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Extraperitoneal Single Port vs Transperitoneal Multiport Robot assisted radical prostatectomy in frail patients: A propensity score matched comparative analysis 体弱患者的腹膜外单孔与经腹膜多孔机器人辅助前列腺癌根治术:倾向得分匹配比较分析
IF 3.5 2区 医学
Ejso Pub Date : 2024-10-04 DOI: 10.1016/j.ejso.2024.108741
Luca Lambertini , Matteo Pacini , Ruben Sauer Calvo , Luca Morgantini , Donato Cannoletta , Fabrizio Di Maida , Francesca Valastro , Andrea Mari , Gabriele Bignante , Francesco Lasorsa , Angelo Orsini , Alessandro Zucchi , Andrea Minervini , Simone Crivellaro
{"title":"Extraperitoneal Single Port vs Transperitoneal Multiport Robot assisted radical prostatectomy in frail patients: A propensity score matched comparative analysis","authors":"Luca Lambertini ,&nbsp;Matteo Pacini ,&nbsp;Ruben Sauer Calvo ,&nbsp;Luca Morgantini ,&nbsp;Donato Cannoletta ,&nbsp;Fabrizio Di Maida ,&nbsp;Francesca Valastro ,&nbsp;Andrea Mari ,&nbsp;Gabriele Bignante ,&nbsp;Francesco Lasorsa ,&nbsp;Angelo Orsini ,&nbsp;Alessandro Zucchi ,&nbsp;Andrea Minervini ,&nbsp;Simone Crivellaro","doi":"10.1016/j.ejso.2024.108741","DOIUrl":"10.1016/j.ejso.2024.108741","url":null,"abstract":"<div><h3>Purpose</h3><div>The rise of frail patients in the worldwide population poses a challenge in the prostate cancer surgical care. In this light, we aimed to compare perioperative and early surgical outcomes of Extraperitoneal Single Port (SP)- vs Transperitoneal Multiport (MP) - Robot Assisted Radical Prostatectomy (RALP) in different frailty settings.</div></div><div><h3>Materials and methods</h3><div>Clinical and surgical data of all consecutive patients treated with RALP between March 2014 and October 2023 were gathered. Propensity score matching was performed to adjust for potential baseline pre-operative confounders. The 5-miFI score was calculated for each patient and then five risk categories were identified (5-mFI score = 0, 1,2,3 and ≥ 4).</div></div><div><h3>Results</h3><div>A total of 549 patients were assessed in the unmatched analysis. After the propensity score, 126 patients for each treatment group were matched. When stratified in different frailty-groups, 30-days postoperative complications occurred significantly more frequently in case of 5-mFI score=3 and &gt;4 (p = 0.001). Moreover, higher rate of both overall (52 vs 23 %, p = 0.01) and major (19.6 vs 8.2 %, p = 0.02) postoperative complications was found in these patients in case of transperitoneal MP RARP as compared to the extraperitoneal SP procedures. Exploring predictors of postoperative early complications in patients with 5-mFI score = 3 and 4, extraperitoneal SP robotic approach showed a significant protective role on both overall (OR 0.21, p = 0.001) and major (OR 0.33, p = 0.001) complications occurrence.</div></div><div><h3>Conclusions</h3><div>In a matched cohort of patients treated with Robot Assisted Radical Prostatectomy, extraperitoneal Single Port approach significantly reduced the overall and major early complications rate in frail patients.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"50 12","pages":"Article 108741"},"PeriodicalIF":3.5,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of Substantial LYMphovascular space invasion on sentinel lymph nodes status and recurrence in Endometrial Cancer patients: SLYM-EC a multicenter retrospective study 实质性淋巴管间隙侵犯对子宫内膜癌患者前哨淋巴结状态和复发的影响:SLYM-EC 多中心回顾性研究
IF 3.5 2区 医学
Ejso Pub Date : 2024-10-03 DOI: 10.1016/j.ejso.2024.108731
Alessandro Buda , Robert Fruscio , Jessica Mauro , Sara Imboden , Elena De Ponti , Emanuele Perrone , Tommaso Grassi , Valentina Bruno , Virginia Garcia-Pineda , Salih Taskin , Stefano Restaino , Franziska Siegenthaler , Jvan Casarin , Diego Raimondo , Vito Andrea Capozzi , Dogan Vatansever , Ilaria Capasso , Enrico Vizza , Mete Gungor , Ignacio Zapardiel , Michael Mueller
