Enfermedades infecciosas y microbiologia clinica最新文献

{"title":"Neumonía neonatal de mala evolución: un agente insospechado","authors":"Judith Lozano González, Alba de Tíscar Sánchez García","doi":"10.1016/j.eimc.2024.10.003","DOIUrl":"10.1016/j.eimc.2024.10.003","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 3","pages":"Pages 178-179"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parvovirus B19 and central nervous system: A case series","authors":"Luis Gago , Elvira Baos , Mercedes Martínez-Rodríguez , Alberto Delgado-Iribarren","doi":"10.1016/j.eimc.2024.10.005","DOIUrl":"10.1016/j.eimc.2024.10.005","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 3","pages":"Pages 183-184"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial resistance and epidemiological aspects of Neisseria gonorrhoeae in the province of Lleida, Spain (2017–2024)","authors":"Alejandro Cumplido ,&nbsp;Jesús Aramburu ,&nbsp;María Font ,&nbsp;Marina Montes ,&nbsp;Raquel Abad ,&nbsp;Eric López ,&nbsp;Albert Bernet ,&nbsp;Saray Mormeneo ,&nbsp;Iván Prats ,&nbsp;Mercè García ,&nbsp;Elena Sánchez ,&nbsp;Alba Bellés","doi":"10.1016/j.eimc.2024.06.016","DOIUrl":"10.1016/j.eimc.2024.06.016","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Neisseria gonorrhoeae</em> (NG) is one of the main causes of sexually transmitted infections and it is reaching high resistance levels worldwide. The aim of this study was to describe the antibiotic resistance, incidence and circulating sequence types of NG in the province of Lleida (Spain).</div></div><div><h3>Methods</h3><div>A total of 487 NG isolates were included in the study (2017–2024). Antibiotic susceptibility testing was performed by gradient diffusion following EUCAST criteria. NG-MAST was performed to 211 isolates in Centro Nacional de Microbiología (Majadahonda, Spain). The study of co-infections was done by real-time PCR (Allplex™ STI, Seegene®).</div></div><div><h3>Results</h3><div>All NG isolates remained susceptible to third-generation cephalosporins. The percentages of resistance to tetracycline, ciprofloxacin and penicillin G were 89.1%, 69.2% and 22.6% respectively. A 7.8% of isolates presented a MIC &gt;1<!--> <!-->mg/L for azithromycin. A decrease in the incidence of gonococcal infections was detected during 2020, followed by a pronounced increase in next years. Ninety-seven different sequence types were detected. ST14994 (14.7%) and ST19792 (6.6%), were the most frequent ST detected in our study. NG appeared as a single STI agent in most cases (77.7%) and <em>Chlamydia trachomatis</em> was the most frequently detected STI agent (74.8%) in samples with co-infections.</div></div><div><h3>Conclusions</h3><div>NG incidence is increasing in our area. The lack of resistance to third-generation cephalosporins and the low level of azithromycin resistance suggest that the use of these antibiotics is a suitable option. Continuous surveillance is essential to prevent the emergence and spread of resistant NG isolates.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 3","pages":"Pages 156-161"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Mycobacterium tuberculosis recombinant proteins-coated gold nanoparticles in improving the interferon-gamma release assay test","authors":"Najmeh Jomehpour ,&nbsp;Mojtaba Sankian ,&nbsp;Saman Soleimanpour ,&nbsp;Mohammad Derakhshan ,&nbsp;Kiarash Ghazvini ,&nbsp;Safora Pordel ,&nbsp;Malihe Moghadam","doi":"10.1016/j.eimc.2024.06.015","DOIUrl":"10.1016/j.eimc.2024.06.015","url":null,"abstract":"<div><h3>Introduction</h3><div>Gold nanoparticles (GNPs) are chemically inert, have low toxicity, and are easy to modify and functionalize for the detection of many pathogens. They have excellent immune modulatory and adjuvant properties. The aim of this study was to improve the diagnosis of latent tuberculosis infection (LTBI) by adding GNPs in tests based on interferon-gamma (IFN-γ) measurement.</div></div><div><h3>Methods</h3><div>GNPs were coated with <em>Mycobacterium tuberculosis</em> (Mtb) recombinant proteins including TB10.4, CFP-10, ESAT-6, and TB7.7. Then, they exposed the whole blood of subjects with active tuberculosis (aTB), LTBI, and healthy controls (HC). Subsequently, IFN-γ produced in GNP tubes (QFT-NG) was measured and compared with IFN-γ produced in tubes without GNPs [QFT-A: (CFP-10, ESAT-6, TB7.7, TB10.4), QFT-B: (CFP-10, ESAT-6, TB7.7)].