Endocrine最新文献

{"title":"Assessment of ICG fluorescence in identification and preservation of parathyroid glands in thyroid surgeries and correlation with postoperative parathormone and serum calcium levels.","authors":"Anupam Lahiri, Vishal Yadav, Vikas Arora, Prerit Sharma, A K Dewan","doi":"10.1007/s12020-024-04158-8","DOIUrl":"10.1007/s12020-024-04158-8","url":null,"abstract":"<p><strong>Introduction: </strong>Intraoperative parathyroid gland (PG) localization remains challenging during thyroid surgeries, contributing to postoperative hypocalcemia and hypoparathyroidism. This study assessed the efficacy of indocyanine green (ICG) fluorescence in identifying and preserving PGs during thyroid surgeries and its correlation with postoperative outcomes.</p><p><strong>Materials and methods: </strong>This ambispective observational study included 57 patients undergoing thyroid surgeries using ICG and compared outcomes with 56 historical controls. ICG was administered intravenously in two 5 mg boluses. Parathyroid identification rates, fluorescence intensity, and postoperative calcium and parathormone levels were assessed. Fluorescence intensity was qualitatively scored on a 1-3 scale.</p><p><strong>Results: </strong>ICG significantly improved PG identification (92.5% vs 69.3% with white light alone). Postoperative hypocalcemia occurred in 22.81% of ICG patients compared to 39.29% in controls (p = 0.045). Hypoparathyroidism rates were 10.53% and 32.14% respectively (p = 0.005). Higher fluorescence intensity (FI) correlated with lower risk of postoperative hypocalcemia (p = 0.026) and combined hypocalcemia and hypoparathyroidism (p = 0.046). Considering both FI 2 and 3 as positive yielded 100% sensitivity and 85.7% accuracy. When only FI 3 was considered positive, sensitivity was 78.4%, specificity was 50%, and accuracy was 69.4%.</p><p><strong>Conclusion: </strong>ICG fluorescence is a safe and effective tool for enhancing PG identification and preservation in thyroid surgeries, significantly reducing postoperative hypocalcemia and hypoparathyroidism. It also helps in confirming the vascularity of the PGs post thyroidectomy. Fluorescence intensity of preserved PGs, rather than quantity, better predicts postoperative outcomes. These findings support the integration of ICG fluorescence imaging and the application of our methodology in thyroid surgeries to improve postoperative results.</p>","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":"564-570"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transoral vestibular robotic thyroidectomy in pediatric thyroid disease: 5 case reports.","authors":"Meng Wang, Yinghao Guo, Gang Wang, Xiaolei Li, Luming Zheng, Qingqing He","doi":"10.1007/s12020-025-04178-y","DOIUrl":"10.1007/s12020-025-04178-y","url":null,"abstract":"<p><strong>Background: </strong>The safety and feasibility of transoral endoscopic thyroidectomy vestibular approach in pediatric patients has been clinically proven, and its cosmetic results have been recognized by children and their families. However, there are no reports on using transoral robotic in pediatric thyroid surgery. In this study, we report the experience of 5 cases of transoral vestibular robotic thyroidectomy in treating of thyroid disease in children.</p><p><strong>Patients and methods: </strong>Retrospective analysis of clinical data of five children who underwent robotic thyroid surgery via the TOVRT in our hospital from February 2021 to April 2023, including operation time, tumor diameter, postoperative hospitalization time, and surgical complications. All five patients were operated on by the same team, and the postoperative pathological results were all follicular adenoma of thyroid. The children had a strong desire for cosmetic surgery, and their families voluntarily chose the robotic surgical system for their surgery.</p><p><strong>Results: </strong>All five patients underwent unilateral thyroid lobectomy without conversion to open surgery. All patients were female, with a mean BMI of (19.63 ± 1.79) kg/m² and the mean age was (14.40 ± 2.33) years. The average operation time was (52.00 ± 5.10) mins, the average tumor diameter was (41.60 ± 8.41) mm, and the average postoperative hospital stay was (3.60 ± 0.49) days. There were no complications such as hypoparathyroidism, recurrent laryngeal nerve injury, genioglossal nerve injury, or skin necrosis.</p><p><strong>Conclusion: </strong>The transoral vestibular robotic thyroidectomy is safe and feasible, providing a new treatment option for pediatric thyroid diseases that require surgical treatment.