{"title":"The impact of Substantial LYMphovascular space invasion on sentinel lymph nodes status and recurrence in Endometrial Cancer patients: SLYM-EC a multicenter retrospective study","authors":"Alessandro Buda ,&nbsp;Robert Fruscio ,&nbsp;Jessica Mauro ,&nbsp;Sara Imboden ,&nbsp;Elena De Ponti ,&nbsp;Emanuele Perrone ,&nbsp;Tommaso Grassi ,&nbsp;Valentina Bruno ,&nbsp;Virginia Garcia-Pineda ,&nbsp;Salih Taskin ,&nbsp;Stefano Restaino ,&nbsp;Franziska Siegenthaler ,&nbsp;Jvan Casarin ,&nbsp;Diego Raimondo ,&nbsp;Vito Andrea Capozzi ,&nbsp;Dogan Vatansever ,&nbsp;Ilaria Capasso ,&nbsp;Enrico Vizza ,&nbsp;Mete Gungor ,&nbsp;Ignacio Zapardiel ,&nbsp;Michael Mueller","doi":"10.1016/j.ejso.2024.108731","DOIUrl":"10.1016/j.ejso.2024.108731","url":null,"abstract":"<div><h3>Introduction</h3><div>To evaluate the prognostic impact of substantial lymph vascular space invasion (LVSI) on the sentinel lymph node involvement and recurrence rate of patients with apparent uterine-confined endometrial cancer.</div></div><div><h3>Materials and methods</h3><div>We enrolled consecutive patients with apparent confined endometrial cancer who underwent surgical staging with sentinel node mapping from 14 European reference centers. LVSI was analyzed semi-quantitatively, according to a 3-tiered scoring system classified as absent, focal, and substantial.</div></div><div><h3>Results</h3><div>Among 2352 eligible patients, 1980 were included in the analysis. Upon final pathology 226 patients (11.4 %) had SLNs involvement. LVSI was diagnosed focal in 152 patients (7.7 %), whereas 357 patients (18.0 %) showed substantial LVSI. Focal or substantial LVSI rate were significantly higher in patients with positive SLNs when compared to patients without SLNs involvement (p &lt; 0.0001). On overall patient-based analysis, the sensitivity, specificity, positive predictive value, and negative predictive value of LVSI for sentinel lymph node metastases were 73 %, 80 %, 32 %, and 96 %, respectively. The 3-year multivariate analysis of recurrence-free survival showed that only the presence of substantial LVSI, and grade 3 disease were associated with relapse. Neither positive sentinel lymph node, deep myometrial infiltration, nor age at surgery were statistically significant.</div></div><div><h3>Conclusions</h3><div>In patients having undergone sentinel node biopsy, positive LVSI demonstrated moderate sensitivity and reasonable specificity in detecting SLN involvement. LVSI positivity does not correlate with nodal involvement. The presence of substantial LVSI remains a strong independent risk factor for recurrence, indicating a role for potential hematogenous dissemination in patients with early-stage disease.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"50 12","pages":"Article 108731"},"PeriodicalIF":3.5,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing prehabilitation in gynecologic malignancies: Improving acceptance, overcoming barriers, and managing program complexity 优化妇科恶性肿瘤的预康复治疗:提高接受度、克服障碍和管理项目复杂性
IF 3.5 2区 医学
Ejso Pub Date : 2024-10-02 DOI: 10.1016/j.ejso.2024.108739
Alexandra Mayer, David Cibula
{"title":"Optimizing prehabilitation in gynecologic malignancies: Improving acceptance, overcoming barriers, and managing program complexity","authors":"Alexandra Mayer,&nbsp;David Cibula","doi":"10.1016/j.ejso.2024.108739","DOIUrl":"10.1016/j.ejso.2024.108739","url":null,"abstract":"<div><div>Prehabilitation aims to improve patients’ physical condition before a stressful event, such as surgery, and enhance recovery. Despite its potential benefits, many emerging prehabilitation programs face challenges in enrolling or retaining patients. In our prehabilitation study PHOCUS, which aims to prepare ovarian cancer patients for surgery, we have also encountered lower acceptance and retention rates. Particularly the most vulnerable patients, who are old and frail, and may benefit the most from the prehabilitation, decline participation due to the complexity of the proposed program.</div><div>In our review we discussed obstacles and barriers that prevent patients' participation based on both literature and our experience. Among the main reasons are patient's low motivation, high intensity of the program and a lack of social support. To overcome these challenges, we suggest increasing the program's flexibility, adapting the program according to individual patient's needs and enhancing patients' education about the benefits of prehabilitation.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"50 12","pages":"Article 108739"},"PeriodicalIF":3.5,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lateral lymph node metastasis without mesenteric lymph node involvement in middle-low rectal cancer: Results of a multicentre lateral node collaborative group study in China 无肠系膜淋巴结受累的中低位直肠癌侧淋巴结转移:中国多中心侧淋巴结协作组研究结果。
