EJNMMI Research最新文献

{"title":"In ovo model with emu eggs as novel alternative to animal testing in preclinical imaging research.","authors":"Olga Perkas, Marta Pomraenke, Veronika Porwoll, Christian Kühnel, Steffen Wiegand, Karl-Heinz Herrmann, Thomas Winkens, Martin Freesmeyer","doi":"10.1186/s13550-025-01314-7","DOIUrl":"10.1186/s13550-025-01314-7","url":null,"abstract":"<p><strong>Background: </strong>Large-size in ovo models are receiving increasing attention since they comply with the 3R requirements (Replacement, Reduction and Refinement) by limiting the number of fully developed laboratory animals. In preclinical imaging research, a specific advantage is that they do not require dedicated scanners for small animals (expensive and rarely available) but are suitable for imaging studies by scanners used for clinical examinations. The present study evaluated large-sized fertilized emu eggs as a candidate model for preclinical imaging research in nuclear medicine by [¹⁸F]FDG-PET/CT, aiming to increase the repertoire of alternative models to conventional animal testing.</p><p><strong>Results: </strong>Of 31 fertilized eggs, 18 eggs had viable peripheral vasculature available for vessel detection via MRI or CT. Both modalities provided reliable information on location and dimension of target blood vessels. Optimization of catheterization proved challenging, and only 5 [¹⁸F]FDG-PET/CT scans were entirely successful in demonstrating the expected biodistribution pattern. In vivo and ex vivo organ activity showed a statistically significant correlation (Spearman's Rho: 0.9091; p = 0.00004).</p><p><strong>Conclusion: </strong>The emu egg model is suitable for preclinical imaging research with clinical scanners. Considering the shorter seasonal availability but longer incubation period of fertilized emu eggs, this model is a valid complement to the recently introduced ostrich egg model, available only in warm periods. In combination, these models offer a year-round flexibility for in ovo imaging research.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"118"},"PeriodicalIF":3.1,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12443669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial perfusion and oxidative metabolism in healthy subjects: sex-specific insights from vasodilatory stress ¹¹C-acetate PET.","authors":"Sang-Geon Cho, Hyung Yoon Kim, Ki Seong Park, Jahae Kim, Jang Bae Moon, Nuri Lee, Hyukjin Park, Jae Yeong Cho, Hyun Ju Yoon, Youngkeun Ahn, Joon-Hyung Doh, Eun-Seok Shin, Kye Hun Kim, Ho-Chun Song","doi":"10.1186/s13550-025-01311-w","DOIUrl":"10.1186/s13550-025-01311-w","url":null,"abstract":"<p><strong>Background: </strong>¹¹C-acetate positron emission tomography (PET) enables simultaneous quantification of myocardial blood flow (MBF) and oxidative metabolism; however, sex-specific normative data under vasodilator stress remain insufficiently defined. We aimed to characterize these parameters in healthy individuals.</p><p><strong>Results: </strong>Eighteen healthy individuals (9 males and 9 females, age/sex-matched; median age 43 years [range 34-65]) with normal echocardiography and no underlying cardiovascular disease underwent one-day rest-stress dynamic ¹¹C-acetate PET with adenosine. Median stress MBF was 2.73 (2.24-3.11) mL/min/g and rest MBF 0.99 (0.82-1.14) mL/min/g. Stress kmono was 0.074 (0.063-0.082)/min, and rest kmono was 0.061 (0.050-0.068)/min. External cardiac work, total myocardial oxygen consumption (MVO₂), and MEE were 4.24 (3.75-5.54) × 10⁵ mL·mmHg/min, 16.5 (14.9-20.9) mL/min, and 17.7% (14.0-24.2%), respectively. Compared to males, females exhibited significantly higher corrected rest MBF (1.14 vs. 0.96 mL/min/g, p = 0.032), stress kmono (0.078 vs. 0.070 /min, p = 0.005), and total MVO₂ (17.6 vs. 15.5 mL/min, p = 0.003). Despite similar external cardiac work, myocardial external efficiency was significantly lower in females (15.5% vs. 20.3%, p = 0.009). MBF and oxidative metabolism were positively correlated in both sexes.