Huiyun Zhu, Yiqi Du, Kaixuan Wang, Zhaoshen Li, Zhendong Jin
{"title":"Consensus guidelines on the diagnosis and treatment of pancreatic pseudocyst and walled-off necrosis from a Chinese multiple disciplinary team expert panel","authors":"Huiyun Zhu, Yiqi Du, Kaixuan Wang, Zhaoshen Li, Zhendong Jin","doi":"10.1097/eus.0000000000000080","DOIUrl":"https://doi.org/10.1097/eus.0000000000000080","url":null,"abstract":"<h3>Objective </h3>\u0000<p>To prepare a set of practice guidelines to standardize the entire process, from diagnosis to treatment and follow-up, for pancreatic pseudocysts and walled-off necrosis.</p>\u0000<h3>Methods </h3>\u0000<p>Thirty-six experts in the fields of digestive endoscopy, pancreatic surgery, interventional radiology, and others presented their opinions via discussions in online conferences by referring to the patient, intervention, comparison, and outcomes principles and then reviewed the evidence and statements using the Delphi method to reach a consensus. The consensus of >80% was finally achieved for the items.</p>\u0000<h3>Results </h3>\u0000<p>The experts discussed and reached a consensus on 29 statements including 10 categories: (1) definition and classification, (2) imaging and endoscopic diagnosis, (3) therapeutic implications, (4) surgical therapy, (5) percutaneous catheter drainage, (6) endoscopic retrograde cholangiopancreatography, (7) EUS-guided drainage, (8) stent selection for EUS-guided drainage, (9) complication related to stents for cyst drainage, and (10) drug treatment and follow-up.</p>\u0000<h3>Conclusion </h3>\u0000<p>This consensus based on the clinical experience of experts in various fields and international evidence-based medicine further standardizes the multidisciplinary diagnosis and treatment processes for pancreatic pseudocysts and walled-off necrosis.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Computed tomography–based radial endobronchial ultrasound image simulation of peripheral pulmonary lesions using deep learning","authors":"Chunxi Zhang, Yongzheng Zhou, Chuanqi Sun, Jilei Zhang, Junxiang Chen, Xiaoxuan Zheng, Ying Li, Xiaoyao Liu, Weiping Liu, Jiayuan Sun","doi":"10.1097/eus.0000000000000079","DOIUrl":"https://doi.org/10.1097/eus.0000000000000079","url":null,"abstract":"<h3>Background and Objectives </h3>\u0000<p>Radial endobronchial ultrasound (R-EBUS) plays an important role during transbronchial sampling of peripheral pulmonary lesions (PPLs). However, existing navigational bronchoscopy systems provide no guidance for R-EBUS. To guide intraoperative R-EBUS probe manipulation, we aimed to simulate R-EBUS images of PPLs from preoperative computed tomography (CT) data using deep learning.</p>\u0000<h3>Materials and Methods </h3>\u0000<p>Preoperative CT and intraoperative ultrasound data of PPLs in 250 patients who underwent R-EBUS–guided transbronchial lung biopsy were retrospectively collected. Two-dimensional CT sections perpendicular to the biopsy path were transformed into ultrasonic reflection and transmission images using an ultrasound propagation model to obtain the initial simulated R-EBUS images. A cycle generative adversarial network was trained to improve the realism of initial simulated images. Objective and subjective indicators were used to evaluate the similarity between real and simulated images.</p>\u0000<h3>Results </h3>\u0000<p>Wasserstein distances showed that utilizing the cycle generative adversarial network significantly improved the similarity between real and simulated R-EBUS images. There was no statistically significant difference in the long axis, short axis, and area between real and simulated lesions (all <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">P</em> > 0.05). Based on the experts’ evaluation, a median similarity score of ≥4 on a 5-point scale was obtained for lesion size, shape, margin, internal echoes, and overall similarity.</p>\u0000<h3>Conclusions </h3>\u0000<p>Simulated R-EBUS images of PPLs generated by our method can closely mimic the corresponding real images, demonstrating the potential of our method to provide guidance for intraoperative R-EBUS probe manipulation.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kathleen Möller, Alina Batali, Christian Jenssen, Barbara Braden, Michael Hocke, Wei On, Simon M. Everett, Yi Dong, Nan Ge, Siyu Sun, Michael Gerber, Siegbert Faiss, David Srivastava, Riccardo de Robertis, Mirko D´Onofrio, Benjamin Misselwitz, Christoph F. Dietrich
