Estudio prospectivo para la detección precoz de carcinoma pulmonar en pacientes con infección por VIH (estudio GESIDA 8815)

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-03-01 DOI:10.1016/j.eimc.2024.03.003

M. Eulalia Valencia , Tatiana Pirogova , Delia Romera , Marta Montero , María Tasías , José Sanz , Alberto Arranz , Jorge Vergas , M. Jesús Tellez , Francisco Fanjul , Antoni Campins , Miguel Cervero , Inmaculada Jarrín , Marta de Miguel , Luz Martín Carbonero , María Yllescas , Juan González

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引用次数: 0

Abstract

Introduction

Lung cancer (LC) screening detects tumors early. The prospective GESIDA 8815 study was designed to assess the usefulness of this strategy in HIV+ people (PLHIV) by performing a low-radiation computed tomography (CT) scan.

Patients and methods

371 heavy smokers patients were included (> 20 packs/year), > 45 years old and with a CD4+ < 200 mm³ nadir. One visit and CT scan were performed at baseline and 4 for follow-up time annually.

Results

329 patients underwent the baseline visit and CT (CT0) and 206 completed the study (CT1 = 285; CT2 = 259; CT3 = 232; CT4 = 206). All were receiving ART. A total > 8 mm lung nodules were detected, and 9 early-stage PCs were diagnosed (4 on CT1, 2 on CT2, 1 on CT3 and 2 on CT4). There were no differences between those who developed LC and those who did not in sex, age, CD4+ nadir, previous lung disease, family history, or amount of packets/year. At each visit, other pathologies were diagnosed, mainly COPD, calcified coronary artery and residual tuberculosis lesions. At the end of the study, 38 patients quit smoking and 75 reduced their consumption. Two patients died from LC and 16 from other causes (P = .025).

Conclusions

The design of the present study did not allow us to define the real usefulness of the strategy. Adherence to the test progressively decreased over time. The diagnosis of other thoracic pathologies is very frequent. Including smokers in an early diagnosis protocol for LC could help to quit smoking.

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来源期刊

Enfermedades infecciosas y microbiologia clinica 医学-传染病学

CiteScore

2.10

自引率

8.00%

发文量

194

审稿时长

29 days

期刊介绍： Hoy está universalmente reconocida la renovada y creciente importancia de la patología infecciosa: aparición de nuevos agentes patógenos, de cepas resistentes, de procesos con expresión clínica hasta ahora desconocida, de cuadros de una gran complejidad. Paralelamente, la Microbiología y la Infectología Clínicas han experimentado un gran desarrollo como respuesta al reto planteado por la actual patología infecciosa. Enfermedades Infecciosas y Microbiología Clínica es la Publicación Oficial de la Sociedad Española SEIMC. Cumple con la garantía científica de esta Sociedad, la doble función de difundir trabajos de investigación, tanto clínicos como microbiológicos, referidos a la patología infecciosa, y contribuye a la formación continuada de los interesados en aquella patología mediante artículos orientados a ese fin y elaborados por autores de la mayor calificación invitados por la revista.