamura","doi":"","DOIUrl":"","url":null,"abstract":"Recently type I hypersensitivity reactions caused by latex gloves have been reported. The protein from latex gloves is considered to be responsible for this allergy. We investigated the extraction conditions and the assay methods for the purpose of the colorimetric determination of the total protein eluted from latex gloves. In a series of experiments, it was demonstrated that elution of the protein was very rapid, and changes of the extraction buffer volume (1.7-20 ml/g) had no appreciable effect on the extraction efficiency. Moreover, comparison experiments of the four assay methods revealed that Ninhydrin method was significantly interfered by low molecular weight substances other than protein and that Bradford method suffered from the poor reproducibility. On the other hand, Lowry method and Bicinchoninic acid (BCA) method gave relatively good results. Based on these experimental results, we established a typical procedure for quantitative analysis of the total protein as follows. Two grams of latex gloves specimens are extracted with 10 ml portions of phosphate buffered saline pH 7.4 (PBS) at room temperature for two hours, and then the resulting solution is assayed by BCA method. According to this procedure, commercially available ten kinds of latex gloves were analyzed. We found that the amount of the extractable protein was considerably varied with the products.","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":" 111","pages":"84-7"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18917223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0