eLife最新文献_第7页

Stopping runaway seizures with a chill pill. 用一片镇定剂阻止失控的癫痫发作

IF 6.4 1区生物学

eLife Pub Date : 2024-09-05 DOI: 10.7554/eLife.102055

Gordon F Buchanan

引用次数: 0

Circular RNA HMGCS1 sponges MIR4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction 环状 RNA HMGCS1 海绵状 MIR4521 加剧 2 型糖尿病诱导的血管内皮功能障碍

IF 7.7 1区生物学

eLife Pub Date : 2024-09-05 DOI: https://doi.org/10.7554/elife.97267.3

Ming Zhang, Guangyi Du, Lianghua Xie, Yang Xu, Wei Chen

{"title":"Circular RNA HMGCS1 sponges MIR4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction","authors":"Ming Zhang, Guangyi Du, Lianghua Xie, Yang Xu, Wei Chen","doi":"https://doi.org/10.7554/elife.97267.3","DOIUrl":"https://doi.org/https://doi.org/10.7554/elife.97267.3","url":null,"abstract":"Noncoding RNA plays a pivotal role as novel regulators of endothelial cell function. Type 2 diabetes, acknowledged as a primary contributor to cardiovascular diseases, plays a vital role in vascular endothelial cell dysfunction due to induced abnormalities of glucolipid metabolism and oxidative stress. In this study, aberrant expression levels of circHMGCS1 and MIR4521 were observed in diabetes-induced human umbilical vein endothelial cell dysfunction. Persistent inhibition of MIR4521 accelerated development and exacerbated vascular endothelial dysfunction in diabetic mice. Mechanistically, circHMGCS1 upregulated arginase 1 by sponging MIR4521, leading to decrease in vascular nitric oxide secretion and inhibition of endothelial nitric oxide synthase activity, and an increase in the expression of adhesion molecules and generation of cellular reactive oxygen species, reduced vasodilation and accelerated the impairment of vascular endothelial function. Collectively, these findings illuminate the physiological role and interacting mechanisms of circHMGCS1 and MIR4521 in diabetes-induced cardiovascular diseases, suggesting that modulating the expression of circHMGCS1 and MIR4521 could serve as a potential strategy to prevent diabetes-associated cardiovascular diseases. Furthermore, our findings provide a novel technical avenue for unraveling ncRNAs regulatory roles of ncRNAs in diabetes and its associated complications.","PeriodicalId":11640,"journal":{"name":"eLife","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Female-dominated disciplines have lower evaluated research quality and funding success rates, for men and women 女性占主导地位的学科，无论男女，其评估研究质量和资助成功率都较低

IF 7.7 1区生物学

eLife Pub Date : 2024-09-05 DOI: https://doi.org/10.7554/elife.97613.3

Alex James, Franca Buelow, Liam Gibson, Ann Brower

引用次数: 0

Female-dominated disciplines have lower evaluated research quality and funding success rates, for men and women. 女性占主导地位的学科，无论男性还是女性，其评估研究质量和资助成功率都较低。

IF 6.4 1区生物学

eLife Pub Date : 2024-09-05 DOI: 10.7554/eLife.97613

Alex James, Franca Buelow, Liam Gibson, Ann Brower

引用次数: 0

Identification of novel myelodysplastic syndromes prognostic subgroups by integration of inflammation, cell-type composition, and immune signatures in the bone marrow. 通过整合骨髓中的炎症、细胞类型组成和免疫特征，识别新型骨髓增生异常综合征预后亚组。

IF 6.4 1区生物学

eLife Pub Date : 2024-09-05 DOI: 10.7554/eLife.97096

Sila Gerlevik, Nogayhan Seymen, Shan Hama, Warisha Mumtaz, I Richard Thompson, Seyed R Jalili, Deniz E Kaya, Alfredo Iacoangeli, Andrea Pellagatti, Jacqueline Boultwood, Giorgio Napolitani, Ghulam J Mufti, Mohammad M Karimi

