Enfermedades infecciosas y microbiologia clinica最新文献

{"title":"¿Qué corticosteroide debería emplearse en la neumonía grave?","authors":"Javier Velasco Montes , María Victoria Pardo Gutiérrez , Carlos Hernando Martín , Silvia González Díez","doi":"10.1016/j.eimc.2024.11.001","DOIUrl":"10.1016/j.eimc.2024.11.001","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Page 121"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143165734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¿Cómo podemos optimizar el abordaje diagnóstico y terapéutico de la neumonía? Recomendaciones basadas en una opinión de expertos. Respuesta de los autores","authors":"Mario Fernández-Ruiz , Juan José Castón , José Luis del Pozo , José María Aguado , en representación de los miembros del Grupo OPENIN («Optimización de procesos clínicos para el diagnóstico y tratamiento de infecciones»)","doi":"10.1016/j.eimc.2024.11.002","DOIUrl":"10.1016/j.eimc.2024.11.002","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 121-122"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143165733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete genome characterization of mcr-1-mediated colistin-resistant Escherichia coli from outpatients in Bulgaria","authors":"Stefana Sabtcheva ,&nbsp;Ivan Stoikov ,&nbsp;Deyan Donchev ,&nbsp;Sylvia Georgieva ,&nbsp;Elina Dobreva ,&nbsp;Ivan Nikolaev Ivanov","doi":"10.1016/j.eimc.2024.10.002","DOIUrl":"10.1016/j.eimc.2024.10.002","url":null,"abstract":"<div><h3>Introduction</h3><div>This study reports the emergence of <em>mcr-1</em>-mediated colistin resistance in human <em>Escherichia coli</em> isolates from Bulgaria.</div></div><div><h3>Methods</h3><div>Three colistin-resistant <em>E. coli</em> isolates were obtained from outpatient urine specimens. They were subjected to PCR for detection of <em>mcr</em> genes and conjugation experiments. Whole-genome sequencing was employed to analyze the genomic characteristics of the isolates.</div></div><div><h3>Results</h3><div>PCR identified <em>mcr-1</em> in all isolates. In <em>E. coli</em> of sequence type (ST) 2067, <em>mcr-1.1</em> was found on a self-transmissible IncI2 plasmid, while <em>mcr-1.32</em> was chromosomal in the remaining two ST131 <em>E. coli</em> isolates. <em>E. coli</em> ST2067 co-harbored quinolones resistance mutations (<em>gyrA</em>^D87N, <em>gyrA</em>^S83L, <em>parC</em>^S80I), β-lactam (<em>bla</em>_TEM-30) and aminoglycoside (<em>aadA1</em>, <em>aac(3)-IId</em>) resistance genes.</div></div><div><h3>Conclusion</h3><div>This report further confirms the role of IncI2 conjugative plasmids in the dissemination of <em>mcr</em> genes. Our findings involving chromosomal <em>mcr-1</em> in high-risk ST131 <em>E. coli</em> strains from outpatients underscores the need for enhanced surveillance and systematic screening to combat colistin resistance.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 97-101"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143166793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aplicación en vida real de un modelo de estratificación para la atención de personas con VIH","authors":"Miguel Suárez-Robles ,&nbsp;Clara Crespillo Andújar ,&nbsp;Sandra Chamorro-Tojeiro ,&nbsp;Begoña Monge-Maillo ,&nbsp;Francesca Norman ,&nbsp;Ignacio Peña ,&nbsp;Martina Corral ,&nbsp;Cristina Arcas ,&nbsp;Santiago Moreno ,&nbsp;Jose A. Pérez-Molina","doi":"10.1016/j.eimc.2024.03.006","DOIUrl":"10.1016/j.eimc.2024.03.006","url":null,"abstract":"<div><h3>Introduction</h3><div>HIV infection has become a chronic disease with a good long-term prognosis, necessitating a change in the care model. For this study, we applied a proposal for an Optimal Care Model (OCM) for people with HIV (PHIV), which includes tools for assessing patient complexity and their classification into profiles to optimize care provision.</div></div><div><h3>Methods</h3><div>Observational, cross-sectional, and retrospective study. Adult PHIV treated at the Tropical Medicine consultations at Ramón y Cajal Hospital from January 1 to June 30, 2023, were included. The complexity calculation and the stratification into profiles for each patient were done according to the OCM.</div></div><div><h3>Results</h3><div>Ninety-four participants were included, 76.6% cisgender men, with a median age of 41 years (range 23-76). Latin America and Africa were the main regions of origin (72.4%). 98% had an undetectable HIV viral load. The degree of complexity was 78.7% low, 11.7% medium, 1% high, and 8.5% extreme. The predominant profile was blue (64.9%), followed by lilac (11.7%), purple (6.3%), and green (4.3%). 7.4% were unclassifiable, of whom 57.2% had high/extreme complexity. Among the unclassifiable, mental health problems were the most common.