EJNMMI Research最新文献

{"title":"Feasibility of safe outpatient treatment in pediatric patients following intraventricular radioimmunotherapy with ¹³¹I-omburtamab for leptomeningeal disease.","authors":"Kavya Prasad, Brian E Serencsits, Bae P Chu, Lawrence T Dauer, Maria Donzelli, Ellen Basu, Kim Kramer, Neeta Pandit-Taskar","doi":"10.1186/s13550-024-01127-0","DOIUrl":"10.1186/s13550-024-01127-0","url":null,"abstract":"<p><strong>Background: </strong>Radiolabeled antibody ¹³¹I-omburtamab was administered intraventricularly in patients with leptomeningeal disease under an institutionally approved study (#NCT03275402). Radiation safety precautions were tailored for individual patients, enabling outpatient treatment based on in-depth, evidence-based recommendations for such precautions. The imperative advancement of streamlined therapeutic administration procedures, eliminating the necessity for inpatient isolation and resource-intensive measures, holds pivotal significance. This development bears broader implications for analogous therapies within the pediatric patient demographic.</p><p><strong>Methods: </strong>Intraventricular radioimmunotherapy (RIT) with 925-1850 MBq (25-50 mCi) of ¹³¹I-omburtamab was administered via the Ommaya reservoir, in designated rooms within the pediatric ambulatory care center. Dosimeters were provided to staff involved in patient care to evaluate exposure during injection and post-administration. Post-administration exposure rate readings from the patient on contact, at 0.3 m, and at 1 m were taken within the first 30 min, and the room was surveyed after patient discharge. Duration of radiation exposure was calculated using standard U.S. Nuclear Regulatory Commission (US NRC) regulatory guidance recommendations combined with mean exposure rates and whole-body clearance estimates. Exposure rate measurements and clearance data provided patient-specific precautions for four cohorts by age: < 3 y/o, 3-10 y/o, 10-18 y/o, and 18+.</p><p><strong>Results: </strong>Post-administration exposure rates for patients ranged from 0.16 to 0.46 µSv/hr/MBq at 0.3 m and 0.03-0.08 µSv/hr/MBq at 1 m. Radiation exposure precautions ranged from 1 to 10 days after release for the four evaluated cohorts. Based on the highest measured exposure rates and slowest whole-body clearance, the longest precautions were approximately 78% lower than the regulatory guidance recommendations. Radiation exposure to staff associated with ¹³¹I-omburtamab per administration was substantially below the annual regulatory threshold for individual exposure monitoring.</p><p><strong>Conclusion: </strong>¹³¹I-omburtamab can be administered on an outpatient basis, using appropriate patient-based radiation safety precautions that employ patient-specific exposure rate and biological clearance parameters. This trial is registered with the National Library of Medicine's ClinicalTrials.gov. The registration number is NCT03275402, and it was registered on 7 September 2017. The web link is included here. https://clinicaltrials.gov/study/NCT03275402 .</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"14 1","pages":"70"},"PeriodicalIF":3.1,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11291838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pons as an optimal background reference region for spinal ¹⁸F-FET PET/MRI evaluation.","authors":"Jing Huang, Jiyuan Wang, Bixiao Cui, Hongwei Yang, Defeng Tian, Jie Ma, Wanru Duan, Zan Chen, Jie Lu","doi":"10.1186/s13550-024-01130-5","DOIUrl":"10.1186/s13550-024-01130-5","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate the effect of various background reference regions on spinal ¹⁸F-FET PET imaging, with a focus on distinguishing between spinal tumors and myelitis. To enhance diagnostic accuracy, we investigated the pons and several other spinal cord area as potential references, given the challenges in interpreting spinal PET results.