Ejso最新文献

{"title":"Comment on predictors of recurrence in early-stage cervical cancer without adjuvant treatment after radical surgery","authors":"Chunjun Xia, Xiangyue Jin, Xi Huang","doi":"10.1016/j.ejso.2025.110244","DOIUrl":"10.1016/j.ejso.2025.110244","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 8","pages":"Article 110244"},"PeriodicalIF":3.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological and prognosis analysis of intraductal papillary neoplasm of the bile duct: A dual-center retrospective study","authors":"Xiaorui Huang ,&nbsp;Zhen Zhang ,&nbsp;Dengsheng Zhu ,&nbsp;Chaobo Li ,&nbsp;Zhiqiang Gao ,&nbsp;Zhiwei Zhang ,&nbsp;Xinyi Guo ,&nbsp;Jingzhao Zhang ,&nbsp;Guangrui Lu ,&nbsp;Tong Guo ,&nbsp;Yahong Yu","doi":"10.1016/j.ejso.2025.110212","DOIUrl":"10.1016/j.ejso.2025.110212","url":null,"abstract":"<div><h3>Background</h3><div>The precise clinical features and prognosis of IPNB remain challenging to define. More research is needed to enhance understanding of the disease.</div></div><div><h3>Methods</h3><div>The study retrospectively analyzes the clinical data of 123 patients with IPNB from two medical centers during January 2013 and May 2024. The clinicopathological characteristics of IPNB were compared across subgroups. Risk factors for invasive IPNB and survival predictors of IPNB were identified by regression analysis. The prognosis of patients with IPNB was evaluated through survival and recurrence analysis.</div></div><div><h3>Result</h3><div>The majority of tumors (51.2 %) were located in the extrahepatic bile ducts, 42.3 % were in the intrahepatic bile ducts, and 6.5 % exhibited diffuse distribution. 23 patients (18.7 %) were diagnosed with low-grade dysplasia, 41 patients (33.3 %) were diagnosed with high-grade dysplasia, and the remaining 59 patients (48.0 %) were diagnosed with invasive carcinomas. Mucin secretion was observed in 33.3 % of cases. Focal bile duct wall thickening and pancreaticobiliary maljunction were identified as independent risk factors for invasive IPNB. The 1-year, 3-year, and 5-year overall survival rates were 97.4 %, 77.2 %, and 70.1 %, respectively. For all IPNB patients, the extrahepatic type and presence of invasive carcinoma were independent predictors of survival. In invasive IPNB, the extrahepatic type, local invasion, and vascular invasion were associated with worse survival.</div></div><div><h3>Conclusion</h3><div>The clinicopathological features of IPNB exhibited significant heterogeneity across subgroups. Early diagnosis and timely surgical intervention are critical for optimizing patients’ long-term outcomes.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 9","pages":"Article 110212"},"PeriodicalIF":3.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic implications of signet ring cell proportion in gastric cancer: Insights from a novel nomogram and biomarker analysis","authors":"Maryam Imran Sheikh,&nbsp;Umer Bin Shahzad,&nbsp;Muhammad Ahmed","doi":"10.1016/j.ejso.2025.110245","DOIUrl":"10.1016/j.ejso.2025.110245","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 9","pages":"Article 110245"},"PeriodicalIF":3.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dilemma of ypN3 esophageal cancer","authors":"Pim B. Olthof ,&nbsp;Bo J. Noordman ,&nbsp;Sofie P.G. Henckens ,&nbsp;Marianne C. Kalff ,&nbsp;Bas P.L. Wijnhoven ,&nbsp;Mark I. van Berge Henegouwen ,&nbsp;Sjoerd Lagarde ,&nbsp;Suzanne S. Gisbertz ,&nbsp;Pieter van der Sluis","doi":"10.1016/j.ejso.2025.110224","DOIUrl":"10.1016/j.ejso.2025.110224","url":null,"abstract":"<div><div>In this study 3901 patients underwent esophagectomy after neoadjuvant treatment and 244 of these patients (6 %) had ypN3 disease. Median overall- and disease-free survival was 10.0 and 6.0 months respectively for ypN3 disease. The R1 margin rate was higher amongst ypN3 patients: 