Ejso最新文献

{"title":"Oesophagectomy following endoscopic resection for oesophageal carcinoma: A Dutch nationwide retrospective cohort study.","authors":"Merel A de Kock, Oleksandr Khoma, Matteo Pittacolo, Pieter C van der Sluis, Sjoerd M Lagarde, Arjun D Koch, Manon C W Spaander, Suzan Nikkessen, Bas P L Wijnhoven","doi":"10.1016/j.ejso.2026.112326","DOIUrl":"https://doi.org/10.1016/j.ejso.2026.112326","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic resection is the standard treatment for early-stage oesophageal carcinoma, but oesophagectomy is recommended when margins are involved or histopathological features suggest a high risk of lymph node metastasis. This study evaluated residual malignancy after endoscopic resection and the accuracy of postoperative risk stratification.</p><p><strong>Methods: </strong>Data were extracted from the Dutch Upper Gastrointestinal Cancer Audit (DUCA) for patients who underwent oesophagectomy after endoscopic resection between 2011 and 2019. Surgical decisions were guided by multidisciplinary team discussion based on endoscopic, radiological and histological risk factors. Outcomes included the presence of residual tumour, discrepancies between clinical and pathological staging, and surgical morbidity and mortality. Secondary outcomes were compared with those of patients undergoing oesophagectomy for locally advanced disease.</p><p><strong>Results: </strong>A total of 146 patients were included, with a median age of 67 years. Residual tumour was identified in 67%, with 63% having intramural tumour and 18.5% lymph node metastases. Clinical-pathological stage discordance occurred in 63% of patients, comprising 24% upstaging and 39% downstaging. Postoperative complications occurred in 61% of patients, with 21.2% experiencing severe complications. The 30-day or in-hospital mortality rate was 1.4%, comparable to outcomes for patients with locally advanced disease.</p><p><strong>Conclusion: </strong>Residual tumour was identified in two-thirds of patients undergoing oesophagectomy after endoscopic resection, with nearly one fifth demonstrating lymph node involvement. Clinical-pathological staging discrepancies were frequent, highlighting limitations in current post-endoscopic risk assessment. These findings apply to a selected subgroup of patients who proceeded to oesophagectomy after endoscopic resection and should not be interpreted as evidence that R0 endoscopic resection is generally non-curative for most early oesophageal cancers. Postoperative outcomes mirrored those of patients undergoing surgery for advanced disease, underscoring the importance of improved risk stratification to reduce overtreatment.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"53 1","pages":"112326"},"PeriodicalIF":3.5,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient selection in those undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases - systematic review and meta-analysis of prognostic factors in large cohorts.","authors":"Amanda Liesegang, Halle Powell, Anshini Jain, Helen Mohan, Jeanne Tie, Nicholas Clemons, Michael Michael, Glen Guerra, Alexander Heriot","doi":"10.1016/j.ejso.2026.112184","DOIUrl":"https://doi.org/10.1016/j.ejso.2026.112184","url":null,"abstract":"<p><strong>Introduction: </strong>Cytoreductive surgery (CRS) with concurrent hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment for colorectal peritoneal metastases (CPM) which can offer a median overall survival of 41 months and improve quality of life. Judicious patient selection is critical for deriving the greatest benefit and avoiding overtreatment. This meta-analysis identifies prognostic factors associated with survival in large cohorts derived from prospectively maintained databases of CRS-HIPEC patient cohorts.</p><p><strong>Materials/methods: </strong>A systematic review and meta-analysis was conducted to evaluate prognostic variables influencing overall survival (OS) and disease-free survival (DFS) in patients with CPM who underwent CRS-HIPEC.</p><p><strong>Results: </strong>Forty-five studies satisfied inclusion criteria for systematic review, with thirty-three studies included for qualitative synthesis. Incomplete cytoreduction, PCI, and grade III-IV complications were the strongest predictors of both OS and DFS. Tumour-specific factors associated with worse OS on pooled analysis included: poor differentiation, signet-ring cell pathology, nodal involvement, T4 stage, and rectal primary. Adjuvant/neoadjuvant systemic treatments had no significant impact on survival in this analysis. RAS mutations may be associated with poorer survival on exploratory analysis.</p><p><strong>Conclusion: </strong>Survival after CRS-HIPEC was best determined by quantity of peritoneal disease (PCI) and the ability to achieve complete cytoreduction (CC-0). Major post-operative complications impact survival beyond short term morbidity. Baseline primary tumour-specific features also impacted survival.