{"title":"男性工人夜班工作与生殖功能的关系研究:系统回顾与荟萃分析。","authors":"Ankit Viramgami, Rakesh Balachandar, Bhavani Shankara Bagepally, Ankit Sheth","doi":"10.1007/s12020-025-04166-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There has been growing interest to study impact of night shift work on male reproductive health, which is regulated by the hypothalamic-pituitary-gonadal axis and influenced by circadian rhythms. This systematic review and meta-analysis aim to explore the association between night shift work and male reproductive health outcomes.</p><p><strong>Methods: </strong>This systematic review and meta-analysis followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines (PROSPERO: CRD42022379770). Studies comparing male reproductive parameters [e.g., semen profile, testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH)] between night shift workers and non-shift workers were systematically searched in PubMed, Scopus and EMBASE databases. Heterogeneity (I<sup>2</sup> and Cochran-Q test), risk of bias (Newcastle-Ottawa Scale and funnel plots), sensitivity analyses were performed when applicable.</p><p><strong>Results: </strong>Eight studies were included in this review from 6397 citations screened. The pooled mean difference in sperm count was -18.38 × 10<sup>6</sup> sperm (-59.82 to 23.07; n = 3, I<sup>2</sup> = 85.12%) and serum testosterone was 15 ng/dL (-19.3 to 49.39; n = 5, I<sup>2</sup> = 63%), indicating that shift workers had lower sperm counts but marginally higher serum testosterone levels compared to controls. The majority of included studies exhibited a high risk of bias in participant selection, group comparability and exposure assessment.</p><p><strong>Conclusion: </strong>The analysis highlights the potential impact of night shift work on sperm parameters and hormone levels. Future research with standardized methods and larger samples is needed to better understand the circadian disruption's effects, informing healthcare practices and policies for male reproductive health.</p>","PeriodicalId":11572,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Study on the association between night shift work and reproductive functions among male workers: a systematic review and meta-analysis.\",\"authors\":\"Ankit Viramgami, Rakesh Balachandar, Bhavani Shankara Bagepally, Ankit Sheth\",\"doi\":\"10.1007/s12020-025-04166-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>There has been growing interest to study impact of night shift work on male reproductive health, which is regulated by the hypothalamic-pituitary-gonadal axis and influenced by circadian rhythms. This systematic review and meta-analysis aim to explore the association between night shift work and male reproductive health outcomes.</p><p><strong>Methods: </strong>This systematic review and meta-analysis followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines (PROSPERO: CRD42022379770). Studies comparing male reproductive parameters [e.g., semen profile, testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH)] between night shift workers and non-shift workers were systematically searched in PubMed, Scopus and EMBASE databases. Heterogeneity (I<sup>2</sup> and Cochran-Q test), risk of bias (Newcastle-Ottawa Scale and funnel plots), sensitivity analyses were performed when applicable.</p><p><strong>Results: </strong>Eight studies were included in this review from 6397 citations screened. The pooled mean difference in sperm count was -18.38 × 10<sup>6</sup> sperm (-59.82 to 23.07; n = 3, I<sup>2</sup> = 85.12%) and serum testosterone was 15 ng/dL (-19.3 to 49.39; n = 5, I<sup>2</sup> = 63%), indicating that shift workers had lower sperm counts but marginally higher serum testosterone levels compared to controls. The majority of included studies exhibited a high risk of bias in participant selection, group comparability and exposure assessment.</p><p><strong>Conclusion: </strong>The analysis highlights the potential impact of night shift work on sperm parameters and hormone levels. Future research with standardized methods and larger samples is needed to better understand the circadian disruption's effects, informing healthcare practices and policies for male reproductive health.</p>\",\"PeriodicalId\":11572,\"journal\":{\"name\":\"Endocrine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-01-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s12020-025-04166-2\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12020-025-04166-2","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Study on the association between night shift work and reproductive functions among male workers: a systematic review and meta-analysis.
Background: There has been growing interest to study impact of night shift work on male reproductive health, which is regulated by the hypothalamic-pituitary-gonadal axis and influenced by circadian rhythms. This systematic review and meta-analysis aim to explore the association between night shift work and male reproductive health outcomes.
Methods: This systematic review and meta-analysis followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines (PROSPERO: CRD42022379770). Studies comparing male reproductive parameters [e.g., semen profile, testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH)] between night shift workers and non-shift workers were systematically searched in PubMed, Scopus and EMBASE databases. Heterogeneity (I2 and Cochran-Q test), risk of bias (Newcastle-Ottawa Scale and funnel plots), sensitivity analyses were performed when applicable.
Results: Eight studies were included in this review from 6397 citations screened. The pooled mean difference in sperm count was -18.38 × 106 sperm (-59.82 to 23.07; n = 3, I2 = 85.12%) and serum testosterone was 15 ng/dL (-19.3 to 49.39; n = 5, I2 = 63%), indicating that shift workers had lower sperm counts but marginally higher serum testosterone levels compared to controls. The majority of included studies exhibited a high risk of bias in participant selection, group comparability and exposure assessment.
Conclusion: The analysis highlights the potential impact of night shift work on sperm parameters and hormone levels. Future research with standardized methods and larger samples is needed to better understand the circadian disruption's effects, informing healthcare practices and policies for male reproductive health.
期刊介绍:
Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology.
Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted.
Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.