</p>","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":"523-528"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of assessing erectile dysfunction in patients with type 2 diabetes mellitus based on glucose fluctuation: a Cross-Sectional study.","authors":"Shenhang Yao, Shimei Xing, Xiangxiang Shan, Wu Dai, Yonghong Cao, Ben Hu","doi":"10.1007/s12020-025-04206-x","DOIUrl":"10.1007/s12020-025-04206-x","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between glucose fluctuation and erectile dysfunction (ED) in patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>This cross-sectional study included 317 male patients with T2DM. Participants were categorized into non-ED group (76 cases) and ED group (241 cases) based on International Index of Erectile Function-5 (IIEF-5) scores. Patients were additionally segmented into quartiles based on time in range (TIR). Demographic and laboratory data were collected, and glucose fluctuation indicators were ascertained using flash glucose monitoring.</p><p><strong>Results: </strong>The ED group exhibited significantly lower TIR and IIEF-5 scores compared to the non-ED group (P < 0.05). An increase in TIR levels corresponded with higher IIEF-5 scores and a significant reduction in ED incidence (P < 0.05). Spearman's correlation analysis indicated a positive correlation between IIEF-5 scores and TIR (r = 0.48, P < 0.01). Restricted cubic spline analysis revealed a negative linear association between TIR and ED (P for linearity <0.05). Multivariate logistic regression analysis, after adjusting for confounding factors, confirmed that low TIR is an independent risk factor for ED (P < 0.05).</p><p><strong>Conclusion: </strong>Glucose fluctuation in T2DM patients correlate with ED, with low TIR being independently and positively associated with ED incidence, suggesting it may be a significant risk factor for ED in patients with T2DM.</p>","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":"650-659"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shear wave elastography for thyroid nodule evaluation in patients with chronic autoimmune thyroiditis.","authors":"Monica Latia, Andreea Bena, Luciana Moisa-Luca, Ștefania Bunceanu, Dana Stoian","doi":"10.1007/s12020-025-04159-1","DOIUrl":"10.1007/s12020-025-04159-1","url":null,"abstract":"<p><strong>Purpose: </strong>Shear wave elastography (SWE) is a valuable tool in discerning the malignancy risk of thyroid nodules. This study investigates whether 2D-SWE can reliably differentiate malignant thyroid nodules in patients with chronic autoimmune thyroiditis (CAT), despite the challenges posed by fibrosis, which can increase tissue stiffness and complicate diagnosis.</p><p><strong>Methods: </strong>This retrospective observational study evaluated 130 thyroid nodules (91 benign, 39 malignant) in patients with underlying CAT using conventional ultrasound (B-mode) and 2D-SWE with SuperSonic Mach30 equipment (Supersonic Imagine, Aix-en-Provence, France). Pathology reports served as the reference standard.</p><p><strong>Results: </strong>Out of the 130 nodules, 30% were malignant, and 70% were benign. 2D-SWE proved to be an excellent distinguisher between benign and malignant nodules. Malignant nodules had significantly higher elasticity indices compared to benign nodules (mean elasticity index: 47.2 kPa vs. 18.1 kPa, p < 0.0001; maximum elasticity index: 75 kPa vs. 26.2 kPa, p < 0.0001). The mean elasticity index was the most reliable elastographic parameter (AUC 0.907, sensitivity 87.2% [95% CI: 77.3-94.0%], specificity 84.6% [95% CI: 75.4-91.5%], and NPV 93.9% for a cut-off value of 30.5 kPa).</p><p><strong>Conclusion: </strong>Our results confirm that 2D-SWE can accurately diagnose malignant thyroid nodules in cases with CAT (p < 0.0001), supporting its use as a complementary tool to conventional ultrasound.</p>","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":"482-490"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capecitabine and temozolomide or temozolomide alone in patients with atypical carcinoids.","authors":"Linda Galvani, Arianna Zappi, Sara Pusceddu, Fabio Gelsomino, Anna La Salvia, Simone Oldani, Francesco Panzuto, Elisa Andrini, Giuseppe Lamberti, Davide Campana","doi":"10.1007/s12020-025-04171-5","DOIUrl":"10.1007/s12020-025-04171-5","url":null,"abstract":"<p><strong>Background: </strong>Lung neuroendocrine neoplasms (NENs) represent about 20% of all lung cancers. Few therapeutic options are available for atypical carcinoids (ACs). Single-agent temozolomide (TEM) is active in lung NENs, but whether the addition of capecitabine (CAPTEM) is associated with improved outcomes, is unknown. We sought to investigate the TEM-based therapies (TEM or CAPTEM) in patients with advanced AC.