{"title":"Comments and illustrations of the European Federation of Societies for Ultrasound in Medicine contrast-enhanced ultrasound guidelines: Multiparametric imaging and EUS-guided sampling in rare pancreatic tumors. Benign mesenchymal pancreatic tumors","authors":"Kathleen Möller, Alina Batali, Christian Jenssen, Barbara Braden, Michael Hocke, Wei On, Simon M. Everett, Yi Dong, Nan Ge, Siyu Sun, Michael Gerber, Siegbert Faiss, David Srivastava, Riccardo de Robertis, Mirko D´Onofrio, Benjamin Misselwitz, Christoph F. Dietrich","doi":"10.1097/eus.0000000000000070","DOIUrl":"https://doi.org/10.1097/eus.0000000000000070","url":null,"abstract":"<p>The focus of the review is on primary benign mesenchymal pancreatic tumors and their imaging appearance. These tumors are extremely rare. Usually, they are not diagnosed until postoperative histology is available, and so even benign tumors have undergone extensive pancreatic resection. The very limited data on abdominal and EUS findings including contrast-enhanced techniques of these pancreatic lesions are summarized here. Case reports will be presented for some of these rare tumors with application of modern ultrasound and endosonographic techniques.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Möller, Tamara Holz, C. Jenssen, Barbara Braden, M. Hocke, Wei On, Simon M Everett, Yi Dong, Nan Ge, Siyu Sun, Michael Gerber, Siegbert Faiss, Christoph Schlag, David Srivastava, C. F. Dietrich
{"title":"Comments and illustrations of the European Federation of Societies for Ultrasound in Medicine contrast-enhanced ultrasonography guidelines: multiparametric imaging and EUS-guided sampling in rare pancreatic tumors. Mesenchymal pancreatic tumors of intermediate biological behaviour","authors":"K. Möller, Tamara Holz, C. Jenssen, Barbara Braden, M. Hocke, Wei On, Simon M Everett, Yi Dong, Nan Ge, Siyu Sun, Michael Gerber, Siegbert Faiss, Christoph Schlag, David Srivastava, C. F. Dietrich","doi":"10.1097/eus.0000000000000071","DOIUrl":"https://doi.org/10.1097/eus.0000000000000071","url":null,"abstract":"\u0000 The focus of the review is on mesenchymal pancreatic tumors with intermediate biological behavior and their imaging appearance. Similar to benign and malignant mesenchymal pancreatic tumors, these tumors are extremely rare. The diagnosis is often confirmed only by postoperative histology. The very limited data on abdominal ultrasound and EUS findings including contrast-enhanced techniques of these pancreatic lesions are summarized here.","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141676646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The factors that influence the diagnostic accuracy and sample adequacy of EUS-guided tissue acquisition for the diagnosis of solid pancreatic lesions","authors":"Liqi Sun, Yuqiong Li, Qiuyue Song, Lisi Peng, Ying Xing, Hao Huang, Zhendong Jin","doi":"10.1097/eus.0000000000000060","DOIUrl":"https://doi.org/10.1097/eus.0000000000000060","url":null,"abstract":"\u0000 \u0000 \u0000 EUS-guided tissue acquisition (EUS-TA) is the preferred method to acquire pancreatic cancer (PC) tissues. The factors associated with false-negative outcomes and inadequate samples should be explored to gain an understanding of EUS-TA.\u0000 \u0000 \u0000 \u0000 The patients who underwent EUS-TA for suspected solid PC but whose results were false-negative were analyzed. The PC patients who underwent EUS-TA with true-positive results on the first day of every month during the study period were selected as the control group. The factors influencing diagnostic accuracy and sample adequacy were explored.\u0000 \u0000 \u0000 \u0000 From November 2017 to January 2022, 184 patients were included in the false-negative group, and 175 patients were included in the control group. Multivariate logistic regression demonstrated that the recent acute pancreatitis [odds ratio (OR): 0.478, 95% confidence interval (CI): 0.250–0.914, P = 0.026] and high echo component within the tumor (OR: 0.103, 95% CI: 0.027–0.400, P = 0.001) were independently associated with false-negative EUS-TA results. Meanwhile, using fine-needle biopsy (FNB) needles (OR: 2.270, 95% CI: 1.277–4.035, P = 0.005), more needle passes (OR: 1.651,95% CI: 1.239–2.199, P = 0.005), large tumor size (OR: 1.053, 95% CI: 1.029–1.077, P < 0.001), and high CA-19-9 level (OR: 1.001, 95% CI: 1.000–1.001, P = 0.019) were independently associated with true-positive EUS-TA outcomes. Three needle passes are needed to achieve optimal EUS-TA outcomes. Tumor location in the body/tail (OR: 1.38, 95% CI: 1.01–1.72; P = 0.04), needle passes ≥3 (OR: 1.90; 95% CI: 1.22–2.56; P < 0.001), and using the FNB needle (OR: 2.10; 95%: 1.48–2.85; P < 0.001) were independently related to sample adequacy.\u0000 \u0000 \u0000 \u0000 Numerous factors were identified to be associated with the diagnostic accuracy and sample adequacy of EUS-TA.\u0000","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julie Buchberg, Karin de Stricker, Per Pfeiffer, Michael B. Mortensen, S. Detlefsen
