Enfermedades infecciosas y microbiologia clinica最新文献

{"title":"Detection of Neisseria gonorrhoeae and Chlamydia trachomatis by PCR in a sample pool (urine, rectum and pharynx) in asymptomatic patients at risk of sexually transmitted infections","authors":"Sofía Narváez ,&nbsp;Natalia Arnalda ,&nbsp;Marisa López ,&nbsp;Andrea Vergara ,&nbsp;Vanessa Guilera ,&nbsp;Iván Chivite ,&nbsp;David García-Hernández ,&nbsp;Ana González-Cordón ,&nbsp;Josep Riera-Monroig ,&nbsp;Irene Fuertes ,&nbsp;Josep Mallolas ,&nbsp;José Luis Blanco ,&nbsp;Jordi Bosch","doi":"10.1016/j.eimc.2024.11.012","DOIUrl":"10.1016/j.eimc.2024.11.012","url":null,"abstract":"<div><h3>Introduction</h3><div>Detection of <em>Neisseria gonorrhoeae</em> (NG) and <em>Chlamydia trachomatis</em> (CT) is periodically indicated in asymptomatic patients with risky sexual practices. The objective of this study was to assess the efficacy of employing a rapid polymerase chain reaction (PCR) test in a combined pool of three samples from the same patient and compare it with the standard PCR performed in the three different samples separately.</div></div><div><h3>Methods</h3><div>Samples were collected from asymptomatic patients at risk of sexually transmitted infections (STI). Urine samples, two pharyngeal swabs, and two rectal swabs were collected from each patient. Two PCR techniques were performed: standard PCR (Allplex CT/NG/MG/TV®, Seegene) in each of the three samples separately, and rapid PCR (Xpert CT/NG®, Cepheid) in a pool of three samples.</div></div><div><h3>Results</h3><div>A total of 429 pooled samples from 403 patients were included in the study, and 426 urine samples, 412 rectal swabs and 426 pharyngeal swabs were also processed. Concordances between pooled and individual PCRs for both CT and NG identification were 94.17%, with 77 (17.9%) positive samples. The concordance for CT was 98.60%, with 38 positive samples (8.88%), being 95.33% for NG, with 51 positive samples (11.88%).</div></div><div><h3>Conclusion</h3><div>The use of a pool of three samples (urine, rectum and pharynx) for the detection of NG and CT using rapid PCR can be a cost-effective alternative to performing conventional PCR in the three samples separately in asymptomatic patients at risk of developing STI.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 7","pages":"Pages 374-377"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced tick species identification in a tertiary care hospital using MALDI–TOF MS: The role of peak numbers","authors":"Antonio Beltrán-Rosel ,&nbsp;Ana M. Palomar ,&nbsp;Pilar Goñi ,&nbsp;Rafael Benito ,&nbsp;Beatriz López-Alonso ,&nbsp;Jorge Ligero-López ,&nbsp;Amparo Boquera-Albert ,&nbsp;María Ducons-Márquez ,&nbsp;Jose A. Oteo","doi":"10.1016/j.eimc.2024.12.016","DOIUrl":"10.1016/j.eimc.2024.12.016","url":null,"abstract":"<div><h3>Introduction</h3><div>Tick bites are a growing public health concern as ticks act as vectors for various pathogens. Accurate tick species identification is vital to assess disease exposure and determine prophylactic measures. MALDI–TOF MS has emerged as a promising tool for precise tick identification. This study evaluates the performance of MALDI–TOF MS in clinical tick identification, focusing on how the number of peaks present in the reference and sample spectra influences the accuracy of the identification process.</div></div><div><h3>Methods</h3><div>Between April 2022 and March 2024, 42 tick specimens sent to our hospital were identified using MALDI–TOF MS. The reference spectrum was created with 70 peaks and expanded to include versions with 40, 100, and 130 peaks using Compass Biotyper Explorer v4.1.1. Spectra were analyzed with Flex Analysis v3.4 software. Identification was performed by querying sample spectra against these libraries, with a log score value (LSV)<!--> <!-->≥<!--> <!-->1.70 considered accurate for species identification.</div></div><div><h3>Results</h3><div>Libraries with 40, 100, and 130 peaks improved identification scores for several species, though the degree varied. The highest scores were achieved in 64.3% of specimens. Combining all libraries as a single database yielded LSVs above the 1.70 threshold for all specimens.