EJNMMI Research最新文献

{"title":"Brown adipose tissue machine learning nnU-Net V2 network using TriDFusion (3DF).","authors":"Daniel Lafontaine, Stephanie Chahwan, Gustavo Barraza, Burcin Agridag Ucpinar, Gunjan Kayal, Nicolás Gómez-Banoy, Paul Cohen, John L Humm, Heiko Schöder","doi":"10.1186/s13550-025-01303-w","DOIUrl":"10.1186/s13550-025-01303-w","url":null,"abstract":"","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"108"},"PeriodicalIF":3.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144845045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[⁶⁸Ga] labelled Exendin for radioguided surgery of intrapancreatic insulin producing lesions in patients with congenital hyperinsulinism.","authors":"Peter Kühnen, Sonal Prasad, Karin Rothe, Kai Huang, Kathrin Hauptmann, Marti Boss, Nicola Beindorff, Erwin Lankes, Steven W Warmann, Miriam Schneider, Paniz Akbarzadeh Taghavi, Lara Lechner, Catharina Lange, Christian Furth, Martin Gotthardt, Winfried Brenner, Oliver Blankenstein, Vikas Prasad","doi":"10.1186/s13550-025-01294-8","DOIUrl":"10.1186/s13550-025-01294-8","url":null,"abstract":"","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"107"},"PeriodicalIF":3.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-based radiolabelled compound-protein interaction prediction for NDUFS1-targeting radiopharmaceutical discovery.","authors":"Muath Almaslamani, Jingyu Yang, Chi Soo Kang, Choong Mo Kang, Jung Mi Park, Sang-Keun Woo","doi":"10.1186/s13550-025-01300-z","DOIUrl":"10.1186/s13550-025-01300-z","url":null,"abstract":"","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"106"},"PeriodicalIF":3.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12343451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue-specific and whole-body insulin sensitivity by integrated imaging and hyperinsulinemic euglycemic clamp: A repeatability study in people with T2DM and overweight/obesity.","authors":"Iina Laitinen, Helena Litorp, Folke Sjöberg, Simon Ekström, Henrik Haraldsson, Stefan Pierrou, Alexander Korenyushkin, Joel Kullberg, Sudeepti Southekal, Ming Lu, Tamer Coskun, Zvonko Milicevic, Lars Johansson","doi":"10.1186/s13550-025-01298-4","DOIUrl":"10.1186/s13550-025-01298-4","url":null,"abstract":"<p><strong>Background: </strong>Assessment of glucose uptake by PET imaging under hyperinsulinemic euglycemic clamp (HEC) is an insightful tool for quantification of insulin resistance, a hallmark of diabetes and an area of interest in drug development. To enable the use of the method in metabolic trials, the repeatability of dynamic whole-body PET/MRI assessments of the tissue-specific glucose uptake and the total body glucose utilisation were investigated. The study included participants with type 2 diabetes mellitus (T2DM) and overweight/obesity, for two repeated examinations in standardised conditions. All participants signed informed consent, and the study plan was approved by the Swedish Ethical Review Authority (#2020-04140). After an overnight fast, HEC was established and a series of [¹⁸F]FDG-PET/MRI scans were performed. Total body glucose utilisation (M-value) was calculated for the duration of the scan and the tissue-specific metabolic rates of glucose uptake (MRGlu) were calculated using Patlak model. The repeatability was assessed by calculating the intraclass correlation coefficient (ICC).</p><p><strong>Results: </strong>Repeatability was assessed in per protocol set of 12 participants (PPS, defined by a consistent HEC) and in full analysis set (FAS n = 16). The measured M-values and tissue MRGlu demonstrated varying levels of insulin resistance. M-value ICC was 0.95 (95% CI 0.86-0.99) for PPS, indicating excellent repeatability. Tissue-specific MRGlu repeatability was excellent for skeletal muscle (ICC 0.94), and good to at least fair for SAT, VAT, myocardium, and brain. The FAS had lower, but at least fair repeatability, emphasising the importance of standardisation in metabolic assessments.</p><p><strong>Conclusion: </strong>Dynamic [¹⁸F]FDG-PET/MRI provides quantitative information on tissue-specific insulin sensitivity during hyperinsulinemic euglycemic clamp with a reliability comparable to total body glucose utilisation assessment. The method has potential to add value in monitoring and evaluating T2DM treatment effects on glucose uptake and insulin resistance in interventional trials.