Exploring the non-linear association and threshold effect of sedentary behavior on testosterone deficiency.

IF 3.7 3区医学 Q2 Medicine

Endocrine Pub Date : 2025-02-28 DOI:10.1007/s12020-025-04199-7

Liangchun Cai, Haiping Xie, Wue Li, Chuhui Chen, Ting Li, Lizhen Xu, Yaqian Mao, Jixing Liang, Junping Wen, Gang Chen

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引用次数: 0

Abstract

Background: Sedentary behavior has emerged as a potential risk factor for various health issues, including hormonal imbalances like testosterone deficiency (TD). However, the relationship between sedentary time and TD remains underexplored, especially with respect to the complex biological mechanisms underlying this association. This study aimed to examine the association between sedentary time and TD in adult males.

Methods: This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey 2011-2016. A total of 6057 male participants aged 20 years and older were included. Sedentary time was categorized into quartiles, and TD was defined as serum testosterone levels below 300 ng/dL. Logistic regression models were employed to assess the association between sedentary time and TD, adjusting for demographic, lifestyle, and health-related covariates. Restricted cubic spline (RCS) analysis and segmented regression were also conducted to explore potential non-linear relationships and thresholds. Subgroup analyses were performed to examine the consistency of associations across various groups.

Results: The analysis revealed a significant positive association between sedentary time and TD. Prolonged sedentary behaviour was consistently associated with higher odds of TD across all models (all p < 0.001). RCS analysis showed a significant non-linear relationship, particularly as sedentary time exceeded 4.5 h per day, with a marked increase in the likelihood of TD (p-non-linear = 0.027). Subgroup analysis indicated that this association was most pronounced in Non-Hispanic Whites, current smokers, and drinkers, and was weaker in individuals with diabetes, where the association lost statistical significance after full adjustment.

Conclusions: This study identifies a significant association between prolonged sedentary behaviour and a higher risk of TD, suggesting that sedentary behavior may play a key role in the development of TD, particularly in specific high-risk populations.

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探讨久坐行为对睾酮缺乏的非线性关联及阈值效应。

背景：久坐行为已成为各种健康问题的潜在风险因素，包括激素失衡，如睾酮缺乏（TD）。然而，久坐时间与TD之间的关系仍未得到充分探讨，特别是关于这种关联背后的复杂生物学机制。这项研究旨在研究成年男性久坐时间与TD之间的关系。方法：本横断面研究分析2011-2016年全国健康与营养检查调查数据。共有6057名年龄在20岁及以上的男性参与者被纳入研究。久坐时间被分为四分位数，TD被定义为血清睾酮水平低于300 ng/dL。采用Logistic回归模型评估久坐时间与TD之间的关系，调整人口统计学、生活方式和健康相关协变量。限制三次样条（RCS）分析和分段回归也用于探索潜在的非线性关系和阈值。进行亚组分析以检查不同组间关联的一致性。结果：分析显示久坐时间与TD之间存在显著的正相关。结论：本研究确定了长期久坐行为与患TD风险较高之间的显著关联，表明久坐行为可能在TD的发展中起关键作用，特别是在特定的高风险人群中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine 医学-内分泌学与代谢

CiteScore

6.40

自引率

5.40%

发文量

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.