Enfermedades infecciosas y microbiologia clinica最新文献

{"title":"Análisis comparativo de las infecciones respiratorias agudas de etiología viral en menores de 6 meses con y sin nirsevimab en Baleares (2022-2023 y 2023-2024)","authors":"Jordi Reina ,&nbsp;Ane Iturbe ,&nbsp;Julia Viana-Ramírez ,&nbsp;Guida Sbert ,&nbsp;Jaume Carrasco ,&nbsp;Joaquín Dueñas","doi":"10.1016/j.eimc.2024.07.007","DOIUrl":"10.1016/j.eimc.2024.07.007","url":null,"abstract":"<div><h3>Introduction</h3><div>Since 2023, a monoclonal antibody (nirsevimab) specifically directed against the preF form of RSV has been marketed in Spain. The impact of late immunization in the population &lt;<!--> <!-->6<!--> <!-->months as a cause of other respiratory infections requiring a hospital visit has been analyzed.</div></div><div><h3>Material and methods</h3><div>The viral etiology of acute respiratory infections (ARIs) diagnosed in the 2022-2023 and 2023-2024 seasons has been prospectively compared, and in this last season between recipients and non-recipients of nirsevimab. Global provisional coverage was 77% of the population.</div></div><div><h3>Results</h3><div>In the 2022-2023 season, 303 &lt;<!--> <!-->6<!--> <!-->months with an ARI were detected, while in the 2023-2024 season there were 278 minors (19% less). The positivity in the first season was 79.9% compared to 70.5% in the current season. A significant difference has been observed in the detection of RSV between both groups and a decrease of 82.9% of cases in the current season. Of the 278 cases &lt;<!--> <!-->6<!--> <!-->months detected in the 2023-2024 season, 192 (69.1%) received immunization with nirsevimab and 86 (30.9%) did not receive it. The percentage of positivity in those immunized was 69.3%, compared to 73.3% in those not immunized. Significant differences have been observed in the detections of RSV and influenza between both groups.</div></div><div><h3>Conclusions</h3><div>Immunization at &lt;<!--> <!-->6<!--> <!-->months with nirsevimab has shown a significant reduction in RSV infections compared to the previous season. It does not seem, however, that it can reduce infections by other respiratory viruses.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 4","pages":"Pages 193-196"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thinking like pediatricians to prevent pneumococcal disease in adults","authors":"Jesús Ruiz Contreras","doi":"10.1016/j.eimc.2025.01.002","DOIUrl":"10.1016/j.eimc.2025.01.002","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 4","pages":"Pages 185-187"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacto de la campaña de inmunización pasiva con nirsevimab en 2023-24 en Castellón. Resultados finales","authors":"Eulalia Gregori-García ,&nbsp;Juan Carlos Gascó-Laborda ,&nbsp;Lledó Lluch-Bacas ,&nbsp;Oscar Pérez-Olaso ,&nbsp;Iris Gómez-Alfaro ,&nbsp;Juan B. Bellido-Blasco","doi":"10.1016/j.eimc.2024.11.007","DOIUrl":"10.1016/j.eimc.2024.11.007","url":null,"abstract":"<div><h3>Introduction</h3><div>In the 2023-2024 season, systematic immunization with the monoclonal antibody nirsevimab was recommended in Spain. The impact that this immunization program had on the target population of the program is analyzed.</div></div><div><h3>Methods</h3><div>Pre-post ecological study comparing 2023-24 vs 2022-23 season. The variation in incidence is described by age groups (0-5, 6-11 and 12-59<!--> <!-->months) and hospitalization. Incidence rates were calculated and relative risks (RR) were estimated for each group.</div></div><div><h3>Results</h3><div>The results were very heterogeneous depending on the age group. In children 0-5<!--> <!-->months old the RR was 0.16 (0.10-0.25); in those aged 6-11<!--> <!-->months, RR of 0.90 (0.56-1.42); and in those aged 12-59<!--> <!-->months, RR 1.36 (1.06-1.74). The greatest decrease in risk was in hospitalized children under 6<!--> <!-->months, RR 0.13 (0.07-0.22).</div></div><div><h3>Conclusion</h3><div>The results support the positive impact that this campaign had, especially on hospitalizations.