Enfermedades infecciosas y microbiologia clinica最新文献

{"title":"Dalbavancina como tratamiento antibiótico de consolidación en endocarditis infecciosa, infección de dispositivos de estimulación cardiaca y bacteriemia: experiencia clínica de 7 años","authors":"Alejandro Salinas-Botrán ,&nbsp;Carmen Olmos-Blanco ,&nbsp;David Fernández de Velasco-Pérez ,&nbsp;Alicia Guzmán-Carreras ,&nbsp;Alejandro Morales-Rosas ,&nbsp;Daniel Gómez-Ramírez","doi":"10.1016/j.eimc.2024.02.010","DOIUrl":"10.1016/j.eimc.2024.02.010","url":null,"abstract":"<div><h3>Introduction</h3><div>Dalbavancin (DBV), a novel lipoglycopeptide with activity against Gram-positive bacterial infections, is approved for the treatment of acute bacterial skin and skin structure infections. It has linear dose-related pharmacokinetics allowing a prolonged interval between doses. It would be a good option for the treatment of patients with Gram-positive cardiovascular infections.</div></div><div><h3>Material and methods</h3><div>Retrospective analysis of patients with cardiovascular infection (bacteremia, implantable electronic device infection and infective endocarditis [IE]) treated with DBV at Hospital Clínico San Carlos (Madrid) for 7 years (2016-2022). Patients were divided into 2 study groups: 1) IE, and 2) bacteremia. Epidemiological, clinical, microbiological and therapeutic data were analyzed.</div></div><div><h3>Results</h3><div>A total of 25 patients were treated with DBV for cardiovascular infection. IE was the most common indication (68%), followed by bacteremia (32%) with male predominance in both groups (64 vs. 62%) and median age of 67,7 and 57,5 years, respectively. Hundred percent of blood cultures were positive to Gram-positive microorganisms (<em>Staphylococcus</em> spp., <em>Streptococcus</em> spp. or <em>Enterococcus</em> spp.) in both study groups. Previously to DBV, all patients received other antibiotic therapy, both in the group of IE (median: 80 days) as in bacteremia (14,8 days). The main reason for the administration of DBV was to continue intravenous antimicrobial therapy outside the hospital in both the EI group (n<!--> <!-->=<!--> <!-->15) and the bacteremia group (n<!--> <!-->=<!--> <!-->8). DBV was used as consolidation therapy in a once- or twice-weekly regimen. Microbiological and clinical successes were reached in 84% of cases (n<!--> <!-->=<!--> <!-->21), 76,4% in IE group and 100% in bacteremia group. No patient documented adverse effects during long-term DBV treatment.</div></div><div><h3>Conclusion</h3><div>DBV is an effective and safety treatment as consolidation antibiotic therapy in IE and bacteremia produced by Gram-positive microorganisms.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 71-79"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140400211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusually high incidence of pneumonia in Navarre, Spain, 2023–2024","authors":"Camino Trobajo-Sanmartín ,&nbsp;María Eugenia Portillo ,&nbsp;Ana Navascués ,&nbsp;Iván Martínez-Baz ,&nbsp;Carmen Ezpeleta ,&nbsp;Jesús Castilla","doi":"10.1016/j.eimc.2024.08.008","DOIUrl":"10.1016/j.eimc.2024.08.008","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the pneumonia incidence in Navarre, Spain, in the 2023–2024 season.</div></div><div><h3>Methods</h3><div>Using electronic medical records, we evaluated the incidence of clinical pneumonia, positive pneumococcal antigen cases and <em>Mycoplasma pneumoniae</em> positive PCR cases by age groups from 2017–2018 to 2023–2024 season.</div></div><div><h3>Results</h3><div>Compared to the average of the 2017–2018 and 2018–2019 seasons, in the 2023–2024 season, pneumonia incidence rate increased by 73% overall and multiplied by 4.43 in the age group of 5–14 years. The rate of confirmed pneumococcal pneumonia increased by 63%, and that of <em>M. pneumoniae</em> multiplied by 19.</div></div><div><h3>Conclusion</h3><div>Pneumonia incidence was unusually high in all ages in the 2023–2024 season and was related to upsurges in pneumococcal and <em>Mycoplasma</em> diseases.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 93-96"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143166762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypervirulent Klebsiella pneumoniae: Epidemiology outside Asian countries, antibiotic resistance association, methods of detection and clinical management","authors":"Silvia García-Cobos ,&nbsp;Jesús Oteo-Iglesias ,&nbsp;María Pérez-Vázquez","doi":"10.1016/j.eimc.2024.12.008","DOIUrl":"10.1016/j.eimc.2024.12.008","url":null,"abstract":"<div><div>Two main <em>Klebsiella pneumoniae</em> pathotypes are of public health concern, classical <em>K. pneumoniae</em> (cKP), with high antibiotic resistance acquisition capacity, and hypervirulent <em>K. pneumoniae</em> (hvKP). The emergence of hypervirulent