</p><p><strong>Conclusions: </strong>This study assesses reference ranges and demonstrates significant sex-based differences in myocardial perfusion and oxidative metabolism using vasodilatory stress ¹¹C-acetate PET. These findings provide a valuable physiological framework for assessing perfusion-metabolism abnormalities in clinical practice.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"116"},"PeriodicalIF":3.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Preclinical evaluation of glycan-targeting monoclonal antibodies for bimodal near-infrared fluorescence and photoacoustic imaging of gastrointestinal cancers.","authors":"Ruben D Houvast, Vincent Q Sier, Maurice van Duijvenvoorde, Victor M Baart, Timo Schomann, JiaXin Chua, Mireille Vankemmelbeke, Lindy G Durrant, Daniëlle Krijgsman, Pieter de Heer, Gert-Jan Hassing, J Sven D Mieog, A Stijn L P Crobach, Jacobus Burggraaf, Peter J K Kuppen, Alexander L Vahrmeijer, Cornelis F M Sier","doi":"10.1186/s13550-025-01308-5","DOIUrl":"10.1186/s13550-025-01308-5","url":null,"abstract":"","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"117"},"PeriodicalIF":3.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging renal mitochondrial dysfunction in chronic kidney disease: a repurposed role for [^99mTc]Tc-MIBI SPECT/CT.","authors":"Soo Bin Park, Chae Hong Lim, So-Young Jin, Yon Hee Kim, Haekyung Lee, Hyoungnae Kim, Hyunjin Noh, Jin Seok Jeon, Soon Hyo Kwon","doi":"10.1186/s13550-025-01306-7","DOIUrl":"10.1186/s13550-025-01306-7","url":null,"abstract":"<p><strong>Background: </strong>[^99mTc]Tc-MIBI is a conventional myocardial perfusion radiotracer, and is predominantly taken up by mitochondria in a manner dependent on mitochondrial membrane potential. This study aimed to repurpose [^99mTc]Tc-MIBI for functional renal imaging to evaluate mitochondrial dysfunction in chronic kidney disease (CKD).</p><p><strong>Results: </strong>A total of 11 patients with newly diagnosed CKD and 27 matched healthy volunteers underwent [99mTc]Tc-MIBI dynamic renal scans and SPECT/CT. Quantitative analyses of the left kidneys assessed time-activity curves, percentage of renal uptake, and standardized uptake values (SUV). Renal mitochondrial content in CKD patients was evaluated using immunohistochemistry of kidney biopsy samples. CKD patients had comparable eGFR to healthy volunteers but exhibited significantly lower renal [^99mTc]Tc-MIBI uptake percentage on dynamic scan and decreased SUV on SPECT/CT. A positive correlation was observed between mean SUV and renal mitochondrial content in CKD patients. Mean SUV was identified as an independent predictor of CKD (odds ratio 0.2, P = 0.037), demonstrating high diagnostic accuracy (AUC = 0.886), whereas conventional biomarkers had limited predictive value.</p><p><strong>Conclusions: </strong>[^99mTc]Tc-MIBI kidney SPECT/CT effectively detected renal mitochondrial dysfunction in patients with CKD, suggests its potential as a noninvasive imaging biomarker. SUV may serve as a quantitative parameter for assessing renal mitochondrial dysfunction.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"115"},"PeriodicalIF":3.