IF 6.4 1区生物学

eLife Pub Date : 2025-09-23 DOI: 10.7554/eLife.108292

J Luke Woodward, Jeffrey Matthew, Rutuparna Joshi, Vishakha Vishwakarma, Ying Xiao, SeYeon Chung

{"title":"Sulfation affects apical extracellular matrix organization during development of the Drosophila embryonic salivary gland tube.","authors":"J Luke Woodward, Jeffrey Matthew, Rutuparna Joshi, Vishakha Vishwakarma, Ying Xiao, SeYeon Chung","doi":"10.7554/eLife.108292","DOIUrl":"10.7554/eLife.108292","url":null,"abstract":"The apical extracellular matrix (aECM) plays a critical role in epithelial tube morphogenesis during organ formation, but its composition and organization remain poorly understood. Using the Drosophila embryonic salivary gland (SG) as a model, we identify Papss, an enzyme that synthesizes the universal sulfate donor PAPS, as a critical regulator of tube lumen expansion. Papss mutants show a disorganized apical membrane, condensed aECM, and disruptions in Golgi structures and intracellular trafficking. SG-specific expression of wild-type Papss, but not the catalytically inactive form, rescues the defects in Papss mutants, suggesting that defects in sulfation are the underlying cause of the phenotypes. Additionally, we identify two zona pellucida (ZP) domain proteins, Piopio (Pio), and Dumpy (Dpy), as key components of the SG aECM. In the absence of Papss, Pio is gradually lost in the aECM, while the Dpy-positive aECM structure is condensed and dissociates from the apical membrane, leading to a thin lumen. Mutations in dpy or pio, or in Notopleural, which encodes a matriptase that cleaves Pio to form the luminal Pio pool, result in a SG lumen with alternating bulges and constrictions, with the loss of pio leading to the loss of Dpy in the lumen. Our findings underscore the essential role of sulfation in organizing the aECM during tubular organ formation and highlight the mechanical support provided by ZP domain proteins in maintaining luminal diameter.","PeriodicalId":11640,"journal":{"name":"eLife","volume":"14 ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hierarchical encoding of natural sound mixtures in ferret auditory cortex. 雪貂听觉皮层自然声音混合的层次编码。

IF 6.4 1区生物学

eLife Pub Date : 2025-09-23 DOI: 10.7554/eLife.106628

Agnès Landemard, Célian Bimbard, Yves Boubenec

{"title":"Hierarchical encoding of natural sound mixtures in ferret auditory cortex.","authors":"Agnès Landemard, Célian Bimbard, Yves Boubenec","doi":"10.7554/eLife.106628","DOIUrl":"10.7554/eLife.106628","url":null,"abstract":"Extracting relevant auditory signals from complex natural scenes is a fundamental challenge for the auditory system. Sounds from multiple sources overlap in time and frequency. In particular, dynamic 'foreground' sounds are often masked by more stationary 'background' sounds. Human auditory cortex exhibits a hierarchical organization where background-invariant representations are progressively enhanced along the processing stream, from primary to non-primary regions. However, we do not know whether this organizational principle is conserved across species and which neural mechanisms drive this invariance. To address these questions, we investigated background invariance in ferret auditory cortex using functional ultrasound imaging, which enables large-scale, high-resolution recordings of hemodynamic responses. We measured responses across primary, secondary, and tertiary auditory cortical regions as ferrets passively listened to mixtures of natural sounds and their components in isolation. We found a hierarchical gradient of background invariance, mirroring findings in humans: responses in primary auditory cortex reflected contributions from both foreground and background sounds, while background invariance increased in higher-order auditory regions. Using a spectrotemporal filter-bank model, we found that in ferrets this hierarchical structure could be largely explained by tuning to low-order acoustic features. However, this model failed to fully account for background invariance in human non-primary auditory cortex, suggesting that additional, higher-order mechanisms are crucial for background segregation in humans.","PeriodicalId":11640,"journal":{"name":"eLife","volume":"14 ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiphase separation in postsynaptic density regulated by membrane geometry via interaction valency and volume. 多相分离突触后密度由膜几何通过相互作用价和体积调节。

