Enfermedades infecciosas y microbiologia clinica最新文献

{"title":"SIPrEP: A tool to monitor HIV pre-exposure prophylaxis in Spain","authors":"Carlos Iniesta ,&nbsp;Victoria Hernando ,&nbsp;Inma Jarrín ,&nbsp;Santiago Pérez de la Cámara ,&nbsp;Javier De la Torre-Lima ,&nbsp;Vicent Villanueva ,&nbsp;Mª Isabel Mayorga ,&nbsp;Josefina Belda ,&nbsp;Maribel Soteras ,&nbsp;Álvaro Torres Lana ,&nbsp;Aitziber Echeverria ,&nbsp;Olga Monteagudo-Piqueras ,&nbsp;Henar Marcos ,&nbsp;Wafa Ben Cheikh ,&nbsp;Julián-Alexander Portocarrero-Núñez ,&nbsp;Débora Álvarez-del Arco ,&nbsp;Asunción Diaz ,&nbsp;Julia del Amo ,&nbsp;SIPrEP","doi":"10.1016/j.eimc.2025.06.007","DOIUrl":"10.1016/j.eimc.2025.06.007","url":null,"abstract":"<div><h3>Objectives</h3><div>Pre-exposure prophylaxis (PrEP) has been available in Spain since November 2019 and implemented nationally in 2021. Monitoring the implementation process is essential to optimize the strategy. This manuscript describes the Spanish PrEP Programme Information System (SIPrEP), its methodology, and characteristics of PrEP users from November 2019 to May 2024.</div></div><div><h3>Methods</h3><div>Nationwide open cohort that collects data on persons ≥16 years who were prescribed PrEP in Spain. The study included participants with public program PrEP prescriptions since November 1, 2019. The project was piloted and fully implemented in July 2020.</div></div><div><h3>Results</h3><div>By May 2024, 28,798 people received public program PrEP in Spain, and 4159 users were included in SIPrEP. Most were men (99%, <em>n</em> <!-->=<!--> <!-->4117), primarily gay, bisexual, and other men who have sex with men (GBMSM) (97%, <em>n</em> <!-->=<!--> <!-->4005), with a median age of 36 years (IQR: 30–43). Most were born in Spain (74%, <em>n</em> <!-->=<!--> <!-->3075), and 36% (<em>n</em> <!-->=<!--> <!-->1503) had university education. Referrals came from STI centers (19%, <em>n</em> <!-->=<!--> <!-->805) and primary care (20%, <em>n</em> <!-->=<!--> <!-->820). At entry, 8% (<em>n</em> <!-->=<!--> <!-->348) had syphilis, 7% chlamydia (<em>n</em> <!-->=<!--> <!-->270) and 7% (<em>n</em> <!-->=<!--> <!-->300) had gonococcal infection. Among users, 15% (<em>n</em> <!-->=<!--> <!-->642) discontinued PrEP, and 34% (<em>n</em> <!-->=<!--> <!-->216) of them restarted later. There were four HIV seroconversions (incidence 0.12/100 person-years [95% CI: 0.05–0.33]).</div></div><div><h3>Conclusions</h3><div>SIPrEP provides valuable real-world data for optimizing interventions but requires improved national coverage.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 8","pages":"Pages 515-522"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of tropical dermatitis","authors":"Miguel Morante-Ruiz ,&nbsp;Lidia Carbonero-Jiménez ,&nbsp;Francisco Javier González-Gasca ,&nbsp;María Antonia Sepúlveda-Berrocal","doi":"10.1016/j.eimc.2025.02.006","DOIUrl":"10.1016/j.eimc.2025.02.006","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 8","pages":"Pages 531-533"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hairy cell leukemia, Legionella and ibrutinib: Old friends and a new foe","authors":"Daniel N. Marco ,&nbsp;Julie Castiaux ,&nbsp;Sara Fernández ,&nbsp;Eric Mariotte","doi":"10.1016/j.eimc.2025.06.015","DOIUrl":"10.1016/j.eimc.2025.06.015","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 8","pages":"Pages 537-539"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quinolone resistance testing in Mycoplasma genitalium infection: A call for caution","authors":"Miguel Fernández-Huerta ,&nbsp;Zaira Moure","doi":"10.1016/j.eimc.2025.05.006","DOIUrl":"10.1016/j.eimc.2025.05.006","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 8","pages":"Pages 