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":" ","pages":"112184"},"PeriodicalIF":3.5,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advert ESSO Congress 2026","authors":"","doi":"10.1016/S0748-7983(26)00701-8","DOIUrl":"10.1016/S0748-7983(26)00701-8","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"52 9","pages":"Article 112082"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148854256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advert BASO-ACS Annual Scientific Conference","authors":"","doi":"10.1016/j.ejso.2026.112093","DOIUrl":"10.1016/j.ejso.2026.112093","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"52 9","pages":"Article 112093"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148854252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IFC: Advert ESSO Advanced Course on the Treatment of Peritoneal Surface Malignancy","authors":"","doi":"10.1016/S0748-7983(26)00700-6","DOIUrl":"10.1016/S0748-7983(26)00700-6","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"52 9","pages":"Article 112081"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148854253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advert ESSO Course on Basics in Liver Surgery","authors":"","doi":"10.1016/S0748-7983(26)00703-1","DOIUrl":"10.1016/S0748-7983(26)00703-1","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"52 9","pages":"Article 112084"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148854255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Scandinavian guidelines on papillary thyroid cancer using the AGREE II instrument.","authors":"Maria Sonesson O'Neill, Tilda Areklätt, Sofie Louise Rygård, Ban Shakir, Katrin Brauckhoff, Stefano Londero, Endre Vedvik Tjellaug, Martin Almquist","doi":"10.1016/j.ejso.2026.111876","DOIUrl":"https://doi.org/10.1016/j.ejso.2026.111876","url":null,"abstract":"<p><strong>Background: </strong>Clinical practice guidelines are intended to help with decision-making. However, their quality differs. Guidelines of low quality are a waste of resources and can cause patient harm. We compared the quality of the Danish, Norwegian, and Swedish guidelines on papillary thyroid cancer (PTC) with those of the American Thyroid Association (ATA, 2015 version).</p><p><strong>Methods: </strong>Three pairs of appraisers independently rated the guidelines using the AGREE II instrument, a validated tool for assessing the quality of guidelines. Furthermore, recommendations on the extent of surgery in low-risk PTC, prophylactic lymph node dissection, thyroxine suppression, radioiodine treatment, active surveillance, and the length of follow-up after treatment, along with the evidence cited to support these recommendations, were compared across the four guidelines.</p><p><strong>Results: </strong>Overall, the ATA guidelines had the highest quality, with a score of over 70 % in four domains, and the highest score in five of six domains. The Danish and Swedish guidelines each reached a score of over 70 % in only one domain, while the Norwegian guidelines did not reach that score in any domain. The overall score was 83 % for the ATA guidelines, 50 % for the Danish, 44 % for the Swedish, and 28 % for the Norwegian. Recommendations varied widely, particularly regarding extent of surgery and indications for radioiodine treatment. The ATA guidelines had the highest number of references supporting the recommendations.</p><p><strong>Conclusion: </strong>The quality of clinical practice guidelines and recommendations on treatment for PTC differed between the Scandinavian countries and the ATA, with the ATA having the highest quality.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":" ","pages":"111876"},"PeriodicalIF":2.9,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148004984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embedding the environmental impact estimation in breast surgery: A modular hybrid blueprint for surgical pathway carbon footprinting","authors":"Aws Almukhtar ,&nbsp;Alona Courtney ,&nbsp;Iris Soteriou ,&nbsp;Daniel Leff","doi":"10.1016/j.ejso.2026.111537","DOIUrl":"10.1016/j.ejso.2026.111537","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"52 ","pages":"Article 111537"},"PeriodicalIF":2.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D surface imaging and simulation in immediate breast reconstruction - The MIBREAST randomised trial","authors":"Astrid Leusink,&nbsp;Madhumitha Ravichandran,&nbsp;Samantha Farnworth,&nbsp;Sofia Sardo Infirri,&nbsp;Rachel O'Connell,&nbsp;Amy Godden,&nbsp;Jennifer Rusby","doi":"10.1016/j.ejso.2026.111538","DOIUrl":"10.1016/j.ejso.2026.111538","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"52 ","pages":"Article 111538"},"PeriodicalIF":2.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body mass index, mammographic density and post-menopausal breast cancer risk: a mediation analysis","authors":"Benoit Jauniaux ,&nbsp;Michelle Harvie ,&nbsp;Matthew Sperrin ,&nbsp;Susan Astley ,&nbsp;Lee Malcolmson ,&nbsp;Gareth Evans ,&nbsp;Andrew Renehan","doi":"10.1016/j.ejso.2026.111541","DOIUrl":"10.1016/j.ejso.2026.111541","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"52 ","pages":"Article 111541"},"PeriodicalIF":2.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}