</div></div><div><h3>Conclusions</h3><div>The study highlights the species-specific nature of peak importance in spectra and underscores the potential of MALDI–TOF MS as a rapid and accurate tool for tick identification in clinical settings. Enhanced spectral libraries could further improve this technique, aiding timely clinical decisions and effective management of tick bites.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 7","pages":"Pages 396-401"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brote de gastroenteritis por norovirus GII.17 en una residencia de mayores","authors":"Paula Martín Bazarra ,&nbsp;Óscar Esparcia Rodríguez ,&nbsp;Angélica Gómez Martínez ,&nbsp;Regina Azancot Carballo ,&nbsp;Caridad Sainz de Baranda Camino ,&nbsp;Nerea García Ibáñez ,&nbsp;María Dolores Fernández García ,&nbsp;Rafael Carranza González","doi":"10.1016/j.eimc.2024.12.006","DOIUrl":"10.1016/j.eimc.2024.12.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Gastrointestinal norovirus infections are highly prevalent, causing outbreaks especially in institutions such as nursing homes. We describe an outbreak caused by an emerging norovirus genotype.</div></div><div><h3>Material and methods</h3><div>We defined a case as a resident or worker of the centre with clinical signs and symptoms of AGE from 14 to 29 May 2022, with no underlying pathology to justify it. A clinical-epidemiological survey was carried out and stool samples were collected from patients with diarrhoea at the time of the study. Virological analysis was performed at the Microbiology Department of our hospital by antigenic detection (Certest®, Biotec SL) and/or multiplex PCR (AllplexTM GI-Virus Assay, Seegene®). Viral genotyping by sequencing was performed by the Centro Nacional de Microbiología (CNM).</div></div><div><h3>Results</h3><div>The outbreak totaled 114 cases (99 residents, 15 workers), extending over 16 days. The most frequent symptoms were vomiting and diarrhoea. The overall attack rate was 30.8% (in workers 12.7%). Cases increased rapidly in the first 48<!--> <!-->hours, falling progressively over successive days. Food contamination was ruled out, with person-to-person transmission being the most likely. Those affected improved clinically in less than 72<!--> <!-->hours, with no deaths. We tested 14 samples from residents, which were positive for norovirus GII. The CNM received 8 samples, detecting norovirus genogroup GII, genotype 17 [P17] in 6.</div></div><div><h3>Conclusions</h3><div>Outbreaks of norovirus GEA in nursing homes can affect numerous users. In our case, norovirus genotype GII.17 was the aetiological agent, confirming its widespread dissemination in the last decade worldwide.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 7","pages":"Pages 378-382"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness of cabotegravir versus tenofovir alafenamide plus emtricitabine versus tenofovir disoproxil fumarate plus emtricitabine for pre-exposure prophylaxis to prevent HIV-1 transmission in gay, bisexual and other men that have sex with men","authors":"Philip Erick Wikman-Jorgensen ,&nbsp;Marta Ruiz-Algueró ,&nbsp;Carlos Iniesta ,&nbsp;Federico Pulido ,&nbsp;Jara Llenas-García","doi":"10.1016/j.eimc.2024.12.023","DOIUrl":"10.1016/j.eimc.2024.12.023","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aims to compare the cost-effectiveness of currently approved daily PrEP in Spain, with tenofovir disoproxil fumarate plus emtricitabine (TDF/FTC), in gay, bisexual and other men who have sex with men (GBMSM) versus newer alternatives like daily tenofovir alafenamide plus emtricitabine (TAF/FTC) or injectable cabotegravir every 2 months (CAB).