Ejso最新文献 - Book学术

Additional breast lesions on MRI in patients with small early-stage luminal-type breast cancer: Implications for future thermal ablation treatment 早期小亮度型乳腺癌患者的MRI附加乳腺病变：对未来热消融治疗的意义

IF 3.5 2区医学

Ejso Pub Date : 2025-05-28 DOI: 10.1016/j.ejso.2025.110173

Ibrahim Aftab Ahmed , Shahar Bano

引用次数: 0

Machine learning prediction of perineural invasion in intrahepatic cholangiocarcinoma 机器学习预测肝内胆管癌神经周围浸润

IF 3.5 2区医学

Ejso Pub Date : 2025-05-27 DOI: 10.1016/j.ejso.2025.110203

Guan Tan, Wen-Qiang Wang, Tong Yuan, Jun-Jie Liu, Zhen-Hui Xie, Zun-Yi Zhang, Zhi-Yong Huang

{"title":"Machine learning prediction of perineural invasion in intrahepatic cholangiocarcinoma","authors":"Guan Tan, Wen-Qiang Wang, Tong Yuan, Jun-Jie Liu, Zhen-Hui Xie, Zun-Yi Zhang, Zhi-Yong Huang","doi":"10.1016/j.ejso.2025.110203","DOIUrl":"10.1016/j.ejso.2025.110203","url":null,"abstract":"<div><h3>Objective</h3><div>Perineural invasion (PNI) significantly influences postoperative recurrence and survival in intrahepatic cholangiocarcinoma (ICC) patients. This study aims to develop and validate an interpretable model that can be used to predict PNI in ICC cases before surgery.</div></div><div><h3>Methods</h3><div>Retrospective clinical information was gathered from ICC patients (n = 250) at our hospital, covering the period from January 2012 to January 2022. The patients were randomly assigned to the training group (n = 176, 70.4 %) and validation group (n = 74, 29.6 %). We employed four machine learning algorithms to establish prediction models, each model's performance was assessed via a receiver operating characteristic (ROC) curve. Decision Curve Analysis (DCA) was performed to evaluate the models' risks and benefits. SHapley Additive exPlanations (SHAP) were used to quantify the contributions of model features, providing both global and local interpretations.</div></div><div><h3>Results</h3><div>Significant differences in tumor size, tumor number, lymph node metastasis, CA199, distant metastasis ratio, HBsAg, PLR, and NLR were observed between the PNI[-] (n = 172, 68.8 %) and PNI[+](n = 78, 31.2 %) groups. The PFS and OS rates in the PNI[-] group were better than those in the PNI[+] group. Based on the evaluation of the validation group, the XGBoost model demonstrated the best predictive performance. SHAP analysis identified tumor number, tumor size, and lymph node metastasis as the top three factors predicting PNI in ICC patients.</div></div><div><h3>Conclusion</h3><div>We developed a reliable predictive model that effectively predicts PNI status in patients with ICC and facilitates personalized clinical decision-making.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 9","pages":"Article 110203"},"PeriodicalIF":3.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor “Clinical management and oncologic outcomes of pure pleomorphic and florid lobular carcinoma in situ of the breast: Results from a large single institution experience” 致编辑的信“单纯乳腺多形性和花型小叶原位癌的临床管理和肿瘤学结果：来自大型单一机构经验的结果”

IF 3.5 2区医学

Ejso Pub Date : 2025-05-26 DOI: 10.1016/j.ejso.2025.110199

Qi Xu

引用次数: 0

Does surgical margin status truly affect local recurrence in benign and borderline phyllodes tumors of the breast? 手术切缘是否真的影响乳腺良性和交界性叶状瘤的局部复发？

IF 3.5 2区医学

Ejso Pub Date : 2025-05-23 DOI: 10.1016/j.ejso.2025.110195

Burak Dinçer , Fisun Ardıç Yükrük , Sultan Çiğdem Irkkan , Cemal Kaya , Ramazan Uçak , Cihangir Özaslan

{"title":"Does surgical margin status truly affect local recurrence in benign and borderline phyllodes tumors of the breast?","authors":"Burak Dinçer , Fisun Ardıç Yükrük , Sultan Çiğdem Irkkan , Cemal Kaya , Ramazan Uçak , Cihangir Özaslan","doi":"10.1016/j.ejso.2025.110195","DOIUrl":"10.1016/j.ejso.2025.110195","url":null,"abstract":"<div><h3>Background</h3><div>Phyllodes tumors of the breast are rare and classified into three groups—benign, borderline, and malignant—based on their malignant potential. Surgical resection is the primary treatment modality; however, the necessity of clear surgical margins remains a topic of debate in the literature. This study aimed to evaluate the relationship between surgical margin status and local recurrence in benign and borderline phyllodes tumors.</div></div><div><h3>Methods</h3><div>A total of 177 patients diagnosed with phyllodes tumors from two centers were included. Patients were analyzed based on demographic, clinical, pathological, and survival data.</div></div><div><h3>Results</h3><div>The median age was 38 years (range: 15–78), and all patients were female. The most commonly performed breast surgery was wide local excision in 173 patients (97.7 %). Final pathological examination revealed that 136 patients (76.8 %) had benign phyllodes tumors, while 41 patients (23.2 %) had borderline phyllodes tumors. The median pathological tumor diameter was 35 mm (IQR: 27–55 mm). During a median follow-up of 60 months, local recurrence occurred in 12 patients (6.8 %), while no systemic metastasis or tumor-related death was observed. Patients with borderline phyllodes tumors had a higher local recurrence rate and shorter recurrence-free survival (RFS) (p = 0.022 and p = 0.013, respectively). Cox regression analysis identified tumor type as the only independent factor affecting RFS, with borderline phyllodes tumors demonstrating a shorter RFS compared to benign phyllodes tumors (p = 0.015).</div></div><div><h3>Conclusion</h3><div>Surgical margin status was not associated with local recurrence in benign and borderline phyllodes tumors. Therefore, re-excision decisions based on margin proximity or positivity should be individualized.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 9","pages":"Article 110195"},"PeriodicalIF":3.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on “Endometrioid borderline ovarian tumour: A multicentre analysis from the MITO-14 study” 《子宫内膜样交界性卵巢肿瘤：来自MITO-14研究的多中心分析》评论

IF 3.5 2区医学

Ejso Pub Date : 2025-05-22 DOI: 10.1016/j.ejso.2025.110184

Renu Sah , Ankita Mathur , Venkata Dileep Kumar Veldi

引用次数: 0

Advert ESSO-EYSAC Hands on Course on Surgical Technique - Abdominal Surgery ESSO-EYSAC实践外科技术课程-腹部外科

IF 3.5 2区医学

Ejso Pub Date : 2025-05-22 DOI: 10.1016/S0748-7983(25)00588-8

引用次数: 0

Challenging cholangiocarcinoma 具有挑战性的胆管癌

IF 3.5 2区医学