IF 6.4 1区生物学

eLife Pub Date : 2025-09-23 DOI: 10.7554/eLife.106602

Risa Yamada, Giovanni B Brandani, Shoji Takada

{"title":"Multiphase separation in postsynaptic density regulated by membrane geometry via interaction valency and volume.","authors":"Risa Yamada, Giovanni B Brandani, Shoji Takada","doi":"10.7554/eLife.106602","DOIUrl":"10.7554/eLife.106602","url":null,"abstract":"Biomolecular condensates are found at various cellular locations, nucleus, cytoplasm, and membrane. These condensates often contain multiple components and can separate into multiple phases with various morphologies such as core-shell droplets, implicating functional roles. Demixing and arrangements of condensates are determined by competitive interactions and their locations. Recent studies reported a puzzling multiphase morphology in postsynaptic density components: AMPA receptor, NMDA receptor, PSD-95, and CaMKII. The multiphase morphology appears reversed when transitioning from the solution to the membrane. Using this system as a model, we study the multiphase behavior of condensates in solution (3D) and domain formation on and beneath the membrane (2D) and elucidate molecular mechanisms behind the puzzle. Our simulations reproduce the core-shell structure in 3D in vitro solution, where AMPA-receptor/PSD-95 form the core and NMDA-receptor/CaMKII form the shell, triggered by CaMKII activation. Then, we obtain a reversed morphology on the membrane. This reversal is primarily driven by CaMKII's high valency and large volume. We find that, in solution, CaMKII's non-specific volume interaction dominates, while on the membrane, specific multivalent interactions overcome the excluded volume interaction of CaMKII. The layered structures of receptors and CaMKIIs reduce the excluded volume effects of CaMKII on receptors, making the multivalent interaction dominant. These findings highlight the differences between condensate formation in solution and membrane domain formation, modulated by their layered arrangement.","PeriodicalId":11640,"journal":{"name":"eLife","volume":"14 ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling. SARS-CoV-2 NSP13与TEAD相互作用抑制Hippo-YAP信号。

IF 6.4 1区生物学

eLife Pub Date : 2025-09-23 DOI: 10.7554/eLife.100248

Fansen Meng, Jong Hwan Kim, Chang-Ru Tsai, Jeffrey D Steimle, Jun Wang, Yufeng Shi, Rich G Li, Bing Xie, Vaibhav Deshmukh, Shijie Liu, Xiao Li, James F Martin

{"title":"SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling.","authors":"Fansen Meng, Jong Hwan Kim, Chang-Ru Tsai, Jeffrey D Steimle, Jun Wang, Yufeng Shi, Rich G Li, Bing Xie, Vaibhav Deshmukh, Shijie Liu, Xiao Li, James F Martin","doi":"10.7554/eLife.100248","DOIUrl":"10.7554/eLife.100248","url":null,"abstract":"The Hippo pathway controls organ development, homeostasis, and regeneration primarily by modulating YAP/TEAD-mediated gene expression. Although emerging studies report Hippo-YAP dysfunction after viral infection, it is largely unknown in the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we analyzed RNA sequencing data from human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) and SARS-CoV-2-infected human lung samples, and observed a decrease in YAP target gene expression. In screening SARS-CoV-2 nonstructural proteins, we found that nonstructural protein 13 (NSP13), a conserved coronavirus helicase, inhibits YAP transcriptional activity independent of the upstream Hippo kinases LATS1/2. Consistently, introducing NSP13 into mouse cardiomyocytes suppresses an active form of YAP (YAP5SA) in vivo. Subsequent investigations on NSP13 mutants revealed that NSP13 helicase activity, including DNA binding and unwinding, is crucial for suppressing YAP transactivation in HEK293T cells. Mechanistically, TEAD4 serves as a platform to recruit NSP13 and YAP. NSP13 likely inactivates the YAP/TEAD4 transcription complex by remodeling chromatin to recruit proteins, such as transcription termination factor 2 (TTF2), to bind the YAP/TEAD/NSP13 complex. These findings reveal a novel YAP/TEAD regulatory mechanism and uncover molecular insights into Hippo-YAP regulation after SARS-CoV-2 infection in humans.","PeriodicalId":11640,"journal":{"name":"eLife","volume":"13 ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rab10 inactivation promotes AMPAR trafficking and spine enlargement during long-term potentiation. Rab10失活促进AMPAR运输和长期增强过程中的脊柱增大。

