Enfermedades infecciosas y microbiologia clinica最新文献_第3页

Acute hepatitis A in a person living with HIV previously vaccinated with immune response 先前接种过免疫应答疫苗的艾滋病毒感染者发生急性甲型肝炎

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1016/j.eimc.2026.503099

Lucía Platero , María del Mar Arcos , Gemma Carrión , Luz Martín-Carbonero

引用次数: 0

Neisseria meningitidis como causa de celulitis, una presentación infrecuente 脑膜炎奈瑟菌作为蜂窝组织炎的病因，是一种罕见的病因

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-03-01 Epub Date: 2026-01-19 DOI: 10.1016/j.eimc.2025.503062

Sofía Veiga Pereira, Rebeca Longueira Suárez, Antonio Moreno Flores, Martín Rubianes González

引用次数: 0

Vesículas genitales dolorosas: ¿siempre es herpes simple? 生殖器血管疼痛：总是简单的疱疹吗？

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.eimc.2025.503064

Nazaret Betanzos , Jorge-Alfredo Pérez-García , Alberto Delgado-Iribarren Martínez-Campero , Jorge Del Romero Guerrero

引用次数: 0

Novel antifungal compounds against Fusarium spp: A systematic review 新型抗镰刀菌化合物的系统综述

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-03-01 Epub Date: 2026-02-12 DOI: 10.1016/j.eimc.2026.503109

Nury Alejandra de León , Neri Alejandro Álvarez-Villalobos , Gloria M. González , Rogelio de J. Treviño-Rangel , Alexandra M. Montoya

{"title":"Novel antifungal compounds against Fusarium spp: A systematic review","authors":"Nury Alejandra de León , Neri Alejandro Álvarez-Villalobos , Gloria M. González , Rogelio de J. Treviño-Rangel , Alexandra M. Montoya","doi":"10.1016/j.eimc.2026.503109","DOIUrl":"10.1016/j.eimc.2026.503109","url":null,"abstract":"<div><div><em>Fusarium</em> spp. has increased in relevance due to its resistance, high mortality, increasing incidence, and low preventability. The scarce treatment options compelled the development of antifungals with novel mechanisms of action. We conducted a systematic review to report on novel compounds and their activity on <em>Fusarium</em> spp. We searched for terms related to novel antifungals against <em>Fusarium</em> across multiple databases, up to February 2024. From 622 articles, only 15 articles met the eligibility criteria. The antifungals reported were manogepix (10), olorofim (3), ibrexafungerp (1), and MGCD290 (1), evaluated against 480 <em>Fusarium</em> isolates. Manogepix MIC/MECs had broad ranges for most <em>Fusarium</em> species, with notable exceptions like <em>F. solani</em> (MEC: ≤0.12μg/mL) and <em>F. fujikuroi</em> (MEC: ≤0.25μg/mL). Olorofim could be a good candidate for fusariosis treatment based on <em>in vitro</em> activity. Ibrexafungerp and MGCD290 did not show good activity as monotherapy. Further work on applications and development of new treatments against the resistant <em>Fusarium</em> species is essential.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"44 3","pages":"Article 503109"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147404502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cuando el viajero envejece: implicaciones sanitarias de los programas culturales para mayores 当旅行者变老时：老年人文化项目对健康的影响

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-03-01 Epub Date: 2026-01-19 DOI: 10.1016/j.eimc.2025.503066

Marta Díaz-Menéndez , Rosa De Miguel-Buckley , Fernando De la Calle-Prieto , Marta Arsuaga

引用次数: 0

From chest to brain: Multiple intracranial mass lesions in an immunocompetent young man 从胸部到脑部：免疫功能正常的年轻男性多发颅内肿块病变

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-03-01 Epub Date: 2026-02-24 DOI: 10.1016/j.eimc.2026.503113

Ana Isabel Vargas Herrera , Miriam Torrecillas , Michele Hernández Cabrera , Ernesto Santana Suárez , Valentina González Pérez , Isabel de Miguel Martínez