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 4","pages":"Pages 215-218"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspergilosis invasiva secundaria a corticoterapia","authors":"Sara Miguel Álvarez,&nbsp;Maravillas Carralón González,&nbsp;Juncal Pérez Somarriba,&nbsp;Vicente Estrada Pérez","doi":"10.1016/j.eimc.2024.12.015","DOIUrl":"10.1016/j.eimc.2024.12.015","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 4","pages":"Pages 234-235"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal sepsis: Epidemiology and comparison between preterm and term newborns","authors":"Eduardo Rubio-Mora,&nbsp;Iván Bloise-Sánchez,&nbsp;Inmaculada Quiles-Melero,&nbsp;Juana Cacho-Calvo,&nbsp;Emilio Cendejas-Bueno","doi":"10.1016/j.eimc.2024.07.010","DOIUrl":"10.1016/j.eimc.2024.07.010","url":null,"abstract":"<div><h3>Introduction</h3><div>Neonatal sepsis is a severe clinical syndrome that continues to be a common and significant health care burden. Knowledge of the local epidemiology allows for a better empirical treatment and improves morbidity and mortality. The aim of this study was to determine the prevalence, epidemiology, and etiology of blood culture-proven sepsis in neonates and to determine whether there are differences between preterm and term newborns.</div></div><div><h3>Methods</h3><div>A retrospective study was carried out in a tertiary hospital in Madrid, Spain, during 2021, including 1443 patients at risk of developing sepsis.</div></div><div><h3>Results</h3><div>The majority of sepsis episodes occurred in preterm newborns (64.81%) and most of them were very low birth weight infants (74.29%). Late-onset sepsis represented 94.92% of all the episodes reported with an incidence of 11.4 (95% CI 8.8–14.8) per 1000 live newborns. Early onset sepsis incidence was 0.6 (95% CI 0.2–1.8) per 1000 live newborns. Coagulase-negative staphylococci took the first place as causative agents of sepsis (66.10%), causing in all the episodes late onset catheter-related bloodstream infection. When the newborns who developed sepsis were compared with those who did not developed sepsis, the presence of venous/arterial access device was significantly associated with sepsis in both preterm (odds ratio (OR) 8.12, 95% CI 0.47–141.40) and term newborns (OR 16.58, 95% CI 1.00–275.20). Recent surgery was nevertheless the main risk factor in term newborns (OR 45.29, 95% CI 13.70–149.70). Among those patients who developed sepsis, no differences between preterm and term newborns were found regarding time onset, mechanism of transmission, etiological agents, and mortality. A 100% of the preterm and 42.11% of the term newborns presented two or more risk factors. The mortality rate observed here has been 1.85% (95% CI 0.33–9.77%).</div></div><div><h3>Conclusion</h3><div>The main risk factors for sepsis were venous/arterial access device (for both preterm and term newborns) and recent surgery (term newborns). Prematurity and being a catheter carrier were strongly associated with late-onset neonatal sepsis, mainly due to coagulase-negative staphylococci. The mortality rate was lower than that observed in other high-income countries.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 4","pages":"Pages 197-204"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bartonella spp. infection in a person with HIV and advanced immunosuppression: A case report","authors":"Roser Navarro-Soler,&nbsp;Juan Martín-Torres,&nbsp;Anatolio Alonso-Crespo,&nbsp;David Rial-Crestelo","doi":"10.1016/j.eimc.2024.12.009","DOIUrl":"10.1016/j.eimc.2024.12.009","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 4","pages":"Pages 232-233"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive pneumococcal disease in a tertiary hospital in Madrid: are we using pneumococcal vaccine correctly?","authors":"María Isabel Serrano-Tomás ,&nbsp;Margarita Cabello ,&nbsp;Paloma Moreno-Nuñez ,&nbsp;Juan Carlos Sanz ,&nbsp;Rafael Cantón ,&nbsp;Ana María Sánchez-Díaz","doi":"10.1016/j.eimc.2024.08.006","DOIUrl":"10.1016/j.eimc.2024.08.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Invasive pneumococcal disease (IPD) is of concern. We describe the epidemiology and assess the vaccination schedule adequacy of IPD episodes (2019–2021) in northern Madrid.</div></div><div><h3>Methods</h3><div>Clinical, laboratory and vaccination data were collected from clinical/epidemiological records. Antimicrobial susceptibility testing was performed according to EUCAST and serotyping by Pneumotest-agglutination/Quellung.