Enfermedades infecciosas y microbiologia clinica最新文献

{"title":"Fresh frozen plasma for neutralizing SARS-CoV-2: “An exploratory cross-sectional study and review of the state of the art”","authors":"Marcial Delgado-Fernández ,&nbsp;Juan Diego Ruiz-Mesa ,&nbsp;Almudena Rojas-González ,&nbsp;Gracia Mar García-Gemar ,&nbsp;Ana Fuentes-López ,&nbsp;Adolfo de Salazar-González ,&nbsp;Federico García-García","doi":"10.1016/j.eimc.2025.03.005","DOIUrl":"10.1016/j.eimc.2025.03.005","url":null,"abstract":"<div><div>Restitution of humoral immunodeficiency is essential to clear SARS-CoV-2. Intravenous unspecific immunoglobulins are expensive and restricted. So recently donated fresh frozen plasma (FFP) could be useful in this scenario but, are all units neutralizing against SARS-CoV-2?</div><div>We explored this on 52 donations obtained from “Centro de Transfusión, Tejidos y Células de Málaga, Spain”, from April to June 2022. Donors status about SARS-CoV-2 previous infection or vaccination was unknown. Neutralizing activity (at dilutions<!--> <!-->≥<!--> <!-->1/160) against real Delta (not circulating), BA.2 (dominant circulating variant), BA.5 (irrupting variant), and BQ.1.1 and XBB.1.5 (not circulating yet) was determined.</div><div>Higher anti-Spike IgG antibodies cut-offs predicted efficacy of FFP. Different cut-offs have been reported in the literature, but all papers have in common that levels over the higher range of quantification can predict neutralizing activity of recently donated FFP against circulating variants of concern, if used early after donation, not requiring clinical data from donors.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 282-290"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Análisis de los costes asociados a la administración intramuscular versus oral de la terapia antirretroviral en el manejo de la infección por el virus de la inmunodeficiencia humana","authors":"Vicente Estrada ,&nbsp;Juan Emilio Losa ,&nbsp;Ramón Morillo-Verdugo ,&nbsp;Montserrat Pérez-Encinas ,&nbsp;Jesús Santos ,&nbsp;Antonio Castro ,&nbsp;María Presa González ,&nbsp;Laura Salinas-Ortega","doi":"10.1016/j.eimc.2024.07.013","DOIUrl":"10.1016/j.eimc.2024.07.013","url":null,"abstract":"<div><h3>Objetive</h3><div>To identify and analyze the resources and costs associated with the administration of intramuscular antiretroviral therapy (ART) cabotegravir<!--> <!-->+<!--> <!-->rilpivirine (CAB<!--> <!-->+<!--> <!-->RPV) compared to oral ART in the management of Human Immunodeficiency Virus Type 1 (HIV-1) infection in Spain.</div></div><div><h3>Methods</h3><div>An economic model was developed to identify resources and analyze costs from the perspective of the National Health System (NHS) and societal, associated with the administration of intramuscular ART (CAB<!--> <!-->+<!--> <!-->RPV) compared to oral ART over a two-year time horizon. Costs included treatment change monitoring, pharmaceutical dispensation, administration, management of adverse events to injection-site reactions (AEs-ISR), travel to the hospital, telepharmacy service, and lost work productivity. Unit costs (€, 2023) were obtained from the literature. Sensitivity analyses were conducted to evaluate the robustness of the model.</div></div><div><h3>Results</h3><div>Intramuscular ART compared to oral ART was associated with an increase in costs of €673.16/patient over two years from the perspective of the NHS, and €719.59/patient from the social perspective. Intramuscular ART would generate increased costs for dispensation (+€97.75), administration (+€394.55), monitoring (+€288.74), management of AEs-ISR (+€6.46), travel (+€8.36), and lost work productivity (+€38.07), compared to oral ART administration.</div></div><div><h3>Conclusion</h3><div>Treating HIV-1 with intramuscular CAB<!--> <!-->+<!--> <!-->RPV leads to increased resource consumption and costs, compared to oral ART.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 251-259"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis infection diagnosis: Current prospects","authors":"Fernando Alcaide ,&nbsp;Luis Anibarro","doi":"10.1016/j.eimc.2025.02.008","DOIUrl":"10.1016/j.eimc.2025.02.008","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 239-241"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proptosis y aumento del perímetro craneal durante el puerperio","authors":"Lucía Guillén Zafra ,&nbsp;Pedro Manuel García-Ceberino ,&nbsp;Diana Alejandra Pantoja Pachajoa ,&nbsp;Juan José Pomares Pomares","doi":"10.1016/j.eimc.2024.09.003","DOIUrl":"10.1016/j.eimc.2024.09.003","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 293-294"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Riesgo similar de hospitalización y letalidad por COVID-19 en trasplantados y pacientes en lista de espera: un análisis comparativo","authors":"Abelardo Claudio Fernández Chávez ,&nbsp;Guillermo Yovany Ordoñez León ,&nbsp;Eva Elisa Álvarez León ,&nbsp;Paloma Moreno Nuñez ,&nbsp;José Porto Tomás ,&nbsp;Jesús María Aranaz Andrés","doi":"10.1016/j.eimc.2024.12.007","DOIUrl":"10.1016/j.eimc.2024.12.007","url":null,"abstract":"<div><h3>Introduction</h3><div>In 2022, Spanish health authorities recommended passive immunization against COVID-19 for solid organ transplant recipients (SOT), due to their deficient post-vaccination humoral response. Patients on the transplant waiting list (SOTwl) were excluded from this strategy.