541-542"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caracterización de los nuevos diagnósticos de VIH realizados en los servicios de urgencias hospitalarios a partir del programa «Deja tu huella»","authors":"Phillipe Calpe Delgado ,&nbsp;Patricia Muñoz ,&nbsp;Alberto Pizarro Portillo ,&nbsp;Virginia Álvarez Rodríguez ,&nbsp;Ángel Iván Díaz Salado ,&nbsp;Isabel Arenas Berenguer ,&nbsp;Marta Álvarez Alonso ,&nbsp;Esther Gargallo García ,&nbsp;Fátima Fernández Salgado ,&nbsp;Alma Elena Real Martín ,&nbsp;Irene Cabrera Rodrigo ,&nbsp;Anaura Carrasquel Regalade ,&nbsp;María Ángeles Moreno Planelles ,&nbsp;Margarita Jurado Otero ,&nbsp;Rodrigo Sanz Lorente ,&nbsp;Luis Pérez Ordoño ,&nbsp;Ana Carrero Fernández ,&nbsp;Juan González del Castillo ,&nbsp;en representación de la red VIH de Madrid","doi":"10.1016/j.eimc.2025.04.001","DOIUrl":"10.1016/j.eimc.2025.04.001","url":null,"abstract":"<div><h3>Introduction</h3><div>The «Leave your mark» program launched recommendations for HIV screening in emergency departments (ED) when patients presented with certain conditions. It is unknown whether the profile of patients diagnosed in the ED is similar to those reported for general population in epidemiological reports.</div></div><div><h3>Methods</h3><div>Retrospective study evaluating the characteristics of patients with new HIV diagnosed in 17 ED over a one-year period was developed. Demographic data (sex at birth, age, country of birth), sexual and risk behaviour, diagnosis in ED, number of emergency visits in previous 5<!--> <!-->years, time from the ED to the specific HIV consultation, and from ED to start antiretroviral treatment were recorded. Information on the first CD4 and viral load was also collected.</div></div><div><h3>Results</h3><div>A total of 169 patients were included. There were 122 (72.2%) migrants, 57 (32.5%) heterosexual, and injection drug use was the transmission route in 14 (8.3%) cases. Data reported for the general population were 49.8%, 25.7%, and 1.7%, respectively. Late diagnosis was found in 80 (47.3%) patients (reported figures by the Ministry, 48.7%). Compared to Spanish, migrant were more frequently women (13.1% vs. 6.4%), heterosexual (38.5% vs. 21.3%), and had worse immunological status (median CD4 count of 310 [IQR 132-457] vs. 444 [IQR 215-607]).</div></div><div><h3>Conclusion</h3><div>ED can play a key role in diagnosing a different patient profile that may not seek care at other healthcare levels.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 8","pages":"Pages 496-503"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Una causa infrecuente de derrame pericárdico","authors":"Juan Gabriel Sánchez-Cano ,&nbsp;Victoria Espejo-Bares ,&nbsp;Laura Muñoz-Echeverría ,&nbsp;Leonor Moreno-Núñez","doi":"10.1016/j.eimc.2024.12.022","DOIUrl":"10.1016/j.eimc.2024.12.022","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 8","pages":"Pages 527-528"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relatos de la piel: manifestaciones dermatológicas tras un viaje a Colombia","authors":"María Ezquerra Marigómez ,&nbsp;María José Cárdenas-Isasi ,&nbsp;Marta Rosas Cancio-Suárez","doi":"10.1016/j.eimc.2025.01.006","DOIUrl":"10.1016/j.eimc.2025.01.006","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 8","pages":"Pages 529-530"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estreptococo grupo B y antibióticos beta-lactámicos, un nuevo paradigma","authors":"Manuel Rosa-Fraile ,&nbsp;Juan-Ignacio Alós","doi":"10.1016/j.eimc.2025.03.004","DOIUrl":"10.1016/j.eimc.2025.03.004","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 8","pages":"Pages 534-535"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of antimicrobial consumption indicators in the