{"title":"Mutational profiling of 103 unresectable pancreatic ductal adenocarcinomas using EUS-guided fine-needle biopsy","authors":"Julie Buchberg, Karin de Stricker, Per Pfeiffer, Michael B. Mortensen, S. Detlefsen","doi":"10.1097/eus.0000000000000072","DOIUrl":"https://doi.org/10.1097/eus.0000000000000072","url":null,"abstract":"\u0000 \u0000 \u0000 Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers, with a 5-year survival rate of around 9%. Only 20% are candidates for surgery. Most unresectable patients undergo EUS-guided fine-needle biopsy (EUS-FNB) for diagnosis. Identification of targetable mutations using next-generation sequencing (NGS) is increasingly requested. Data on feasibility of EUS-FNB for NGS and knowledge regarding mutational profile of unresectable PDAC are scarce. We evaluated the “technical yield” of EUS-FNB for NGS in unresectable PDAC: relative fraction of diagnostic EUS-FNBs meeting technical criteria. We also investigated the “molecular yield”: relative fraction of EUS-FNBs included in NGS containing sufficient DNA for detection of at least one mutation. Furthermore, we determined the relative frequency of cancer-associated mutations in unresectable PDAC.\u0000 \u0000 \u0000 \u0000 Formalin-fixed and paraffin-embedded EUS-FNBs diagnostic of unresectable PDAC and fulfilling these criteria were included (n = 105): minimum 3-mm2 tissue, minimum of 2-mm2 tumor area, and minimum 20% relative tumor area. NGS was performed using Ion GeneStudio S5 Prime System and Oncomine™ Comprehensive Assay v.3 including 161 cancer-related genes.\u0000 \u0000 \u0000 \u0000 Technical yield was 48% (105/219) and molecular yield was 98% (103/105). Most frequently mutated genes were KRAS (89.3%) and TP53 (69.9%), followed by CDKN2A (24.3%), ARID1A (9.7%), SMAD4 (7.8%), TSC2 (7.8%), and CCND3 (6.8%).\u0000 \u0000 \u0000 \u0000 EUS-FNB for NGS of unresectable PDAC is feasible. Our technical criteria for NGS, using leftovers in formalin-fixed and paraffin-embedded blocks after routine pathology diagnosis, were met by around half of EUS-FNBs. Almost all EUS-FNBs fulfilling the technical criteria yielded a successful NGS analysis.\u0000","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141681010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of EUS in the diagnosis of early chronic pancreatitis.","authors":"Yaya Bai, Xianzheng Qin, Xiang Ao, Taojing Ran, Chunhua Zhou, Duowu Zou","doi":"10.1097/eus.0000000000000077","DOIUrl":"https://doi.org/10.1097/eus.0000000000000077","url":null,"abstract":"<p><p>The diagnosis of early chronic pancreatitis (ECP) is challenging due to the lack of standardized diagnostic criteria. EUS has been considered a sensitive diagnostic modality for chronic pancreatitis (CP), with advancements in technique such as EUS-guided fine needle aspiration and biopsy (EUS-FNA/FNB) being developed. However, their role in the diagnosis of ECP remains unelucidated. This review thereby aimed to provide an overview of the clinical landscape of EUS in the field of ECP.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Endoscopic UltrasoundPub Date : 2024-07-01Epub Date: 2024-08-20DOI: 10.1097/eus.0000000000000075
Victor Lira de Oliveira, Marcos Eduardo Lera Dos Santos, Mateus Bond Boghossian, João Remí de Freitas Júnior, Maria Luíza Lemos Pires Pereira, Carolina Vaz Turiani, Eduardo Guimarães Hourneaux de Moura
{"title":"Double EUS-guided bypass for gastric outlet and biliary tract malignant obstruction: A standardized one-step approach (with videos).","authors":"Victor Lira de Oliveira, Marcos Eduardo Lera Dos Santos, Mateus Bond Boghossian, João Remí de Freitas Júnior, Maria Luíza Lemos Pires Pereira, Carolina Vaz Turiani, Eduardo Guimarães Hourneaux de Moura","doi":"10.1097/eus.0000000000000075","DOIUrl":"https://doi.org/10.1097/eus.0000000000000075","url":null,"abstract":"","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Endoscopic UltrasoundPub Date : 2024-07-01Epub Date: 2024-08-16DOI: 10.1097/eus.0000000000000068
Zhenming Zhang, Yao Luo, Min Shi, Shengping Li, Yu Bao
{"title":"EUS-FNA to diagnose a submucosal oropharyngeal carcinoma.","authors":"Zhenming Zhang, Yao Luo, Min Shi, Shengping Li, Yu Bao","doi":"10.1097/eus.0000000000000068","DOIUrl":"https://doi.org/10.1097/eus.0000000000000068","url":null,"abstract":"","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}