引用次数: 0

Analysis of the clinical complexity of people living with HIV based on the GeSIDA stratification system 基于GeSIDA分层系统的HIV感染者临床复杂性分析

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-03-01 Epub Date: 2026-02-24 DOI: 10.1016/j.eimc.2026.503135

Julia Barrado Cuchillo , Adrián Valls Carbó , María José Núñez Orantos , Noemí Cabello Clotet , Juncal Pérez-Somarriba Moreno , Ana Muñoz Gómez , Carolina Olmos Mata , Virginia Víctor Palomares , Vicente Estrada Pérez

{"title":"Analysis of the clinical complexity of people living with HIV based on the GeSIDA stratification system","authors":"Julia Barrado Cuchillo , Adrián Valls Carbó , María José Núñez Orantos , Noemí Cabello Clotet , Juncal Pérez-Somarriba Moreno , Ana Muñoz Gómez , Carolina Olmos Mata , Virginia Víctor Palomares , Vicente Estrada Pérez","doi":"10.1016/j.eimc.2026.503135","DOIUrl":"10.1016/j.eimc.2026.503135","url":null,"abstract":"<div><h3>Introduction</h3><div>Thanks to improvements in antiretroviral therapy (ART), HIV infection has become a chronic disease in developed countries. The stratification of the complexity of chronic patients is a procedure used in other diseases that allows for identifying the risk level of patients and organizing care based on their characteristics.</div><div>The objective of this study is to analyze the complexity of a large cohort of people living with HIV (PLWH) on ART and in regular follow-up consultations.</div></div><div><h3>Methods</h3><div>Descriptive study of complexity according to the GeSIDA stratification scale (GSS), which includes social aspects, risk behaviors, comorbidities, psychological and cognitive status, and viral control in a cohort of PLWH on ART. Patients were classified as extreme, high, medium, or low complexity based on their GSS score.</div></div><div><h3>Results</h3><div>A total of 1127 patients were included, 83.7% male, with a mean age of 48 years (SD: 13.10). 65.3% had low complexity, 18.5% medium, 8.3% high, and 7.9% extreme complexity. The most determining factors for higher complexity on the GSS were lower social support, drug use and risky sexual behaviors. Female sex, lower educational level, history of AIDS, a lower CD4 count and a lower CD4/CD8 ratio were associated with higher complexity.</div></div><div><h3>Conclusions</h3><div>The GSS identifies most PLWH on ART as low complexity. There are clinical factors associated with greater complexity, suggesting that there are subgroups of PLWH who should receive differentiated clinical care to prevent complications and improve their quality of life.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"44 3","pages":"Article 503135"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147404827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparación entre RT-PCR y TMA en la detección de SARS-CoV-2 y propuesta de algoritmo diagnóstico basado en valores de corte 比较RT-PCR和TMA在SARS-CoV-2检测中的作用以及拟议的基于截断值的诊断算法

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-03-01 Epub Date: 2026-01-20 DOI: 10.1016/j.eimc.2025.503068

Albert Bernet Sánchez , Alba Bellés Bellés , Eric López González , Iván Prats Sanchez , Saray Mormeneo Bayo , María Riesgo Magaña , Mercè García González