</p><p><strong>Results: </strong>A retrospective analysis was conducted on 30 patients, 15 with cervical myelitis and 15 with cervical tumors, who underwent O-(2-[¹⁸F]-fluoroethyl)-L-tyrosine (FET) PET/MR imaging. The stability of uptake across four regions, including the pons, C2, C2-C7, and T1-T3, was compared. The standardized uptake value ratio (SUVR) was then evaluated using various background regions, and their effectiveness in differentiating between spinal tumors and myelitis was compared. Additionally, we correlated the SUVR values derived from these regions with the Ki-67 proliferation index in tumor patients. The study found no significant difference in SUVmax (U = 110, p = 0.93) and SUVmean (U = 89, p = 0.35) values at lesion sites between myelitis and tumor patients. The pons had the highest average uptake (p < 0.001) compared to the other three regions. However, its coefficient of variation (CV) was significantly lower than that of the C2-C7 (p < 0.0001) and T1-T3 segments (p < 0.05). The SUVRmax values, calculated using the regions of pons, C2-C7 and T1-T3, were found to significantly differentiate between tumors and myelitis (p < 0.05). However, only the pons-based SUVRmean was able to significantly distinguish between the two groups (p < 0.05). Additionally, the pons-based SUVRmax (r = 0.63, p = 0.013) and SUVRmean (r = 0.67, p = 0.007) demonstrated a significant positive correlation with the Ki-67 index.</p><p><strong>Conclusions: </strong>This study suggests that the pons may be considered a suitable reference region for spinal ¹⁸F-FET PET imaging, which can improve the differentiation between spinal tumors and myelitis. The significant correlation between pons-based SUVR values and the Ki-67 index further highlights the potential of this approach in assessing tumor cell proliferation.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"14 1","pages":"69"},"PeriodicalIF":3.1,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11282009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141765741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18 F-Choline-PET/CT for non-FDG-avid salivary gland cancer: a preliminary report.","authors":"Gregoire B Morand, Sevda Karimian, Niels J Rupp, Martin W Huellner","doi":"10.1186/s13550-024-01132-3","DOIUrl":"10.1186/s13550-024-01132-3","url":null,"abstract":"","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"14 1","pages":"68"},"PeriodicalIF":3.1,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac sympathetic activity and lethal arrhythmic events: insight into bell-shaped relationship between ¹²³I-meta-iodobenzylguanidine activity and event rates.","authors":"Kenichi Nakajima, Tomoaki Nakata, Takahiro Doi, Derk O Verschure, Viviana Frantellizzi, Maria Silvia De Feo, Hayato Tada, Hein J Verberne","doi":"10.1186/s13550-024-01131-4","DOIUrl":"10.1186/s13550-024-01131-4","url":null,"abstract":"<p><strong>Background: </strong>¹²³I-meta-iodobenzylguanidine (mIBG) has been applied to patients with chronic heart failure (CHF). However, the relationship between ¹²³I-mIBG activity and lethal arrhythmic events (ArE) is not well defined. This study aimed to determine this relationship in Japanese and European cohorts.</p><p><strong>Results: </strong>We calculated heart-to-mediastinum (H/M) count ratios and washout rates (WRs) of 827 patients using planar ¹²³I-mIBG imaging. We defined ArEs as sudden cardiac death, arrhythmic death, and potentially lethal events such as sustained ventricular tachycardia, cardiac arrest with resuscitation, and appropriate implantable cardioverter defibrillator (ICD) discharge, either from a single ICD or as part of a cardiac resynchronization therapy device (CRTD). We analyzed the incidence of ArE with respect to H/M ratios, WRs and New York Heart Association (NYHA) functional classes among Japanese (J; n = 581) and European (E; n = 246) cohorts. We also simulated ArE rates versus H/M ratios under specific conditions using a machine-learning model incorporating 13 clinical variables. Consecutive patients with CHF were selected in group J, whereas group E comprised candidates for cardiac electronic devices. Groups J and E mostly comprised patients with NYHA functional classes I/II (95%) and II/III (91%), respectively, and 21% and 72% were respectively implanted with ICD/CRTD devices. The ArE rate increased with lower H/M ratios in group J, but the relationship was bell-shaped, with a high ArE rate within the intermediate H/M range, in group E. This bell-shaped curve was also evident in patients with NYHA classes II/III in the combined J and E groups, particularly in those with a high (> 15%) mIBG WR and with ischemic, but not in those with non-ischemic etiologies. Machine learning-based prediction of ArE risk aligned with these findings, indicating a bell-shaped curve in NYHA class II/III but not in class I.</p><p><strong>Conclusions: </strong>The relationship between cardiac ¹²³I-mIBG activity and lethal arrhythmic events is influenced by the background of patients. The bell-shaped relationship in NYHA classes II/III, high WR, and ischemic etiology likely aids in identifying patients at high risk for ArEs.