</div></div><div><h3>Conclusions</h3><div>The OCM tools for People Living with HIV (PLWH) allow for the classification and stratification of most patients in a consultation with a non-standard population. Patients who did not fit into the pre-established profiles presented high complexity. Creating a profile focused on mental health or mixed profiles could facilitate the classification of more patients.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 80-85"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causa inesperada de insuficiencia cardiaca en varón con válvulas mitral y aórtica protésicas","authors":"Yolanda García Collado,&nbsp;Lourdes Balderas Fernández,&nbsp;Laura Mora Navas,&nbsp;María Victoria García López","doi":"10.1016/j.eimc.2024.06.010","DOIUrl":"10.1016/j.eimc.2024.06.010","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 113-114"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141839392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dalbavancina como tratamiento antibiótico de consolidación en endocarditis infecciosa, infección de dispositivos de estimulación cardiaca y bacteriemia: experiencia clínica de 7 años","authors":"Alejandro Salinas-Botrán ,&nbsp;Carmen Olmos-Blanco ,&nbsp;David Fernández de Velasco-Pérez ,&nbsp;Alicia Guzmán-Carreras ,&nbsp;Alejandro Morales-Rosas ,&nbsp;Daniel Gómez-Ramírez","doi":"10.1016/j.eimc.2024.02.010","DOIUrl":"10.1016/j.eimc.2024.02.010","url":null,"abstract":"<div><h3>Introduction</h3><div>Dalbavancin (DBV), a novel lipoglycopeptide with activity against Gram-positive bacterial infections, is approved for the treatment of acute bacterial skin and skin structure infections. It has linear dose-related pharmacokinetics allowing a prolonged interval between doses. It would be a good option for the treatment of patients with Gram-positive cardiovascular infections.</div></div><div><h3>Material and methods</h3><div>Retrospective analysis of patients with cardiovascular infection (bacteremia, implantable electronic device infection and infective endocarditis [IE]) treated with DBV at Hospital Clínico San Carlos (Madrid) for 7 years (2016-2022). Patients were divided into 2 study groups: 1) IE, and 2) bacteremia. Epidemiological, clinical, microbiological and therapeutic data were analyzed.</div></div><div><h3>Results</h3><div>A total of 25 patients were treated with DBV for cardiovascular infection. IE was the most common indication (68%), followed by bacteremia (32%) with male predominance in both groups (64 vs. 62%) and median age of 67,7 and 57,5 years, respectively. Hundred percent of blood cultures were positive to Gram-positive microorganisms (<em>Staphylococcus</em> spp., <em>Streptococcus</em> spp. or <em>Enterococcus</em> spp.) in both study groups. Previously to DBV, all patients received other antibiotic therapy, both in the group of IE (median: 80 days) as in bacteremia (14,8 days). The main reason for the administration of DBV was to continue intravenous antimicrobial therapy outside the hospital in both the EI group (n<!--> <!-->=<!--> <!-->15) and the bacteremia group (n<!--> <!-->=<!--> <!-->8). DBV was used as consolidation therapy in a once- or twice-weekly regimen. Microbiological and clinical successes were reached in 84% of cases (n<!--> <!-->=<!--> <!-->21), 76,4% in IE group and 100% in bacteremia group. No patient documented adverse effects during long-term DBV treatment.</div></div><div><h3>Conclusion</h3><div>DBV is an effective and safety treatment as consolidation antibiotic therapy in IE and bacteremia produced by Gram-positive microorganisms.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 71-79"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140400211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusually high incidence of pneumonia in Navarre, Spain, 2023–2024","authors":"Camino Trobajo-Sanmartín ,&nbsp;María Eugenia Portillo ,&nbsp;Ana Navascués ,&nbsp;Iván Martínez-Baz ,&nbsp;Carmen Ezpeleta ,&nbsp;Jesús Castilla","doi":"10.1016/j.eimc.2024.08.008","DOIUrl":"10.1016/j.eimc.2024.08.008","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the pneumonia incidence in Navarre, Spain, in the 2023–2024 season.</div></div><div><h3>Methods</h3><div>Using electronic medical records, we evaluated the incidence of clinical pneumonia, positive pneumococcal antigen cases and <em>Mycoplasma pneumoniae</em> positive PCR cases by age groups from 2017–2018 to 2023–2024 season.</div></div><div><h3>Results</h3><div>Compared to the average of the 2017–2018 and 2018–2019 seasons, in the 2023–2024 season, pneumonia incidence rate increased by 73% overall and multiplied by 4.43 in the age group of 5–14 years. The rate of confirmed pneumococcal pneumonia increased by 63%, and that of <em>M. pneumoniae</em> multiplied by 19.</div></div><div><h3>Conclusion</h3><div>Pneumonia incidence was unusually high in all ages in the 2023–2024 season and was related to upsurges in pneumococcal and <em>Mycoplasma</em> diseases.