{"title":"Identification of novel myelodysplastic syndromes prognostic subgroups by integration of inflammation, cell-type composition, and immune signatures in the bone marrow.","authors":"Sila Gerlevik, Nogayhan Seymen, Shan Hama, Warisha Mumtaz, I Richard Thompson, Seyed R Jalili, Deniz E Kaya, Alfredo Iacoangeli, Andrea Pellagatti, Jacqueline Boultwood, Giorgio Napolitani, Ghulam J Mufti, Mohammad M Karimi","doi":"10.7554/eLife.97096","DOIUrl":"10.7554/eLife.97096","url":null,"abstract":"Mutational profiles of myelodysplastic syndromes (MDS) have established that a relatively small number of genetic aberrations, including SF3B1 and SRSF2 spliceosome mutations, lead to specific phenotypes and prognostic subgrouping. We performed a multi-omics factor analysis (MOFA) on two published MDS cohorts of bone marrow mononuclear cells (BMMNCs) and CD34 + cells with three data modalities (clinical, genotype, and transcriptomics). Seven different views, including immune profile, inflammation/aging, retrotransposon (RTE) expression, and cell-type composition, were derived from these modalities to identify the latent factors with significant impact on MDS prognosis. SF3B1 was the only mutation among 13 mutations in the BMMNC cohort, indicating a significant association with high inflammation. This trend was also observed to a lesser extent in the CD34 + cohort. Interestingly, the MOFA factor representing the inflammation shows a good prognosis for MDS patients with high inflammation. In contrast, SRSF2 mutant cases show a granulocyte-monocyte progenitor (GMP) pattern and high levels of senescence, immunosenescence, and malignant myeloid cells, consistent with their poor prognosis. Furthermore, MOFA identified RTE expression as a risk factor for MDS. This work elucidates the efficacy of our integrative approach to assess the MDS risk that goes beyond all the scoring systems described thus far for MDS.","PeriodicalId":11640,"journal":{"name":"eLife","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use. 从青春期到成年期，持续注意力的强大大脑网络可预测日后的药物使用情况。

IF 6.4 1区生物学

eLife Pub Date : 2024-09-05 DOI: 10.7554/eLife.97150

Yihe Weng, Johann Kruschwitz, Laura M Rueda-Delgado, Kathy L Ruddy, Rory Boyle, Luisa Franzen, Emin Serin, Tochukwu Nweze, Jamie Hanson, Alannah Smyth, Tom Farnan, Tobias Banaschewski, Arun L W Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny A Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Jane McGrath, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Nathalie Holz, Juliane Fröhner, Michael N Smolka, Nilakshi Vaidya, Gunter Schumann, Henrik Walter, Robert Whelan

{"title":"A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use.","authors":"Yihe Weng, Johann Kruschwitz, Laura M Rueda-Delgado, Kathy L Ruddy, Rory Boyle, Luisa Franzen, Emin Serin, Tochukwu Nweze, Jamie Hanson, Alannah Smyth, Tom Farnan, Tobias Banaschewski, Arun L W Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny A Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Jane McGrath, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Nathalie Holz, Juliane Fröhner, Michael N Smolka, Nilakshi Vaidya, Gunter Schumann, Henrik Walter, Robert Whelan","doi":"10.7554/eLife.97150","DOIUrl":"10.7554/eLife.97150","url":null,"abstract":"Substance use, including cigarettes and cannabis, is associated with poorer sustained attention in late adolescence and early adulthood. Previous studies were predominantly cross-sectional or under-powered and could not indicate if impairment in sustained attention was a predictor of substance use or a marker of the inclination to engage in such behavior. This study explored the relationship between sustained attention and substance use across a longitudinal span from ages 14 to 23 in over 1000 participants. Behaviors and brain connectivity associated with diminished sustained attention at age 14 predicted subsequent increases in cannabis and cigarette smoking, establishing sustained attention as a robust biomarker for vulnerability to substance use. Individual differences in network strength relevant to sustained attention were preserved across developmental stages and sustained attention networks generalized to participants in an external dataset. In summary, brain networks of sustained attention are robust, consistent, and able to predict aspects of later substance use.","PeriodicalId":11640,"journal":{"name":"eLife","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circular RNA HMGCS1 sponges MIR4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction. 环状 RNA HMGCS1 可吸附 MIR4521，从而加剧 2 型糖尿病诱发的血管内皮功能障碍。