</p><p><strong>Material and methods: </strong>This was a retrospective analysis of prospectively collected data from patients with AC of the lung referred to our institution from January 2003 to January 2023 who have received chemotherapy with either TEM or CAPTEM as any line treatment. Primary endpoint was progression free survival (PFS), secondary endpoints included overall response rate (ORR) and overall survival (OS).</p><p><strong>Results: </strong>In this study we included 31 patients with advanced AC. Median Ki-67 was 14.4% (3-30). CAPTEM in 17 patients (54.8%), while TEM was administered in 14 patients (45.2%). Overall, ORR was 39% (N = 12/31, all partial responses), while median PFS and OS were 57.4 months (95%CI: 43.2-71.7) and 24.4 months (95% confidence interval [95%CI]: 14.7-34.1). Median PFS was 33.9 months (15.6-52.1) in the CAPTEM group, while it was 15.5 (7.3-23.8) in the TEM group (p = 0.047). When adjusting for potential confounding factors, treatment with TEM vs CAPTEM retained its independent association with an increased risk of progression (HR: 4.01 [95%CI: 1.18-13.68]; p = 0.027).</p><p><strong>Conclusions: </strong>Treatment with CAPTEM is associated with longer PFS than TEM alone in patients with AC. Prospective studies with larger sample size are needed to validate this finding.</p>","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":"660-667"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the non-linear association and threshold effect of sedentary behavior on testosterone deficiency.","authors":"Liangchun Cai, Haiping Xie, Wue Li, Chuhui Chen, Ting Li, Lizhen Xu, Yaqian Mao, Jixing Liang, Junping Wen, Gang Chen","doi":"10.1007/s12020-025-04199-7","DOIUrl":"10.1007/s12020-025-04199-7","url":null,"abstract":"<p><strong>Background: </strong>Sedentary behavior has emerged as a potential risk factor for various health issues, including hormonal imbalances like testosterone deficiency (TD). However, the relationship between sedentary time and TD remains underexplored, especially with respect to the complex biological mechanisms underlying this association. This study aimed to examine the association between sedentary time and TD in adult males.</p><p><strong>Methods: </strong>This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey 2011-2016. A total of 6057 male participants aged 20 years and older were included. Sedentary time was categorized into quartiles, and TD was defined as serum testosterone levels below 300 ng/dL. Logistic regression models were employed to assess the association between sedentary time and TD, adjusting for demographic, lifestyle, and health-related covariates. Restricted cubic spline (RCS) analysis and segmented regression were also conducted to explore potential non-linear relationships and thresholds. Subgroup analyses were performed to examine the consistency of associations across various groups.</p><p><strong>Results: </strong>The analysis revealed a significant positive association between sedentary time and TD. Prolonged sedentary behaviour was consistently associated with higher odds of TD across all models (all p < 0.001). RCS analysis showed a significant non-linear relationship, particularly as sedentary time exceeded 4.5 h per day, with a marked increase in the likelihood of TD (p-non-linear = 0.027). Subgroup analysis indicated that this association was most pronounced in Non-Hispanic Whites, current smokers, and drinkers, and was weaker in individuals with diabetes, where the association lost statistical significance after full adjustment.</p><p><strong>Conclusions: </strong>This study identifies a significant association between prolonged sedentary behaviour and a higher risk of TD, suggesting that sedentary behavior may play a key role in the development of TD, particularly in specific high-risk populations.</p>","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":"638-649"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of metabolic phenotypes with cardiovascular events in patients aged 18-45 with acute coronary syndrome.","authors":"Rongdi Xu, Chen Wang, Hongliang Cong, Le Wang","doi":"10.1007/s12020-025-04169-z","DOIUrl":"10.1007/s12020-025-04169-z","url":null,"abstract":"<p><strong>Background: </strong>Obesity and metabolic syndrome are related to cardiovascular events. However, the association different metabolic phenotypes and obesity with cardiovascular events among young adults aged 18-45 with acute coronary syndrome (ACS) remains unclear. The study aimed to investigate the prognosis of patients aged 18-45 years with ACS based on their metabolic phenotype.