and antibiotic-resistant <em>K. pneumoniae</em>, especially carbapenem resistance, is worrisome and require effective methods for detection and treatment. Different evolutionary paths contribute to the emergence of hypervirulence and antibiotic resistance, commonly via the acquisition of resistance plasmids by hvKP (CR-hvKP) or the acquisition of virulence plasmids by CRKp (hv-CRKp). ST11-KL64 together with <em>bla</em>_KPC-2, is the most extended hv-CRKP lineage acquiring virulence plasmids with associated biomarkers, <em>rmpA</em>, <em>rmpa2</em>, <em>iroBCDEN</em>, <em>iucABCDiutA</em>, and <em>peg344</em>. In addition to ST11, other hv-CRKP clones have been reported in Europe such as ST101, ST147 and ST512, highlighting the association of ST147 with OXA-48 and NDM carbapenemases. Although still very rare in Spain, hvKP cases are increasing in recent years, mainly due to ST23-K1, ST380-K2 and ST86-K2. Management of hvKP infections requires active antibiotic therapy based primarily on antibiotic susceptibility patters and site of infection.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 102-109"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143166794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of UV-C disinfection and copper plating on healthcare-associated infections in a NICU with high ESBL infections","authors":"Daniela de la Rosa-Zamboni,&nbsp;Mónica Villa-Guillén,&nbsp;Anaíd Bustos-Hamdan,&nbsp;María Isabel Rosas-Mateos,&nbsp;Marisol Medina-Pelcastre,&nbsp;Margarita Torres-García,&nbsp;María Isabel Franco-Hernández,&nbsp;María del Carmen Castellanos-Cruz,&nbsp;Israel Parra-Ortega,&nbsp;Edmedt Fest-Parra,&nbsp;María Citlalli Casillas-Casillas,&nbsp;Ana Carmen Guerrero-Díaz","doi":"10.1016/j.eimc.2024.02.009","DOIUrl":"10.1016/j.eimc.2024.02.009","url":null,"abstract":"<div><h3>Introduction</h3><div>Healthcare-associated infections (HCAIs) in neonates are frequent and highly lethal, in particular those caused by extended spectrum beta-lactamase (ESBL) producing bacteria. We evaluated the beneficial effects of ultraviolet C (UV-C) disinfection and copper adhesive plating on HCAIs in the Neonatal Intensive Care Unit (NICU) of a third level paediatric hospital in Mexico City, both in combination of hand-hygiene (HH) and prevention bundles.</div></div><div><h3>Methods</h3><div>All NICU patients were included. There were 4 periods (P): P1: HH monitoring and prevention bundles; P2: P1<!--> <!-->+<!--> <!-->UV-C disinfection; P3: P2<!--> <!-->+<!--> <!-->Copper adhesive plating on frequent-contact surfaces and P4: Monitoring of P3 actions.</div></div><div><h3>Results</h3><div>552 neonates were monitored during 15,467 patient days (PD). HCAI rates decreased from 11.03/1000 PD in P1 to 5.35/1000 PD in P4 (<em>p</em> <!-->=<!--> <!-->0.006). HCAIs with bacterial isolates dropped from 5.39/1000 PD in PI to 1.79/1000 PD in P4 (<em>p</em> <!-->=<!--> <!-->0.011). UV-C and copper were associated with significant HCAI prevention (RR 0.49, CI_95% 0.30–0.81, <em>p</em> <!-->=<!--> <!-->0.005) and with lesser HCAIs with bacterial isolates (RR 0.33, CI_95% 0.14–0.77, <em>p</em> <!-->=<!--> <!-->0.011).</div></div><div><h3>Conclusions</h3><div>Copper adhesive plating combined with UV-C disinfection were associated with a drop in HCAI rates and with the elimination of ESBL-caused HCAIs. Hence, we propose that these strategies be considered in MDRO proliferation preventions.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 64-70"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140407999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythema induratum of Bazin—A cutaneous manifestation of tuberculosis","authors":"Maria Ana Quadros Flores ,&nbsp;Gustavo Almeida Silva ,&nbsp;Paulo Filipe ,&nbsp;Sérgio Eduardo Paulo","doi":"10.1016/j.eimc.2024.06.006","DOIUrl":"10.1016/j.eimc.2024.06.006","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 110-112"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141851985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dalbavancin: A new milestone in the treatment of Gram-positive infections","authors":"Arístides de Alarcón González","doi":"10.1016/j.eimc.2024.12.004","DOIUrl":"10.1016/j.eimc.2024.12.004","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 61-63"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143166761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving SARS-CoV-2 severity among hospital and university affiliates in Spain and Greater Boston","authors":"Fares Amer ,&nbsp;Fan-Yun Lan ,&nbsp;Mario Gil-Conesa ,&nbsp;Amalia Sidossis ,&nbsp;Daniel Bruque ,&nbsp;Eirini Iliaki ,&nbsp;Jane Buley ,&nbsp;Neetha Nathan ,&nbsp;Lou Ann Bruno-Murtha ,&nbsp;Silvia Carlos ,&nbsp;Stefanos N. Kales ,&nbsp;Alejandro Fernandez-Montero","doi":"10.1016/j.eimc.2023.12.011","DOIUrl":"10.1016/j.eimc.2023.12.011","url":null,"abstract":"<div><h3>Introduction</h3><div>The COVID-19 pandemic caused by the SARS-CoV-2 virus greatly affected healthcare workers and healthcare systems. It also challenged schools and universities worldwide negatively affecting in-person education. We conducted this study is to assess the evolution of SARs-CoV-2 virulence over the course of the pandemic.