IF 6.4 1区生物学

eLife Pub Date : 2025-09-23 DOI: 10.7554/eLife.103879

Jie Wang, Jun Nishiyama, Paula Parra-Bueno, Elwy Okaz, Goksu Oz, Xiaodan Liu, Tetsuya Watabe, Irena Suponitsky-Kroyter, Timothy E McGraw, Erzsebet M Szatmari, Ryohei Yasuda

引用次数: 0

Neural dynamics of reversal learning in the prefrontal cortex and recurrent neural networks. 反向学习在前额叶皮层和循环神经网络中的神经动力学。

IF 6.4 1区生物学

eLife Pub Date : 2025-09-23 DOI: 10.7554/eLife.103660

Christopher M Kim, Carson C Chow, Bruno B Averbeck

{"title":"Neural dynamics of reversal learning in the prefrontal cortex and recurrent neural networks.","authors":"Christopher M Kim, Carson C Chow, Bruno B Averbeck","doi":"10.7554/eLife.103660","DOIUrl":"10.7554/eLife.103660","url":null,"abstract":"In probabilistic reversal learning, the choice option yielding reward with higher probability switches at a random trial. To perform optimally in this task, one has to accumulate evidence across trials to infer the probability that a reversal has occurred. We investigated how this reversal probability is represented in cortical neurons by analyzing the neural activity in the prefrontal cortex of monkeys and recurrent neural networks trained on the task. We found that in a neural subspace encoding reversal probability, its activity represented integration of reward outcomes as in a line attractor model. The reversal probability activity at the start of a trial was stationary, stable, and consistent with the attractor dynamics. However, during the trial, the activity was associated with task-related behavior and became non-stationary, thus deviating from the line attractor. Fitting a predictive model to neural data showed that the stationary state at the trial start serves as an initial condition for launching the non-stationary activity. This suggested an extension of the line attractor model with behavior-induced non-stationary dynamics. The non-stationary trajectories were separable indicating that they can represent distinct probabilistic values. Perturbing the reversal probability activity in the recurrent neural networks biased choice outcomes demonstrating its functional significance. In sum, our results show that cortical networks encode reversal probability in stable stationary state at the start of a trial and utilize it to initiate non-stationary dynamics that accommodates task-related behavior while maintaining the reversal information.","PeriodicalId":11640,"journal":{"name":"eLife","volume":"13 ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A SHERLOCK toolbox for eco-epidemiological surveillance of African trypanosomes in domestic pigs from Western Africa. 西非家猪非洲锥虫生态流行病学监测SHERLOCK工具箱。

IF 6.4 1区生物学

eLife Pub Date : 2025-09-22 DOI: 10.7554/eLife.106823

Roger Eloiflin, Elena Pérez-Antón, Aïssata Camara, Annick Dujeancourt-Henry, Salimatou Boiro, Martial N Djetchi, Mélika Barkissa Traoré, Mathurin Koffi, Dramane Kaba, Yann Le Pennec, Bakary Doukouré, Abdoulaye Dansy Camara, Moïse Kagbadouno, Pascal Campagne, Mamadou Camara, Vincent Jamonneau, Sophie Thévenon, Jean-Mathieu Bart, Lucy Glover, Brice Rotureau