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"14 1","pages":"67"},"PeriodicalIF":3.1,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[⁶⁸Ga]Ga-FAPI versus 2-[¹⁸F]FDG PET/CT in patients with autoimmune thyroiditis: a case control study.","authors":"Kim M Pabst, Lukas Kessler, Justin Ferdinandus, Rainer Hamacher, Timo Bartel, Jens T Siveke, Michael Nader, Tim Brandenburg, Mélanie Desaulniers, Ken Herrmann, Wolfgang P Fendler","doi":"10.1186/s13550-024-01129-y","DOIUrl":"10.1186/s13550-024-01129-y","url":null,"abstract":"<p><strong>Purpose: </strong>Radiolabelled fibroblast activation protein inhibitors (FAPIs) are becoming increasingly important for imaging various tumour diseases. However, it is essential to be aware of potential pitfalls. Here, we investigate FAP expression in the thyroid gland in autoimmune thyroiditis (AIT).</p><p><strong>Methods: </strong>AIT patients with pathological thyroid uptake on [⁶⁸Ga]Ga-FAPI PET were compared with glucose metabolism on 2-[¹⁸F]FDG PET in terms of SUV_max/SUV_peak/SUV_mean/tissue-to-background ratio (TBR), and with a healthy control group.</p><p><strong>Results: </strong>Between September 2019 and July 2021, 6 patients presented with a visually increased thyroid uptake and TBR on [⁶⁸Ga]Ga-FAPI PET. In the retrospective clinical work-up, all patients had known or newly diagnosed AIT. Compared to a matched healthy control group, FAP expression and glucose metabolism were significantly increased ([⁶⁸Ga]Ga-FAPI (SUV_peak): 7.0 vs. 1.7; p = 0.004/(TBR_bloodpool): 6.8 vs. 1.7; p = 0.002; 2-[¹⁸F]FDG (SUV_peak): 3.9 vs. 1.4; p = 0.004/(TBR_bloodpool): 4.0 vs. 1.2; p = 0.041). However, there was no significant difference in median uptake between [⁶⁸Ga]Ga-FAPI and 2-[18F]FDG PET (SUV_peak: 7.3 vs. 5.6; p = 0.104).</p><p><strong>Conclusion: </strong>Patients with AIT show higher thyroid uptake on [⁶⁸Ga]Ga-FAPI and 2-[¹⁸F]FDG PET. Incidental thyroid uptake is another pitfall in the interpretation of [⁶⁸Ga]Ga-FAPI PET and should prompt a clinical work-up.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"14 1","pages":"66"},"PeriodicalIF":3.1,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11258103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141633044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and gender effects on striatal dopamine transporter density and cerebral perfusion in individuals with non-degenerative parkinsonism: a dual-phase ¹⁸F-FP-CIT PET study.","authors":"Ji-Young Kim, Seo Young Kang, Byung Seok Moon, Bom Sahn Kim, Jee Hyang Jeong, Hai-Jeon Yoon","doi":"10.1186/s13550-024-01126-1","DOIUrl":"10.1186/s13550-024-01126-1","url":null,"abstract":"<p><strong>Background: </strong>Dual-phase fluorine-18 labeled N-3-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (¹⁸F-FP-CIT) positron emission tomography (PET) scans could be used to support disorders like Parkinson's disease (PD). Dopamine transporter (DAT) binding and cerebral perfusion are associated with ageing and gender. We investigated the effects of age and gender on non-degenerative parkinsonism, using automated quantification in striatum: specific binding ratios (SBRs) for DAT binding in delayed phase PET (dCIT) and standardized-uptake-value ratios (SUVRs) for cerebral perfusion in early phase PET (eCIT). We also examined the correlations between SBR and SUVR.</p><p><strong>Methods: </strong>This retrospective study analyzed subjects with dual-phase ¹⁸F-FP-CIT PET scans. The eCIT images were acquired immediately post-injection, and dCIT images were taken 120 min later. With Brightonix software, automated quantification of SBRs for dCIT and SUVRs for eCIT were acquired from visually normal scans. The effects of aging and gender were assessed by regressing SBRs and SUVRs on age for both genders. The correlations between SUVRs and SBRs were evaluated.</p><p><strong>Results: </strong>We studied 79 subjects (34 males and 45 females). An age-related reduction in SBRs was observed in the dorsal striatum, ventral striatum, caudate nucleus, and putamen for both genders. SUVRs were found to negatively correlate with age in the dorsal striatum, ventral striatum, caudate nucleus, and putamen for males and in the dorsal striatum and caudate nucleus for females. Positive correlations between SBRs and SUVRs in the dorsal striatum, ventral striatum, caudate nucleus, and putamen for male and in the dorsal striatum, caudate nucleus, and putamen for females.