Endocrinology and Metabolism最新文献_第3页

Obstructive Sleep Apnea Screening and Effects of Surgery in Acromegaly: A Prospective Study. 肢端肥大症患者阻塞性睡眠呼吸暂停筛查和手术效果：一项前瞻性研究

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-06-26 DOI: 10.3803/EnM.2024.1933

Jaeyoung Cho, Jung Hee Kim, Yong Hwy Kim, Jinwoo Lee

{"title":"Obstructive Sleep Apnea Screening and Effects of Surgery in Acromegaly: A Prospective Study.","authors":"Jaeyoung Cho, Jung Hee Kim, Yong Hwy Kim, Jinwoo Lee","doi":"10.3803/EnM.2024.1933","DOIUrl":"10.3803/EnM.2024.1933","url":null,"abstract":"Backgruound: To identify a screening tool for obstructive sleep apnea (OSA) and evaluate the effects of endoscopic transsphenoidal surgery on improving OSA in patients with acromegaly.Methods: We prospectively enrolled adults with acromegaly scheduled for endoscopic transsphenoidal surgery. All measurements were conducted when participants were admitted for a baseline work-up for acromegaly before surgery and surveillance approximately 3 to 6 months after surgery. Respiratory event index (REI) was used as a surrogate for apnea-hypopnea index (Trial Registration: NCT03526016).Results: Of the 35 patients with acromegaly (median age, 47 years; 40% men; median body mass index, 24.4 kg/m2), 24 (68.6%) had OSA (REI ≥5/hour), 15 (42.9%) had moderate-to-severe OSA (REI ≥15/hour). At baseline, serum insulin-like growth factor 1 (IGF-1) levels were positively correlated with the REI (ρ=0.53, P=0.001). The sensitivity and negative predictive value of a Snoring, Tiredness, Observed apnea, high blood Pressure-Body mass index, age, Neck circumference, and Gender (STOP-Bang) score ≥ 3 were 93.3% and 87.5%, respectively, detecting moderate-to-severe OSA. Biochemical acromegaly remission was achieved in 32 (91.4%) patients. The median difference in the REI was -9.5/hour (95% confidence interval, -13.3 to -5.3). Half of the 24 patients diagnosed with OSA preoperatively had REI <5/hour postoperatively. In a linear mixed-effects model, changes in the REI across surgery were related to changes in IGF-1 levels.Conclusion: The STOP-Bang questionnaire is a reliable tool for OSA among patients with acromegaly. Improvement in OSA severity after surgery is related to decreased IGF-1 levels.","PeriodicalId":11636,"journal":{"name":"Endocrinology and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

For the Forthcoming Winning Shot in the Battle against Cushing Disease. 为即将到来的对抗库欣病的制胜一击而战。

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-08-06 DOI: 10.3803/EnM.2024.2075

Sang Ouk Chin

引用次数: 0

Dynamic Risk Model for the Medical Treatment of Graves' Hyperthyroidism according to Treatment Duration. 根据治疗持续时间确定巴塞杜氏甲状腺功能亢进症药物治疗的动态风险模型。

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-05-23 DOI: 10.3803/EnM.2024.1918

Meihua Jin, Chae A Kim, Min Ji Jeon, Won Bae Kim, Tae Yong Kim, Won Gu Kim

{"title":"Dynamic Risk Model for the Medical Treatment of Graves' Hyperthyroidism according to Treatment Duration.","authors":"Meihua Jin, Chae A Kim, Min Ji Jeon, Won Bae Kim, Tae Yong Kim, Won Gu Kim","doi":"10.3803/EnM.2024.1918","DOIUrl":"10.3803/EnM.2024.1918","url":null,"abstract":"Backgruound: Changes in thyrotropin receptor antibody (TRAb) levels are associated with the clinical outcomes of Graves' hyperthyroidism. However, the effects of the patterns of TRAb changes on patient prognosis according to the treatment duration of antithyroid drugs (ATDs) are not well established.Methods: In this retrospective cohort study, 1,235 patients with Graves' hyperthyroidism who were treated with ATDs for more than 12 months were included. Patients were divided into two groups according to treatment duration: group 1 (12-24 months) and group 2 (>24 months). Risk prediction models comprising age, sex, and either TRAb levels at ATD withdrawal (model A) or patterns of TRAb changes (model B) were compared.Results: The median treatment duration in groups 1 (n=667, 54%) and 2 (n=568, 46%) was 17.3 and 37.1 months, respectively. The recurrence rate was significantly higher in group 2 (47.9%) than in group 1 (41.4%, P=0.025). Group 2 had significantly more goiter, thyroid eye disease, and fluctuating and smoldering type of TRAb pattern compared with group 1 (all P<0.001). The patterns of TRAb changes were an independent risk factor for recurrence after adjusting for other confounding factors in all patients, except in group 1. Integrated discrimination improvement and net reclassification improvement analyses showed that model B performed better than model A in all patients, except in group 1.Conclusion: The dynamic risk model, including the patterns of TRAb changes, was more suitable for predicting prognosis in patients with Graves' hyperthyroidism who underwent longer ATD treatment duration.","PeriodicalId":11636,"journal":{"name":"Endocrinology and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging Gaps Amidst Limited Evidence for Glucocorticoid-Induced Adrenal Insufficiency. 在糖皮质激素诱发肾上腺功能不全的有限证据中填补空白

