Enfermedades infecciosas y microbiologia clinica最新文献_第6页

Enfermedad de Chagas y coinfección por el VIH 恰加斯病和艾滋病毒合并感染

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-02-01 DOI: 10.1016/j.eimc.2024.09.008

Jesús Fernández Plaza , Javier Guzmán , Sandra Chamorro-Tojeiro , José A. Pérez-Molina

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Análisis del diagnóstico serológico de la sífilis: una propuesta de mejora 梅毒血清学诊断分析：改进建议

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-02-01 DOI: 10.1016/j.eimc.2024.09.010

Javier Gutiérrez Ballesteros , Sonsoles Garcinuño Pérez , Marta Domínguez-Gil González , Silvia Rojo Rello

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Nuevo secuenciotipo ST6423 de Klebsiella pneumoniae hipervirulenta portador de carbapenemasa OXA-48-like causante de bacteriemia en un paciente inmunocomprometido 在免疫受损患者身上发现的高毒性OXA-48样碳青霉烯质的肺炎克雷伯氏菌新序列型ST6423

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-02-01 DOI: 10.1016/j.eimc.2024.08.014

Carmen Palacios Clar, Diego García Martínez de Artola, Julia Alcoba Flórez

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¿Qué corticosteroide debería emplearse en la neumonía grave? 严重肺炎应该使用哪种皮质类固醇？

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-02-01 DOI: 10.1016/j.eimc.2024.11.001

Javier Velasco Montes , María Victoria Pardo Gutiérrez , Carlos Hernando Martín , Silvia González Díez

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Peritonitis bacteriana aguda por Staphylococcus lugdunensis resistente a meticilina 耐甲氧西林卢格敦葡萄球菌引起的急性细菌性腹膜炎

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-02-01 DOI: 10.1016/j.eimc.2024.08.010

David Roa Alonso , Víctor Antón Berenguer , Alberto Orejas Gallego , Ricardo Díaz Abad

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Causa inesperada de insuficiencia cardiaca en varón con válvulas mitral y aórtica protésicas 患有人工二尖瓣和主动脉瓣的男性心力衰竭的意外原因

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-02-01 DOI: 10.1016/j.eimc.2024.06.010

Yolanda García Collado, Lourdes Balderas Fernández, Laura Mora Navas, María Victoria García López

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Complete genome characterization of mcr-1-mediated colistin-resistant Escherichia coli from outpatients in Bulgaria 保加利亚门诊患者mcr-1介导的耐粘菌素大肠杆菌的全基因组特征

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-02-01 DOI: 10.1016/j.eimc.2024.10.002

Stefana Sabtcheva , Ivan Stoikov , Deyan Donchev , Sylvia Georgieva , Elina Dobreva , Ivan Nikolaev Ivanov

{"title":"Complete genome characterization of mcr-1-mediated colistin-resistant Escherichia coli from outpatients in Bulgaria","authors":"Stefana Sabtcheva , Ivan Stoikov , Deyan Donchev , Sylvia Georgieva , Elina Dobreva , Ivan Nikolaev Ivanov","doi":"10.1016/j.eimc.2024.10.002","DOIUrl":"10.1016/j.eimc.2024.10.002","url":null,"abstract":"<div><h3>Introduction</h3><div>This study reports the emergence of <em>mcr-1</em>-mediated colistin resistance in human <em>Escherichia coli</em> isolates from Bulgaria.</div></div><div><h3>Methods</h3><div>Three colistin-resistant <em>E. coli</em> isolates were obtained from outpatient urine specimens. They were subjected to PCR for detection of <em>mcr</em> genes and conjugation experiments. Whole-genome sequencing was employed to analyze the genomic characteristics of the isolates.</div></div><div><h3>Results</h3><div>PCR identified <em>mcr-1</em> in all isolates. In <em>E. coli</em> of sequence type (ST) 2067, <em>mcr-1.1</em> was found on a self-transmissible IncI2 plasmid, while <em>mcr-1.32</em> was chromosomal in the remaining two ST131 <em>E. coli</em> isolates. <em>E. coli</em> ST2067 co-harbored quinolones resistance mutations (<em>gyrA</em><sup>D87N</sup>, <em>gyrA</em><sup>S83L</sup>, <em>parC</em><sup>S80I</sup>), β-lactam (<em>bla</em><sub>TEM-30</sub>) and aminoglycoside (<em>aadA1</em>, <em>aac(3)-IId</em>) resistance genes.</div></div><div><h3>Conclusion</h3><div>This report further confirms the role of IncI2 conjugative plasmids in the dissemination of <em>mcr</em> genes. Our findings involving chromosomal <em>mcr-1</em> in high-risk ST131 <em>E. coli</em> strains from outpatients underscores the need for enhanced surveillance and systematic screening to combat colistin resistance.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 97-101"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143166793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aplicación en vida real de un modelo de estratificación para la atención de personas con VIH 艾滋病毒感染者护理分层模式的实际应用

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-02-01 DOI: 10.1016/j.eimc.2024.03.006