{"title":"Comparación entre RT-PCR y TMA en la detección de SARS-CoV-2 y propuesta de algoritmo diagnóstico basado en valores de corte","authors":"Albert Bernet Sánchez , Alba Bellés Bellés , Eric López González , Iván Prats Sanchez , Saray Mormeneo Bayo , María Riesgo Magaña , Mercè García González","doi":"10.1016/j.eimc.2025.503068","DOIUrl":"10.1016/j.eimc.2025.503068","url":null,"abstract":"<div><h3>Introduction</h3><div>SARS-CoV-2 caused a pandemic with more than 778 million cases and 7 million deaths. The high diagnostic demand forced laboratories to incorporate new techniques, such as transcription-mediated amplification (TMA). This study compares TMA with RT-PCR in routine clinical samples and evaluates the relationship between relative light units (RLU) and RT-PCR results to define possible cut-off ranges.</div></div><div><h3>Methods</h3><div>A prospective study was carried out over one year in the microbiology laboratory of Hospital Universitari Arnau de Vilanova de Lleida. All samples for SARS-CoV-2 were processed using TMA (Aptima® Hologic), and a portion was analyzed in parallel with RT-PCR (LightMix®, GeneXpert®, or Cobas®). Concordance between techniques, sensitivity, and specificity were calculated. RT-PCR was considered the reference technique.</div></div><div><h3>Results</h3><div>A total of 15,156 samples were analyzed with both techniques. Concordance was substantial (κ=0.692), with a sensitivity of 97.89% and a specificity of 64.74%. Of the results, 11.28% corresponded to false positives and 8.44% to false negatives for TMA. RLU values between 350 and 559, considered negative by the TMA system, were positive by RT-PCR in 20.56%. In intermediate RLU values (560-899), the probability of having a negative RT-PCR was around 50%, dropping to 3.78% for values between 1000 and 1099.</div></div><div><h3>Conclusions</h3><div>These results support the use of TMA as a screening method, provided the positivity threshold is lowered to 350 RLU and positive cases are confirmed by RT-PCR.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"44 3","pages":"Article 503068"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147404830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

No hay calma después de la tormenta: infecciones asociadas tras inundaciones y danas 风暴过后没有平静：与洪水和灾害相关的感染

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-03-01 Epub Date: 2026-02-11 DOI: 10.1016/j.eimc.2026.503115

Víctor García Bustos , Miguel Salavert Lletí

引用次数: 0

Sospecha de alergia a amoxicilina en urgencias pediátricas: baja confirmación diagnóstica y elevada tasa de cambios antibióticos inapropiados 儿科急诊中疑似阿莫西林过敏：诊断确认率低，抗生素不适当改变率高

IF 2.5 4区医学

Enfermedades infecciosas y microbiologia clinica Pub Date : 2026-03-01 Epub Date: 2026-01-19 DOI: 10.1016/j.eimc.2025.503077

Iciar Echavarren Churruca , Gabriela Milagros Acuña Vila , Carmen Gómez Traseira , Begoña de Miguel Lavisier , Miguel Ángel Molina Gutiérrez

{"title":"Sospecha de alergia a amoxicilina en urgencias pediátricas: baja confirmación diagnóstica y elevada tasa de cambios antibióticos inapropiados","authors":"Iciar Echavarren Churruca , Gabriela Milagros Acuña Vila , Carmen Gómez Traseira , Begoña de Miguel Lavisier , Miguel Ángel Molina Gutiérrez","doi":"10.1016/j.eimc.2025.503077","DOIUrl":"10.1016/j.eimc.2025.503077","url":null,"abstract":"<div><h3>Introduction</h3><div>Reactions to β-lactam antibiotics account for up to 80% of pediatric consultations for suspected drug allergy. This study aimed to describe the characteristics of children evaluated in the emergency department for suspected allergy to amoxicillin or amoxicillin-clavulanate.</div></div><div><h3>Materials and methods</h3><div>We conducted a descriptive, retrospective study in a tertiary hospital (January 2019-May 2024), including patients ≤16 years with a diagnosis of suspected allergy to these antibiotics.</div></div><div><h3>Results</h3><div>Eighty-two cases were analyzed; 93.9% presented with cutaneous lesions and none showed hemodynamic instability. Two patients received intramuscular epinephrine for immediate reactions consistent with mild anaphylaxis. Antibiotic treatment was discontinued in 95.1% of cases, and 54.7% of the substitutions were considered inappropriate. A total of 69.5% were referred to Allergy, and only 7patients (12.3%) were confirmed to have true amoxicillin allergy.</div></div><div><h3>Conclusions</h3><div>Suspected amoxicillin allergy in pediatric emergency care generally has a favorable prognosis. The low diagnostic confirmation rate and frequent inappropriate antibiotic changes highlight the need to improve adherence to clinical guidelines.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"44 3","pages":"Article 503077"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147404501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0