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-08-01 DOI: 10.3803/EnM.2024.2065

Seung Hun Lee

引用次数: 0

Treatment Patterns and Preferences for Graves' Disease in Korea: Insights from a Nationwide Cohort Study. 韩国巴塞杜氏病的治疗模式和偏好：来自全国队列研究的启示。

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-08-05 DOI: 10.3803/EnM.2024.2042

Kyeong Jin Kim, Jimi Choi, Soo Myoung Shin, Jung A Kim, Kyoung Jin Kim, Sin Gon Kim

{"title":"Treatment Patterns and Preferences for Graves' Disease in Korea: Insights from a Nationwide Cohort Study.","authors":"Kyeong Jin Kim, Jimi Choi, Soo Myoung Shin, Jung A Kim, Kyoung Jin Kim, Sin Gon Kim","doi":"10.3803/EnM.2024.2042","DOIUrl":"10.3803/EnM.2024.2042","url":null,"abstract":"Treatment patterns and preferences for patients with Graves' disease (GD) vary across countries. In this study, we assessed the initial therapies and subsequent treatment modalities employed for GD in real-world clinical practice in Korea. We analyzed 452,001 patients with GD from 2004 to 2020, obtained from the Korean National Health Insurance Service database. Initial treatments included antithyroid drug (ATD) therapy (98% of cases), thyroidectomy (1.3%), and radioactive iodine (RAI) therapy (0.7%). The rates of initial treatment failure were 58.5% for ATDs, 21.3% for RAI, and 2.1% for thyroidectomy. Even among cases of ATD treatment failure or recurrence, the rates of RAI therapy remained low. Regarding initial treatment, the 5-year remission rate was 46.8% among patients administered ATDs versus 91.0% among recipients of RAI therapy; at 10 years, these rates were 59.2% and 94.0%, respectively. Our findings highlight a marked disparity in the use of RAI therapy in Korea compared to Western countries. Further research is required to understand the reasons for these differences in treatment patterns.","PeriodicalId":11636,"journal":{"name":"Endocrinology and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential Impact of Subcutaneous and Visceral Fat on Bone Changes after Gastrectomy. 皮下脂肪和内脏脂肪对胃切除术后骨骼变化的不同影响

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-07-17 DOI: 10.3803/EnM.2024.1956