IF 3.5 2区 医学
Ejso Pub Date : 2024-10-02 DOI: 10.1016/j.ejso.2024.108737
Fei Huang , Tixian Xiao , Guangzhe Shen , Sicheng Zhou , Fuqiang Zhao , Shiwen Mei , Wei Zhao , Nian Chen , Qian Liu , the Chinese Lateral Node Collaborative Group
{"title":"Lateral lymph node metastasis without mesenteric lymph node involvement in middle-low rectal cancer: Results of a multicentre lateral node collaborative group study in China","authors":"Fei Huang ,&nbsp;Tixian Xiao ,&nbsp;Guangzhe Shen ,&nbsp;Sicheng Zhou ,&nbsp;Fuqiang Zhao ,&nbsp;Shiwen Mei ,&nbsp;Wei Zhao ,&nbsp;Nian Chen ,&nbsp;Qian Liu ,&nbsp;the Chinese Lateral Node Collaborative Group","doi":"10.1016/j.ejso.2024.108737","DOIUrl":"10.1016/j.ejso.2024.108737","url":null,"abstract":"<div><h3>Background</h3><div>Characteristics and prognoses of lateral lymph node (LLN) metastasis but not mesenteric lymph node (LN) metastasis are poorly understood. This study explored patterns of mesenteric and LLN metastases in rectal cancer patients.</div></div><div><h3>Method</h3><div>This retrospective, multicentre study was conducted at three institutions and included patients who underwent total mesorectal excision (TME) with lateral lymph node dissection (LLND) for rectal cancer (<em>n</em> = 271).</div></div><div><h3>Results</h3><div>Among the patients with LLN metastases, 210 patients (77.5 %) with clinical stage T3-4 disease and 157 patients (57.9 %) with clinical stage N1-N2 disease underwent TME as well as LLND. The prognoses of patients with metastasis confined to LLNs were significantly better than those of patients with both mesenteric and LLN metastases (3-year overall survival: 85.0 % vs. 51.0 %, p = 0.005; 3-year disease-free survival: 75.0 % vs. 26.5 %, p = 0.003) and were similar to those of patients with metastasis confined to mesenteric LNs (3-year overall survival: 85.0 % vs. 83.8 %, p = 0.607; 3-year disease-free survival 75.0 % vs. 68.8 %, p = 0.717). Patients with metastases confined to LLN had a lower proportion of poor histological types (20.0 % vs. 65.3 %, p = 0.002), lymphatic invasion (20.0 % vs. 59.2 %, p = 0.036) and number of LLN metastases (1.6 vs 2.7, p = 0.004), and all metastases were confined to the internal iliac or obturator region (100.0 % vs. 77.6 %, p = 0.008) compared to patients with both mesenteric and LLN metastasis.</div></div><div><h3>Conclusions</h3><div>Approximately a quarter of patients with rectal cancer have LLN metastases but no mesenteric LN metastases. These patients have favourable pathological features and prognoses and can be managed and treated for mesenteric LN metastasis.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"50 12","pages":"Article 108737"},"PeriodicalIF":3.5,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Registry-based study comparing health-related quality of life between patients with primary rectal cancer and locally recurrent rectal cancer 比较原发性直肠癌和局部复发性直肠癌患者的健康相关生活质量的登记研究。
IF 3.5 2区 医学
Ejso Pub Date : 2024-10-02 DOI: 10.1016/j.ejso.2024.108736
Niamh McKigney , Amy Downing , Galina Velikova , Julia M. Brown , Deena P. Harji
