Enfermedades infecciosas y microbiologia clinica最新文献

{"title":"Proptosis y aumento del perímetro craneal durante el puerperio","authors":"Lucía Guillén Zafra , Pedro Manuel García-Ceberino , Diana Alejandra Pantoja Pachajoa , Juan José Pomares Pomares","doi":"10.1016/j.eimc.2024.09.003","DOIUrl":"10.1016/j.eimc.2024.09.003","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 293-294"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Riesgo similar de hospitalización y letalidad por COVID-19 en trasplantados y pacientes en lista de espera: un análisis comparativo","authors":"Abelardo Claudio Fernández Chávez ,&nbsp;Guillermo Yovany Ordoñez León ,&nbsp;Eva Elisa Álvarez León ,&nbsp;Paloma Moreno Nuñez ,&nbsp;José Porto Tomás ,&nbsp;Jesús María Aranaz Andrés","doi":"10.1016/j.eimc.2024.12.007","DOIUrl":"10.1016/j.eimc.2024.12.007","url":null,"abstract":"<div><h3>Introduction</h3><div>In 2022, Spanish health authorities recommended passive immunization against COVID-19 for solid organ transplant recipients (SOT), due to their deficient post-vaccination humoral response. Patients on the transplant waiting list (SOTwl) were excluded from this strategy.</div></div><div><h3>Objective</h3><div>To compare the risk of hospitalization, ICU admission, and mortality due to COVID-19 between SOT and SOTwl patients.</div></div><div><h3>Methods</h3><div>Patients seen in the Preventive Medicine Department at Ramón y Cajal Hospital between 03/14/2020 and 04/13/2022. The relative risk (RR) of hospitalization, ICU admission, and mortality was estimated among SOT and SOTwl patients, adjusted for age, sex, and vaccine doses.</div></div><div><h3>Results</h3><div>A total of 1292 patients were analyzed. SOT patients (n<!--> <!-->=<!--> <!-->1153) were older and had similar risks of hospitalization (RR 0.97, 95% <span>C</span>I 0.57-1.64), ICU admission (RR 1.74, 95% CI 0.44-6.86), and death (RR 0.89, 95% CI 0.45-1.77) compared to SOTwl patients (n<!--> <!-->=<!--> <!-->139).</div></div><div><h3>Conclusion</h3><div>The risks of hospitalization, ICU admission, and mortality were similar between SOT and SOTwl patients.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 277-281"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between serum 25-hydroxyvitamin D3 and oxidative balance score in patients with tuberculosis infection","authors":"Yan Yong,&nbsp;Li-hong Zhou,&nbsp;Sheng-ya Yang,&nbsp;Xiao-qin Ran,&nbsp;Qing-shan Cai","doi":"10.1016/j.eimc.2024.09.012","DOIUrl":"10.1016/j.eimc.2024.09.012","url":null,"abstract":"<div><h3>Background</h3><div>Previous study had reported the imbalance of pro- and anti-oxidants in tuberculosis (TB), which was involved in the TB progression. This study aimed to identify the key oxidative stress indicator associated with oxidative balance in patients with TB infection.</div></div><div><h3>Methods</h3><div>Overall, 339 participants with TB were included in this study. The oxidative balance score (OBS) was composed of scores of dietary and lifestyle factors. Trend regression analysis, generalized additive model, polynomial regression, and threshold effect analysis, were used to examine the relationship between the serum 25-hydroxyvitamin D3 25(OH)D3 and OBS. Moreover, the correlation between serum 25(OH)D3 and OBS components was explored via Pearson analysis, and mediation analysis was used to explore the function of OBS components.</div></div><div><h3>Results</h3><div>Linear regression analysis showed that among 6 oxidative stress indicators, only serum 25(OH)D3 was independently related to the OBS. A positive association between them was then found (<em>P</em> for trend<!--> <!-->&lt;<!--> <!-->0.05) in a non-linear relationship (all <em>P</em> <!-->&lt;<!--> <!-->0.05). The 25(OH)D3 concentration of 51.9<!--> <!-->nmol/L was identified as the key turning point by threshold effect analysis, and their association was only found when it &lt;51.9<!--> <!-->nmol/L. Further, we revealed that 25(OH)D3 mainly correlated with 2 OBS components including BMI and riboflavin. Moreover, BMI and riboflavin were found to mediate the association of serum 25(OH)D3 with OBS by mediation analysis (all <em>P</em> <!-->&lt;<!--> <!-->0.05).</div></div><div><h3>Conclusions</h3><div>In summary, our study revealed relationship between the serum 25(OH)D3 and OBS in patients with TB, which provided a piece of evidence that vitamin D can assist the treatment of TB.