Sungjoon Cho, Sungjae Shin, Seunghyun Lee, Yumie Rhee, Hyoung-Il Kim, Namki Hong

{"title":"Differential Impact of Subcutaneous and Visceral Fat on Bone Changes after Gastrectomy.","authors":"Sungjoon Cho, Sungjae Shin, Seunghyun Lee, Yumie Rhee, Hyoung-Il Kim, Namki Hong","doi":"10.3803/EnM.2024.1956","DOIUrl":"10.3803/EnM.2024.1956","url":null,"abstract":"Backgruound: Osteoporosis and fragility fractures are crucial musculoskeletal complications in long-term survivors of gastric cancer. However, the relationship between changes in body composition after gastrectomy and bone loss has not been investigated. Therefore, this study aimed to explore whether computed tomography (CT)-derived body composition parameters are associated with bone loss after gastrectomy in patients with gastric cancer.Methods: We retrospectively reviewed medical records and abdomen CT scans of patients who underwent gastrectomy at Yonsei University Severance Hospital between 2009 and 2018. Patients with non-metastatic gastric adenocarcinoma and preoperative and postoperative non-contrast CT scans were analyzed. Section area of skeletal muscle (SMA), visceral fat (VFA), and subcutaneous fat (SFA) were assessed using semi-automatic segmentation software. Changes in trabecular bone attenuation of L1 mid-vertebra level (L1 Hounsfield units [HU]) were measured.Results: Fifty-seven patients (mean age, 65.5±10.6; 70.2% males) were analyzed, and the median duration was 31 months. Fortyseven patients (82.5%) lost weight after gastrectomy. Baseline SMA and VFA did not differ between the bone loss and preserved groups; however, baseline SFA was significantly higher in the bone preserved group than in the bone loss group (P=0.020). In a multivariable linear regression model adjusted for confounding factors, one standard deviation higher VFA at baseline was associated with greater annualized L1 HU loss (%) (P=0.034). However, higher preoperative SFA was associated with protection against bone loss after gastrectomy (P=0.025).Conclusion: Higher preoperative SFA exhibited a protective effect against bone loss after gastrectomy in patients with non-metastatic gastric cancer, whereas VFA exhibited a negative effect.","PeriodicalId":11636,"journal":{"name":"Endocrinology and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of Energy and Glucose Homeostasis by the Nucleus of the Solitary Tract and the Area Postrema. 孤束核和后区对能量和葡萄糖平衡的调节

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-08-01 DOI: 10.3803/EnM.2024.2025

Kyla Bruce, Ameth N Garrido, Song-Yang Zhang, Tony K T Lam

引用次数: 0

End-to-End Semi-Supervised Opportunistic Osteoporosis Screening Using Computed Tomography. 利用计算机断层扫描进行端到端半监督机会性骨质疏松症筛查

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-06-01 Epub Date: 2024-05-09 DOI: 10.3803/EnM.2023.1860

Jieun Oh, Boah Kim, Gyutaek Oh, Yul Hwangbo, Jong Chul Ye

{"title":"End-to-End Semi-Supervised Opportunistic Osteoporosis Screening Using Computed Tomography.","authors":"Jieun Oh, Boah Kim, Gyutaek Oh, Yul Hwangbo, Jong Chul Ye","doi":"10.3803/EnM.2023.1860","DOIUrl":"10.3803/EnM.2023.1860","url":null,"abstract":"Backgruound: Osteoporosis is the most common metabolic bone disease and can cause fragility fractures. Despite this, screening utilization rates for osteoporosis remain low among populations at risk. Automated bone mineral density (BMD) estimation using computed tomography (CT) can help bridge this gap and serve as an alternative screening method to dual-energy X-ray absorptiometry (DXA).Methods: The feasibility of an opportunistic and population agnostic screening method for osteoporosis using abdominal CT scans without bone densitometry phantom-based calibration was investigated in this retrospective study. A total of 268 abdominal CT-DXA pairs and 99 abdominal CT studies without DXA scores were obtained from an oncology specialty clinic in the Republic of Korea. The center axial CT slices from the L1, L2, L3, and L4 lumbar vertebrae were annotated with the CT slice level and spine segmentation labels for each subject. Deep learning models were trained to localize the center axial slice from the CT scan of the torso, segment the vertebral bone, and estimate BMD for the top four lumbar vertebrae.Results: Automated vertebra-level DXA measurements showed a mean absolute error (MAE) of 0.079, Pearson's r of 0.852 (P<0.001), and R2 of 0.714. Subject-level predictions on the held-out test set had a MAE of 0.066, Pearson's r of 0.907 (P<0.001), and R2 of 0.781.Conclusion: CT scans collected during routine examinations without bone densitometry calibration can be used to generate DXA BMD predictions.","PeriodicalId":11636,"journal":{"name":"Endocrinology and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11220219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond Bone: Embracing Osteosarcopenia for Comprehensive Fracture Prevention. 超越骨骼：拥抱骨质疏松症，全面预防骨折。

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-06-01 Epub Date: 2024-05-16 DOI: 10.3803/EnM.2024.2002

Beom-Jun Kim

引用次数: 0

Lipid Swings Provoke Vascular Inflammation. 血脂波动引发血管炎症

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-06-01 Epub Date: 2024-06-24 DOI: 10.3803/EnM.2024.302

Jae-Han Jeon

引用次数: 0