Enfermedades infecciosas y microbiologia clinica最新文献_第2页

In vitro activity of eravacycline against anaerobic bacteria isolated from clinically significant samples 依瓦环素体外抗厌氧菌活性的研究

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-04-01 Epub Date: 2026-02-05 DOI: 10.1016/j.eimc.2026.503103

Fernando Cobo, Javier Rodríguez-Granger, Antonio Sampedro-Martínez, Juan Antonio Reguera-Márquez, José María Navarro-Marí

{"title":"In vitro activity of eravacycline against anaerobic bacteria isolated from clinically significant samples","authors":"Fernando Cobo, Javier Rodríguez-Granger, Antonio Sampedro-Martínez, Juan Antonio Reguera-Márquez, José María Navarro-Marí","doi":"10.1016/j.eimc.2026.503103","DOIUrl":"10.1016/j.eimc.2026.503103","url":null,"abstract":"<div><h3>Introduction</h3><div>The objective of this study was to evaluate the <em>in vitro</em> activity of eravacycline against 173 anaerobic isolates and compare it with the activity of other antimicrobials used against infections caused by anaerobic microorganisms.</div></div><div><h3>Methods</h3><div>Minimal inhibitory concentrations (MICs) for eravacycline, delafloxacin, piperacillin–tazobactam, meropenem, clindamycin, metronidazole and amoxicillin–clavulanic acid were determined against 173 anaerobic bacterial isolates obtained from several types of human clinical specimens.</div></div><div><h3>Results</h3><div>MICs were lower for eravacycline than for all other antibiotics tested with the exception of delafloxacin against <em>Bacteroides</em>, <em>Prevotella</em>, Gram-positive anerobic cocci (GPACs) and <em>Clostridium</em> and piperacillin–tazobactam against <em>Clostridium</em>. Two (2.8%) isolates of <em>Bacteroides</em> spp. showed a MIC≥4μg/mL, along with two (22%) isolates of <em>Phocaeicola</em> spp. and two (11%) of GPACs.</div></div><div><h3>Conclusions</h3><div>With some exceptions, the present results show lower MICs for eravacycline in comparison to the other antibiotics used against anaerobes.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"44 4","pages":"Article 503103"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147656306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Sobre el tratamiento de la Fiebre Q 关于治疗Q热

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-04-01 Epub Date: 2026-02-05 DOI: 10.1016/j.eimc.2026.503108

Javier Velasco Montes , María Victoria Pardo Gutiérrez , Carlos Hernando Martín , Silvia González Díez

引用次数: 0

Urinary tract infection: From evidence to clinical practice 尿路感染：从证据到临床实践

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-04-01 Epub Date: 2026-02-19 DOI: 10.1016/j.eimc.2026.503140

Carlos Pigrau , Ibai Los-Arcos

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Una causa infrecuente de hipertrofia amigdalar 扁桃体肥大的罕见原因

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-04-01 Epub Date: 2026-02-05 DOI: 10.1016/j.eimc.2026.503110

Juan Gabriel Sánchez-Cano , Teresa Conde Gómez-Menor , María Ángeles Mate Bayón , Leonor Moreno Núñez

引用次数: 0

High frequency of Streptococcus pneumoniae serotype 10A identified by PCR in cerebrospinal fluid culture-negative paediatric clinical samples 脑脊液培养阴性儿童临床标本中10A型肺炎链球菌的PCR检测频率较高

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-04-01 Epub Date: 2026-01-22 DOI: 10.1016/j.eimc.2025.503070

Juan Carlos Sanz , Marta Pérez-Abeledo , Ana Garrido-Buenache , Susana Jiménez , Fernando Martín , Jesús Iñigo

{"title":"High frequency of Streptococcus pneumoniae serotype 10A identified by PCR in cerebrospinal fluid culture-negative paediatric clinical samples","authors":"Juan Carlos Sanz , Marta Pérez-Abeledo , Ana Garrido-Buenache , Susana Jiménez , Fernando Martín , Jesús Iñigo","doi":"10.1016/j.eimc.2025.503070","DOIUrl":"10.1016/j.eimc.2025.503070","url":null,"abstract":"<div><h3>Introduction</h3><div>The aim of this study was to determine the distribution of <em>Streptococcus pneumoniae</em> (SP) serotypes in cerebrospinal fluid (CSF) samples, according to the microbiological detection strategy.</div></div><div><h3>Methods</h3><div>Pneumococcal strains identification and serotyping were performed by conventional CSF culture and Quellung serotyping (CI-CS). In CSF culture-negative samples, identification and serotyping were conducted using direct PCR serotyping (PCR-DS).</div></div><div><h3>Results</h3><div>Between 2018 and 2024, 144 strains/CSF samples (31 children and 113 adult cases) were studied. Serotypes 3, 8, 10A, 23B, 12B/12F and 6C accounted for the 54.9%. Serotype 10A represented 36.4% of those detected by PCR-DS in culture-negative CSF samples (4/11 cases [4/8 paediatric]) versus 6.0% detected by CI-CS (8/133 cases [3/23 paediatric]; <em>p</em>  <!-->0.01).</div></div><div><h3>Conclusions</h3><div>Direct PCR detection and serotyping in CSF clinical samples can complement the culture-Quellung serotyping and enhance the diagnosis of paediatric pneumococcal meningitis caused by serotype 10A.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"44 4","pages":"Article 503070"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147656304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic drug monitoring of a posaconazole-cyclosporine interaction in a patient with bone marrow aplasia: A case report 骨髓发育不全患者泊沙康唑-环孢素相互作用的治疗药物监测：1例报告