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studies on the impact of modifications at the Gln-Trp site in RM2-based GRPR ligands.","authors":"Sebastian Fischer, Lena Koller, Sandra Dominelli, Roswitha Beck, Hans-Jürgen Wester, Thomas Günther","doi":"10.1186/s13550-025-01241-7","DOIUrl":"10.1186/s13550-025-01241-7","url":null,"abstract":"<p><strong>Background: </strong>One of the most studied, and preclinically as well as clinically applied gastrin-releasing peptide receptor (GRPR) ligands represents the antagonist RM2 (DOTA-Pip⁵-D-Phe⁶-Gln⁷-Trp⁸-Ala⁹-Val¹⁰-Gly¹¹-His¹²-Sta¹³-Leu¹⁴-NH₂). As an improved in vivo stability was observed for a RM2 analog comprising the unnatural amino acid α-methyl-L-tryptophan instead of L-Trp, we aimed to elucidate the impact of other unnatural amino acids (homoserine [Hse], β-(3-benzothienyl)alanine [Bta]) at the metabolically less stable Gln-Trp site. Furthermore, we conjugated either DOTA, NOTA or NODAGA to the RM2 peptide and its modified derivatives, and evaluated each analog preclinically using ⁶⁸Ga and ⁶⁴Cu, as well as ¹⁷⁷Lu (only DOTA-comprising compounds).</p><p><strong>Results: </strong>GRPR affinity and lipophilicity of RM2 derivatives were in a range of 1.2-8.4 nM and - 2.9 to - 1.1 (^nat/68Ga-labeled), 1.7-33.0 nM and - 2.4 to - 1.6 (^nat/64Cu-labeled), as well as 3.0-19.7 nM and - 3.2 to - 1.8 (^nat/177Lu-labeled), respectively. Both, [¹⁷⁷Lu]Lu-[Hse⁷]RM2 and [¹⁷⁷Lu]Lu-[Bta⁸]RM2 revealed distinctly lower in vivo stability (< 20% intact at 15 min post-injection) than [¹⁷⁷Lu]Lu-[α-Me-Trp⁸]RM2 (= [¹⁷⁷Lu]Lu-AMTG) and [¹⁷⁷Lu]Lu-RM2 (> 30% intact at 30 min post-injection). Both [⁶⁸Ga]Ga-RM2 and [⁶⁸Ga]Ga-AMTG exhibited high tumor (~ 15 percentage injected dose per gram, %ID/g) and pancreas uptake (> 25%ID/g), whereas [⁶⁸Ga]Ga-[Hse⁷]RM2 and [⁶⁸Ga]Ga-[Bta⁸]RM2 revealed lower tumor (~ 7.5%ID/g) but also substantially lower pancreas uptake (< 8%ID/g) at 1 h post-injection. At 24 h post-injection (p.i.), [¹⁷⁷Lu]Lu-RM2 and [¹⁷⁷Lu]Lu-AMTG exhibited high (> 8% ID/g) while [¹⁷⁷Lu]Lu-[Hse⁷]RM2 and [¹⁷⁷Lu]Lu-[Bta⁸]RM2 displayed low tumor retention (~ 2%ID/g). All compounds showed low activity levels in the pancreas at 24 h post-injection (< 1%ID/g).</p><p><strong>Conclusion: </strong>Substitution of the Gln-Trp site in RM2 by artificial amino acids had a distinct impact on overall pharmacokinetics. While Hse (instead of Gln) and Bta (instead of Trp) led to a decreased, α-Me-Trp (instead of Trp) led to an increased in vivo stability, which resulted in improved pharmacokinetics over time in case of the latter. However, at 1 h post-injection both [⁶⁸Ga]Ga-[Hse⁷]RM2 and [⁶⁸Ga]Ga-[Bta⁸]RM2 displayed slightly higher tumor-to-pancreas and tumor-to-intestine ratios, rendering homoserine and β-(3-benzothienyl)alanine potential options for the modification of GRPR ligands with regard to imaging properties.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"114"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yttrium-90 selective internal radiation therapy for right hepatic malignancies: a clinical outcome study.","authors":"Xin Huang, Yong Liao, Ziwei Liang, Junpeng Ma, Bin Liang, Shizhong Yang, Guangxin Li, Tiantian Zhang, Linxia Zheng, Yafei Zhang, Mulan Tang, Bo Jia, Lin Zhang, Xiaobin Feng","doi":"10.1186/s13550-025-01307-6","DOIUrl":"10.1186/s13550-025-01307-6","url":null,"abstract":"<p><strong>Background: </strong>Surgical resection offers long-term survival for liver malignancies, but insufficient future liver remnant (FLR) volume often precludes operability. This study evaluated yttrium-90 selective internal radiation therapy (⁹⁰Y-SIRT) for controlling right-liver tumors and inducing compensatory left-lobe hyperplasia.