Enfermedades infecciosas y microbiologia clinica最新文献

{"title":"Enfermedad de Chagas y coinfección por el VIH","authors":"Jesús Fernández Plaza , Javier Guzmán , Sandra Chamorro-Tojeiro , José A. Pérez-Molina","doi":"10.1016/j.eimc.2024.09.008","DOIUrl":"10.1016/j.eimc.2024.09.008","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 117-119"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Análisis del diagnóstico serológico de la sífilis: una propuesta de mejora","authors":"Javier Gutiérrez Ballesteros , Sonsoles Garcinuño Pérez , Marta Domínguez-Gil González , Silvia Rojo Rello","doi":"10.1016/j.eimc.2024.09.010","DOIUrl":"10.1016/j.eimc.2024.09.010","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 119-120"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dalbavancin as sequential therapy in infective endocarditis: Real-life experience in elder and comorbid patients","authors":"Eduardo Aparicio-Minguijón ,&nbsp;Jorge Boán ,&nbsp;Antonio Terrón ,&nbsp;Carlos Heredia ,&nbsp;Cristina Puente ,&nbsp;Asunción Pérez-Jacoiste Asín ,&nbsp;M. Ángeles Orellana ,&nbsp;Laura Domínguez ,&nbsp;José Manuel Caro ,&nbsp;M. Jesús López-Gude ,&nbsp;Eva María Aguilar-Blanco ,&nbsp;Andrea Eixerés-Esteve ,&nbsp;Francisco López-Medrano","doi":"10.1016/j.eimc.2024.04.009","DOIUrl":"10.1016/j.eimc.2024.04.009","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to evaluate the effectiveness of dalbavancin as sequential therapy in patients with infective endocarditis (IE) due to gram positive bacteria (GPB) in a real-life heterogenous cohort with comorbid patients.</div></div><div><h3>Methods</h3><div>A single center retrospective cohort study including all patients with definite IE treated with dalbavancin between January 2017 and February 2022 was developed. A 6-month follow-up was performed. The main outcomes were clinical cure rate, clinical and microbiological relapse, 6-month mortality, and adverse effects (AEs) rate.</div></div><div><h3>Results</h3><div>The study included 61 IE episodes. The median age was 78.5 years (interquartile range [IQR] 63.2–85.2), 78.7% were male, with a median Charlson comorbidity index of 7 (IQR 4–9) points. Overall, 49.2% suffered native valve IE. The most common microorganism was <span><span>Staphylococcus aureus</span></span> (26.3%) followed by <span><span>Enterococcus faecalis</span></span> (21.3%). The median duration of initial antimicrobial therapy and dalbavancin therapy were 27 (IQR 20–34) and 14 days (IQR 14–28) respectively. The total reduction of hospitalization was 1090 days. The most frequent dosage was 1500<!--> <!-->mg of dalbavancin every 14 days (96.7%). An AE was detected in 8.2% of patients, only one (1.6%) was attributed to dalbavancin (infusion reaction). Clinical cure was achieved in 86.9% of patients. One patient (1.6%) with <em>Enterococcus faecalis</em> IE suffered relapse. The 6-month mortality was 11.5%, with only one IE-related death (1.6%).</div></div><div><h3>Conclusion</h3><div>This study shows a high efficacy of dalbavancin in a heterogeneous real-world cohort of IE patients, with an excellent safety profile. Dalbavancin allowed a substantial reduction of in-hospital length of stay.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 86-92"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141415987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peritonitis bacteriana aguda por Staphylococcus lugdunensis resistente a meticilina","authors":"David Roa Alonso ,&nbsp;Víctor Antón Berenguer ,&nbsp;Alberto Orejas Gallego ,&nbsp;Ricardo Díaz Abad","doi":"10.1016/j.eimc.2024.08.010","DOIUrl":"10.1016/j.eimc.2024.08.010","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 115-116"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuevo secuenciotipo ST6423 de Klebsiella pneumoniae hipervirulenta portador de carbapenemasa OXA-48-like causante de bacteriemia en un paciente inmunocomprometido","authors":"Carmen Palacios Clar,&nbsp;Diego García Martínez de Artola,&nbsp;Julia Alcoba Flórez","doi":"10.1016/j.eimc.2024.08.014","DOIUrl":"10.1016/j.eimc.2024.08.014","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 116-117"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143165732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¿Qué corticosteroide debería emplearse en la neumonía grave?","authors":"Javier Velasco Montes ,&nbsp;María Victoria Pardo Gutiérrez ,&nbsp;Carlos Hernando Martín ,&nbsp;Silvia González Díez","doi":"10.1016/j.eimc.2024.11.001","DOIUrl":"10.1016/j.eimc.2024.11.001","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Page 121"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143165734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¿Cómo podemos optimizar el abordaje diagnóstico y terapéutico de la neumonía? Recomendaciones basadas en una opinión de expertos. Respuesta de los autores","authors":"Mario Fernández-Ruiz ,&nbsp;Juan José Castón ,&nbsp;José Luis del Pozo ,&nbsp;José María Aguado ,&nbsp;en representación de los