{"title":"A SHERLOCK toolbox for eco-epidemiological surveillance of African trypanosomes in domestic pigs from Western Africa.","authors":"Roger Eloiflin, Elena Pérez-Antón, Aïssata Camara, Annick Dujeancourt-Henry, Salimatou Boiro, Martial N Djetchi, Mélika Barkissa Traoré, Mathurin Koffi, Dramane Kaba, Yann Le Pennec, Bakary Doukouré, Abdoulaye Dansy Camara, Moïse Kagbadouno, Pascal Campagne, Mamadou Camara, Vincent Jamonneau, Sophie Thévenon, Jean-Mathieu Bart, Lucy Glover, Brice Rotureau","doi":"10.7554/eLife.106823","DOIUrl":"10.7554/eLife.106823","url":null,"abstract":"Animal African trypanosomosis (AAT), caused by protist parasites of the genus Trypanosoma, puts upward of a million head of livestock at risk across 37 countries in Africa. The economic impact of AAT and the presence of human-infectious trypanosomes in animals place a clear importance on improving diagnostics for animal trypanosomes to map the distribution of the veterinary parasites and identify reservoirs of human-infectious trypanosomes. We have adapted the CRISPR-based detection toolkit SHERLOCK (Specific High-sensitivity Enzymatic Reporter unLOCKing) for trypanosomatid parasites responsible for AAT (SHERLOCK4AAT) including Pan-trypanosomatid, Trypanozoon, T. vivax, T. congolense, T. theileri, T. simiae, and T. suis assays. To test the applicability of this technique in the field, we analysed dried blood spots collected from 200 farm and 224 free-ranging pigs in endemic and historical human African trypanosomiasis foci in Guinea and Côte d'Ivoire, respectively. The results revealed that SHERLOCK4AAT can detect and discriminate between trypanosome species involved in multiple infections with a high sensitivity. 62.7% [58.1, 67.3] of pigs were found infected with at least one trypanosome species. T. brucei gambiense, a human-infectious trypanosome, was found in one animal at both sites, highlighting the risk that these animals may act as persistent reservoirs. These data suggest that, due to their proximity to humans and their attractiveness to tsetse flies, pigs could act as sentinels to monitor T. b. gambiense circulation using the SHERLOCK4AAT toolbox.","PeriodicalId":11640,"journal":{"name":"eLife","volume":"14 ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning. 利用深度迁移学习识别2型糖尿病和肥胖相关的人类β细胞。

IF 6.4 1区生物学

eLife Pub Date : 2025-09-22 DOI: 10.7554/eLife.96713

Gitanjali Roy, Rameesha Syed, Olivia Lazaro, Sylvia Robertson, Sean D McCabe, Daniela Rodriguez, Alex M Mawla, Travis S Johnson, Michael A Kalwat

