Ejso最新文献

{"title":"ChatGPT-4o outperforms gemini advanced in assisting multidisciplinary decision-making for advanced gastric cancer","authors":"Huizi Li ,&nbsp;Jiaobao Huang ,&nbsp;Kuntang Liu ,&nbsp;Jibiao Liu ,&nbsp;Queling Liu ,&nbsp;Zhiyong Zhou ,&nbsp;Zhen Zong ,&nbsp;Shengxun Mao","doi":"10.1016/j.ejso.2025.110096","DOIUrl":"10.1016/j.ejso.2025.110096","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>The treatment of advanced gastric cancer (GC) requires precise and comprehensive clinical decision-making. Artificial intelligence (AI) chatbots offer potential tools to enhance multidisciplinary team (MDT) discussions. This study aims to compare the performances of ChatGPT-4o and Gemini Advanced in generating treatment recommendations for advanced GC.</div></div><div><h3>Methods</h3><div>The study involved three steps: (1) evaluating responses to ten critical clinical questions, (2) analyzing clinical cases from MDT meetings at our institution, and (3) reviewing rare GC cases from PubMed. It included 95 advanced GC patients discussed between November 2022 and July 2024, and 14 rare cases from PubMed. Prompts designed from advanced GC cases were submitted to ChatGPT-4o and Gemini Advanced using a standardized format. Outputs were evaluated for accuracy and completeness using a structured 4-point Likert scale. Interrater reliability was calculated to ensure consistency among evaluators.</div></div><div><h3>Results</h3><div>For the ten clinical questions, ChatGPT-4o achieved better performances compared to Gemini Advanced. In MDT cases, ChatGPT-4o provided more valuable recommendations in surgical suggestion, chemotherapy recommendation, and chemotherapy regimens. Subgroup analysis confirmed these findings in both routine and complex cases with high interrater reliability. ChatGPT-4o also outperformed Gemini Advanced in the analysis of rare GC cases from PubMed, showing superior accuracy with high interrater reliability.</div></div><div><h3>Conclusions</h3><div>While our findings suggest that AI chatbots can generate clinically relevant and guideline-based treatment recommendations, their use in MDT decision-making should be viewed as supportive rather than autonomous. We emphasize that while AI chatbots have potential as decision-support tools, but they should be integrated only under expert supervision in a real-world clinical context.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 8","pages":"Article 110096"},"PeriodicalIF":3.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grading risk of microvascular invasion impacts survival in hepatocellular carcinoma patients undergoing adjuvant transarterial chemoembolization: A multicenter study","authors":"Jin-Pian Lu ,&nbsp;Jin-Kai Feng ,&nbsp;Yang Zhao ,&nbsp;Bin Chen ,&nbsp;Peng-Ping Li ,&nbsp;Chao He ,&nbsp;Lin Gong ,&nbsp;Ling-Ling Bao","doi":"10.1016/j.ejso.2025.110102","DOIUrl":"10.1016/j.ejso.2025.110102","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the influence of postoperative adjuvant transarterial chemoembolization (PA-TACE) on the prognosis of hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI) following liver resection (LR), and explore whether grading risk of MVI can impact the survival of HCC patients undergoing PA-TACE.</div></div><div><h3>Methods</h3><div>Patients who had HCC with MVI were consecutively enrolled. Overall survival (OS) and recurrence-free survival (RFS) were compared between the PA-TACE and LR groups. Univariate and multivariate analyses were performed to identify independent prognostic factors for these patients. Subgroup survival analysis was conducted using the grading risk of MVI.</div></div><div><h3>Results</h3><div>The median OS and RFS of the PA-TACE group were significantly longer than the LR group. PA-TACE was associated with significantly better OS (<em>P</em> = 0.032) and RFS (<em>P</em> = 0.023) compared with LR alone. In subgroup analysis, there were no significant differences in prognosis between the PA-TACE and LR groups for HCC patients with low-risk MVI. For HCC patients with high-risk MVI, the PA-TACE group had significantly better prognosis than the LR group (for OS, <em>P</em> = 0.017; for RFS, <em>P</em> = 0.018).</div></div><div><h3>Conclusion</h3><div>PA-TACE should be performed selectively in HCC patients with high-risk MVI after curative liver resection. Nonetheless, for HCC patients with low-risk MVI, PA-TACE is not recommended.