</div></div><div><h3>Results</h3><div>IPD was identified in 103 patients (71 [IQR 23.5] year-old; 50.4% males), 85.4% associated with bacteremia and a high mortality rate (19.4%). Serotypes 8 (29.9%), 3 and 22F (8% each) were dominant (45.9%), all antibiotic-susceptible. β-Lactams increased MICs and macrolide resistance were mainly linked to serotypes 19A, 23F, 24F, 6C, and 15A. Only 10.5% of adults eligible for vaccination had an adequate vaccine regimen before IPD being 40% due to nonvaccine-preventable serotypes (13, 23B, 24F, 31).</div></div><div><h3>Conclusion</h3><div>IPD episodes were dominated by antibiotic-susceptible ST8 and frequently occurred in adults at risk. Despite recommendations, vaccination adherence rates were very low.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 4","pages":"Pages 210-214"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Zhuhai DL Biotech's BT24 automated blood culture system","authors":"Blanca Carrasco,&nbsp;Elena Hidalgo,&nbsp;Gloria Zaragoza,&nbsp;Juan-Ignacio Alós","doi":"10.1016/j.eimc.2024.07.003","DOIUrl":"10.1016/j.eimc.2024.07.003","url":null,"abstract":"<div><h3>Introduction</h3><div>For the microbiological diagnosis of bacteremia and fungemia, it is essential to use automated blood culture systems that guarantee good performance in the detection of microorganisms.</div><div>We evaluated the BT24 system for blood cultures (BCs) by comparing it with the BACTEC™ FX system in detection of positive spiked BCs and bottles, subsequent growth of the microorganism, and time to detection (TTD).</div></div><div><h3>Methods</h3><div>The parallel analysis of both systems was performed with 160 strains of 31 different species, each inoculated under the same conditions and simultaneously in six BC bottles.</div><div>The Chi-square test was used for comparison per BC and per bottle detection. Wilcoxon test and Student's <em>t</em>-test were used for comparison of TTDs.</div></div><div><h3>Results</h3><div>Overall, the following BC (aerobic bottle<!--> <!-->+<!--> <!-->anaerobic bottle) were detected as positive: 160/160 (100%) in BACTEC FX and 158/160 (98.7%) in BT24 (<em>p</em> <!-->=<!--> <!-->0.31). Furthermore, the following pediatric BCs (1 single bottle, aerobic) were also detected: 159/160 (99.4%) in BACTEC FX and 156/160 (97.5%) in BT24 (<em>p</em> <!-->=<!--> <!-->0.17).</div><div>TTDs were longer with BT24 system than with BACTEC FX system, especially for <em>Staphylococcus aureus</em> strains.</div></div><div><h3>Conclusions</h3><div>We consider the BT24 system with good performance and specificity comparable to the reference system, but inferior in TTD.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 4","pages":"Pages 188-192"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lesión genital inusual simulando carcinoma epidermoide: un desafío diagnóstico","authors":"Marta Cebolla-Verdugo ,&nbsp;David Moyano-Bueno ,&nbsp;Álvaro Prados-Carmona ,&nbsp;Ricardo Ruiz-Villaverde","doi":"10.1016/j.eimc.2024.07.012","DOIUrl":"10.1016/j.eimc.2024.07.012","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 4","pages":"Pages 229-230"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dientamoeba fragilis: An emerging pathogen","authors":"Candela Menéndez Fernández-Miranda ,&nbsp;Jonathan Fernández-Suárez ,&nbsp;Alicia García Pérez ,&nbsp;José Antonio Boga ,&nbsp;Mercedes Rodríguez-Pérez ,&nbsp;Azucena Rodríguez-Guardado","doi":"10.1016/j.eimc.2024.08.015","DOIUrl":"10.1016/j.eimc.2024.08.015","url":null,"abstract":"<div><div><em>Dientamoeba fragilis</em> is a protozoan of the gastrointestinal tract, very prevalent in our environment and responsible for diverse clinical symptoms mainly abdominal pain, diarrhoea and eosinophilia, although some infected patients are asymptomatic. Since the first description just a century ago, there are many unanswered questions: its different morphologies and the role of each of them, its actual prevalence, the mode of transmission, its pathogenicity, or the treatment of choice, continue to be source of controversy. Risk factors associated with infection by <em>D. fragilis</em> are: contact with children, residence in a rural area, and co-infection by <em>Enterobius vermicularis</em>. New molecular diagnostic techniques in the form of commercial multi-diagnostic panels are now considered first choice techniques. Paromomycin show higher cure rates, than metronidazole.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 4","pages":"Pages 219-226"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}