miembros del Grupo OPENIN («Optimización de procesos clínicos para el diagnóstico y tratamiento de infecciones»)","doi":"10.1016/j.eimc.2024.11.002","DOIUrl":"10.1016/j.eimc.2024.11.002","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 121-122"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143165733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete genome characterization of mcr-1-mediated colistin-resistant Escherichia coli from outpatients in Bulgaria","authors":"Stefana Sabtcheva ,&nbsp;Ivan Stoikov ,&nbsp;Deyan Donchev ,&nbsp;Sylvia Georgieva ,&nbsp;Elina Dobreva ,&nbsp;Ivan Nikolaev Ivanov","doi":"10.1016/j.eimc.2024.10.002","DOIUrl":"10.1016/j.eimc.2024.10.002","url":null,"abstract":"<div><h3>Introduction</h3><div>This study reports the emergence of <em>mcr-1</em>-mediated colistin resistance in human <em>Escherichia coli</em> isolates from Bulgaria.</div></div><div><h3>Methods</h3><div>Three colistin-resistant <em>E. coli</em> isolates were obtained from outpatient urine specimens. They were subjected to PCR for detection of <em>mcr</em> genes and conjugation experiments. Whole-genome sequencing was employed to analyze the genomic characteristics of the isolates.</div></div><div><h3>Results</h3><div>PCR identified <em>mcr-1</em> in all isolates. In <em>E. coli</em> of sequence type (ST) 2067, <em>mcr-1.1</em> was found on a self-transmissible IncI2 plasmid, while <em>mcr-1.32</em> was chromosomal in the remaining two ST131 <em>E. coli</em> isolates. <em>E. coli</em> ST2067 co-harbored quinolones resistance mutations (<em>gyrA</em>^D87N, <em>gyrA</em>^S83L, <em>parC</em>^S80I), β-lactam (<em>bla</em>_TEM-30) and aminoglycoside (<em>aadA1</em>, <em>aac(3)-IId</em>) resistance genes.</div></div><div><h3>Conclusion</h3><div>This report further confirms the role of IncI2 conjugative plasmids in the dissemination of <em>mcr</em> genes. Our findings involving chromosomal <em>mcr-1</em> in high-risk ST131 <em>E. coli</em> strains from outpatients underscores the need for enhanced surveillance and systematic screening to combat colistin resistance.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 97-101"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143166793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aplicación en vida real de un modelo de estratificación para la atención de personas con VIH","authors":"Miguel Suárez-Robles ,&nbsp;Clara Crespillo Andújar ,&nbsp;Sandra Chamorro-Tojeiro ,&nbsp;Begoña Monge-Maillo ,&nbsp;Francesca Norman ,&nbsp;Ignacio Peña ,&nbsp;Martina Corral ,&nbsp;Cristina Arcas ,&nbsp;Santiago Moreno ,&nbsp;Jose A. Pérez-Molina","doi":"10.1016/j.eimc.2024.03.006","DOIUrl":"10.1016/j.eimc.2024.03.006","url":null,"abstract":"<div><h3>Introduction</h3><div>HIV infection has become a chronic disease with a good long-term prognosis, necessitating a change in the care model. For this study, we applied a proposal for an Optimal Care Model (OCM) for people with HIV (PHIV), which includes tools for assessing patient complexity and their classification into profiles to optimize care provision.</div></div><div><h3>Methods</h3><div>Observational, cross-sectional, and retrospective study. Adult PHIV treated at the Tropical Medicine consultations at Ramón y Cajal Hospital from January 1 to June 30, 2023, were included. The complexity calculation and the stratification into profiles for each patient were done according to the OCM.</div></div><div><h3>Results</h3><div>Ninety-four participants were included, 76.6% cisgender men, with a median age of 41 years (range 23-76). Latin America and Africa were the main regions of origin (72.4%). 98% had an undetectable HIV viral load. The degree of complexity was 78.7% low, 11.7% medium, 1% high, and 8.5% extreme. The predominant profile was blue (64.9%), followed by lilac (11.7%), purple (6.3%), and green (4.3%). 7.4% were unclassifiable, of whom 57.2% had high/extreme complexity. Among the unclassifiable, mental health problems were the most common.</div></div><div><h3>Conclusions</h3><div>The OCM tools for People Living with HIV (PLWH) allow for the classification and stratification of most patients in a consultation with a non-standard population. Patients who did not fit into the pre-established profiles presented high complexity. Creating a profile focused on mental health or mixed profiles could facilitate the classification of more patients.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 80-85"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causa inesperada de insuficiencia cardiaca en varón con válvulas mitral y aórtica protésicas","authors":"Yolanda García Collado,&nbsp;Lourdes Balderas Fernández,&nbsp;Laura Mora Navas,&nbsp;María Victoria García López","doi":"10.1016/j.eimc.2024.06.010","DOIUrl":"10.1016/j.eimc.2024.06.010","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 2","pages":"Pages 113-114"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141839392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}