</div></div><div><h3>Results</h3><div>The results showed that the IFN-γ production in the GNPs tubes was significantly higher than in tubes without GNPs in aTB, LTBI, and HC subjects. In aTB patients, the mean difference (MD) between the QFT-NG and QFT-A tubes was 0.44, with a <em>P</em>-value of 0.04, and a 95% CI: 0.07–0.88. Furthermore, in LTBI individuals, the QFT-NG and QFT-A tubes exhibited an MD<!--> <!-->=<!--> <!-->0.21, <em>P</em>-value<!--> <!-->=<!--> <!-->0.03, 95% CI: 0.15–0.4. In the aTB and LTBI subjects were detected in the QFT-NG tubes with a sensitivity of 95%, 100% and specificity 100%, 86%, respectively.</div></div><div><h3>Conclusion</h3><div>The use of GNPs coated with Mtb recombinant proteins can aid in detecting LTBI subjects by increasing IFN-γ levels.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 3","pages":"Pages 148-155"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exceptional cause of brain abscess","authors":"Sofía De la Villa ,&nbsp;Verónica Parras ,&nbsp;Leire Pérez-Latorre ,&nbsp;Pablo Martín-Rabadán","doi":"10.1016/j.eimc.2024.09.011","DOIUrl":"10.1016/j.eimc.2024.09.011","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 3","pages":"Pages 177-178"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RIME sine rash asociada a infección por Mycoplasma pneumoniae","authors":"Antonio Bustos-Merlo,&nbsp;Ana Peragón-Ortega,&nbsp;Antonio Rosales-Castillo,&nbsp;Pedro Alberto Alarcón-Blanco","doi":"10.1016/j.eimc.2024.10.004","DOIUrl":"10.1016/j.eimc.2024.10.004","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 3","pages":"Pages 180-181"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complicated malaria caused by Plasmodium falciparum with parasitemia >50%","authors":"Miguel Morante-Ruiz,&nbsp;Cristina Ortega-Portas,&nbsp;Luis José Betancourt-Cuadra,&nbsp;Miguel Górgolas Hernández-Mora","doi":"10.1016/j.eimc.2024.07.006","DOIUrl":"10.1016/j.eimc.2024.07.006","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 3","pages":"Pages 175-176"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence status of vaccine-preventable diseases in migrants living in shelter centers in Barcelona, Spain","authors":"Carles Rubio Maturana ,&nbsp;Marta Guerrero ,&nbsp;Maria Casas Claramunt ,&nbsp;Susana Nuria Ayala-Cortés ,&nbsp;Victoria López ,&nbsp;Patricia Martínez-Vallejo ,&nbsp;Begoña Treviño ,&nbsp;Elena Sulleiro ,&nbsp;Juliana Esperalba ,&nbsp;Ariadna Rando ,&nbsp;Diana Pou ,&nbsp;Maria Luisa Aznar ,&nbsp;Pau Bosch-Nicolau ,&nbsp;Fernando Salvador ,&nbsp;Inés Oliveira-Souto ,&nbsp;Israel Molina ,&nbsp;Núria Serre-Delcor","doi":"10.1016/j.eimc.2024.04.005","DOIUrl":"10.1016/j.eimc.2024.04.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Almost 281 million people were living in a foreign country in 2022, and more than 100 million were displaced because of war conflicts and human right violations. Vaccination coverage of infectious diseases in migrants from some disadvantaged settings could be lower than reception countries populations, consequently seroprevalence studies and better access to vaccination could contribute to reducing these differences.</div></div><div><h3>Methods</h3><div>A descriptive retrospective cross-sectional study was conducted including migrants, living ≤5 years in the reception country and ≥16 years old, who requested a medical exam between January 1st, 2020 and January 31st, 2021. Seroprevalence assessment was performed, and vaccination was offered to those individuals without immunity to hepatitis B, hepatitis A, varicella, measles, mumps, and rubella.</div></div><div><h3>Results</h3><div>A total of 315 migrants were attended during the study period. Immunity protection at arrival was 252/296 (85.1%) for measles, 274/295 (92.9%) for rubella, 257/296 (86.8%) for mumps, 264/295 (89.5%) for varicella, 267/313 (85.3%) for hepatitis A, and 104/300 (34.6%) for hepatitis B. The final immunity protection after full vaccination schedules was 278/296 (93.9%) for measles, 287/295 (97.3%) for rubella, 274/296 (92.6%) for mumps, 276/295 (93.6%) for varicella, 280/313 (89.5%) for hepatitis A, and 139/300 (46.3%) for hepatitis B.</div></div><div><h3>Conclusions</h3><div>The vaccination intervention has increased immunity rates for the studied diseases in the attended migrants in our center, however, such interventions should be maintained to reach local population immunization levels. Moreover, the collaboration between shelter and reference specialized health centers is fundamental to implement such vaccination programs.