</p><p><strong>Results: </strong>Thirty-seven patients (29 hepatocellular carcinomas, 2 intrahepatic cholangiocarcinoma, 6 liver metastasis of colorectal cancer) with right-liver tumors underwent ⁹⁰Y-SIRT. Tumor volume decreased significantly by 133 mL at 1 month and 206 mL at 3 months post-treatment (both P < 0.001). Right-liver volume reduction averaged 182 mL at 1 month (P < 0.001) and 300 mL at 3 months (P < 0.001). Concurrently, left-liver volume increased by 55 mL (P < 0.001) and 127 mL (P < 0.001) at 1 and 3 months, respectively, while FLR percentage rose by 5.8% (P < 0.001) and 11.9% (P < 0.001). Per mRECIST criteria, 3-month imaging revealed an objective response rate (ORR) of 78.4% and disease control rate (DCR) of 91.9%. In 14 patients downstaged to resection/transplantation, ICG-R15 levels remained stable, confirming preserved liver reserve function post-90Y-SIRT. These findings demonstrate ⁹⁰Y-SIRT effectively controls right-lobe tumor progression and stimulates compensatory left-lobe hypertrophy, enabling FLR expansion. The treatment achieved high ORR, significant tumor downstaging, and pathological necrosis without compromising hepatic functional reserve.</p><p><strong>Conclusions: </strong>90Y-SIRT represents a safe and efficacious strategy to convert initially unresectable patients into surgical candidates.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"113"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-driven body composition monitoring and its prognostic role in mCRPC undergoing lutetium-177 PSMA radioligand therapy: insights from a retrospective single-center analysis.","authors":"Tristan Ruhwedel, Julian Rogasch, Markus Galler, Imke Schatka, Christoph Wetz, Christian Furth, Nadine Biernath, Maria De Santis, Seyd Shnayien, Johannes Kolck, Dominik Geisel, Holger Amthauer, Nick Lasse Beetz","doi":"10.1186/s13550-025-01312-9","DOIUrl":"10.1186/s13550-025-01312-9","url":null,"abstract":"<p><strong>Background: </strong>Body composition (BC) analysis is performed to quantify the relative amounts of different body tissues as a measure of physical fitness and tumor cachexia. We hypothesized that relative changes in body composition (BC) parameters, assessed by an artificial intelligence-based, PACS-integrated software, between baseline imaging before the start of radioligand therapy (RLT) and interim staging after two RLT cycles could predict overall survival (OS) in patients with metastatic castration-resistant prostate cancer.</p><p><strong>Methods: </strong>We conducted a single-center, retrospective analysis of 92 patients with mCRPC undergoing [¹⁷⁷Lu]Lu-PSMA RLT between September 2015 and December 2023. All patients had [⁶⁸ Ga]Ga-PSMA-11 PET/CT at baseline (≤ 6 weeks before the first RLT cycle) and at interim staging (6-8 weeks after the second RLT cycle) allowing for longitudinal BC assessment.</p><p><strong>Results: </strong>During follow-up, 78 patients (85%) died. Median OS was 16.3 months. Median follow-up time in survivors was 25.6 months. The 1 year mortality rate was 32.6% (95%CI 23.0-42.2%) and the 5 year mortality rate was 92.9% (95%CI 85.8-100.0%). In multivariable regression, relative change in visceral adipose tissue (VAT) (HR: 0.26; p = 0.006), previous chemotherapy of any type (HR: 2.4; p = 0.003), the presence of liver metastases (HR: 2.4; p = 0.018) and a higher baseline De Ritis ratio (HR: 1.4; p < 0.001) remained independent predictors of OS. Patients with a higher decrease in VAT (< -20%) had a median OS of 10.2 months versus 18.5 months in patients with a lower VAT decrease or VAT increase (≥ -20%) (log-rank test: p = 0.008). In a separate Cox model, the change in VAT predicted OS (p = 0.005) independent of the best PSA response after 1-2 RLT cycles (p = 0.09), and there was no interaction between the two (p = 0.09).</p><p><strong>Conclusions: </strong>PACS-Integrated, AI-based BC monitoring detects relative changes in the VAT, Which was an independent predictor of shorter OS in our population of patients undergoing RLT.