</div></div><div><h3>Objective</h3><div>To compare the risk of hospitalization, ICU admission, and mortality due to COVID-19 between SOT and SOTwl patients.</div></div><div><h3>Methods</h3><div>Patients seen in the Preventive Medicine Department at Ramón y Cajal Hospital between 03/14/2020 and 04/13/2022. The relative risk (RR) of hospitalization, ICU admission, and mortality was estimated among SOT and SOTwl patients, adjusted for age, sex, and vaccine doses.</div></div><div><h3>Results</h3><div>A total of 1292 patients were analyzed. SOT patients (n<!--> <!-->=<!--> <!-->1153) were older and had similar risks of hospitalization (RR 0.97, 95% <span>C</span>I 0.57-1.64), ICU admission (RR 1.74, 95% CI 0.44-6.86), and death (RR 0.89, 95% CI 0.45-1.77) compared to SOTwl patients (n<!--> <!-->=<!--> <!-->139).</div></div><div><h3>Conclusion</h3><div>The risks of hospitalization, ICU admission, and mortality were similar between SOT and SOTwl patients.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 277-281"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between serum 25-hydroxyvitamin D3 and oxidative balance score in patients with tuberculosis infection","authors":"Yan Yong,&nbsp;Li-hong Zhou,&nbsp;Sheng-ya Yang,&nbsp;Xiao-qin Ran,&nbsp;Qing-shan Cai","doi":"10.1016/j.eimc.2024.09.012","DOIUrl":"10.1016/j.eimc.2024.09.012","url":null,"abstract":"<div><h3>Background</h3><div>Previous study had reported the imbalance of pro- and anti-oxidants in tuberculosis (TB), which was involved in the TB progression. This study aimed to identify the key oxidative stress indicator associated with oxidative balance in patients with TB infection.</div></div><div><h3>Methods</h3><div>Overall, 339 participants with TB were included in this study. The oxidative balance score (OBS) was composed of scores of dietary and lifestyle factors. Trend regression analysis, generalized additive model, polynomial regression, and threshold effect analysis, were used to examine the relationship between the serum 25-hydroxyvitamin D3 25(OH)D3 and OBS. Moreover, the correlation between serum 25(OH)D3 and OBS components was explored via Pearson analysis, and mediation analysis was used to explore the function of OBS components.</div></div><div><h3>Results</h3><div>Linear regression analysis showed that among 6 oxidative stress indicators, only serum 25(OH)D3 was independently related to the OBS. A positive association between them was then found (<em>P</em> for trend<!--> <!-->&lt;<!--> <!-->0.05) in a non-linear relationship (all <em>P</em> <!-->&lt;<!--> <!-->0.05). The 25(OH)D3 concentration of 51.9<!--> <!-->nmol/L was identified as the key turning point by threshold effect analysis, and their association was only found when it &lt;51.9<!--> <!-->nmol/L. Further, we revealed that 25(OH)D3 mainly correlated with 2 OBS components including BMI and riboflavin. Moreover, BMI and riboflavin were found to mediate the association of serum 25(OH)D3 with OBS by mediation analysis (all <em>P</em> <!-->&lt;<!--> <!-->0.05).</div></div><div><h3>Conclusions</h3><div>In summary, our study revealed relationship between the serum 25(OH)D3 and OBS in patients with TB, which provided a piece of evidence that vitamin D can assist the treatment of TB.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 260-266"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lesiones papulares y pancitopenia en paciente con inmunosupresión severa por VIH","authors":"Laia Arbós Junyent ,&nbsp;Antonio Casabella Pernas ,&nbsp;Granada Olga Perea Duran ,&nbsp;Marta Navarro Vilasaró","doi":"10.1016/j.eimc.2024.08.016","DOIUrl":"10.1016/j.eimc.2024.08.016","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 291-292"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of novel antigens for distinguishing between active tuberculosis and latent tuberculosis infection in interferon-γ release assays","authors":"Haiping Dong ,&nbsp;Bin Huang ,&nbsp;Haobin Kuang ,&nbsp;Hua Li ,&nbsp;Yuan Yuan ,&nbsp;Shaoling Wu ,&nbsp;Jingyuan Feng ,&nbsp;Jianrong Lou ,&nbsp;Feng Liang ,&nbsp;Min Wang ,&nbsp;Fanrong Meng ,&nbsp;Weiyong Wang ,&nbsp;Xiang Yang ,&nbsp;Jinxing Hu","doi":"10.1016/j.eimc.2024.09.001","DOIUrl":"10.1016/j.eimc.2024.09.