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 3","pages":"Pages 139-147"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141137887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estudio prospectivo para la detección precoz de carcinoma pulmonar en pacientes con infección por VIH (estudio GESIDA 8815)","authors":"M. Eulalia Valencia ,&nbsp;Tatiana Pirogova ,&nbsp;Delia Romera ,&nbsp;Marta Montero ,&nbsp;María Tasías ,&nbsp;José Sanz ,&nbsp;Alberto Arranz ,&nbsp;Jorge Vergas ,&nbsp;M. Jesús Tellez ,&nbsp;Francisco Fanjul ,&nbsp;Antoni Campins ,&nbsp;Miguel Cervero ,&nbsp;Inmaculada Jarrín ,&nbsp;Marta de Miguel ,&nbsp;Luz Martín Carbonero ,&nbsp;María Yllescas ,&nbsp;Juan González","doi":"10.1016/j.eimc.2024.03.003","DOIUrl":"10.1016/j.eimc.2024.03.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Lung cancer (LC) screening detects tumors early. The prospective GESIDA 8815 study was designed to assess the usefulness of this strategy in HIV+ people (PLHIV) by performing a low-radiation computed tomography (CT) scan.</div></div><div><h3>Patients and methods</h3><div>371 heavy smokers patients were included (&gt;<!--> <!-->20 packs/year), &gt;<!--> <!-->45<!--> <!-->years old and with a CD4+ &lt;<!--> <!-->200<!--> <!-->mm³ nadir. One visit and CT scan were performed at baseline and 4 for follow-up time annually.</div></div><div><h3>Results</h3><div>329 patients underwent the baseline visit and CT (CT0) and 206 completed the study (CT1<!--> <!-->=<!--> <!-->285; CT2<!--> <!-->=<!--> <!-->259; CT3<!--> <!-->=<!--> <!-->232; CT4<!--> <!-->=<!--> <!-->206). All were receiving ART. A total &gt;<!--> <!-->8<!--> <!-->mm lung nodules were detected, and 9 early-stage PCs were diagnosed (4 on CT1, 2 on CT2, 1 on CT3 and 2 on CT4). There were no differences between those who developed LC and those who did not in sex, age, CD4+ nadir, previous lung disease, family history, or amount of packets/year. At each visit, other pathologies were diagnosed, mainly COPD, calcified coronary artery and residual tuberculosis lesions. At the end of the study, 38 patients quit smoking and 75 reduced their consumption. Two patients died from LC and 16 from other causes (<em>P</em> <!-->=<!--> <!-->.025).</div></div><div><h3>Conclusions</h3><div>The design of the present study did not allow us to define the real usefulness of the strategy. Adherence to the test progressively decreased over time. The diagnosis of other thoracic pathologies is very frequent. Including smokers in an early diagnosis protocol for LC could help to quit smoking.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 3","pages":"Pages 125-132"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Carrion's disease: A systematic review in South American countries and meta-analysis","authors":"Mauro A.F. Guimarães ,&nbsp;Laura A. Xavier ,&nbsp;Alice F. Silva ,&nbsp;Felipe C.M. Iani ,&nbsp;Cecília M.M. Anjos ,&nbsp;Cristiane F.O. Scarponi","doi":"10.1016/j.eimc.2024.11.005","DOIUrl":"10.1016/j.eimc.2024.11.005","url":null,"abstract":"<div><div><em>Bartonella bacilliformis</em> can cause a potentially fatal infection, Carrion's disease. This review synthesized data on the prevalence of this bacterial infection in South American countries. A comprehensive literature search relevant articles (published between 2010 and 2022) was conducted in four databases. Full texts were selected based on PECOTS eligibility and JBI methodological quality. The pooled bacterial infection rate was calculated using a random-effects meta-analysis model. Subgroup and meta-regression analyses were used to investigate statistical heterogeneity. Five studies (covering 717 individuals from Peru and Ecuador) were eligible for meta-analysis. The percentage of seropositive IgG antibodies against <em>B. bacilliformis</em> was 28.21% (95% CI: 6.29–33.39) among healthy Ecuadorian children. In Peru, the pooled bacterial detection rate in symptomatic individuals was 15.60% (95% CI: 4.24–31.98), using molecular tests. Carrion's disease is endemic in the Andean valleys, but a gradual reduction in infection rates among acute febrile patients in Peru has been observed in recent years. Laboratory diagnosis of this infection continues to be neglected in other South American countries. Public managers must plan effective arrangements in primary care services, integrating various technological levels to ensure comprehensive health care.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 3","pages":"Pages 165-171"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}