[A 13-week toxicity study of simultaneous administration of cochineal and aluminum potassium sulfate in rats].

Y Kawasaki, T Umemura, K Sai, R Hasegawa, J Momma, M Saitoh, Y Matsushima, Y Nakaji, M Tsuda, Y Kurokawa
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Abstract

Cochineal (C), a scarlet material extracted from the powdered pregnant insect, Dactylopius Coceus Costa, is used as a color food additive in the form of aluminum lakes. A 13 week subchronic toxicity study was conducted to investigate the effects of simultaneous administration of C and aluminum potassium sulfate (A). Male and female Wistar rats (5-weeks-old, 15 rats/group) were given diets containing 0.75%A and 0.75%C (1.5%AC), 1.5%A and 1.5%C (3%AC), 3%C alone or 3%A alone. The following results were obtained. 1) No toxic symptoms or death occurred in any treated group. Body weight gain in male rats of the 3%A group decreased significantly. 2) Serum levels of phospholipids, triglycerides (TG) and total cholesterol in male rats and TG in female rats fed 3%C, 3%A or 3%AC were significantly decreased at the 13th week. The serum level of glutamate dehydrogenase (GIDH) in male rats treated with 1.5% or 3%AC was increased at the 4th week but no difference from control was observed at the 13th week. 3) No histopathological changes attributable to A and/or C administration were observed. In this 13-week oral toxicity study, no dose-dependent synergistic effects of simultaneous administration of C and A were found except for an increase in serum GIDH.

[大鼠同时给药胭脂虫和硫酸铝钾13周毒性研究]。
胭脂虫属(C)是一种从粉状怀孕昆虫中提取的猩红色物质,以铝湖的形式用作彩色食品添加剂。以5周龄Wistar大鼠为研究对象,分别饲喂含0.75%A和0.75%C (1.5%AC)、1.5%A和1.5%C (3%AC)、3%C单用或3%A单用的饲粮,研究C和硫酸铝钾(A)同时给药13周的亚慢性毒性作用。得到了以下结果:1)所有治疗组均未出现中毒症状或死亡。3%A组雄性大鼠体增重明显下降。2)饲喂3%C、3%A、3%AC的雄性大鼠血清磷脂、甘油三酯(TG)、总胆固醇水平和雌性大鼠血清TG水平在第13周显著降低。1.5%或3%AC处理的雄性大鼠血清谷氨酸脱氢酶(GIDH)水平在第4周升高,但在第13周与对照组无差异。3)未观察到A和/或C给药引起的组织病理学改变。在这项为期13周的口服毒性研究中,除了血清GIDH升高外,未发现同时给药C和A的剂量依赖性协同效应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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