</p><p><strong>Methods: </strong>This study included 1787 patients with ACS ≤ 45 years of age who underwent coronary angiography. Patients were divided into four groups according to metabolic phenotype: metabolically healthy non-obesity (MHN); MHO; metabolically unhealthy non-obesity (MUN); and metabolically unhealthy obesity (MUO). The primary outcome was major adverse cardiovascular events (MACE), including all-cause death, myocardial infarction, stroke, or unplanned revascularization.</p><p><strong>Results: </strong>Among 1787 patients with ACS, the median age was 41.6 years, 1675 (93.7%) were men, 1111 (62.2%) had obesity, and 659 (36.9%) were classified as MHO. During a median 65 months follow-up, 404 MACE occurred. Multivariate analysis showed that MHO was correlated with a decreased risk of MACE, while MUN significantly increased the risk compared to MHN (MHO: HR 0.69, 95%CI 0.52-0.92, P = 0.011; MUN: HR 1.47, 95%CI 1.07-2.02 P = 0.018). Moreover, restricted cubic spline analysis revealed a linear relationship between body mass index (BMI) and the incidence of MACE (P_nonlinear= 0.304, P_overall < 0.001).</p><p><strong>Conclusions: </strong>MHO was correlated with a decreased risk of MACE, while MUN significantly increased the risk compared to MHN. Moreover, there was a linear relationship between BMI and the incidence of MACE.</p>","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":"457-466"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the association between night shift work and reproductive functions among male workers: a systematic review and meta-analysis.","authors":"Ankit Viramgami, Rakesh Balachandar, Bhavani Shankara Bagepally, Ankit Sheth","doi":"10.1007/s12020-025-04166-2","DOIUrl":"10.1007/s12020-025-04166-2","url":null,"abstract":"<p><strong>Background: </strong>There has been growing interest to study impact of night shift work on male reproductive health, which is regulated by the hypothalamic-pituitary-gonadal axis and influenced by circadian rhythms. This systematic review and meta-analysis aim to explore the association between night shift work and male reproductive health outcomes.</p><p><strong>Methods: </strong>This systematic review and meta-analysis followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines (PROSPERO: CRD42022379770). Studies comparing male reproductive parameters [e.g., semen profile, testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH)] between night shift workers and non-shift workers were systematically searched in PubMed, Scopus and EMBASE databases. Heterogeneity (I² and Cochran-Q test), risk of bias (Newcastle-Ottawa Scale and funnel plots), sensitivity analyses were performed when applicable.</p><p><strong>Results: </strong>Eight studies were included in this review from 6397 citations screened. The pooled mean difference in sperm count was -18.38 × 10⁶ sperm (-59.82 to 23.07; n = 3, I² = 85.12%) and serum testosterone was 15 ng/dL (-19.3 to 49.39; n = 5, I² = 63%), indicating that shift workers had lower sperm counts but marginally higher serum testosterone levels compared to controls. The majority of included studies exhibited a high risk of bias in participant selection, group comparability and exposure assessment.</p><p><strong>Conclusion: </strong>The analysis highlights the potential impact of night shift work on sperm parameters and hormone levels. Future research with standardized methods and larger samples is needed to better understand the circadian disruption's effects, informing healthcare practices and policies for male reproductive health.</p>","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":"410-419"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress regulatory hormones and cancer: the contribution of epinephrine and cancer therapeutic value of beta blockers.","authors":"Rajan Kumar Tiwari, Shiv Govind Rawat, Siddharth Rai, Ajay Kumar","doi":"10.1007/s12020-025-04161-7","DOIUrl":"10.1007/s12020-025-04161-7","url":null,"abstract":"<p><p>The word \"cancer\" evokes myriad emotions, ranging from fear and despair to hope and determination. Cancer is aptly defined as a complex and multifaceted group of diseases that has unapologetically led to the loss of countless lives and affected innumerable families across the globe. The battle with cancer is not only a physical battle, but also an emotional, as well as a psychological skirmish for patients and for their loved ones. Cancer has been a part of our history, stories, and lives for centuries and has challenged the ingenuity of health and medical science, and the resilience of the human spirit. From the early days of surgery and radiation therapy to cutting-edge developments in chemotherapeutic agents, immunotherapy, and targeted treatments, the medical field continues to make significant headway in the fight against cancer. However, even after all these advancements, cancer is still among the leading cause of death globally. This