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 260-266"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lesiones papulares y pancitopenia en paciente con inmunosupresión severa por VIH","authors":"Laia Arbós Junyent ,&nbsp;Antonio Casabella Pernas ,&nbsp;Granada Olga Perea Duran ,&nbsp;Marta Navarro Vilasaró","doi":"10.1016/j.eimc.2024.08.016","DOIUrl":"10.1016/j.eimc.2024.08.016","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 291-292"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of novel antigens for distinguishing between active tuberculosis and latent tuberculosis infection in interferon-γ release assays","authors":"Haiping Dong ,&nbsp;Bin Huang ,&nbsp;Haobin Kuang ,&nbsp;Hua Li ,&nbsp;Yuan Yuan ,&nbsp;Shaoling Wu ,&nbsp;Jingyuan Feng ,&nbsp;Jianrong Lou ,&nbsp;Feng Liang ,&nbsp;Min Wang ,&nbsp;Fanrong Meng ,&nbsp;Weiyong Wang ,&nbsp;Xiang Yang ,&nbsp;Jinxing Hu","doi":"10.1016/j.eimc.2024.09.001","DOIUrl":"10.1016/j.eimc.2024.09.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Tuberculosis (TB) remains a significant global health threat, with latent tuberculosis infection (LTBI) serving as a major reservoir for new TB cases. This study aimed to identify antigens capable of distinguishing between active tuberculosis (ATB) and LTBI in interferon-γ release assays (IGRA).</div></div><div><h3>Methods</h3><div>Four candidate antigens for LTBI and two for ATB were selected based on a literature review. These antigens were synthesized genetically, subcloned, expressed in bacteria, and purified. Clinical samples were collected from individuals diagnosed with ATB and LTBI to aid in assay development. Novel IGRA assays were then developed using these antigens, and their discriminatory efficacy was assessed.</div></div><div><h3>Results</h3><div>Among the six candidate antigens tested, only three (Rv2028c, Rv2029c and Rv0475) showed promising discriminatory potential for LTBI. Particularly, Rv0475 (HBHA), expressed in <em>Escherichia coli</em> without methylation, exhibited greater stimulation activity in LTBI compared to ATB. Individually, these antigens demonstrated sensitivities ranging from 72.4% to 93.3% and specificities ranging from 79.3% to 89.7%. The combined stimulation of multiple antigens can improve the sensitivity and specificity of the diagnosis.</div></div><div><h3>Conclusion</h3><div>Our findings highlight the potential of three LTBI antigens and their combination in distinguishing between ATB and LTBI. Adding this antigen combination to the traditional IGRA assay could significantly improve the clinical differentiation of healthy individuals, LTBI, and ATB. Further investigation in larger and more diverse patient cohorts is warranted to validate the utility of these antigen combinations in clinical settings.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 242-250"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leishmaniasis cutánea simulando un sarcoma de Kaposi en un paciente VIH","authors":"Diego de la Vega Ruiz ,&nbsp;María Uxúa Floristán Muruzábal ,&nbsp;Fernando Javier Pinedo Moraleda ,&nbsp;María Velasco Arribas","doi":"10.1016/j.eimc.2025.02.002","DOIUrl":"10.1016/j.eimc.2025.02.002","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 304-306"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secular trends in periprosthetic joint infections following primary hip and knee arthroplasties: A 15-year cohort study from the VINCat Program (2008–2022)","authors":"Joaquín López-Contreras ,&nbsp;Pol Duch Llorach ,&nbsp;Nerea Roch Villaverde ,&nbsp;Alexander Almendral ,&nbsp;Ana Felisa López ,&nbsp;Marilo Marimon ,&nbsp;M. Angeles Domínguez-Luzón ,&nbsp;Jose Carlos Martinez-Pastor ,&nbsp;Joan Ramoneda Salas ,&nbsp;Natividad Benito ,&nbsp;Laura Morata ,&nbsp;Ricardo Zules-Oña ,&nbsp;Enrique Limón ,&nbsp;Miquel Pujol ,&nbsp;on behalf of the VINCat Orthopedic Surgery Module Team","doi":"10.1016/j.eimc.2025.02.007","DOIUrl":"10.1016/j.eimc.2025.02.007","url":null,"abstract":"<div><h3>Background</h3><div>The VINCat program, established in Catalonia, Spain, in 2006, is a comprehensive infection prevention program for healthcare-associated infections. This study aims to analyze long-term trends in periprosthetic joint infections (PJI) following primary hip and knee arthroplasties over 15-year period (2008–2022).</div></div><div><h3>Methods</h3><div>PJI was defined according to CDC-NHSN criteria and updated in 2016 to incorporate the Musculoskeletal Infection Society classification. Data on PJI following total hip arthroplasty (THA), total knee arthroplasty (TKA), and hip hemiarthroplasty (HHA) were prospectively collected and analyzed across three periods: 2008–2012, 2013–2017, and 2018–2022.</div></div><div><h3>Results</h3><div>Sixty-seven hospitals participated in the surveillance, reporting 189,063 procedures, including 61,267 THA (median age: 69 years, 47% female), 115,940 TKA (median age: 73 years, 68% female), and 11,856 HHA (median age: 86 years, 73% females). PJI incidence rates for THA were 0.9%, 1.1%, and 1.2% across the three periods (odds ratio (OR):1.14, 95% CI: 0.96–1.35). For TKA, rates were 0.9%, 1.0%, and 0.9% (OR:0.95, 95% CI: 0.83–1.09). The incidence of HHA-PJI declined from 3.4% to 2.3% and 1.8% (OR:0.77, 95% CI:0.58–1.03). Overall, the most common etiology was coagulase negative staphylococci followed by <em>Staphylococcus aureus</em>. PJIs were diagnosed after hospital discharge in 87.1% of THA, 89.6% of TKA, and 73.9% of HHA.