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Tuberculosis (TB) remains a significant global health threat, with latent tuberculosis infection (LTBI) serving as a major reservoir for new TB cases. This study aimed to identify antigens capable of distinguishing between active tuberculosis (ATB) and LTBI in interferon-γ release assays (IGRA).</div></div><div><h3>Methods</h3><div>Four candidate antigens for LTBI and two for ATB were selected based on a literature review. These antigens were synthesized genetically, subcloned, expressed in bacteria, and purified. Clinical samples were collected from individuals diagnosed with ATB and LTBI to aid in assay development. Novel IGRA assays were then developed using these antigens, and their discriminatory efficacy was assessed.</div></div><div><h3>Results</h3><div>Among the six candidate antigens tested, only three (Rv2028c, Rv2029c and Rv0475) showed promising discriminatory potential for LTBI. Particularly, Rv0475 (HBHA), expressed in <em>Escherichia coli</em> without methylation, exhibited greater stimulation activity in LTBI compared to ATB. Individually, these antigens demonstrated sensitivities ranging from 72.4% to 93.3% and specificities ranging from 79.3% to 89.7%. The combined stimulation of multiple antigens can improve the sensitivity and specificity of the diagnosis.</div></div><div><h3>Conclusion</h3><div>Our findings highlight the potential of three LTBI antigens and their combination in distinguishing between ATB and LTBI. Adding this antigen combination to the traditional IGRA assay could significantly improve the clinical differentiation of healthy individuals, LTBI, and ATB. Further investigation in larger and more diverse patient cohorts is warranted to validate the utility of these antigen combinations in clinical settings.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 242-250"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leishmaniasis cutánea simulando un sarcoma de Kaposi en un paciente VIH","authors":"Diego de la Vega Ruiz ,&nbsp;María Uxúa Floristán Muruzábal ,&nbsp;Fernando Javier Pinedo Moraleda ,&nbsp;María Velasco Arribas","doi":"10.1016/j.eimc.2025.02.002","DOIUrl":"10.1016/j.eimc.2025.02.002","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 5","pages":"Pages 304-306"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secular trends in periprosthetic joint infections following primary hip and knee arthroplasties: A 15-year cohort study from the VINCat Program (2008–2022)","authors":"Joaquín López-Contreras ,&nbsp;Pol Duch Llorach ,&nbsp;Nerea Roch Villaverde ,&nbsp;Alexander Almendral ,&nbsp;Ana Felisa López ,&nbsp;Marilo Marimon ,&nbsp;M. Angeles Domínguez-Luzón ,&nbsp;Jose Carlos Martinez-Pastor ,&nbsp;Joan Ramoneda Salas ,&nbsp;Natividad Benito ,&nbsp;Laura Morata ,&nbsp;Ricardo Zules-Oña ,&nbsp;Enrique Limón ,&nbsp;Miquel Pujol ,&nbsp;on behalf of the VINCat Orthopedic Surgery Module Team","doi":"10.1016/j.eimc.2025.02.007","DOIUrl":"10.1016/j.eimc.2025.02.007","url":null,"abstract":"<div><h3>Background</h3><div>The VINCat program, established in Catalonia, Spain, in 2006, is a comprehensive infection prevention program for healthcare-associated infections. This study aims to analyze long-term trends in periprosthetic joint infections (PJI) following primary hip and knee arthroplasties over 15-year period (2008–2022).</div></div><div><h3>Methods</h3><div>PJI was defined according to CDC-NHSN criteria and updated in 2016 to incorporate the Musculoskeletal Infection Society classification. Data on PJI following total hip arthroplasty (THA), total knee arthroplasty (TKA), and hip hemiarthroplasty (HHA) were prospectively collected and analyzed across three periods: 2008–2012, 2013–2017, and 2018–2022.</div></div><div><h3>Results</h3><div>Sixty-seven hospitals participated in the surveillance, reporting 189,063 procedures, including 61,267 THA (median age: 69 years, 47% female), 115,940 TKA (median age: 73 years, 68% female), and 11,856 HHA (median age: 86 years, 73% females). PJI incidence rates for THA were 0.9%, 1.1%, and 1.2% across the three periods (odds ratio (OR):1.14, 95% CI: 0.96–1.35). For TKA, rates were 0.9%, 1.0%, and 0.9% (OR:0.95, 95% CI: 0.83–1.09). The incidence of HHA-PJI declined from 3.4% to 2.3% and 1.8% (OR:0.77, 95% CI:0.58–1.03). Overall, the most common etiology was coagulase negative staphylococci followed by <em>Staphylococcus aureus</em>. PJIs were diagnosed after hospital discharge in 87.1% of THA, 89.6% of TKA, and 73.9% of HHA.</div></div><div><h3>Conclusions</h3><div>The incidence of PJI remains low despite an aging population undergoing orthopedic surgery, highlighting the effectiveness of current infection prevention strategies. A robust, long-term surveillance system is crucial for monitoring epidemiological trends and guiding the implementation of evidence-based preventive measures.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 ","pages":"Pages S44-S51"},"PeriodicalIF":2.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}