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-04-01 Epub Date: 2026-02-05 DOI: 10.1016/j.eimc.2026.503112

Laura Amaro Álvarez , Vicente Merino Bohórquez , Belén Gutiérrez Gutiérrez , María Dolores Madrigal Toscano

引用次数: 0

Análisis sobre la actividad in vitro de delafloxacino frente a bacteroides y sus posibles aplicaciones clínicas 甲氟沙星对细菌的体外活性及其可能的临床应用分析

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-03-01 Epub Date: 2026-01-20 DOI: 10.1016/j.eimc.2025.503060

Maialen Larrea Ayo , Iker Alonso González , Regino Rodríguez Álvarez , Maider Zuriarrain Alonso , Clara Lejarraga Cañas , Begoña Vilar Achabal

{"title":"Análisis sobre la actividad in vitro de delafloxacino frente a bacteroides y sus posibles aplicaciones clínicas","authors":"Maialen Larrea Ayo , Iker Alonso González , Regino Rodríguez Álvarez , Maider Zuriarrain Alonso , Clara Lejarraga Cañas , Begoña Vilar Achabal","doi":"10.1016/j.eimc.2025.503060","DOIUrl":"10.1016/j.eimc.2025.503060","url":null,"abstract":"<div><h3>Introduction</h3><div>Resistance to β-lactams has risen globally among <em>Bacteroides</em> species. Consequently, delafloxacin has emerged as a therapeutic alternative against these microorganisms. The main objective of this study is to analyse the MIC of delafloxacin in <em>Bacteroides</em> spp. isolates and compare it with commonly used anaerobic antimicrobial agents.</div></div><div><h3>Method</h3><div>The susceptibility of delafloxacin and other anaerobic antibiotics was assessed in 370 isolates of the genus <em>Bacteroides</em> and MIC<sub>50</sub> and MIC<sub>90</sub> values were determined for all antibiotics.</div></div><div><h3>Results</h3><div>In <em>Bacteroides</em> spp. and the <em>Bacteroides fragilis</em> <em>sensu stricto</em> group the MIC<sub>50</sub> values for delafloxacin were lower than those of other antibiotics, except for tigecycline and metronidazole.</div></div><div><h3>Conclusion</h3><div>Given the potent <em>in vitro</em> anaerobic activity and its broad spectrum, delafloxacin may represent a favourable alternative in the treatment of mixed bacterial infections, particularly those involving multidrug-resistant strains.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"44 3","pages":"Article 503060"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147404499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corynebacterium kroppenstedtii and granulomatous mastitis: The importance of recognizing when normal flora matters 克氏棒状杆菌和肉芽肿性乳腺炎：认识正常菌群的重要性

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-03-01 Epub Date: 2026-02-16 DOI: 10.1016/j.eimc.2026.503101

María Lezaun Andreu , Belén María Lambán Per , Paula Martín Soler , Andrea Carilla San Román , Amparo Boquera Albert , Juan Manuel García-Lechuz Moya

{"title":"Corynebacterium kroppenstedtii and granulomatous mastitis: The importance of recognizing when normal flora matters","authors":"María Lezaun Andreu , Belén María Lambán Per , Paula Martín Soler , Andrea Carilla San Román , Amparo Boquera Albert , Juan Manuel García-Lechuz Moya","doi":"10.1016/j.eimc.2026.503101","DOIUrl":"10.1016/j.eimc.2026.503101","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Corynebacterium kroppenstedtii</em> is a gram-positive, non-spore-forming, non-motile, lipophilic bacillus that belongs to the normal human skin flora. Granulomatous mastitis is a benign inflammatory breast condition with a complex diagnosis and treatment. Numerous studies have linked <em>C. kroppenstedtii</em> to granulomatous mastitis.</div></div><div><h3>Methods</h3><div>We conducted a clinical review on three patients with granulomatous mastitis caused by <em>C. kroppenstedtii</em>, identified by MALDI-TOF MS. We tested antibiotic susceptibility combining both disk diffusion and gradient diffusion assays, following EUCAST and CLSI guidelines.</div></div><div><h3>Results</h3><div>In all three cases, <em>C. kroppenstedtii</em> was isolated in pure culture. Antibiotic susceptibility results were similar for most antibiotics, with variable susceptibility to clindamycin and tetracycline.</div></div><div><h3>Conclusions</h3><div>These three cases support the role of <em>C. kroppenstedtii</em> in the etiopathogenesis of granulomatous mastitis highlighting the importance of evaluating is isolation in patients with this disease.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"44 3","pages":"Article 503101"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147404500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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When the masks came off: The resurgence of invasive pneumococcal disease and the road ahead 当口罩摘下：侵袭性肺炎球菌疾病的复苏和未来的道路

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-03-01 Epub Date: 2025-12-21 DOI: 10.1016/j.eimc.2025.503045

Diego Viasus , Jordi Carratalà

引用次数: 0

Neisseria zoodegmatis, an uncommon pathogen after a dog bite 动物退化奈瑟菌，一种罕见的病原体后，狗咬

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1016/j.eimc.2026.503104

Roberto Rilo-Antelo , Jesús Alonso-Claro , Alejandro Seoane-Estévez , Germán Bou

引用次数: 0