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 93-96"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143166762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypervirulent Klebsiella pneumoniae: Epidemiology outside Asian countries, antibiotic resistance association, methods of detection and clinical management","authors":"Silvia García-Cobos ,&nbsp;Jesús Oteo-Iglesias ,&nbsp;María Pérez-Vázquez","doi":"10.1016/j.eimc.2024.12.008","DOIUrl":"10.1016/j.eimc.2024.12.008","url":null,"abstract":"<div><div>Two main <em>Klebsiella pneumoniae</em> pathotypes are of public health concern, classical <em>K. pneumoniae</em> (cKP), with high antibiotic resistance acquisition capacity, and hypervirulent <em>K. pneumoniae</em> (hvKP). The emergence of hypervirulent and antibiotic-resistant <em>K. pneumoniae</em>, especially carbapenem resistance, is worrisome and require effective methods for detection and treatment. Different evolutionary paths contribute to the emergence of hypervirulence and antibiotic resistance, commonly via the acquisition of resistance plasmids by hvKP (CR-hvKP) or the acquisition of virulence plasmids by CRKp (hv-CRKp). ST11-KL64 together with <em>bla</em>_KPC-2, is the most extended hv-CRKP lineage acquiring virulence plasmids with associated biomarkers, <em>rmpA</em>, <em>rmpa2</em>, <em>iroBCDEN</em>, <em>iucABCDiutA</em>, and <em>peg344</em>. In addition to ST11, other hv-CRKP clones have been reported in Europe such as ST101, ST147 and ST512, highlighting the association of ST147 with OXA-48 and NDM carbapenemases. Although still very rare in Spain, hvKP cases are increasing in recent years, mainly due to ST23-K1, ST380-K2 and ST86-K2. Management of hvKP infections requires active antibiotic therapy based primarily on antibiotic susceptibility patters and site of infection.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 102-109"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143166794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of UV-C disinfection and copper plating on healthcare-associated infections in a NICU with high ESBL infections","authors":"Daniela de la Rosa-Zamboni,&nbsp;Mónica Villa-Guillén,&nbsp;Anaíd Bustos-Hamdan,&nbsp;María Isabel Rosas-Mateos,&nbsp;Marisol Medina-Pelcastre,&nbsp;Margarita Torres-García,&nbsp;María Isabel Franco-Hernández,&nbsp;María del Carmen Castellanos-Cruz,&nbsp;Israel Parra-Ortega,&nbsp;Edmedt Fest-Parra,&nbsp;María Citlalli Casillas-Casillas,&nbsp;Ana Carmen Guerrero-Díaz","doi":"10.1016/j.eimc.2024.02.009","DOIUrl":"10.1016/j.eimc.2024.02.009","url":null,"abstract":"<div><h3>Introduction</h3><div>Healthcare-associated infections (HCAIs) in neonates are frequent and highly lethal, in particular those caused by extended spectrum beta-lactamase (ESBL) producing bacteria. We evaluated the beneficial effects of ultraviolet C (UV-C) disinfection and copper adhesive plating on HCAIs in the Neonatal Intensive Care Unit (NICU) of a third level paediatric hospital in Mexico City, both in combination of hand-hygiene (HH) and prevention bundles.</div></div><div><h3>Methods</h3><div>All NICU patients were included. There were 4 periods (P): P1: HH monitoring and prevention bundles; P2: P1<!--> <!-->+<!--> <!-->UV-C disinfection; P3: P2<!--> <!-->+<!--> <!-->Copper adhesive plating on frequent-contact surfaces and P4: Monitoring of P3 actions.</div></div><div><h3>Results</h3><div>552 neonates were monitored during 15,467 patient days (PD). HCAI rates decreased from 11.03/1000 PD in P1 to 5.35/1000 PD in P4 (<em>p</em> <!-->=<!--> <!-->0.006). HCAIs with bacterial isolates dropped from 5.39/1000 PD in PI to 1.79/1000 PD in P4 (<em>p</em> <!-->=<!--> <!-->0.011). UV-C and copper were associated with significant HCAI prevention (RR 0.49, CI_95% 0.30–0.81, <em>p</em> <!-->=<!--> <!-->0.005) and with lesser HCAIs with bacterial isolates (RR 0.33, CI_95% 0.14–0.77, <em>p</em> <!-->=<!--> <!-->0.011).</div></div><div><h3>Conclusions</h3><div>Copper adhesive plating combined with UV-C disinfection were associated with a drop in HCAI rates and with the elimination of ESBL-caused HCAIs. Hence, we propose that these strategies be considered in MDRO proliferation preventions.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 64-70"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140407999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythema induratum of Bazin—A cutaneous manifestation of tuberculosis","authors":"Maria Ana Quadros Flores ,&nbsp;Gustavo Almeida Silva ,&nbsp;Paulo Filipe ,&nbsp;Sérgio Eduardo Paulo","doi":"10.1016/j.eimc.2024.06.006","DOIUrl":"10.1016/j.eimc.2024.06.006","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 110-112"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141851985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}