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 8","pages":"Article 110102"},"PeriodicalIF":3.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The establishment of machine learning prognostic prediction models for pineal region tumors based on SEER-A multicenter real-world study","authors":"Hao Wu ,&nbsp;Aierpati Maimaiti ,&nbsp;Jinlong Huang ,&nbsp;Jing Xue ,&nbsp;Qiang Fu ,&nbsp;Zening Wang ,&nbsp;Mamutijiang Muertizha ,&nbsp;Yang Li ,&nbsp;Di Li ,&nbsp;Qingjiu Zhou ,&nbsp;Yongxin Wang","doi":"10.1016/j.ejso.2025.110058","DOIUrl":"10.1016/j.ejso.2025.110058","url":null,"abstract":"<div><h3>Background</h3><div>Pineal region tumors (PRT) are rare intracranial neoplasms with diverse pathological types and growth characteristics, leading to varied clinical manifestations. This study aims to develop machine learning (ML) models for survival prediction, offering valuable insights for medical practice in the management of PRTs.</div></div><div><h3>Methods</h3><div>Clinical information on PRTs was extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The Kaplan-Meier (K-M) analysis was used to analyze the survival of PRT patients. Univariate and multivariate Cox regression analyses were conducted to identify risk factors for the survival of PRT patients. Then, nomograms were constructed. Seven ML models including Decision Tree, Logistic Regression, LightGBM, Random Forest, XGBoost, K-Nearest Neighbor Algorithm (KNN), and Support Vector Machine (SVM), were developed to predict the prognosis of PRT patients. The predictive value of ML models was evaluated by the area under the receiver's operating characteristic curve (AUC-ROC), tenfold cross verification, calibration curve, and decision curve analysis (DCA).</div></div><div><h3>Results</h3><div>Univariate and multivariate Cox regression revealed that age, histopathology, radiotherapy, and tumor size were independent risk factors for overall survival (OS). Histopathology, surgery, radiotherapy, and tumor size were risk factors for cancer-specific survival (CSS). K-M survival analysis revealed that age, histopathology, marital status, radiotherapy, sex, and surgery significantly impacted OS, while age, histopathology, marital status, race, radiotherapy, sex, and surgery significantly influenced CSS. In the prediction of OS, the ML models with the best clinical utility were RF, Logistic Regression, and XGBoost. For CSS, the most effective models were RF, LightGBM, and RF.</div></div><div><h3>Conclusion</h3><div>ML models demonstrate significant potential and high predictive efficacy in forecasting long-term postoperative survival in PRT patients, providing substantial clinical value.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 8","pages":"Article 110058"},"PeriodicalIF":3.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mitomycin versus Oxaliplatin debate on HIPEC in colorectal cancers - An updated systematic review and Meta-analysis","authors":"Mufaddal Kazi ,&nbsp;Atul Ajith ,&nbsp;Aditi Bhatt","doi":"10.1016/j.ejso.2025.110080","DOIUrl":"10.1016/j.ejso.2025.110080","url":null,"abstract":"<div><h3>Introduction</h3><div>Following the PRODIGE-7 trial, surgeons have shifted to the use of Mitomycin-based HIPEC from Oxaliplatin for colorectal peritoneal metastasis. While preclinical studies have demonstrated the superiority of Mitomycin over oxaliplatin, clinical studies report variable results. The objective of the meta-analysis was to determine the most efficacious drug after cytoreduction for colorectal peritoneal metastasis.</div></div><div><h3>Methods</h3><div>he databases searched were PubMed, Cochrane Library, Scopus, CINHAL (EBSCO), and Google Scholar based on the following concepts: colorectal, peritoneal, cytoreduction, Mitomycin, and Oxaliplatin. The risk of bias was assessed using the Newcastle-Ottawa scale and certainty of the evidence was assessed using the GRADE Pro tool. The analysis was carried out using the log hazard ratio as the outcome measure for survival data. All syntheses used the Random-effects model and were reported for Oxaliplatin-based HIPEC with MMC as the reference.