Enfermedades infecciosas y microbiologia clinica最新文献

Fiebre y lesiones cutáneas en paciente en quimioterapia 化疗患者的发烧和皮肤损伤

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-05-01 DOI: 10.1016/j.eimc.2024.09.009

José González Fernández , Alejandro Tomás Esteban Escudero , Mar García García

引用次数: 0

Absceso en extremidad superior por una especie inusual de Clostridium en una niña inmunocompetente 具有免疫能力的女童因不寻常的梭状芽胞杆菌而导致上肢脓肿

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-05-01 DOI: 10.1016/j.eimc.2024.12.017

Iker Alonso-González, Nerea Antona-Urieta, Begoña Vilar Achabal, Clara Lejarraga-Cañas

引用次数: 0

A lesion on the right arm for 30 years 右臂上的损伤持续了30年

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-05-01 DOI: 10.1016/j.eimc.2024.09.013

Ali Mert , Abdurrahman Kaya

引用次数: 0

La mosca fantasma ataca sin ser vista 幽灵苍蝇攻击看不见的

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-05-01 DOI: 10.1016/j.eimc.2024.11.006

Yolanda García Gambín , María Asunción Iborra-Bendicho , Laura Moreno Parrado , Manuel Segovia-Hernández

引用次数: 0

Precisión diagnóstica de LIAISON MeMed BV® para la bacteriemia en el servicio de urgencias LIAISON MeMed BV®在急诊科细菌性血症诊断的准确性

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-05-01 DOI: 10.1016/j.eimc.2025.01.001

Laura Serrano Martín , Elena de Rafael González , Javier Cabañas Morafraile , Agustín Julián-Jiménez , en nombre del grupo URGEN-LABQMIC del CHUT del Instituto de Investigación Sanitaria de Castilla La Mancha (IDISCAM)

引用次数: 0

Molecular assays for the initial diagnosis of tuberculosis in a low-prevalence setting: A comparative study 分子检测在低患病率环境下对肺结核的初步诊断：一项比较研究

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-05-01 DOI: 10.1016/j.eimc.2024.11.013

Ana Fernández-Blázquez , Álvaro Leal-Negredo , Christian Sabater-Cabrera , Miguel Arias-Guillén , José-María García-García , Juan José Palacios Gutiérrez

{"title":"Molecular assays for the initial diagnosis of tuberculosis in a low-prevalence setting: A comparative study","authors":"Ana Fernández-Blázquez , Álvaro Leal-Negredo , Christian Sabater-Cabrera , Miguel Arias-Guillén , José-María García-García , Juan José Palacios Gutiérrez","doi":"10.1016/j.eimc.2024.11.013","DOIUrl":"10.1016/j.eimc.2024.11.013","url":null,"abstract":"<div><h3>Introduction</h3><div>The WHO's End TB Strategy promotes using rapid molecular assays as initial diagnosis to reduce tuberculosis globally. This prospective study assessed commercial molecular platforms’ effectiveness in diagnosing or ruling out tuberculosis (TB) in a low-prevalence setting.</div></div><div><h3>Methods</h3><div>One hundred clinical samples (80 respiratory/20 non-respiratory) were included among all samples routinely received in a mycobacterial laboratory. Five real-time polymerase-chain-reaction (RT-PCR) assays (Xpert-MTB/Rif-Ultra, BDMAX-MDR-TB, RealTime-MTB, FluoroType-MTBDR, Anyplex-MTB/NTM) were characterized and compared through blinded-parallel analysis. Sensitivity, specificity, likelihood ratios, and Cohen's Kappa were calculated to assess the accuracy and agreement of RT-PCR results with culture.</div></div><div><h3>Results</h3><div>Sensitivity ranged 88.89–100%, improving initial screening by 30–40%. Specificity was 96.70–98.98%. RT-PCR showed excellent discriminatory power, as TB patients were 26.9–91.0 times more likely to test positive. Cohen's Kappa showed substantial to excellent concordance (0.78–0.94).</div></div><div><h3>Conclusion</h3><div>RT-PCR improves TB initial diagnosis, offering tailored solutions for diverse laboratories, revolutionizing control strategies with its operational flexibility.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 272-276"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Mycobacterium bovis infection: A multicentre retrospective study conducted by the Madrid Study Group for Mycobacteria (GEMIMAD) 人牛分枝杆菌感染：马德里分枝杆菌研究组（GEMIMAD）开展的一项多中心回顾性研究

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-05-01 DOI: 10.1016/j.eimc.2024.09.014

Loreto Sangorrin-Lapieza , Alba Ruedas-López , Jaime Esteban , Carlos Toro , Laura Barrado , María Jesús Ruiz-Serrano , Jorge Anel , Diego Domingo , Alhena Reyes , Paula López-Roa