IF 6.4 1区生物学

eLife Pub Date : 2024-09-05 DOI: 10.7554/eLife.97267

Ming Zhang, Guangyi Du, Lianghua Xie, Yang Xu, Wei Chen

{"title":"Circular RNA HMGCS1 sponges MIR4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction.","authors":"Ming Zhang, Guangyi Du, Lianghua Xie, Yang Xu, Wei Chen","doi":"10.7554/eLife.97267","DOIUrl":"10.7554/eLife.97267","url":null,"abstract":"Noncoding RNA plays a pivotal role as novel regulators of endothelial cell function. Type 2 diabetes, acknowledged as a primary contributor to cardiovascular diseases, plays a vital role in vascular endothelial cell dysfunction due to induced abnormalities of glucolipid metabolism and oxidative stress. In this study, aberrant expression levels of circHMGCS1 and MIR4521 were observed in diabetes-induced human umbilical vein endothelial cell dysfunction. Persistent inhibition of MIR4521 accelerated development and exacerbated vascular endothelial dysfunction in diabetic mice. Mechanistically, circHMGCS1 upregulated arginase 1 by sponging MIR4521, leading to decrease in vascular nitric oxide secretion and inhibition of endothelial nitric oxide synthase activity, and an increase in the expression of adhesion molecules and generation of cellular reactive oxygen species, reduced vasodilation and accelerated the impairment of vascular endothelial function. Collectively, these findings illuminate the physiological role and interacting mechanisms of circHMGCS1 and MIR4521 in diabetes-induced cardiovascular diseases, suggesting that modulating the expression of circHMGCS1 and MIR4521 could serve as a potential strategy to prevent diabetes-associated cardiovascular diseases. Furthermore, our findings provide a novel technical avenue for unraveling ncRNAs regulatory roles of ncRNAs in diabetes and its associated complications.","PeriodicalId":11640,"journal":{"name":"eLife","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UPR^ER-immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food. UPRER- 免疫轴是一种生理性食物评估系统，可促进对劣质食物的厌恶行为。

IF 6.4 1区生物学

eLife Pub Date : 2024-09-05 DOI: 10.7554/eLife.94181

Pengfei Liu, Xinyi Liu, Bin Qi

{"title":"UPRER-immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food.","authors":"Pengfei Liu, Xinyi Liu, Bin Qi","doi":"10.7554/eLife.94181","DOIUrl":"10.7554/eLife.94181","url":null,"abstract":"To survive in challenging environments, animals must develop a system to assess food quality and adjust their feeding behavior accordingly. However, the mechanisms that regulate this chronic physiological food evaluation system, which monitors specific nutrients from ingested food and influences food-response behavior, are still not fully understood. Here, we established a low-quality food evaluation assay system and found that heat-killed E. coli (HK-E. coli), a low-sugar food, triggers cellular UPRER and immune response. This encourages animals to avoid low-quality food. The physiological system for evaluating low-quality food depends on the UPRER (IRE-1/XBP-1) - Innate immunity (PMK-1/p38 MAPK) axis, particularly its neuronal function, which subsequently regulates feeding behaviors. Moreover, animals can adapt to a low-quality food environment through sugar supplementation, which inhibits the UPRER -PMK-1 regulated stress response by increasing vitamin C biosynthesis. This study reveals the role of the cellular stress response pathway as physiological food evaluation system for assessing nutritional deficiencies in food, thereby enhancing survival in natural environments.","PeriodicalId":11640,"journal":{"name":"eLife","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UPRER–immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food UPRER 免疫轴是一种生理性食物评估系统，可促进对劣质食物的厌恶行为

IF 7.7 1区生物学

eLife Pub Date : 2024-09-05 DOI: https://doi.org/10.7554/elife.94181.3

Pengfei Liu, Xinyi Liu, Bin Qi

{"title":"UPRER–immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food","authors":"Pengfei Liu, Xinyi Liu, Bin Qi","doi":"https://doi.org/10.7554/elife.94181.3","DOIUrl":"https://doi.org/https://doi.org/10.7554/elife.94181.3","url":null,"abstract":"To survive in challenging environments, animals must develop a system to assess food quality and adjust their feeding behavior accordingly. However, the mechanisms that regulate this chronic physiological food evaluation system, which monitors specific nutrients from ingested food and influences food-response behavior, are still not fully understood. Here, we established a low-quality food evaluation assay system and found that heat-killed E. coli (HK-E. coli), a low-sugar food, triggers cellular UPRER and immune response. This encourages animals to avoid low-quality food. The physiological system for evaluating low-quality food depends on the UPRER (IRE-1/XBP-1) - Innate immunity (PMK-1/p38 MAPK) axis, particularly its neuronal function, which subsequently regulates feeding behaviors. Moreover, animals can adapt to a low-quality food environment through sugar supplementation, which inhibits the UPRER -PMK-1 regulated stress response by increasing vitamin C biosynthesis. This study reveals the role of the cellular stress response pathway as physiological food evaluation system for assessing nutritional deficiencies in food, thereby enhancing survival in natural environments.","PeriodicalId":11640,"journal":{"name":"eLife","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stopping runaway seizures with a chill pill 用一片感冒药阻止失控的癫痫发作

IF 7.7 1区生物学

eLife Pub Date : 2024-09-05 DOI: https://doi.org/10.7554/elife.102055

Gordon F Buchanan

引用次数: 0