</div></div><div><h3>Results</h3><div>Thirteen studies with 3406 patients were included in the quantitative meta-analysis. The pooled hazard ratio for overall survival was 1.03 (95 % CI: 0.786–1.349) from ten studies. Six studies reported disease-free survival and the pooled hazard ratio was 0.941 (95 % CI: 0.683–1.297). Both survival estimates had moderate statistical heterogeneity. The evidence was of very low certainty for all the outcomes due to the non-randomized nature of studies, clinical and statistical heterogeneity, serious risk of bias due to uncontrolled measured confounding, selection bias, and unequal follow-up durations.</div></div><div><h3>Conclusion</h3><div>Our systematic review and meta-analysis found no significant difference in survival outcomes or postoperative morbidity between MMC and Oxaliplatin-based HIPEC.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 8","pages":"Article 110080"},"PeriodicalIF":3.5,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastasectomy versus stereotactic body radiotherapy for patients with oligometastatic colorectal lung metastases: a systematic review","authors":"Simone A. Gooijer ,&nbsp;Anna S.M. Gazendam ,&nbsp;Bart Torensma ,&nbsp;Jurriaan B. Tuynman ,&nbsp;Max Dahele ,&nbsp;David J. Heineman ,&nbsp;Jerry Braun ,&nbsp;Chris Dickhoff ,&nbsp;Suresh Senan ,&nbsp;Wilhelmina H. Schreurs ,&nbsp;Famke L. Schneiders ,&nbsp;Martijn van Dorp","doi":"10.1016/j.ejso.2025.110056","DOIUrl":"10.1016/j.ejso.2025.110056","url":null,"abstract":"<div><div>Metastasectomy and stereotactic body radiotherapy (SBRT) are both guideline-recommended treatment modalities for patients with oligometastatic colorectal lung metastases (CLM). Few evidence is available comparing different local therapies in an oligometastatic population. This systematic review aimed to compare the efficacy of metastasectomy with SBRT for patients with oligometastatic CLM. A systematic literature search was performed according to the PRISMA guidelines to identify studies on metastasectomy and SBRT for patients with oligometastatic CLM. Studies published between 2000 and 2023 were identified through Medline, Embase, and the Cochrane databases. Overall survival (OS), progression-free survival (PFS), and local recurrence rate (LRR) were assessed and compared between both groups. The risk of bias was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool. A total of 141 studies on metastasectomy (n = 29932) and 16 studies on SBRT (n = 1381) were included in the final analysis. The pooled five-year OS was 52.2 % (CI: 49.8–54.5) and 45.0 % (CI: 31.2–58.9) following metastasectomy and SBRT, respectively (p = 0.213). The pooled five-year PFS was 35.1 % (CI: 32.2–38.1) following metastasectomy and 11.7 % (CI: 0–38.2) following SBRT (p &lt; 0.001). The pooled LRR was 10.5 % (CI: 5.5–15.5) following metastasectomy and 28.1 % (CI: 20.8–35.4) following SBRT (p &lt; 0.001). The average GRADE score of the included studies was low. The data suggest that patients with oligometastatic CLM have a comparable OS rate after metastasectomy or SBRT, but PFS and LRR favour a surgical approach. This systematic review supports initiating a randomized controlled trial comparing surgery and SBRT in operable patients with oligometastatic CLM.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 8","pages":"Article 110056"},"PeriodicalIF":3.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing surgical timing following neoadjuvant therapy for gastric Cancer: Insights from a multicenter retrospective analysis","authors":"Jie Chen ,&nbsp;Keshu Hu ,&nbsp;Jun Lu ,&nbsp;Hongda Pan ,&nbsp;Yakai Huang ,&nbsp;Zhenjia Yu ,&nbsp;Tianyu Gao ,&nbsp;Yong Fan ,&nbsp;Chen Li ,&nbsp;Fenglin Liu","doi":"10.1016/j.ejso.2025.110063","DOIUrl":"10.1016/j.ejso.2025.110063","url":null,"abstract":"<div><h3>Background</h3><div>Neoadjuvant therapy (NAT) is a cornerstone in the treatment of locally advanced gastric cancer, improving surgical outcomes and survival. However, the optimal timing for surgery following NAT remains controversial. This study evaluates the impact of the interval between NAT and surgery on overall survival (OS) and explores associated clinicopathological factors.</div></div><div><h3>Methods</h3><div>A retrospective analysis of 893 patients undergoing NAT and curative surgery for gastric adenocarcinoma across three centers in China was conducted. Surgical intervals were categorized (∼28 days, 29–42 days, &gt;42 days). Survival analyses employed restricted cubic spline (RCS) models, Kaplan-Meier methods, and Cox proportional hazards regression.