{"title":"Registry-based study comparing health-related quality of life between patients with primary rectal cancer and locally recurrent rectal cancer","authors":"Niamh McKigney ,&nbsp;Amy Downing ,&nbsp;Galina Velikova ,&nbsp;Julia M. Brown ,&nbsp;Deena P. Harji","doi":"10.1016/j.ejso.2024.108736","DOIUrl":"10.1016/j.ejso.2024.108736","url":null,"abstract":"<div><h3>Aim</h3><div>National clinical registries offer the benefits of a comprehensive dataset, particularly when linked with patient-reported outcome (PRO) data. This aim of this study was to utilise UK registry data to assess cross-sectional differences in health-related quality of life (HrQoL) in patients with primary rectal (PRC) and locally recurrent rectal cancer (LRRC).</div></div><div><h3>Materials and methods</h3><div>Data were extracted from the COloRECTal cancer Repository (CORECT-R) and the Locally Recurrent Rectal Cancer – Quality of Life (LRRC-QoL) datasets. Propensity score matching was undertaken in a 1:1 ratio using two covariates: age and sex. The primary outcome was the FACT-C Colorectal Cancer Subscale (CCS). Statistical significance was determined using p &lt; 0.05 and clinical significance using effect size (ES) and minimally important clinical difference (MCID).</div></div><div><h3>Results</h3><div>A matched cohort with 72 patients in each group was identified. Overall FACT-C CCS scores were worse in patients with LRRC from a statistical (11.80 vs 18.03, p &lt; 0.001) and clinically meaningful perspective (ES 1.63, MCID 6.23). Patients with PRC reported better digestion (p &lt; 0.001, ES 0.85), better control over their bowels (p &lt; 0.001, ES 1.03) and increased appetite (p &lt; 0.001, ES 1.74, MCID 2.08). Patients with LRRC reported worse stomach swelling (p &lt; 0,001, ES 0.97) and more diarrhoea (p &lt; 0.001, ES 0.92), however they reported better body image (p &lt; 0.001, ES 0.80).</div></div><div><h3>Conclusion</h3><div>Patients with LRRC reported significantly worse overall scores in the FACT-C CCS from both a statistical and clinical perspective, demonstrating the ability of the FACT-C to distinguish between these patient groups and the benefits of the inclusion of PROs within colorectal cancer registries, specifically including patients with advanced/recurrent disease.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"50 12","pages":"Article 108736"},"PeriodicalIF":3.5,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors of mastectomy in breast cancer patients with complete remission of primary tumor after neoadjuvant therapy: A retrospective study 新辅助治疗后原发肿瘤完全缓解的乳腺癌患者进行乳房切除术的预测因素:一项回顾性研究。
IF 3.5 2区 医学
Ejso Pub Date : 2024-10-02 DOI: 10.1016/j.ejso.2024.108732
Damiano Gentile , Federica Martorana , Andreas Karakatsanis , Francesco Caruso , Michele Caruso , Gaetano Castiglione , Alfio Di Grazia , Francesco Pane , Antonio Rizzo , Paolo Vigneri , Corrado Tinterri , Giuseppe Catanuto
{"title":"Predictors of mastectomy in breast cancer patients with complete remission of primary tumor after neoadjuvant therapy: A retrospective study","authors":"Damiano Gentile ,&nbsp;Federica Martorana ,&nbsp;Andreas Karakatsanis ,&nbsp;Francesco Caruso ,&nbsp;Michele Caruso ,&nbsp;Gaetano Castiglione ,&nbsp;Alfio Di Grazia ,&nbsp;Francesco Pane ,&nbsp;Antonio Rizzo ,&nbsp;Paolo Vigneri ,&nbsp;Corrado Tinterri ,&nbsp;Giuseppe Catanuto","doi":"10.1016/j.ejso.2024.108732","DOIUrl":"10.1016/j.ejso.2024.108732","url":null,"abstract":"<div><h3>Introduction</h3><div>Neoadjuvant therapy (NAT) should increase the rate of breast-conserving surgery (BCS) in non-metastatic breast cancer (BC) patients, especially in those achieving tumor shrinkage. Still, the conversion from a pre-planned mastectomy to BCS in patients responding to NAT is not a widespread standard. We aimed to identify factors influencing surgical choices in this setting.</div></div><div><h3>Materials and methods</h3><div>We retrospectively collected data of BC patients with complete remission of primitive tumor (ypT0) after NAT, treated with BCS or mastectomy in two Italian breast units. Predictors of mastectomy were explored using logistic regression. Distant recurrence and event-free survival were assessed in the BCS and mastectomy cohort.