Effect of β3-adrenergic receptor agonists on [¹⁸F] fluorodeoxyglucose uptake in brown adipose tissues in positron emission tomography images of elderly patients.

IF 3.1 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

EJNMMI Research Pub Date : 2025-08-04 DOI:10.1186/s13550-025-01286-8

John Kenneth V Gacula, Kenichiro Ogane, Kaori Fuse, Miyako Morooka Chikanishi, Kimiteru Ito

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Abstract

Background: Brown adipose tissues (BAT) are highly vascularized, mitochondria-rich tissues involved in thermogenesis. Physiological [¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG) uptake in BAT can be influenced by several factors, including the use of medications that act on β-adrenergic receptors. Recently, increased [¹⁸F]FDG BAT uptake has been observed in elderly patients (≥ 60 years old) receiving β3-adrenergic receptor agonists. With the increasing use of β3-adrenergic receptor agonists for managing overactive bladder, there is limited understanding of their potential association with increased [¹⁸F]FDG BAT uptake. This study retrospectively investigated whether treatment with β3-adrenergic receptor agonists is associated with increased [¹⁸F]FDG BAT uptake among elderly patients. [¹⁸F]FDG positron emission tomography (PET) images were analyzed visually and through SUVmax measurements across eight predefined regions of interest (ROI): cervical, periclavicular, axillary, mediastinal, paravertebral, paraabdominal aortic, perirenal, and perisplenic regions. Patients' medication history and clinical records were reviewed to assess β3-adrenergic receptor agonist use relative to their [¹⁸F]FDG PET study.

Results: Forty-four elderly patients, each with a single [¹⁸F]FDG PET scan, were included in the analysis. Among the eight ROIs, the perirenal region showed a statistically significant increase in [¹⁸F]FDG BAT uptake in patients receiving β3-adrenergic receptor agonists compared with those not receiving, based on both visual analysis (p < 0.001) and SUVmax measurements (p = 0.030). All patients receiving β3-adrenergic receptor agonists demonstrated increased [¹⁸F]FDG BAT uptake in the paravertebral region.

Conclusion: In patients aged ≥ 60 years, β3-adrenergic receptor agonist therapy appears to be associated with increased [¹⁸F]FDG BAT uptake, particularly in the perirenal area.

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β3-肾上腺素能受体激动剂对老年患者正电子发射断层成像中棕色脂肪组织[18F]氟脱氧葡萄糖摄取的影响

背景：棕色脂肪组织（BAT）是高度血管化的，线粒体丰富的组织，参与产热。BAT生理[18F]氟脱氧葡萄糖（[18F]FDG）摄取可受到多种因素的影响，包括作用于β-肾上腺素能受体的药物的使用。最近，在接受β3-肾上腺素能受体激动剂治疗的老年患者（≥60岁）中观察到FDG - BAT摄取增加[18F]。随着β3-肾上腺素能受体激动剂越来越多地用于治疗膀胱过度活动，人们对其与FDG - BAT摄取增加的潜在关联的了解有限[18F]。本研究回顾性调查了β3-肾上腺素能受体激动剂治疗是否与老年患者[18F]FDG - BAT摄取增加有关。[18F]FDG正电子发射断层扫描（PET）图像通过视觉和SUVmax测量在八个预定义的感兴趣区域（ROI）进行分析：颈椎、锁骨周围、腋窝、纵隔、椎旁、腹主动脉旁、肾周和脾周区域。回顾患者的用药史和临床记录，以评估β3-肾上腺素能受体激动剂的使用与他们[18F]FDG PET研究的关系。结果：分析纳入44例老年患者，每位患者均进行了单次[18F]FDG PET扫描。在8个ROIs中，与未接受β3-肾上腺素能受体激动剂的患者相比，接受β3-肾上腺素能受体激动剂的患者肾周区FDG BAT摄取[18F]有统计学意义的增加，基于两种视觉分析[18F]椎旁区FDG BAT摄取。结论：在年龄≥60岁的患者中，β3-肾上腺素能受体激动剂治疗似乎与[18F]FDG - BAT摄取增加有关，尤其是在肾周区域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

EJNMMI Research RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING&nb-

CiteScore

5.90

自引率

3.10%

发文量

审稿时长

13 weeks

期刊介绍： EJNMMI Research publishes new basic, translational and clinical research in the field of nuclear medicine and molecular imaging. Regular features include original research articles, rapid communication of preliminary data on innovative research, interesting case reports, editorials, and letters to the editor. Educational articles on basic sciences, fundamental aspects and controversy related to pre-clinical and clinical research or ethical aspects of research are also welcome. Timely reviews provide updates on current applications, issues in imaging research and translational aspects of nuclear medicine and molecular imaging technologies. The main emphasis is placed on the development of targeted imaging with radiopharmaceuticals within the broader context of molecular probes to enhance understanding and characterisation of the complex biological processes underlying disease and to develop, test and guide new treatment modalities, including radionuclide therapy.