Miguel Suárez-Robles , Clara Crespillo Andújar , Sandra Chamorro-Tojeiro , Begoña Monge-Maillo , Francesca Norman , Ignacio Peña , Martina Corral , Cristina Arcas , Santiago Moreno , Jose A. Pérez-Molina

{"title":"Aplicación en vida real de un modelo de estratificación para la atención de personas con VIH","authors":"Miguel Suárez-Robles , Clara Crespillo Andújar , Sandra Chamorro-Tojeiro , Begoña Monge-Maillo , Francesca Norman , Ignacio Peña , Martina Corral , Cristina Arcas , Santiago Moreno , Jose A. Pérez-Molina","doi":"10.1016/j.eimc.2024.03.006","DOIUrl":"10.1016/j.eimc.2024.03.006","url":null,"abstract":"<div><h3>Introduction</h3><div>HIV infection has become a chronic disease with a good long-term prognosis, necessitating a change in the care model. For this study, we applied a proposal for an Optimal Care Model (OCM) for people with HIV (PHIV), which includes tools for assessing patient complexity and their classification into profiles to optimize care provision.</div></div><div><h3>Methods</h3><div>Observational, cross-sectional, and retrospective study. Adult PHIV treated at the Tropical Medicine consultations at Ramón y Cajal Hospital from January 1 to June 30, 2023, were included. The complexity calculation and the stratification into profiles for each patient were done according to the OCM.</div></div><div><h3>Results</h3><div>Ninety-four participants were included, 76.6% cisgender men, with a median age of 41 years (range 23-76). Latin America and Africa were the main regions of origin (72.4%). 98% had an undetectable HIV viral load. The degree of complexity was 78.7% low, 11.7% medium, 1% high, and 8.5% extreme. The predominant profile was blue (64.9%), followed by lilac (11.7%), purple (6.3%), and green (4.3%). 7.4% were unclassifiable, of whom 57.2% had high/extreme complexity. Among the unclassifiable, mental health problems were the most common.</div></div><div><h3>Conclusions</h3><div>The OCM tools for People Living with HIV (PLWH) allow for the classification and stratification of most patients in a consultation with a non-standard population. Patients who did not fit into the pre-established profiles presented high complexity. Creating a profile focused on mental health or mixed profiles could facilitate the classification of more patients.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 80-85"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

¿Cómo podemos optimizar el abordaje diagnóstico y terapéutico de la neumonía? Recomendaciones basadas en una opinión de expertos. Respuesta de los autores 我们如何优化肺炎的诊断和治疗方法？基于专家意见的建议。提交人的答复

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-02-01 DOI: 10.1016/j.eimc.2024.11.002

Mario Fernández-Ruiz , Juan José Castón , José Luis del Pozo , José María Aguado , en representación de los miembros del Grupo OPENIN («Optimización de procesos clínicos para el diagnóstico y tratamiento de infecciones»)

引用次数: 0

Hypervirulent Klebsiella pneumoniae: Epidemiology outside Asian countries, antibiotic resistance association, methods of detection and clinical management 高致病性肺炎克雷伯菌：亚洲以外国家的流行病学、抗生素耐药性关联、检测方法和临床管理

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-02-01 DOI: 10.1016/j.eimc.2024.12.008

Silvia García-Cobos , Jesús Oteo-Iglesias , María Pérez-Vázquez

{"title":"Hypervirulent Klebsiella pneumoniae: Epidemiology outside Asian countries, antibiotic resistance association, methods of detection and clinical management","authors":"Silvia García-Cobos , Jesús Oteo-Iglesias , María Pérez-Vázquez","doi":"10.1016/j.eimc.2024.12.008","DOIUrl":"10.1016/j.eimc.2024.12.008","url":null,"abstract":"<div><div>Two main <em>Klebsiella pneumoniae</em> pathotypes are of public health concern, classical <em>K. pneumoniae</em> (cKP), with high antibiotic resistance acquisition capacity, and hypervirulent <em>K. pneumoniae</em> (hvKP). The emergence of hypervirulent and antibiotic-resistant <em>K. pneumoniae</em>, especially carbapenem resistance, is worrisome and require effective methods for detection and treatment. Different evolutionary paths contribute to the emergence of hypervirulence and antibiotic resistance, commonly via the acquisition of resistance plasmids by hvKP (CR-hvKP) or the acquisition of virulence plasmids by CRKp (hv-CRKp). ST11-KL64 together with <em>bla</em><sub>KPC-2</sub>, is the most extended hv-CRKP lineage acquiring virulence plasmids with associated biomarkers, <em>rmpA</em>, <em>rmpa2</em>, <em>iroBCDEN</em>, <em>iucABCDiutA</em>, and <em>peg344</em>. In addition to ST11, other hv-CRKP clones have been reported in Europe such as ST101, ST147 and ST512, highlighting the association of ST147 with OXA-48 and NDM carbapenemases. Although still very rare in Spain, hvKP cases are increasing in recent years, mainly due to ST23-K1, ST380-K2 and ST86-K2. Management of hvKP infections requires active antibiotic therapy based primarily on antibiotic susceptibility patters and site of infection.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 102-109"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143166794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0