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"112"},"PeriodicalIF":3.1,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is CXCR4-targeted ⁶⁸Ga-pentixafor PET/CT a reliable AVS-free modality for surgical decision-making and prognostic prediction in primary aldosteronism with bilateral adrenal lesions?","authors":"Zhiwei Shu, Yao He, Tingting Long, Min Guo, Zhuying Xia, Xiaodan Fu, Bingsheng Li, Bo Zhang, Yi Yang, Jiaxian Chen, Tiejian Jiang, Xiang Chen, Kai Cheng, Longfei Liu, Yu Gan","doi":"10.1186/s13550-025-01309-4","DOIUrl":"10.1186/s13550-025-01309-4","url":null,"abstract":"<p><strong>Background: </strong>For patients diagnosed with primary aldosteronism (PA) accompanied by bilateral adrenal lesions, identifying optimal candidates for surgical intervention remains a significant clinical challenge. Although adrenal venous sampling (AVS) is currently the gold standard for lateralizing aldosterone hypersecretion, its technical complexity, invasiveness, and interpretive difficulties restrict its widespread adoption. In this study, we aimed to investigate the clinical application of ⁶⁸Ga-pentixafor positron emission tomography/computed tomography (PET/CT) as a non-invasive imaging modality in AVS-free surgical decision-making for PA patients with bilateral adrenal lesions.</p><p><strong>Results: </strong>Among the 51 patients who underwent ⁶⁸Ga-pentixafor PET/CT, 36 patients had adrenalectomy, with the surgical side determined by PET/CT lateralization. The postoperative complete biochemical and clinical success rates for these patients were 91.67% and 100%, respectively. Additionally, receiver operating characteristic curve analysis indicated that PET/CT results were favorable predictors of postoperative outcomes in surgical patients. Postoperative pathological evaluation of ⁶⁸Ga-pentixafor PET/CT-guided surgical patients revealed that 86.11% had adrenocortical adenomas with positive CYP11B2 and CXCR4 expression.</p><p><strong>Conclusion: </strong>CXCR4-targeted ⁶⁸Ga-pentixafor PET/CT can be effectively utilized in surgery decision-making for PA patients with bilateral adrenal lesions, offering a potential alternative to AVS and maybe applied to predict postoperative biochemical and clinical success.</p><p><strong>Trial registration: </strong>⁶⁸Ga-Pentixafor PET/CT for Guiding Surgical Treatment of Primary Aldosteronism With Bilateral Adrenal Lesions; Trial registration number: NCT06247566; Date of registration: 2021-11-01; URL of trial registry record: https://clinicaltrials.gov/study/NCT06247566 .</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"111"},"PeriodicalIF":3.1,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of renal function decline in patients with gastroenteropancreatic neuroendocrine tumors undergoing [177Lu]Lu-DOTA-TATE therapy.","authors":"Felix L Herr, Christian Dascalescu, Victoria Fusch, Caroline Smith, Ricarda Ebner, Mathias J Zacherl, Florian Eckenweber, Konrad Klimek, Christoph J Auernhammer, Christine Spitzweg, Jens Ricke, Maurice M Heimer, Clemens C Cyran, Rudolf A Werner, Gabriel T Sheikh","doi":"10.1186/s13550-025-01305-8","DOIUrl":"10.1186/s13550-025-01305-8","url":null,"abstract":"","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"110"},"PeriodicalIF":3.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of oral protein intake on [¹⁸F]FET uptake in brain tumours.","authors":"Karl-Josef Langen, Norbert Galldiks, Philipp Lohmann, Felix M Mottaghy","doi":"10.1186/s13550-025-01304-9","DOIUrl":"10.1186/s13550-025-01304-9","url":null,"abstract":"","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"109"},"PeriodicalIF":3.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}