</div></div><div><h3>Methods</h3><div>We fitted a dynamic compartmentalized Markov model that represents the dynamics of HIV-1 transmission in GBMSM in Spain. The model was calibrated to replicate the epidemiological data of the HIV epidemic in GBMSM in Spain from 2013 to 2018. We used the perspective of the national health system and applied a 40-year time horizon. Quality-adjusted life years (QALYs) were the health outcome variable, and the cost was accounted for in 2018 Euros (€). Our outcome variable was the incremental cost-effectiveness ratio (ICER) for PrEP. We used the 2018 gross domestic product per capita of Spain (€25,854) as the willingness-to-pay (WTP) threshold.</div></div><div><h3>Results</h3><div>The 2019 scenario with no PrEP in place would yield 17,424,891 QALYs and a cost of 2018 €17,345,310,254. The present scenario of daily TDF/FTC yields 18,615,325 QALYs, an increase of 1,190,434 QALYs at a cost of 2018 €15,354,878,534 (decrease of −2018 €1,990,431,719), generating an ICER of −2018 €1672 per QALY gained. The introduction of daily TAF/FTC in the present scenario would yield an increase in 449,392 QALYs at an additional cost of 2018 €13,634,260,217. The ICER would thus be 2018 €30,339 per QALY gained. Introducing CAB in the present scenario would yield an increase of 573,007 QALYs at an additional cost of 2018 €16,754,471,790 (average cost-effectiveness ratio<!--> <!-->=<!--> <!-->29,239). Compared to TAF, the increase in QALYs would be 123,614 at an additional cost of 2018 €5,707,367,590, yielding an ICER of 2018 €46,170/QALY gained. A one-way sensitivity analysis and a probabilistic sensitivity analysis was carried out.</div></div><div><h3>Conclusion</h3><div>The present Spanish policy of PrEP is a cost-saving strategy. TAF/FTC and CAB are not cost-effective at current market prices.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 7","pages":"Pages 416-425"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of infectious diseases consultation and oral sequential therapy in the management of post-surgical mediastinitis","authors":"Marta Represa ,&nbsp;Olalla Lima ,&nbsp;Marina Ávila ,&nbsp;Pablo Rubiñán ,&nbsp;Clara Torres ,&nbsp;Stefanie Sansón-León ,&nbsp;Julio Lugo ,&nbsp;Maximiliano Álvarez-Fernández ,&nbsp;Martin Rubianes ,&nbsp;Juan José Legarra ,&nbsp;María Teresa Pérez-Rodríguez","doi":"10.1016/j.eimc.2024.12.019","DOIUrl":"10.1016/j.eimc.2024.12.019","url":null,"abstract":"<div><h3>Introduction</h3><div>Post-cardiac surgery mediastinitis (PSM) is a serious, complex, and multifactorial complication of surgical procedures. Infectious diseases consultation (IDC) has demonstrated improvement in other complex infectious diseases. The objective of the study was to evaluate the impact of IDC in the management and outcome of patients with PSM.</div></div><div><h3>Methods</h3><div>Observational retrospective study, of adult patients with PSM between January 2010 and June 2021. After January 2016, IDC was performed in all the patients with PSM. The primary endpoint was clinical success, a composite variable of clinical cure, and absence of adverse events, or recurrence. Also, in-hospital stay, and clinical cure was evaluated in patients that received oral sequential therapy (OST).</div></div><div><h3>Results</h3><div>A total of 84 patients with PSM were included, 48 pre-IDC and 36 in IDC period. No differences in clinical success were observed between the two periods (pre-IDC 60% vs, IDC 77%, <em>p</em> <!-->=<!--> <!-->0.104). During the IDC period the rate of adequate targeted antibiotic treatment was higher (pre-IDC 71% vs. IDC 94%, <em>p</em> <!-->=<!--> <!-->0.016). Gram-negative bacilli infections (pre-IDC 42% vs. IDC 78%, <em>p</em> <!-->=<!--> <!-->0.002) and polymicrobial infections (pre-IDC 37% vs. IDC 63%, <em>p</em> <!-->=<!--> <!-->0.004) increased in the IDC period. Multivariate analysis did not show any variable associated with clinical success. OST was similar in both periods, and a shorter in-hospital stay was observed in the patients who underwent OST (no-OST, 70 days vs. OST, 44 days, <em>p</em> <!-->=<!--> <!-->0.003).</div></div><div><h3>Conclusions</h3><div>IDC was related with a higher adequate targeted antimicrobial therapy. We observed that OST offers a promising strategy in the management of this infection.