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"105"},"PeriodicalIF":3.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preclinical study on the influence of linkers in [⁶⁸Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression.","authors":"Esther Olaniran Håkansson, Ivan V Zelepukin, Karim Obeid, Athanasios Bitzios, Ekaterina Bezverkhniaia, Amulya Sunkara, Ulrika Rosenström, Anna Orlova, Luke R Odell, Panagiotis Kanellopoulos","doi":"10.1186/s13550-025-01301-y","DOIUrl":"10.1186/s13550-025-01301-y","url":null,"abstract":"<p><strong>Background: </strong>Gastrin-releasing peptide receptor (GRPR) is overexpressed in several cancers, including prostate and breast, making it an attractive target for radiopharmaceutical development. Studies on GRPR-targeting radioligands highlight the critical role of the spacer region between the GRPR-recognition motif and radiolabeled moiety, which can significantly influence peptide pharmacokinetics and pharmacodynamics. Herein, we investigated the impact of structurally restricted spacers on the performance of RM26-based radioligands.</p><p><strong>Results: </strong>Three novel radioligands were designed to each bear a NOTA chelator via different spacers composed of N-acetyl-lysine followed by either o-ethyltoluene (oET), o-methylanisole (oMA), or m-methylanisole (mMA) motifs. The peptides were successfully labeled with Ga-68, achieving high radiochemical yield, purity, and molar activity. The resulting [⁶⁸Ga]-labeled peptides demonstrated high and GRPR-specific binding to prostate cancer PC-3 cells, antagonistic behavior, and the IC₅₀ values to GRPR were in the single-digit nanomolar range. Biodistribution studies at 2 h post-injection in PC-3 xenograft-bearing mice revealed high, GRPR-mediated tumor uptake for all three radioligands. In addition, high hepatobiliary excretion with elevated uptake in the liver and the gastrointestinal tract and pronounced pancreatic uptake were observed.</p><p><strong>Conclusions: </strong>Among the three radioligands, the peptide bearing the N-acetyl-lysine-oET spacer exhibited the fastest background clearance and better PET imaging of prostate cancer xenografts. The incorporation of conformationally restricted spacers is a promising strategy for developing tracers with high GRPR binding and good imaging properties, but further optimization is necessary to reduce uptake in healthy tissues.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"104"},"PeriodicalIF":3.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI ensemble model of plaque and perivascular adipose tissue as PET-equivalent for identifying carotid atherosclerotic inflammation.","authors":"Fan Yu, Xiaoran Li, Yue Zhang, Yi Shan, Bixiao Cui, Liqun Jiao, Jie Lu","doi":"10.1186/s13550-025-01293-9","DOIUrl":"10.1186/s13550-025-01293-9","url":null,"abstract":"<p><strong>Background: </strong>Severe cerebrovascular events are associated with carotid atherosclerotic plaque progression and rupture that is mediated by inflammation. ¹⁸F-fluorodeoxyglucose ([¹⁸F]FDG) PET is important for assessing the inflammation of carotid atherosclerotic plaque, but it suffers from the limitations of radiation exposure. Additionally, inflammation of perivascular adipose tissue (PVAT) has been found to promote atherosclerosis progression through paracrine signaling mechanisms. The study aimed to develop an ensemble model based on carotid plaque and PVAT MRI radiomics for identifying highly inflammatory plaques (HIPs).</p><p><strong>Results: </strong>159 asymptomatic carotid atherosclerosis patients (137 males; 65 ± 8 years old) with 209 plaques (104 HIPs) were consecutively enrolled. 47.95% (70/146) of cases and 53.97% (34/63) were defined as HIPs in the training and testing datasets, respectively. There was more lipid core, more intraplaque hemorrhage, and less calcification in the HIPs compared to the non-highly inflammatory plaques (NHIPs) in the training dataset (p = 0.002, 0.019, and 0.013, respectively). Notably, the incidence of indistinct PVAT (IPVAT) in HIPs was higher than that in NHIPs, both in the training (81.43% vs. 46.05%; p < 0.001) and the testing (88.24% vs. 58.62%; p = 0.007) datasets. The correlations between plaque MRI characteristics and [¹⁸F]FDG uptake differed between the NHIPs and HIPs. However, IPVAT consistently correlated with SUV_max (r = 0.35, 0.30; p < 0.001, p = 0.002; for NHIPs and HIPs, respectively). The ensemble model that integrates the radiomics of carotid plaque and PVAT outperformed all models in predicting HIP (area under the curve [AUC] = 0.92/0.91, training/testing dataset). The follow-up further validated the PET for predicting plaque progression with the same accuracy as the ensemble model (AUC: 0.85 vs. 0.79).