emergency department","authors":"Jesus Ruiz-Ramos ,&nbsp;Álvaro Eloy Monje-López ,&nbsp;Laura Escolà-Vergé ,&nbsp;Sergio Herrera-Mateo ,&nbsp;Héctor Hernández-Ontiveros ,&nbsp;Pol Duch-Llorach ,&nbsp;Edurne Fernández-de-Gamara-Martínez ,&nbsp;María Alba Rivera-Martínez ,&nbsp;Celso Soares Pereira-Batista ,&nbsp;Joaquín López-Contreras","doi":"10.1016/j.eimc.2025.01.009","DOIUrl":"10.1016/j.eimc.2025.01.009","url":null,"abstract":"<div><h3>Background</h3><div>Monitoring antimicrobial use in the emergency department is complex due to the wide variety of existing indicators. We evaluated the differences between various indicators used to evaluate antimicrobial use in these units.</div></div><div><h3>Methods</h3><div>Retrospective analysis of administrative data from all adult patients admitted to an emergency unit (2019–2024). Aggregated quarterly data included the percentage of patients treated, DDDs/100 admissions, DDD/100 patients-day and DOT/100 admissions. An autoregressive integrated moving average (ARIMA) model was used to investigate the association between DDD/100 admissions and the other antimicrobial use indicators.</div></div><div><h3>Findings</h3><div>Annual median antimicrobial drug use measured by DDDs/100 admissions was 11.7 (IQR 10.8–12.4). Significant differences in antimicrobial consumption correlation were noted when comparing DDD/100 admissions and DDD/100 patient-days for cephalosporins, lincosamides, and carbapenems. Significant differences in the comparison between DDD<span> and DOT were found for imipenem, clindamycin, piperacillin–tazobactam, gentamicin, and vancomycin.</span></div></div><div><h3>Conclusions</h3><div>Aggregate antimicrobial use measured by DDDs or DOTs is consistent, though discrepancies in correlation may occur for antibiotics with multiple daily doses. DDD/100 admissions is a suitable indicator, but complementing it with DDD/100 patient-days, DOT, and percentage of patients receiving antibiotics provides valuable information for monitoring antimicrobial use.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 8","pages":"Pages 489-495"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of Oropouche virus among international travelers: A growing concern in non-endemic areas","authors":"Aida Peiró-Mestres ,&nbsp;Elisa Riera ,&nbsp;Claudia Flores Calderón ,&nbsp;Jessica Navero-Castillejos ,&nbsp;Miguel J. Martinez ,&nbsp;Daniel Camprubí-Ferrer","doi":"10.1016/j.eimc.2025.01.005","DOIUrl":"10.1016/j.eimc.2025.01.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Oropouche fever is an emerging disease caused by an arthropod-borne virus, Oropouche virus. This virus is mainly circulating in Central and South America. In 2024 they have been reported an ongoing outbreak.</div></div><div><h3>Methods</h3><div>For this study, travelers returning from endemic areas with dengue-like symptoms and negative results for dengue from March to October 2024, were tested for Oropouche through RT-PCR.</div></div><div><h3>Results</h3><div>Among 43 patients tested, we detected an imported case of Oropouche fever imported from Cuba in a traveler presenting biphasic fever and neurological symptoms. The virus was detected by RT-PCR in urine samples collected more than one month after the onset of symptoms, suggesting prolonged viral shedding and expanding the diagnostic period for molecular confirmation of the infection.</div></div><div><h3>Conclusion</h3><div>Although only few cases have been yet reported in European travelers, the expansion of the virus in the Americas supports laboratory preparedness and clinical awareness.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 8","pages":"Pages 523-526"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}