</div></div><div><h3>Results</h3><div>Patients operated on within 28 days post-NAT had the most favorable OS, while intervals longer than 28 days were independently associated with worse outcomes. RCS analysis revealed increased risks for intervals longer than 28 days. Prolonged intervals showed declining effectiveness in tumor regression. Stratified analyses indicated that patients with poor NAT response (TRG 3) particularly benefited from surgery within 4 weeks, while delays were detrimental.</div></div><div><h3>Conclusions</h3><div>Timely surgery, especially within 4 weeks post-NAT, optimizes survival outcomes, particularly in patients with limited NAT response. This study underscores the need for individualized surgical timing and calls for prospective multicenter validation.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 8","pages":"Article 110063"},"PeriodicalIF":3.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes and risk factors for liver transplantation using steatotic grafts for hepatocellular carcinoma: a multicenter study","authors":"Kai Wang ,&nbsp;Libin Dong ,&nbsp;Xiaobo Wang ,&nbsp;Zhoucheng Wang ,&nbsp;Xun Qiu ,&nbsp;Hanzhi Xu ,&nbsp;Xiao Xu","doi":"10.1016/j.ejso.2025.110061","DOIUrl":"10.1016/j.ejso.2025.110061","url":null,"abstract":"<div><h3>Introduction</h3><div>A growing number of steatotic grafts have been used in liver transplantation (LT), including hepatocellular carcinoma (HCC) patients. However, the impact of steatotic grafts on the prognosis of HCC recipients remains unclear. This study aims to evaluate the impact of steatotic graft in long-term prognosis for HCC recipients and development an algorithm for minimizing the risk of these grafts.</div></div><div><h3>Materials and methods</h3><div>The clinicopathologic data of HCC patients undergoing LT from 2003 to 2022 in the United Network for Organ Sharing database was analyzed. The disease-free survival (DFS) and overall survival (OS) of recipients were compared between non-steatotic (macrosteatosis &lt;30 %) and steatotic (macrosteatosis ≥30 %) graft groups after propensity score matching (PSM). Interaction analysis was conducted to identify factors that amplified the negative impact of steatotic grafts on DFS.</div></div><div><h3>Results</h3><div>A total of 8345 eligible HCC patients were included. Three factors exhibited significant interaction effect with steatotic grafts: cold ischemia time ≥6h (HR = 1.447; P = 0.023), donor body mass index ≥40 (HR = 1.771; P = 0.018) and recipient with non-alcoholic fatty liver disease (HR = 1.632; P = 0.032). Hazard Associated with Macrosteatotic Liver (HAML) score was created based on these three factors. In HAML ≥1 cohort, the DFS and OS of steatotic graft group were significantly reduced compared to non-steatotic graft group. But in HAML = 0 cohort, no significant differences in DFS and OS were observed between the two groups.</div></div><div><h3>Conclusions</h3><div>The risk of steatotic grafts in LT for HCC could be minimized through evaluating HAML score.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 8","pages":"Article 110061"},"PeriodicalIF":3.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncological outcomes of thoracic duct preservation and resection for esophageal carcinoma based on an understanding of its surgical microanatomy in the era of minimally invasive esophagectomy and neoadjuvant chemotherapy","authors":"Shota Igaue ,&nbsp;Takeo Fujita ,&nbsp;Junya Oguma ,&nbsp;Koshiro Ishiyama ,&nbsp;Kazuma Sato ,&nbsp;Daisuke Kurita ,&nbsp;Yuto Kubo ,&nbsp;Kentaro Kubo ,&nbsp;Daichi Utsunomiya ,&nbsp;Eigo Akimoto ,&nbsp;Ryoko Nozaki ,&nbsp;Ryota Kakuta ,&nbsp;Yasuyuki Seto ,&nbsp;Hiroyuki Daiko","doi":"10.1016/j.ejso.2025.110062","DOIUrl":"10.1016/j.ejso.2025.110062","url":null,"abstract":"<div><h3>Background</h3><div>Although the oncological benefits of thoracic duct (TD) resection have been reported, recent research has questioned its impact on survival. With advancements in minimally invasive esophagectomy (MIE) and a deeper understanding of the microanatomy, standardizing techniques for TD resection/preservation have become increasingly important. We demonstrated a minimally invasive surgical procedure for esophagectomy, with and without TD resection, in patients who received neoadjuvant chemotherapy.