{"title":"Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning.","authors":"Gitanjali Roy, Rameesha Syed, Olivia Lazaro, Sylvia Robertson, Sean D McCabe, Daniela Rodriguez, Alex M Mawla, Travis S Johnson, Michael A Kalwat","doi":"10.7554/eLife.96713","DOIUrl":"10.7554/eLife.96713","url":null,"abstract":"Diabetes affects >10% of adults worldwide and is caused by impaired production or response to insulin, resulting in chronic hyperglycemia. Pancreatic islet β-cells are the sole source of endogenous insulin, and our understanding of β-cell dysfunction and death in type 2 diabetes (T2D) is incomplete. Single-cell RNA-seq data supports heterogeneity as an important factor in β-cell function and survival. However, it is difficult to identify which β-cell phenotypes are critical for T2D etiology and progression. Our goal was to prioritize specific disease-related β-cell subpopulations to better understand T2D pathogenesis and identify relevant genes for targeted therapeutics. To address this, we applied a deep transfer learning tool, DEGAS, which maps disease associations onto single-cell RNA-seq data from bulk expression data. Independent runs of DEGAS using T2D or obesity status identified distinct β-cell subpopulations. A singular cluster of T2D-associated β-cells was identified; however, β-cells with high obese-DEGAS scores contained two subpopulations derived largely from either non-diabetic (ND) or T2D donors. The obesity-associated ND cells were enriched for translation and unfolded protein response genes compared to T2D cells. We selected CDKN1C and DLK1 for validation by immunostaining in human pancreas sections from healthy and T2D donors. Both CDKN1C and DLK1 were heterogeneously expressed among β-cells. CDKN1C was increased in β-cells from T2D donors, in agreement with the DEGAS predictions, while DLK1 appeared depleted from T2D islets of some donors. In conclusion, DEGAS has the potential to advance our holistic understanding of the β-cell transcriptomic phenotypes, including features that distinguish β-cells in obese ND or lean T2D states. Future work will expand this approach to additional human islet omics datasets to reveal the complex multicellular interactions driving T2D.","PeriodicalId":11640,"journal":{"name":"eLife","volume":"13 ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

My grandmother's rug. 我祖母的地毯。

IF 6.4 1区生物学

eLife Pub Date : 2025-09-22 DOI: 10.7554/eLife.109153

Eve Marder

引用次数: 0

Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala. 人类单个神经元的活动是由基底外侧杏仁核的颅内θ波爆发刺激调节的。

IF 6.4 1区生物学

eLife Pub Date : 2025-09-19 DOI: 10.7554/eLife.106481

Justin M Campbell, Rhiannon L Cowan, Krista L Wahlstrom, Martina K Hollearn, Dylan Jensen, Tyler Davis, Shervin Rahimpour, Ben Shofty, Amir Arain, John D Rolston, Stephan Hamann, Shuo Wang, Lawrence N Eisenman, James Swift, Tao Xie, Peter Brunner, Joseph Manns, Cory Inman, Elliot H Smith, Jon Timothy Willie

{"title":"Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala.","authors":"Justin M Campbell, Rhiannon L Cowan, Krista L Wahlstrom, Martina K Hollearn, Dylan Jensen, Tyler Davis, Shervin Rahimpour, Ben Shofty, Amir Arain, John D Rolston, Stephan Hamann, Shuo Wang, Lawrence N Eisenman, James Swift, Tao Xie, Peter Brunner, Joseph Manns, Cory Inman, Elliot H Smith, Jon Timothy Willie","doi":"10.7554/eLife.106481","DOIUrl":"10.7554/eLife.106481","url":null,"abstract":"Direct electrical stimulation of the human brain has been used for numerous clinical and scientific applications. At present, however, little is known about how intracranial stimulation affects activity at the microscale. In this study, we recorded intracranial EEG data from a cohort of patients with medically refractory epilepsy as they completed a visual recognition memory task. During the memory task, brief trains of intracranial theta burst stimulation (TBS) were delivered to the basolateral amygdala (BLA). Using simultaneous microelectrode recordings, we isolated neurons in the hippocampus, amygdala, orbitofrontal cortex, and anterior cingulate cortex and tested whether stimulation enhanced or suppressed firing rates. Additionally, we characterized the properties of modulated neurons, clustered presumed excitatory and inhibitory neurons by waveform morphology, and examined the extent to which modulation affected memory task performance. We observed a subset of neurons (~30%) whose firing rate was modulated by TBS, exhibiting highly heterogeneous responses with respect to onset latency, duration, and direction of effect. Notably, location and baseline activity predicted which neurons were most susceptible to modulation, although the impact of this neuronal modulation on memory remains unclear. These findings advance our limited understanding of how focal electrical fields influence neuronal firing at the single-cell level.","PeriodicalId":11640,"journal":{"name":"eLife","volume":"14 ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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