Study on the association between night shift work and reproductive functions among male workers: a systematic review and meta-analysis.

IF 3.7 3区医学 Q2 Medicine

Endocrine Pub Date : 2025-01-20 DOI:10.1007/s12020-025-04166-2

Ankit Viramgami, Rakesh Balachandar, Bhavani Shankara Bagepally, Ankit Sheth

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引用次数: 0

Abstract

Background: There has been growing interest to study impact of night shift work on male reproductive health, which is regulated by the hypothalamic-pituitary-gonadal axis and influenced by circadian rhythms. This systematic review and meta-analysis aim to explore the association between night shift work and male reproductive health outcomes.

Methods: This systematic review and meta-analysis followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines (PROSPERO: CRD42022379770). Studies comparing male reproductive parameters [e.g., semen profile, testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH)] between night shift workers and non-shift workers were systematically searched in PubMed, Scopus and EMBASE databases. Heterogeneity (I² and Cochran-Q test), risk of bias (Newcastle-Ottawa Scale and funnel plots), sensitivity analyses were performed when applicable.

Results: Eight studies were included in this review from 6397 citations screened. The pooled mean difference in sperm count was -18.38 × 10⁶ sperm (-59.82 to 23.07; n = 3, I² = 85.12%) and serum testosterone was 15 ng/dL (-19.3 to 49.39; n = 5, I² = 63%), indicating that shift workers had lower sperm counts but marginally higher serum testosterone levels compared to controls. The majority of included studies exhibited a high risk of bias in participant selection, group comparability and exposure assessment.

Conclusion: The analysis highlights the potential impact of night shift work on sperm parameters and hormone levels. Future research with standardized methods and larger samples is needed to better understand the circadian disruption's effects, informing healthcare practices and policies for male reproductive health.

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男性工人夜班工作与生殖功能的关系研究：系统回顾与荟萃分析。

背景：夜班工作受下丘脑-垂体-性腺轴的调节和昼夜节律的影响，对男性生殖健康的影响研究越来越受到关注。本系统综述和荟萃分析旨在探讨夜班工作与男性生殖健康结果的关系。方法：本系统评价和荟萃分析遵循系统评价和荟萃分析首选报告项目（PRISMA） 2020指南（PROSPERO: CRD42022379770）。在PubMed、Scopus和EMBASE数据库中系统检索了夜班工人和非夜班工人之间的男性生殖参数[如精液谱、睾酮、促卵泡激素（FSH）、黄体生成素（LH）]的比较研究。异质性（I2和Cochran-Q检验）、偏倚风险（Newcastle-Ottawa量表和漏斗图）、敏感性分析在适用时进行。结果：本综述从筛选的6397篇引文中纳入了8项研究。精子总数的合并平均差异为-18.38 × 106个精子(-59.82 ~ 23.07；n = 3, I2 = 85.12%)，血清睾酮15 ng/dL (-19.3 ~ 49.39；n = 5, I2 = 63%)，表明与对照组相比，轮班工人的精子数量较低，但血清睾酮水平略高。大多数纳入的研究在受试者选择、组间可比性和暴露评估方面存在较高的偏倚风险。结论：该分析强调了夜班工作对精子参数和激素水平的潜在影响。未来需要采用标准化方法和更大样本进行研究，以更好地了解昼夜节律中断的影响，为男性生殖健康的医疗保健实践和政策提供信息。

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来源期刊

Endocrine 医学-内分泌学与代谢

CiteScore

6.40

自引率

5.40%

发文量

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.