</div></div><div><h3>Methods</h3><div>This multicenter, retrospective cohort study evaluated patients with cT1–3 thoracic esophageal cancer who underwent thoracoscopic McKeown esophagectomy after neoadjuvant chemotherapy at two Japanese cancer centers between 2012 and 2019. The effects of TD preservation and resection were compared using propensity score-matching. Short- and long-term outcomes were analyzed.</div></div><div><h3>Results</h3><div>We showed the standard procedure for TD resection and preservation and demonstrated that recognizing membrane structures is crucial for precise resection of the esophagus and regional lymph nodes. After matching, 255 patients in each group were analyzed. The TD resection group showed no significant differences in short-term outcomes, complication rates, or thoracic lymph node harvest compared to the TD preservation group. Both groups had similar 5-year overall and recurrence-free survival rates, with no significant differences in recurrence patterns.</div></div><div><h3>Conclusions</h3><div>In the context of modern esophageal carcinoma treatment, in which MIE and neoadjuvant chemotherapy are standard practices, the impact of TD resection on prognosis is limited. Recognizing membrane structures is crucial for accurate esophagectomy using the MIE approach.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 8","pages":"Article 110062"},"PeriodicalIF":3.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Outcomes of intraperitoneal chemotherapy for the treatment of gastric cancer with peritoneal metastasis: A comprehensive systematic review and meta-analysis","authors":"K.P. Ameya,&nbsp;Durairaj Sekar","doi":"10.1016/j.ejso.2025.110026","DOIUrl":"10.1016/j.ejso.2025.110026","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 8","pages":"Article 110026"},"PeriodicalIF":3.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgery-related change in cancer cell adhesion associates with recurrence in patients undergoing colorectal cancer surgery","authors":"Stine Bull Jessen ,&nbsp;Rasmus Peuliche Vogelsang ,&nbsp;Troels Gammeltoft Dolin ,&nbsp;Jannie Jørgensen ,&nbsp;Josephine Bjergbæk Olsson ,&nbsp;Tove Kirkegaard ,&nbsp;Ismail Gögenur ,&nbsp;Jesper Thorvald Troelsen","doi":"10.1016/j.ejso.2025.110055","DOIUrl":"10.1016/j.ejso.2025.110055","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to investigate the effect of pre- and postoperative serum on the adhesion of cultured colon cancer cells and their relationship with colorectal cancer recurrence.</div></div><div><h3>Background</h3><div>Colorectal cancer is common, and surgery is the primary treatment choice. However, surgical procedures may be associated with an increased risk of recurrence.</div></div><div><h3>Method</h3><div>434 patients undergoing curatively intended colorectal cancer surgery at Copenhagen University Hospital, Herlev, Denmark, between July 15, 2014, and March 31, 2019, were included in the study. Pre- and postoperative serum samples were collected, and the effect on cellular adhesion was analyzed using a novel high-throughput approach based on CRISPR/Cas9 modified Caco-2 cells and secreted luciferase, named the AdhesionScore assay. The relative risk of postoperative recurrence was estimated using Cox proportional regression analysis.</div></div><div><h3>Results</h3><div>The difference in adhesion between modified Caco-2 cells seeded in the pre- and postoperative serum showed a significant increase in postoperative adhesion in patients with a recurrence event (p=0.0293). Modeling the adhesion data using multiple logistic regression and Cox proportional regression analyses showed a statistically significant association between increased postoperative adhesion and recurrence (p=0.0155 and p=0.0126, respectively). Patients with the highest AdhesionScore showed the greatest risk of recurrence (HR=7, 95% CI 1.6-37.8, p=0.0130).</div></div><div><h3>Conclusions</h3><div>The study found that a difference in the adhesion of Caco-2 cells seeded in pre- and postoperative serum was associated with cancer recurrence following intended curative surgery. This suggests that increased postoperative adhesion may serve as a novel biological marker of recurrence in patients undergoing surgery for colorectal cancer.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 8","pages":"Article 110055"},"PeriodicalIF":3.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}