</p><p><strong>Conclusions: </strong>The ensemble model integrating the radiomics of carotid plaque and perivascular adipose tissue provides an equivalent tool to PET in the visualization of the evaluation of carotid atherosclerosis inflammation and progression.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"103"},"PeriodicalIF":3.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of relative Patlak plot Ki' images as an alternative to standard Patlak plot Ki images in clinical practice.","authors":"Masatoyo Nakajo, Hirofumi Kawakami, Yutaro Kiyao, Mitsuho Hirahara, Akie Katsuki, Atushi Tani, Yukari Eizuru, Koji Takumi, Kiyohisa Kamimura, Fumiko Kanzaki, Takashi Yoshiura","doi":"10.1186/s13550-025-01295-7","DOIUrl":"10.1186/s13550-025-01295-7","url":null,"abstract":"","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"102"},"PeriodicalIF":3.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of β3-adrenergic receptor agonists on [¹⁸F] fluorodeoxyglucose uptake in brown adipose tissues in positron emission tomography images of elderly patients.","authors":"John Kenneth V Gacula, Kenichiro Ogane, Kaori Fuse, Miyako Morooka Chikanishi, Kimiteru Ito","doi":"10.1186/s13550-025-01286-8","DOIUrl":"10.1186/s13550-025-01286-8","url":null,"abstract":"<p><strong>Background: </strong>Brown adipose tissues (BAT) are highly vascularized, mitochondria-rich tissues involved in thermogenesis. Physiological [¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG) uptake in BAT can be influenced by several factors, including the use of medications that act on β-adrenergic receptors. Recently, increased [¹⁸F]FDG BAT uptake has been observed in elderly patients (≥ 60 years old) receiving β3-adrenergic receptor agonists. With the increasing use of β3-adrenergic receptor agonists for managing overactive bladder, there is limited understanding of their potential association with increased [¹⁸F]FDG BAT uptake. This study retrospectively investigated whether treatment with β3-adrenergic receptor agonists is associated with increased [¹⁸F]FDG BAT uptake among elderly patients. [¹⁸F]FDG positron emission tomography (PET) images were analyzed visually and through SUVmax measurements across eight predefined regions of interest (ROI): cervical, periclavicular, axillary, mediastinal, paravertebral, paraabdominal aortic, perirenal, and perisplenic regions. Patients' medication history and clinical records were reviewed to assess β3-adrenergic receptor agonist use relative to their [¹⁸F]FDG PET study.</p><p><strong>Results: </strong>Forty-four elderly patients, each with a single [¹⁸F]FDG PET scan, were included in the analysis. Among the eight ROIs, the perirenal region showed a statistically significant increase in [¹⁸F]FDG BAT uptake in patients receiving β3-adrenergic receptor agonists compared with those not receiving, based on both visual analysis (p < 0.001) and SUVmax measurements (p = 0.030). All patients receiving β3-adrenergic receptor agonists demonstrated increased [¹⁸F]FDG BAT uptake in the paravertebral region.</p><p><strong>Conclusion: </strong>In patients aged ≥ 60 years, β3-adrenergic receptor agonist therapy appears to be associated with increased [¹⁸F]FDG BAT uptake, particularly in the perirenal area.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"101"},"PeriodicalIF":3.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total-body ¹⁸F-FDG PET/CT: more choices to promote clinical scanning efficiency.","authors":"Jie Xiao, Shuguang Chen, Xiaoguang Hou, Haojun Yu, Siwei Liu, Taoying Gu, Guobing Liu, Qi Ge, Jingyi Wang, Hongcheng Shi","doi":"10.1186/s13550-025-01290-y","DOIUrl":"10.1186/s13550-025-01290-y","url":null,"abstract":"<p><strong>Background: </strong>The study aims to maximize clinical scan efficiency for Total-body (TB) ¹⁸F-FDG PET/CT systems by optimizing scan strategies based on theoretical models and clinical experience from a single center.