</p><p><strong>Conclusions: </strong>Using quantified values from dual-phase ¹⁸F-FP-CIT PET with a single injection, we demonstrate a negative impact of age on SBRs (DAT binding) in the striatum for both genders and SUVRs (cerebral perfusion) in the dorsal striatum and caudate nucleus for both genders and in the ventral striatum and putamen for males. Additionally, we found positive associations between SBR and SUVR values in the dorsal striatum, caudate nucleus, and putamen for both genders and in the ventral striatum for males.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"14 1","pages":"65"},"PeriodicalIF":3.1,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11254898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pivotal role of endoplasmic reticulum in FDG uptake in cancer cells.","authors":"Francesca Vitale, Maddalena Ghelardoni, Sabrina Chiesa, Sonia Carta, Serena Losacco, Anna Maria Orengo, Silvia Bruno, Silvia Ravera, Matteo Bauckneht, Mattia Riondato, Isabella Donegani, Edoardo Dighero, Jonathan Martinelli, Cecilia Marini, Gianmario Sambuceti","doi":"10.1186/s13550-024-01124-3","DOIUrl":"10.1186/s13550-024-01124-3","url":null,"abstract":"","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"14 1","pages":"64"},"PeriodicalIF":3.1,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11245458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical evaluation of [¹⁸F]SYN1 and [¹⁸F]SYN2, novel radiotracers for PET myocardial perfusion imaging.","authors":"Seweryn Krajewski, Lukasz Steczek, Karina Gotowicz, Urszula Karczmarczyk, Joanna Towpik, Ewa Witkowska-Patena, Krzysztof Łyczko, Maciej Mazur, Przemysław Kozanecki, Joanna Włostowska, Juhani Knuuti, Mirosław Dziuk, Piotr Garnuszek, Cezary Kozanecki","doi":"10.1186/s13550-024-01122-5","DOIUrl":"10.1186/s13550-024-01122-5","url":null,"abstract":"<p><strong>Background: </strong>Positron emission tomography (PET) is now an established diagnostic method for myocardial perfusion imaging (MPI) in coronary artery disease, which is the main cause of death globally. The available tracers show several limitations, therefore, the ¹⁸F-labelled tracer is in high demand nowadays. The preclinical studies on normal Wistar rats aimed to characterise two potential, novel radiotracers, [¹⁸F]SYN1 and [¹⁸F]SYN2, to evaluate which is a better candidate for PET MPI cardiotracer.</p><p><strong>Results: </strong>The dynamic microPET images showed rapid myocardial uptake for both tracers. However, the uptake was higher and also stable for [¹⁸F]SYN2, with an average standardized uptake value of 3.8. The biodistribution studies confirmed that [¹⁸F]SYN2 uptake in the cardiac muscle was high and stable (3.02%ID/g at 15 min and 2.79%ID/g at 6 h) compared to [¹⁸F]SYN1 (1.84%ID/g at 15 min and 0.32%ID/g at 6 h). The critical organs determined in dosimetry studies were the small intestine and the kidneys. The estimated effective dose for humans was 0.00714 mSv/MBq for [¹⁸F]SYN1 and 0.0109 mSv/MBq for [¹⁸F]SYN2. The tested dose level of 2 mg/kg was considered to be the No Observed Adverse Effect Level (NOAEL) for both candidates. The better results were achieved for [¹⁸F]SYN2, therefore, further preclinical studies were conducted only for this tracer. Radioligand binding assays showed significant responses in 3 from 68 assays: muscarinic acetylcholine M₁ and M₂ receptors and potassium channel hERG. The compound was mostly metabolised via an oxidative N-dealkylation, while the fluor substituent was not separated from the molecule.</p><p><strong>Conclusion: </strong>[¹⁸F]SYN2 showed a favourable pharmacodynamic and pharmacokinetic profile, which enabled a clear visualization of the heart in microPET. The compound was well-tolerated in studies in normal rats with moderate radiation exposure. The results encourage further exploration of [¹⁸F]SYN2 in clinical studies.