Shear wave elastography for thyroid nodule evaluation in patients with chronic autoimmune thyroiditis.

IF 3.7 3区医学 Q2 Medicine

Endocrine Pub Date : 2025-01-19 DOI:10.1007/s12020-025-04159-1

Monica Latia, Andreea Bena, Luciana Moisa-Luca, Ștefania Bunceanu, Dana Stoian

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引用次数: 0

Abstract

Purpose: Shear wave elastography (SWE) is a valuable tool in discerning the malignancy risk of thyroid nodules. This study investigates whether 2D-SWE can reliably differentiate malignant thyroid nodules in patients with chronic autoimmune thyroiditis (CAT), despite the challenges posed by fibrosis, which can increase tissue stiffness and complicate diagnosis.

Methods: This retrospective observational study evaluated 130 thyroid nodules (91 benign, 39 malignant) in patients with underlying CAT using conventional ultrasound (B-mode) and 2D-SWE with SuperSonic Mach30 equipment (Supersonic Imagine, Aix-en-Provence, France). Pathology reports served as the reference standard.

Results: Out of the 130 nodules, 30% were malignant, and 70% were benign. 2D-SWE proved to be an excellent distinguisher between benign and malignant nodules. Malignant nodules had significantly higher elasticity indices compared to benign nodules (mean elasticity index: 47.2 kPa vs. 18.1 kPa, p < 0.0001; maximum elasticity index: 75 kPa vs. 26.2 kPa, p < 0.0001). The mean elasticity index was the most reliable elastographic parameter (AUC 0.907, sensitivity 87.2% [95% CI: 77.3-94.0%], specificity 84.6% [95% CI: 75.4-91.5%], and NPV 93.9% for a cut-off value of 30.5 kPa).

Conclusion: Our results confirm that 2D-SWE can accurately diagnose malignant thyroid nodules in cases with CAT (p < 0.0001), supporting its use as a complementary tool to conventional ultrasound.

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剪切波弹性成像对慢性自身免疫性甲状腺炎患者甲状腺结节的评价。

目的：横波弹性成像（SWE）是鉴别甲状腺结节恶性风险的一种有价值的工具。本研究探讨了2D-SWE是否能够可靠地鉴别慢性自身免疫性甲状腺炎（CAT）患者的恶性甲状腺结节，尽管纤维化会增加组织硬度并使诊断复杂化。方法：本回顾性观察研究采用常规超声（b超）和超声Mach30设备的2D-SWE （SuperSonic Imagine, Aix-en-Provence，法国）对原发性CAT患者的130例甲状腺结节（91例为良性，39例为恶性）进行评估。病理报告作为参考标准。结果：130例结节中，30%为恶性，70%为良性。2D-SWE被证明是良、恶性结节的优秀鉴别工具。恶性结节的弹性指数明显高于良性结节（平均弹性指数：47.2 kPa比18.1 kPa, p）。结论：我们的结果证实了2D-SWE可以准确诊断CAT病例中的恶性甲状腺结节(p

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine 医学-内分泌学与代谢

CiteScore

6.40

自引率

5.40%

发文量

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.