urges us to understand the central hallmarks of neoplastic cells to identify novel molecular targets for the development of promising therapeutic approaches. Growing research suggests that stress mediators, including epinephrine, play a critical role in the development and progression of cancer by inducing neoplastic features through activating adrenergic receptors, particularly β-adrenoreceptors. Further, our experimental data has also shown that epinephrine mediates the growth of T-cell lymphoma by inducing proliferation, glycolysis, and apoptosis evasion via altering the expression levels of key regulators of these vital cellular processes. The beauty of receptor-based therapy lies in its precision and higher therapeutic value. Interestingly, the enhanced expression of β-adrenergic receptors (ADRBs), namely ADRB2 (β2-adrenoreceptor) and ADRB3 (β3-adrenoreceptor) has been noted in many cancers, such as breast, colon, gastric, pancreatic, and prostate and has been reported to play a pivotal role in facilitating cancer growth mainly by promoting proliferation, evasion of apoptosis, angiogenesis, invasion and metastasis, and chemoresistance. The present review article is an attempt to summarize the available findings which indicate a distinct relationship between stress hormones and cancer, with a special emphasis on epinephrine, considered as a key stress regulatory molecule. This article also discusses the possibility of using beta-blockers for cancer therapy.</p>","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":"359-386"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonlinear association between liver fat content and lumbar bone mineral density in overweight and obese individuals: evidence from a large-scale health screening data in China.","authors":"Ao Liu, Yongbing Sun, Xin Qi, Yang Zhou, Jing Zhou, Zhonglin Li, Xiaoling Wu, Zhi Zou, Xue Lv, Hao Li, Yongli Li","doi":"10.1007/s12020-025-04168-0","DOIUrl":"10.1007/s12020-025-04168-0","url":null,"abstract":"<p><strong>Background: </strong>The impact of fatty liver disease on lumbar bone mineral density (BMD) represents an intriguing area of study, particularly in light of established research linking obesity to bone metabolism. However, there remains limited investigation into the correlation between quantifying liver fat content (LFC) and lumbar BMD among overweight and obese populations, particularly within the Chinese demographic. This study aims to accurately quantify LFC and investigate its association with lumbar BMD in overweight or obese individuals.</p><p><strong>Methods: </strong>This cross-sectional study was conducted at the Health Management Center of Henan Provincial People's Hospital from January 2019 to February 2023, involving 6996 participants with a body mass index (BMI) of 24 kg/m² or higher. LFC and lumbar BMD were assessed using computed tomography. The study utilized one-way ANOVA, subgroup analysis, multifactor regression analysis, smooth curve fitting, and threshold and saturation effect analysis to explore the relationship between LFC and lumbar BMD. Furthermore, inflammatory cell analysis was included to investigate the potential mediating role of inflammatory cells in the association between LFC and lumbar BMD.</p><p><strong>Results: </strong>After adjusting for confounding variables, multivariate regression analysis revealed a significant negative association between LFC and lumbar BMD (β = -0.323, 95% CI: -0.464 to -0.183, P < 0.001). Particularly, participants in the highest baseline LFC quartile (Q4 group) exhibited a more pronounced negative impact on lumbar BMD compared to those in the lowest quartile (Q1 group) (β = -5.026, 95% CI: -7.040 to -3.012, P < 0.001). Threshold saturation effect analysis identified a turning point in the LFC-BMD relationship (K = 5.4). Below this point, LFC showed a positive correlation with lumbar BMD (β = 0.962, 95% CI: 0.016-1.907, P < 0.05), whereas above it, LFC was significantly negatively correlated with lumbar BMD (β = -0.405, 95% CI: -0.558 to -0.253, P < 0.001). Additionally, mediation analysis indicated that leukocytes and monocytes potentially mediated the association between LFC and lumbar BMD, with mediation ratios of -5.78 and -6.68%, respectively.</p><p><strong>Conclusion: </strong>Among individuals categorized as overweight or obese, elevated levels of LFC were associated with reduced lumbar BMD, particularly noticeable above a threshold of 5.4%. Additionally, various types of inflammatory cells are presumed to exert a substantial mediating influence on the correlation between LFC and lumbar BMD.</p>","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":"446-456"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}