</div></div><div><h3>Results</h3><div>243 patients were included, 147 (60.5 %) treated with BCS and 96 (39.5 %) treated with mastectomy. In the mastectomy group, there were more centrally-located, multiple and larger tumors. At univariate regression analysis, central location, baseline tumor extension on ultrasound (US) and magnetic resonance imaging (MRI), multiple foci and clinical stage were significantly associated with the chance of receiving mastectomy. At multivariate analysis, only baseline focality on US and extension on MRI retained significance as predictors of mastectomy. Distant recurrence and event-free survival were significantly longer in patients undergoing BCS.</div></div><div><h3>Conclusion</h3><div>Baseline tumor extension and focality were the main predictors of mastectomy in patients with ypT0 after NAT. However, BCS did not negatively affect survival outcomes in our cohort. An effort should be made to avoid potentially unnecessary mastectomy in this population, aiming at minimizing surgery-associated toxicities and improving patients’ quality of life.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"50 12","pages":"Article 108732"},"PeriodicalIF":3.5,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trophoblastic disease and choriocarcinoma. 滋养细胞疾病和绒毛膜癌。
IF 3.5 2区 医学
Ejso Pub Date : 2024-10-01 DOI: 10.1016/j.ejso.2024.108727
Graziella Camilleri, Jean Calleja-Aguis, Edith Said
{"title":"Trophoblastic disease and choriocarcinoma.","authors":"Graziella Camilleri, Jean Calleja-Aguis, Edith Said","doi":"10.1016/j.ejso.2024.108727","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108727","url":null,"abstract":"<p><p>Gestational trophoblastic disease (GTD) is a group of diseases associated with pregnancies that demonstrate abnormal development of trophoblastic cells. GTD includes hydatidiform moles (HM) that may continue to further develop into gestational trophoblastic neoplasms (GTN), such as choriocarcinoma (CC). Gestational CC is a malignant mass development that may arise from HM, from other (normal) pregnancies or from other gestational events (such as ectopic pregnancies). The aim of this review is to outline current understating of the genetics and epigenetics of GTD and gestational CC and the link between the two diseases.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":" ","pages":"108727"},"PeriodicalIF":3.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility of major hepatectomy following preoperative chemotherapy for advanced perihilar cholangiocarcinoma. 晚期肝周胆管癌术前化疗后行大肝切除术的可行性。
IF 3.5 2区 医学
Ejso Pub Date : 2024-10-01 DOI: 10.1016/j.ejso.2024.108733
Atsushi Takahashi, Ryuji Yoshioka, Shuichi Koike, Masahiro Fujisawa, Masaru Oba, Yoshinori Takeda, Yuki Fukumura, Yoshihito Kotera, Yoshihiro Mise, Akio Saiura
{"title":"Feasibility of major hepatectomy following preoperative chemotherapy for advanced perihilar cholangiocarcinoma.","authors":"Atsushi Takahashi, Ryuji Yoshioka, Shuichi Koike, Masahiro Fujisawa, Masaru Oba, Yoshinori Takeda, Yuki Fukumura, Yoshihito Kotera, Yoshihiro Mise, Akio Saiura","doi":"10.1016/j.ejso.2024.108733","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108733","url":null,"abstract":"<p><strong>Background: </strong>The safety of major hepatectomy following preoperative chemotherapy for perihilar cholangiocarcinoma (PHCC) is underexplored. This study evaluates the impact of preoperative chemotherapy on surgical outcomes and assesses chemotherapy-induced liver injury in patients with advanced PHCC.</p><p><strong>Methods: </strong>This retrospective study included 62 PHCC patients who underwent surgery between January 2019 and January 2024. Patients were divided into an upfront surgery group (UFS, n = 31) and a preoperative chemotherapy group (POC, n = 31). Preoperative chemotherapy was indicated when R0/R1 resection was unachievable, complex surgery was needed, or future liver reserve was insufficient. Baseline characteristics, surgical procedures, postoperative complications, and pathological findings were compared.</p><p><strong>Results: </strong>Postoperative complications were comparable between groups, with Clavien-Dindo grade ≥3a rates of 30.7 % in the POC group and 24.3 % in the UFS group. Despite longer operative times and hospital stays in the POC group, no significant differences in hepatotoxicity or pathological findings, including Kleiner and Rubbia-Brandt scores, were observed. Notably, a pathological complete response was achieved in 12.9 % of the POC group.