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"14 1","pages":"63"},"PeriodicalIF":3.1,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11231114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasensitive detection of uveal melanoma using [¹⁸F]AlF-NOTA-PRGD2 PET imaging.","authors":"Ling Wang, Xue Zhu, Yan Xue, Zhihong Huang, Wenjun Zou, Zhengwei Zhang, Mengxi Yu, Donghui Pan, Ke Wang","doi":"10.1186/s13550-024-01123-4","DOIUrl":"10.1186/s13550-024-01123-4","url":null,"abstract":"<p><strong>Background: </strong>Uveal melanoma (UM) is the most common primary intraocular tumor in adults, and early detection is critical to improve the clinical outcome of this disease. In this study, the diagnostic effectiveness of [¹⁸F]AlF-NOTA-PRGD2 (an investigational medicinal product) positron emission tomography (PET) imaging in UM xenografts and UM patients were evaluated. The cell uptake, cell binding ability and in vitro stability of [¹⁸F]AlF-NOTA-PRGD2 were evaluated in 92-1 UM cell line. MicroPET imaging and biodistribution study of [¹⁸F]AlF-NOTA-PRGD2 were conducted in 92-1 UM xenografts. Then, UM patients were further recruited for evaluating the diagnostic effectiveness of [¹⁸F]AlF-NOTA-PRGD2 PET imaging (approval no. NCT02441972 in clinicaltrials.gov). In addition, comparison of [¹⁸F]AlF-NOTA-PRGD2 and ¹⁸F-labelled fluorodeoxyglucose ([¹⁸F]FDG) PET imaging in UM xenografts and UM patients were conducted.</p><p><strong>Results: </strong>The in vitro data showed that [¹⁸F]AlF-NOTA-PRGD2 had a high cell uptake, cell binding ability and in vitro stability in 92-1 UM cell line. The in vivo data indicated that 92-1 UM tumors were clearly visualized with the [¹⁸F]AlF-NOTA-PRGD2 tracer in the subcutaneous and ocular primary UM xenografts model at 60 min post-injection. And the tumor uptake of the tracer was 2.55 ± 0.44%ID/g and 1.73 ± 0.15%ID/g at these two tissue locations respectively, at 7 days after animal model construction. The clinical data showed that tumors in UM patients were clearly visualized with the [¹⁸F]AlF-NOTA-PRGD2 tracer at 60 min post-injection. In addition, [¹⁸F]AlF-NOTA-PRGD2 tracer showed higher sensitivity and specificity for PET imaging in UM xenografts and UM patients compared to [¹⁸F]FDG tracer.</p><p><strong>Conclusion: </strong>[¹⁸F]AlF-NOTA-PRGD2 PET imaging may be a more preferred approach in the diagnosis of primary UM compared to [¹⁸F]FDG PET imaging. Additionally, due to the high tumor-to-background ratio, [¹⁸F]AlF-NOTA-PRGD2 PET imaging seems also to be applicable for the diagnosis of UM patients with liver metastasis.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov: NCT02441972, Registered 1 January 2012, https://clinicaltrials.gov/study/NCT02441972 .</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"14 1","pages":"62"},"PeriodicalIF":3.1,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11226693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical value of ⁶⁸Ga-pentixafor PET/CT in patients with primary aldosteronism and bilateral lesions: preliminary results of a single-centre study.","authors":"Rui Zuo, Shuang Liu, Wenbo Li, Zhu Xia, Lu Xu, Hua Pang","doi":"10.1186/s13550-024-01125-2","DOIUrl":"10.1186/s13550-024-01125-2","url":null,"abstract":"<p><strong>Background: </strong>Subtype diagnosis of primary aldosteronism (PA) is used to determine treatment, and the potential utility of ⁶⁸Ga-pentixafor PET/CT for investigation of PA has long been recognized. The study aimed to evaluate the clinical value of ⁶⁸Ga-pentixafor PET/CT in the diagnosis and prognosis of patients with bilateral lesions identified by CT.</p><p><strong>Methods: </strong>In total, 25 patients with PA and bilateral lesions on CT were retrospectively evaluated. All patients underwent ⁶⁸Ga-Pentixafor PET/CT and adrenal vein sampling. The analysis focused on establishing the relationship between bilateral adrenal lesions SUVmax and the ratio of bilateral adrenal lesions SUVmax (CON) and clinical diagnosis, treatment outcomes, and KCNJ5 gene status.</p><p><strong>Results: </strong>The concordance rate between ⁶⁸Ga-Pentixafor PET/CT and adrenal venous sampling was 65.2% (15/23). The lateralization results of ⁶⁸Ga-pentixafor PET/CT supported the clinical decisions of 20 patients with PA, 90% of whom showed effectiveness in treatment. The SUVmax on the dominant side of the surgically treated patients was higher than that of patients treated with drugs. The SUVmax of the KCNJ5 mutant group was higher than that of the KCNJ5 wild group, and ⁶⁸Ga-Pentixafor uptake was correlated with KCNJ5 gene status.</p><p><strong>Conclusions: </strong>⁶⁸Ga-Pentixafor PET/CT proves beneficial for patients with PA with bilateral lesions on CT. The treatment is generally effective based on the results of PET lateralization. Simultaneously, a certain relationship exists between ⁶⁸Ga-Pentixafor PET/CT and KCNJ5 gene status, warranting further analysis.</p>","PeriodicalId":11611,"journal":{"name":"EJNMMI Research","volume":"14 1","pages":"61"},"PeriodicalIF":3.1,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}