{"title":"Human Mycobacterium bovis infection: A multicentre retrospective study conducted by the Madrid Study Group for Mycobacteria (GEMIMAD)","authors":"Loreto Sangorrin-Lapieza , Alba Ruedas-López , Jaime Esteban , Carlos Toro , Laura Barrado , María Jesús Ruiz-Serrano , Jorge Anel , Diego Domingo , Alhena Reyes , Paula López-Roa","doi":"10.1016/j.eimc.2024.09.014","DOIUrl":"10.1016/j.eimc.2024.09.014","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to evaluate trends and clinical characteristics of <em>Mycobacterium bovis</em> human tuberculosis cases, describe the epidemiological features, and compare risk factors associated with extrapulmonary and pulmonary tuberculosis.</div></div><div><h3>Methods</h3><div>A retrospective cohort analysis was conducted on <em>M. bovis</em> infection cases confirmed by culture from seven clinical microbiology laboratories in Madrid, Spain, from 2010 to 2022. Sociodemographic and clinical data were extracted from the hospital database. Tuberculosis (TB) cases were classified as extrapulmonary (EPTB) and pulmonary tuberculosis (PTB), with disseminated TB cases excluded from statistical analysis.</div></div><div><h3>Results</h3><div>Among 3670 patients with <em>Mycobacterium tuberculosis complex</em> infection, <em>M. bovis</em> was identified in 66 patients, representing 1.8% of the total. PTB and EPTB were identified in 45.5% and 39.4% of cases, respectively, with 15.1% having disseminated TB. PTB was significantly associated with males and Spanish nationality, while EPTB was more prevalent among females and those with a rural lifestyle.</div></div><div><h3>Conclusions</h3><div>The study revealed an escalating trend in <em>M. bovis</em> tuberculosis cases. Middle-aged patients, including a substantial immigrant population, were predominantly affected. Female gender and a rural lifestyle were associated to extrapulmonary disease.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 267-271"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fresh frozen plasma for neutralizing SARS-CoV-2: “An exploratory cross-sectional study and review of the state of the art” 用于中和SARS-CoV-2的新鲜冷冻血浆：“探索性横断面研究和最新进展”

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-05-01 DOI: 10.1016/j.eimc.2025.03.005

Marcial Delgado-Fernández , Juan Diego Ruiz-Mesa , Almudena Rojas-González , Gracia Mar García-Gemar , Ana Fuentes-López , Adolfo de Salazar-González , Federico García-García

{"title":"Fresh frozen plasma for neutralizing SARS-CoV-2: “An exploratory cross-sectional study and review of the state of the art”","authors":"Marcial Delgado-Fernández , Juan Diego Ruiz-Mesa , Almudena Rojas-González , Gracia Mar García-Gemar , Ana Fuentes-López , Adolfo de Salazar-González , Federico García-García","doi":"10.1016/j.eimc.2025.03.005","DOIUrl":"10.1016/j.eimc.2025.03.005","url":null,"abstract":"<div><div>Restitution of humoral immunodeficiency is essential to clear SARS-CoV-2. Intravenous unspecific immunoglobulins are expensive and restricted. So recently donated fresh frozen plasma (FFP) could be useful in this scenario but, are all units neutralizing against SARS-CoV-2?</div><div>We explored this on 52 donations obtained from “Centro de Transfusión, Tejidos y Células de Málaga, Spain”, from April to June 2022. Donors status about SARS-CoV-2 previous infection or vaccination was unknown. Neutralizing activity (at dilutions≥1/160) against real Delta (not circulating), BA.2 (dominant circulating variant), BA.5 (irrupting variant), and BQ.1.1 and XBB.1.5 (not circulating yet) was determined.</div><div>Higher anti-Spike IgG antibodies cut-offs predicted efficacy of FFP. Different cut-offs have been reported in the literature, but all papers have in common that levels over the higher range of quantification can predict neutralizing activity of recently donated FFP against circulating variants of concern, if used early after donation, not requiring clinical data from donors.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 282-290"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Análisis de los costes asociados a la administración intramuscular versus oral de la terapia antirretroviral en el manejo de la infección por el virus de la inmunodeficiencia humana 在控制人体免疫缺陷病毒感染方面，肌肉内与口服抗逆转录病毒治疗的相关费用分析

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-05-01 DOI: 10.1016/j.eimc.2024.07.013

Vicente Estrada , Juan Emilio Losa , Ramón Morillo-Verdugo , Montserrat Pérez-Encinas , Jesús Santos , Antonio Castro , María Presa González , Laura Salinas-Ortega

{"title":"Análisis de los costes asociados a la administración intramuscular versus oral de la terapia antirretroviral en el manejo de la infección por el virus de la inmunodeficiencia humana","authors":"Vicente Estrada , Juan Emilio Losa , Ramón Morillo-Verdugo , Montserrat Pérez-Encinas , Jesús Santos , Antonio Castro , María Presa González , Laura Salinas-Ortega","doi":"10.1016/j.eimc.2024.07.013","DOIUrl":"10.1016/j.eimc.2024.07.013","url":null,"abstract":"<div><h3>Objetive</h3><div>To identify and analyze the resources and costs associated with the administration of intramuscular antiretroviral therapy (ART) cabotegravir+rilpivirine (CAB+RPV) compared to oral ART in the management of Human Immunodeficiency Virus Type 1 (HIV-1) infection in Spain.</div></div><div><h3>Methods</h3><div>An economic model was developed to identify resources and analyze costs from the perspective of the National Health System (NHS) and societal, associated with the administration of intramuscular ART (CAB+RPV) compared to oral ART over a two-year time horizon. Costs included treatment change monitoring, pharmaceutical dispensation, administration, management of adverse events to injection-site reactions (AEs-ISR), travel to the hospital, telepharmacy service, and lost work productivity. Unit costs (€, 2023) were obtained from the literature. Sensitivity analyses were conducted to evaluate the robustness of the model.</div></div><div><h3>Results</h3><div>Intramuscular ART compared to oral ART was associated with an increase in costs of €673.16/patient over two years from the perspective of the NHS, and €719.59/patient from the social perspective. Intramuscular ART would generate increased costs for dispensation (+€97.75), administration (+€394.55), monitoring (+€288.74), management of AEs-ISR (+€6.46), travel (+€8.36), and lost work productivity (+€38.07), compared to oral ART administration.</div></div><div><h3>Conclusion</h3><div>Treating HIV-1 with intramuscular CAB+RPV leads to increased resource consumption and costs, compared to oral ART.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 251-259"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuberculosis infection diagnosis: Current prospects 结核感染诊断：当前前景

IF 2.6 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-05-01 DOI: 10.1016/j.eimc.2025.02.008

Fernando Alcaide , Luis Anibarro

引用次数: 0