</div></div><div><h3>Conclusions</h3><div>The incidence of PJI remains low despite an aging population undergoing orthopedic surgery, highlighting the effectiveness of current infection prevention strategies. A robust, long-term surveillance system is crucial for monitoring epidemiological trends and guiding the implementation of evidence-based preventive measures.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 ","pages":"Pages S44-S51"},"PeriodicalIF":2.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Análisis comparativo de las infecciones respiratorias agudas de etiología viral en menores de 6 meses con y sin nirsevimab en Baleares (2022-2023 y 2023-2024)","authors":"Jordi Reina ,&nbsp;Ane Iturbe ,&nbsp;Julia Viana-Ramírez ,&nbsp;Guida Sbert ,&nbsp;Jaume Carrasco ,&nbsp;Joaquín Dueñas","doi":"10.1016/j.eimc.2024.07.007","DOIUrl":"10.1016/j.eimc.2024.07.007","url":null,"abstract":"<div><h3>Introduction</h3><div>Since 2023, a monoclonal antibody (nirsevimab) specifically directed against the preF form of RSV has been marketed in Spain. The impact of late immunization in the population &lt;<!--> <!-->6<!--> <!-->months as a cause of other respiratory infections requiring a hospital visit has been analyzed.</div></div><div><h3>Material and methods</h3><div>The viral etiology of acute respiratory infections (ARIs) diagnosed in the 2022-2023 and 2023-2024 seasons has been prospectively compared, and in this last season between recipients and non-recipients of nirsevimab. Global provisional coverage was 77% of the population.</div></div><div><h3>Results</h3><div>In the 2022-2023 season, 303 &lt;<!--> <!-->6<!--> <!-->months with an ARI were detected, while in the 2023-2024 season there were 278 minors (19% less). The positivity in the first season was 79.9% compared to 70.5% in the current season. A significant difference has been observed in the detection of RSV between both groups and a decrease of 82.9% of cases in the current season. Of the 278 cases &lt;<!--> <!-->6<!--> <!-->months detected in the 2023-2024 season, 192 (69.1%) received immunization with nirsevimab and 86 (30.9%) did not receive it. The percentage of positivity in those immunized was 69.3%, compared to 73.3% in those not immunized. Significant differences have been observed in the detections of RSV and influenza between both groups.</div></div><div><h3>Conclusions</h3><div>Immunization at &lt;<!--> <!-->6<!--> <!-->months with nirsevimab has shown a significant reduction in RSV infections compared to the previous season. It does not seem, however, that it can reduce infections by other respiratory viruses.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 4","pages":"Pages 193-196"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thinking like pediatricians to prevent pneumococcal disease in adults","authors":"Jesús Ruiz Contreras","doi":"10.1016/j.eimc.2025.01.002","DOIUrl":"10.1016/j.eimc.2025.01.002","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 4","pages":"Pages 185-187"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacto de la campaña de inmunización pasiva con nirsevimab en 2023-24 en Castellón. Resultados finales","authors":"Eulalia Gregori-García ,&nbsp;Juan Carlos Gascó-Laborda ,&nbsp;Lledó Lluch-Bacas ,&nbsp;Oscar Pérez-Olaso ,&nbsp;Iris Gómez-Alfaro ,&nbsp;Juan B. Bellido-Blasco","doi":"10.1016/j.eimc.2024.11.007","DOIUrl":"10.1016/j.eimc.2024.11.007","url":null,"abstract":"<div><h3>Introduction</h3><div>In the 2023-2024 season, systematic immunization with the monoclonal antibody nirsevimab was recommended in Spain. The impact that this immunization program had on the target population of the program is analyzed.</div></div><div><h3>Methods</h3><div>Pre-post ecological study comparing 2023-24 vs 2022-23 season. The variation in incidence is described by age groups (0-5, 6-11 and 12-59<!--> <!-->months) and hospitalization. Incidence rates were calculated and relative risks (RR) were estimated for each group.</div></div><div><h3>Results</h3><div>The results were very heterogeneous depending on the age group. In children 0-5<!--> <!-->months old the RR was 0.16 (0.10-0.25); in those aged 6-11<!--> <!-->months, RR of 0.90 (0.56-1.42); and in those aged 12-59<!--> <!-->months, RR 1.36 (1.06-1.74). The greatest decrease in risk was in hospitalized children under 6<!--> <!-->months, RR 0.13 (0.07-0.22).</div></div><div><h3>Conclusion</h3><div>The results support the positive impact that this campaign had, especially on hospitalizations.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 4","pages":"Pages 215-218"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}