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 7","pages":"Pages 383-388"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opportunities and challenges in the use of pool sampling for sexually transmitted infections","authors":"Laura Villa ,&nbsp;Fernando Vazquez","doi":"10.1016/j.eimc.2025.04.002","DOIUrl":"10.1016/j.eimc.2025.04.002","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 7","pages":"Pages 371-373"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidencia de neumonía neumocócica y por cualquier causa en adultos en Cataluña tras la implementación de la vacunación antineumocócica universal en pediatría: 2015-2016 vs. 2017-2018","authors":"Verònica Torras-Vives ,&nbsp;Cinta de Diego-Cabanes ,&nbsp;Eva M. Satué-Gracia ,&nbsp;Maria José Forcadell-Peris ,&nbsp;Olga Ochoa-Gondar ,&nbsp;Ángel Vila-Córcoles","doi":"10.1016/j.eimc.2025.01.011","DOIUrl":"10.1016/j.eimc.2025.01.011","url":null,"abstract":"<div><h3>Introduction</h3><div>To analyze the incidence of pneumonia in adults following public funding of the 13-valent pneumococcal conjugate vaccine (PCV13) for children in Catalonia.</div></div><div><h3>Methods</h3><div>Two cohorts were analyzed: 2,025,730 individuals aged ≥50 years in 2015-2016 (pre-funding) and 2,059,645 in 2017-2018 (post-funding). Hospitalizations for pneumococcal pneumonia (PP) and all-cause pneumonia (ACP) were identified through the CMBD database across 68 Catalonian hospitals. Incidence rate ratios (IRR) between periods were estimated.</div></div><div><h3>Results</h3><div>PP incidence increased from 83.6/100,000 (2015-2016) to 90.7/100,000 (2017-2018) (IRR: 1.09; 95% <span>C</span>I: 1.03-1.14), while ACP decreased slightly from 617.9/100,000 to 609.7/100,000 (IRR: 0.99; 95% CI: 0.97-1.00). ACP reductions were significant in individuals aged 65-79, those with chronic lung disease, and men. PP increased significantly in those aged &gt;80 years.</div></div><div><h3>Conclusion</h3><div>Adult hospitalized pneumonia incidence did not significantly decrease in the two years following PCV13 public funding for children.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 7","pages":"Pages 444-447"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recuperación del patrón de incremento de las infecciones de transmisión sexual (ITS) después de la pandemia de COVID-19: el caso de la gonococia en Cataluña, España","authors":"Evelin López-Corbeto ,&nbsp;Julia Valera Paloma ,&nbsp;Marcos Montoro Fernández ,&nbsp;Rossie Lugo Colón ,&nbsp;Laura Clotet Romero ,&nbsp;Víctor Guadalupe Fernandez ,&nbsp;Pilar Ciruela Navas ,&nbsp;Jordi Casabona Barbara ,&nbsp;en nombre del Grupo de ITS de la comisión de vigilancia epidemiológica de Cataluña","doi":"10.1016/j.eimc.2024.11.008","DOIUrl":"10.1016/j.eimc.2024.11.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Sexually transmitted infections (STI) have shown a sustained increase in recent years. Changes in epidemiological patterns highlight the need to adapt public health strategies for their prevention and control. The objective of this study is to describe the trend of reported gonorrhea cases in Catalonia (Spain) from 2017 to 2023 and to compare the epidemiological pattern of reported cases before, during, and after the COVID-19 pandemic.</div></div><div><h3>Methods</h3><div>Descriptive analysis of reported gonorrhea cases in Catalonia among individuals aged ≥<!--> <!-->14<!--> <!-->years between 2017 and 2023. Incidence rates (IR) were calculated overall and by sex, age, and origin. A descriptive analysis was conducted to compare reported cases across the pre-pandemic (2017-2019), pandemic (2020), and post-pandemic (2021-2023) periods.</div></div><div><h3>Results</h3><div>The IR of gonorrhea showed an average increase of 32.9% between 2017-2019 and 37.9% between 2021-2023, reaching 164.0 cases per 100,000 inhabitants in 2023. During the pandemic, there was an increase in the proportion of cases among MSM (13.3%), alcohol use (40.0%), having ≥<!--> <!