IF 3.5 2区医学

Ejso Pub Date : 2025-03-02 DOI: 10.1016/j.ejso.2025.109737

Rong-Zhen Xie , Ze-Ning Huang , Xing-Qi Zhang , Yu-Qin Sun , Jiao-Bao Huang , Qi-Yue Chen , Jian-Wei Xie , Chao-Hui Zheng , Chang-Ming Huang , Jian-Xian Lin , Ping Li

{"title":"Long-term survival analysis after radical gastrectomy for Epstein-Barr virus-associated gastric cancer: A multicenter study","authors":"Rong-Zhen Xie , Ze-Ning Huang , Xing-Qi Zhang , Yu-Qin Sun , Jiao-Bao Huang , Qi-Yue Chen , Jian-Wei Xie , Chao-Hui Zheng , Chang-Ming Huang , Jian-Xian Lin , Ping Li","doi":"10.1016/j.ejso.2025.109737","DOIUrl":"10.1016/j.ejso.2025.109737","url":null,"abstract":"<div><h3>Background</h3><div>The prognosis of Epstein-Barr virus-associated gastric cancer (EBVaGC)needs to be validated by high-quality studies. This study aimed to assess the long-term survival of EBVaGC patients after radical gastrectomy using multicenter data to explore the potential value of EBV infection status as a prognostic predictor.</div></div><div><h3>Methods</h3><div>We analyzed the clinical data of patients with EBVaGC and Epstein-Barr virus-negative gastric cancer (EBVnGC) who underwent radical gastrectomy from January 2013 to July 2020. The Kaplan-Meier method and Cox regression analysis were used to evaluate overall survival (OS) and disease-free survival (DFS). A Random Survival Forest (RSF) model was constructed to predict the prognosis.</div></div><div><h3>Results</h3><div>After propensity score matching, 205 and 410 patients were included in the EBVaGC and EBVnGC groups, respectively. The 3-year OS and DFS rates in the EBVaGC group were significantly higher than those in the EBVnGC group. Multivariate analysis indicated that EBER(Epstein-Barr virus-encoded small RNA) positivity was an independent protective factor for OS and DFS. Among stage II and III EBVaGC patients, those receiving ≥4 cycles of chemotherapy had a 3-year OS significantly better than those receiving <4 cycles. The RSF model based on EBER status outperformed the Cox model and TNM staging system in predicting the 3-year OS and DFS.</div></div><div><h3>Conclusion</h3><div>The prognostic prediction model established based on the EBER status has good clinical application value and can provide a new reference for clinical follow-up management. It is recommended that patients with stage II and III EBVaGC receive at least four cycles of chemotherapy postoperatively to improve survival.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 6","pages":"Article 109737"},"PeriodicalIF":3.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to letter to the editor: Potential confounding factors in the analysis of postoperative outcomes 回复致编辑的信：术后结果分析中的潜在混杂因素。

IF 3.5 2区医学

Ejso Pub Date : 2025-03-01 DOI: 10.1016/j.ejso.2024.108701

Yizhou Huang , Maohui Chen , Chun Chen, Bin Zheng

引用次数: 0

Potential confounding factors in the analysis of postoperative outcomes 术后结果分析中的潜在干扰因素。

IF 3.5 2区医学

Ejso Pub Date : 2025-03-01 DOI: 10.1016/j.ejso.2024.108702

Senzhong Zheng, Yang Chen

引用次数: 0

Reply to: Vascularized reconstruction following extremity sarcoma resection – More than just a means to close a wound 答复四肢肉瘤切除术后的血管重建--不仅仅是封闭伤口的手段

IF 3.5 2区医学

Ejso Pub Date : 2025-03-01 DOI: 10.1016/j.ejso.2024.108536

Madeleine Nguyen Hoang

引用次数: 0

51.3 ESSO Announcements

IF 3.5 2区医学

Ejso Pub Date : 2025-03-01 DOI: 10.1016/j.ejso.2025.109711

引用次数: 0

Management of B3 breast lesions: Potential clinical implications from a retrospective study conducted in an accredited Breast Unit following the 2024 EUSOMA guidelines B3乳腺病变的管理：根据2024年EUSOMA指南，在认可的乳腺单位进行的回顾性研究的潜在临床意义。

IF 3.5 2区医学

Ejso Pub Date : 2025-03-01 DOI: 10.1016/j.ejso.2025.109579

Fabio Corsi , Giulia Fanny Cabri , Sara Albasini , Daniela Bossi , Marta Truffi

{"title":"Management of B3 breast lesions: Potential clinical implications from a retrospective study conducted in an accredited Breast Unit following the 2024 EUSOMA guidelines","authors":"Fabio Corsi , Giulia Fanny Cabri , Sara Albasini , Daniela Bossi , Marta Truffi","doi":"10.1016/j.ejso.2025.109579","DOIUrl":"10.1016/j.ejso.2025.109579","url":null,"abstract":"<div><div>B3 breast lesions present significant challenge in breast surgery. Despite their relatively low risk of malignancy without cellular atypia, overtreatment remains common. We retrospectively evaluate the management of B3 lesions in an accredited-EUSOMA Breast Unit, comparing 10-years practices with 2016 and 2019 international Consensus Conferences and with 2024 EUSOMA guidelines. The study included 354 patients diagnosed with B3 lesions, evaluating guideline adherence, malignancy risk in non-adherent cases, and biopsy-to-final pathology concordance. Adherence to guidelines varied by lesion type, with 46.3 % of cases potentially involving avoidable surgeries, 9.1 % of which were found to be malignant. Additionally, discrepancies between biopsy and final histology were significant, with 43.2 % of lesions showing different histological types. These findings emphasize the importance of updated guidelines to reduce overtreatment, encourage minimally invasive treatments and highlight the need of multidisciplinary discussions in managing B3 lesions, especially when there is a discrepancy between imaging and preoperative biopsy.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 3","pages":"Article 109579"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IFC: Advert ESSO Hands on Course on Oncological Standards in Minimally Invasive Colorectal Cancer Surgery

IF 3.5 2区医学

Ejso Pub Date : 2025-03-01 DOI: 10.1016/S0748-7983(25)00086-1

引用次数: 0

Multidisciplinary team meeting (MDT) in cancer care: All that glitters is not gold 癌症护理中的多学科小组会议（MDT）：金无足赤，人无完人。

IF 3.5 2区医学

Ejso Pub Date : 2025-03-01 DOI: 10.1016/j.ejso.2024.108751

I.T. Rubio , Wyld Lynda

引用次数: 0

Advert BASO/Rosetrees Research Grants in Cancer Surgery

IF 3.5 2区医学