</p><p><strong>Conclusion: </strong>Major hepatectomy following preoperative chemotherapy for PHCC is safe and does not increase the risk of postoperative complications or hepatotoxicity. Further studies are warranted to refine resectability criteria and optimize patient selection.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":" ","pages":"108733"},"PeriodicalIF":3.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to "A nomogram for predicting colorectal cancer liver metastasis using circulating tumor cells from the first drainage vein" 回复 "利用第一引流静脉的循环肿瘤细胞预测结直肠癌肝转移的提名图"。
IF 3.5 2区 医学
Ejso Pub Date : 2024-10-01 DOI: 10.1016/j.ejso.2024.108728
Xiaoyu Yang, Xue Bi
{"title":"Reply to \"A nomogram for predicting colorectal cancer liver metastasis using circulating tumor cells from the first drainage vein\"","authors":"Xiaoyu Yang,&nbsp;Xue Bi","doi":"10.1016/j.ejso.2024.108728","DOIUrl":"10.1016/j.ejso.2024.108728","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"50 12","pages":"Article 108728"},"PeriodicalIF":3.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aliado - A design concept of AI for decision support in oncological liver surgery. Aliado - 用于肿瘤肝脏手术决策支持的人工智能设计理念。
IF 3.5 2区 医学
Ejso Pub Date : 2024-09-29 DOI: 10.1016/j.ejso.2024.108669
A Schulze, M Haselbeck-Köbler, J M Brandenburg, M T J Daum, K März, S Hornburg, H Maurer, F Myers, G Reichert, S Bodenstedt, F Nickel, M Kriegsmann, M O Wielpütz, S Speidel, L Maier-Hein, B P Müller-Stich, A Mehrabi, M Wagner
{"title":"Aliado - A design concept of AI for decision support in oncological liver surgery.","authors":"A Schulze, M Haselbeck-Köbler, J M Brandenburg, M T J Daum, K März, S Hornburg, H Maurer, F Myers, G Reichert, S Bodenstedt, F Nickel, M Kriegsmann, M O Wielpütz, S Speidel, L Maier-Hein, B P Müller-Stich, A Mehrabi, M Wagner","doi":"10.1016/j.ejso.2024.108669","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108669","url":null,"abstract":"<p><strong>Background: </strong>The interest in artificial intelligence (AI) is increasing. Systematic reviews suggest that there are many machine learning algorithms in surgery, however, only a minority of the studies integrate AI applications in clinical workflows. Our objective was to design and evaluate a concept to use different kinds of AI for decision support in oncological liver surgery along the treatment path.</p><p><strong>Methods: </strong>In an exploratory co-creation between design experts, surgeons, and data scientists, pain points along the treatment path were identified. Potential designs for AI-assisted solutions were developed and iteratively refined. Finally, an evaluation of the design concept was performed with n = 20 surgeons to get feedback on the different functionalities and evaluate the usability with the System Usability Scale (SUS). Participating surgeons had a mean of 14.0 ± 5.0 years of experience after graduation.</p><p><strong>Results: </strong>The design concept was named \"Aliado\". Five different scenarios were identified where AI could support surgeons. Mean score of SUS was 68.2 ( ± 13.6 SD). The highest valued functionalities were \"individualized prediction of survival, short-term mortality and morbidity\", and \"individualized recommendation of surgical strategy\".</p><p><strong>Conclusion: </strong>Aliado is a design prototype that shows how AI could be integrated into the clinical workflow. Even without a fleshed out user interface, the SUS already yielded borderline good results. Expert surgeons rated the functionalities favorably, and most of them expressed their willingness to work with a similar application in the future. Thus, Aliado can serve as a surgical vision of how an ideal AI-based assistance could look like.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":" ","pages":"108669"},"PeriodicalIF":3.5,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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