</div></div><div><h3>Methods</h3><div>A combined cohort of University students in Spain and HCWs from the two hospitals in Spain, and one healthcare system in the Greater Boston area was followed prospectively from March 8th, 2020, to January 31st, 2022 for diagnosis with COVID-19 by PCR testing and related sequelae. Follow-up time was divided into four periods according to distinct waves of infection during the pandemic. Severity of COVID-19 was measured by case-hospitalization rate. Descriptive statistics and multivariable-adjusted statistics using the Poisson mixed-effects regression model were applied. As a sensitivity analysis, information on SARS-CoV-2 RNA in wastewater and COVID-19 deaths through May 30, 2023 from the Boston area was collected.</div></div><div><h3>Results</h3><div>For the last two periods of the study (January 1st to December 15th, 2021 and December 16th, 2021 to January 31st, 2022) and relative to the first period (March 8th to May 31st, 2020), the incidence rate ratios (IRRs) of hospitalization were 0.08 (95% CI, 0.03–0.17) and 0.03 (95% CI, 0.01–0.15), respectively. In addition, a relative risk 0.012 CI95% (0.012–0.012) was observed when comparing COVID-19 mortality versus SARS-CoV-2 RNA copies/mL in Boston-area wastewater over the period (16th December 2021 to 30th May 2023) and relative to the first period.</div></div><div><h3>Conclusions</h3><div>The severity of COVID-19 and immunity of our populations evolved over time, resulting in a decrease in case severity. We found the case-hospitalization rate decreased more than 90% in our cohort despite an increase in incidence.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 1","pages":"Pages 17-22"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139666939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of carbapenemases in Enterobacterales susceptible in vitro to meropenem","authors":"Luana Silva Dornelles ,&nbsp;Mariana Preussler Mott ,&nbsp;Gabriela da Silva Collar ,&nbsp;Luciana Giordani ,&nbsp;Rodrigo Minuto Paiva ,&nbsp;Larissa Lutz","doi":"10.1016/j.eimc.2024.07.015","DOIUrl":"10.1016/j.eimc.2024.07.015","url":null,"abstract":"<div><h3>Introduction</h3><div>Carbapenemase-producing Enterobacterales (CPE) is a global threat. We evaluate the prevalence of CPE among isolates categorized as meropenem-susceptible, but that meet the European Committee on Antimicrobial Susceptibility Testing (EUCAST) screening cut-off values for carbapenemase detection, and analyze the susceptibility of these isolates to new available drugs.</div></div><div><h3>Methods</h3><div>We analyzed 257 isolates from patients hospitalized in a tertiary hospital in Brazil, from July 2022 to April 2023. Only isolates that met the screening cut-off values established by EUCAST for detection of carbapenemases were analyzed (i.e. meropenem inhibition zones of 25–27<!--> <!-->mm by disk diffusion). The detection of carbapenemases was performed by immnunochromatographic testing and confirmed by high-resolution melting-PCR (HRM-qPCR).</div></div><div><h3>Results</h3><div>We identified 12 (4.7%) CPE including 7 KPC, 4 NDM, and 1 OXA-48-like. The isolates were susceptible to ceftazidime–avibactam (72.7%), meropenem–vaborbactam (100%), imipenem–relebactam (63.6%) and ceftolozane–tazobactam (36.4%).</div></div><div><h3>Conclusion</h3><div>We highlight the importance of tracking carbapenemases for epidemiological control and therapeutic guidance.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 1","pages":"Pages 32-35"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A man with recurrent axillary abscess","authors":"Gamze Durmaz ,&nbsp;Esin Beycan ,&nbsp;Abdurrahman Kaya ,&nbsp;Ali Mert","doi":"10.1016/j.eimc.2024.03.012","DOIUrl":"10.1016/j.eimc.2024.03.012","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 1","pages":"Pages 47-48"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140789052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¿Debemos implantar un marcapasos a todo paciente joven con bloqueo auriculoventricular de alto grado? La importancia de la sospecha clínica en la carditis de Lyme","authors":"Ester Minguez de la Guía,&nbsp;Macarena López Vázquez,&nbsp;Pablo Miguel Valentín García,&nbsp;Miguel José Corbi Pascual","doi":"10.1016/j.eimc.2024.07.004","DOIUrl":"10.1016/j.eimc.2024.07.004","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 1","pages":"Pages 51-52"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}