</p><p><strong>Results: </strong>This prospective study include two parts. The first part involved simulation experiments using theoretical models to maximize patient throughput and/or minimizing radiotracer activity across four clinical scanning scenarios: fixed working time, predetermined radiotracer activity, integration of various injection activity regimens for a fixed number of patients, and incorporation of dynamic scans into routine static scans within a fixed working time. The optimal scan strategies for these scenarios were then proposed. The second part validated the estimated throughput results through high-throughput tests performed in the real clinical settings with an fixed working time of 8 h. Under a fixed working time of 8 h, the theoretical patient throughput for full-activity, half-activity, 1/3-activity, and 1/10-activity injection regimens was 60, 48, 43, 30 patients, respectively. The corresponding real clinical throughput achieved was 60, 49, 48, 28 patients. For a total ¹⁸F-FDG activity of 37,000 to 148,000 MBq (1 to 4 Ci), the 1/3-activity injection regimen yielded the highest patient throughput, ranging 52 to 72 patients. Strategically combining various injection activity regimens could reduce radiotracer activity consumption. Additionally, placing full-activity dynamic scans after routine static scans for full-activity, half-activity, and 1/3-activity, and before 1/10 activity, proved to ba more economical strategies.</p><p><strong>Conclusions: </strong>Optimized scan strategies for typical clinical scenarios of TB ¹⁸F-FDG PET/CT systems were proposed, which could promote clinical scan efficiency and accommodate diverse clinical requirements. These strategies enable centers to balance throughput and activity efficiency while maintaining diagnostic quality.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"99"},"PeriodicalIF":3.1,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood-based transcriptomic biomarkers for response to [¹⁷⁷Lu]Lu-DOTA-TATE therapy in neuroendocrine tumors.","authors":"Hyunpil Sung, Sungwoo Bae, Minseok Suh, Hongyoon Choi, Hyung-Jun Im, Gi Jeong Cheon, Keon Wook Kang","doi":"10.1186/s13550-025-01284-w","DOIUrl":"10.1186/s13550-025-01284-w","url":null,"abstract":"<p><strong>Background: </strong>[¹⁷⁷Lu]Lu-DOTA-TATE is an effective treatment for metastatic neuroendocrine tumors (NETs) expressing somatostatin receptors. While the tumor uptake [¹⁷⁷Lu]Lu-DOTA-TATE of has shown potential as a predictive biomarker, patient response to the treatment varies significantly. In this study, we aim to identify a predictive blood-based transcriptomic biomarker to better understand individual responses to [¹⁷⁷Lu]Lu-DOTA-TATE therapy.</p><p><strong>Results: </strong>Twenty-six patients were prospectively enrolled in this study. Responders were defined as patients who showed partial response or stable disease and non-responders were defined as patients who showed progressive disease according to RECIST1.1 criteria. Of the 26 patients, responders (n = 20) exhibited distinct gene expression profiles compared to non-responders (n = 6). Among the 21 differentially expressed genes identified between the groups, 13 genes were upregulated in non-responders and were associated with the innate immune system. Weighted Gene Co-expression Network Analysis identified a significant gene module linked to treatment response, with eEF1A1 emerging as a key hub gene correlated with favorable outcomes. Baseline clinical and laboratory parameters did not differ significantly according to treatment response.</p><p><strong>Conclusions: </strong>This study identifies specific blood transcriptomic profiles associated with the innate immune response and a key hub gene linked to treatment outcomes, suggesting an immune-related component in response to [¹⁷⁷Lu]Lu-DOTA-TATE therapy. These findings may guide patient selection based on systemic immune markers and inform future therapeutic strategies.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"15 1","pages":"100"},"PeriodicalIF":3.1,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}