-->6 sexual partners (30.5%), and new sexual partners (74.3%). In the post-pandemic period, the highest percentage increase was observed in women (115.7%), Spanish nationals (124.9%), cases reported in sexual and reproductive health units (30.9%), symptomatic cases (58.0%), and reinfections (33.0%). Additionally, there was a decrease in the average age, particularly among women, in contact tracing studies (13.1%), and in antibiotic resistance.</div></div><div><h3>Conclusions</h3><div>Gonorrhea continues to rise, especially among young people and women. Strengthening its visibility and prioritizing it in STI prevention and control programs is crucial to mitigate its impact on public health.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 6","pages":"Pages 345-352"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bronchopulmonary colonization patterns in Spanish people with cystic fibrosis: Results of a national multicentre study","authors":"Ainhize Maruri-Aransolo ,&nbsp;Esther Quintana ,&nbsp;Malkoa Michelena-González ,&nbsp;María Dolores Pastor-Vivero ,&nbsp;Antonio Álvarez ,&nbsp;Rosa Girón ,&nbsp;Teresa Alarcón ,&nbsp;Carmen Luna-Paredes ,&nbsp;Luis Máiz ,&nbsp;Saioa Vicente ,&nbsp;Marta Ruiz de Valbuena ,&nbsp;María Concepción Prados ,&nbsp;Silvia Castillo-Corullón ,&nbsp;María José Selma ,&nbsp;Amparo Solé ,&nbsp;Maria Cols-Roig ,&nbsp;Pedro Mondéjar-López ,&nbsp;Estela Pérez Ruiz ,&nbsp;Casilda Olveira ,&nbsp;Pilar Caro Aguilera ,&nbsp;Rafael Cantón","doi":"10.1016/j.eimc.2024.08.013","DOIUrl":"10.1016/j.eimc.2024.08.013","url":null,"abstract":"<div><h3>Background</h3><div>We investigate bronchopulmonary colonization patterns in Spanish people with CF (pwCF), gathering clinical, demographic, and microbiological data to supplement nine years of registry information, comparing 2021 findings with a similar multicenter study conducted in 2013.</div></div><div><h3>Methods</h3><div>Sixteen CF units from 14 hospitals across Spain participated, each randomly recruiting around 20 patients. Patients provided sputum samples for culture. The clinical, demographical, microbiological, and treatment data from the previous year were recorded.</div></div><div><h3>Results</h3><div>Overall, 326 patients (48.5% females) were recruited: 185 adult and 141 pediatrics, with a median age [<em>q</em>3–<em>q</em>1] of 30 [38–24] and 12 [16–6] years, respectively. p.Phe508del mutation was present in 30.6% and 46.4% of patients with homozygosis or heterozygosis, respectively. Median FEV₁ (%) was significantly lower in adults (62%, range 75–43%) compared with pediatrics (90%, range 104–81%) (<em>p</em> <!-->&lt;<!--> <!-->0.001). Pancreatic insufficiency was observed in 77.3%, carbohydrate metabolism alteration in 27.3%, and CF-related diabetes in 19.6% of patients. Lower prevalence of <em>Staphylococcus aureus</em> and <em>Pseudomonas aeruginosa</em> colonization were noted compared to 2013, along with a significantly lower correlation in lung function among pwCF colonized by <em>P. aeruginosa</em> (<em>p</em> <!-->&lt;<!--> <!-->0.001). Half of pwCF (51%) exhibited a single pathogen in culture, two in 30%, and three or more in 2.4%. Co-colonization of <em>P. aeruginosa</em> and <em>S. aureus</em> (36.1%) was the most prevalent combination. High resistance rates were observed in <em>P. aeruginosa</em> and methicillin resistant <em>S. aureus</em> isolates.</div></div><div><h3>Conclusions</h3><div>We provide a valuable and representative current insight into the observed evolution in the clinical, demographic, and microbiological aspects in recent years among pwCF in Spain.</div></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 6","pages":"Pages 309-316"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystic fibrosis microbiology research in Spain","authors":"Antonio Oliver","doi":"10.1016/j.eimc.2025.04.003","DOIUrl":"10.1016/j.eimc.2025.04.003","url":null,"abstract":"","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"43 6","pages":"Pages 307-308"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}