21 % compared to 4 %. Out of the 244 patients with ypN3 disease, 12 (5 %) were preoperatively staged cN3. Conversely, 11 % of the total 108 patients staged cN3 before neoadjuvant therapy, had ypN3 disease. Current staging is insufficiently accurate to preoperatively identify patients with ypN3 disease for which better imagine modalities are needed. The outcomes of patients with ypN3 disease are dismal, the survival rates in this study question the benefit of surgery in these patients. Improvement in neo-adjuvant therapy and staging might help to select patients with advanced nodal disease who will benefit from surgery.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 9","pages":"Article 110224"},"PeriodicalIF":3.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional outcomes and impact of malnutrition in a randomised comparison between standard and prolonged time to surgery after neoadjuvant chemoradiotherapy for oesophageal cancer","authors":"Jessica Ericson ,&nbsp;Fredrik Klevebro ,&nbsp;Berit Sunde ,&nbsp;Eva Szabo ,&nbsp;Ingvar Halldestam ,&nbsp;Ulrika Smedh ,&nbsp;Bengt Wallner ,&nbsp;Jan Johansson ,&nbsp;Gjermund Johnsen ,&nbsp;Eirik Kjus Aahlin ,&nbsp;Hans-Olaf Johannessen ,&nbsp;Geir-Olav Hjortland ,&nbsp;Sissi Stove Lorentzen ,&nbsp;Malene Slott ,&nbsp;Wolfgang Schröder ,&nbsp;Ioannis Rouvelas ,&nbsp;Magnus Nilsson","doi":"10.1016/j.ejso.2025.110228","DOIUrl":"10.1016/j.ejso.2025.110228","url":null,"abstract":"<div><h3>Background</h3><div>Prolonged time to surgery (TTS) after neoadjuvant chemoradiotherapy (nCRT) may enable malnourished oesophageal cancer patients' nutritional status to recover better, possibly improving outcomes with fewer complications and better overall survival (OS) after oesophagectomy.</div></div><div><h3>Methods</h3><div>This is a substudy within a multicentre randomised controlled trial comparing outcomes in patients with oesophageal cancer after standard TTS of 4–6 weeks to prolonged TTS of 10–12 weeks after nCRT. Patients were categorised as malnourished or non-malnourished at baseline and compared regarding weight, dysphagia, postoperative complications, and OS.</div></div><div><h3>Results</h3><div>The mean weight from baseline to time of surgery decreased significantly in patients allocated to standard TTS (p &lt; 0.001) while patients with prolonged TTS recovered during the extended time to similar weight as at baseline (p = 0.131). The mean dysphagia score at the time of surgery improved significantly in both groups (p &lt; 0.001). There were no significant differences between patients allocated to standard versus prolonged TTS regarding postoperative complications, regardless of malnourishment status at baseline. No significant differences in OS after prolonged TTS compared to standard TTS, was observed in neither malnourished patients (hazard ratio, HR 1.72 (95 %, CI: 0.82–3.59, p = 0.147) nor non-malnourished patients (HR 1.26 (95 % CI:0.82–1.94, p = 0.291).</div></div><div><h3>Conclusions</h3><div>Prolonged TTS was associated with better weight recovery at the time of surgery compared to standard TTS. Patients malnourished at baseline did not benefit in terms of less postoperative complications after prolonged TTS.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 9","pages":"Article 110228"},"PeriodicalIF":3.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Prognosis of rare histological subtypes of breast cancer – insights from the Bulgarian National Cancer Registry” [Eur. J. Surg. Oncol. 51:4 (2025) 109712]","authors":"Mariela Vasileva-Slaveva ,&nbsp;Angel Yordanov ,&nbsp;Ivan Ivanov ,&nbsp;Vasil Nanev ,&nbsp;Miroslava Chortova ,&nbsp;Alexandrina Vlahova ,&nbsp;Lyubov Simeonova ,&nbsp;Margarita Taushanova ,&nbsp;Jean Calleja Agius ,&nbsp;Klejda Harasani ,&nbsp;Metodi Metodiev","doi":"10.1016/j.ejso.2025.110190","DOIUrl":"10.1016/j.ejso.2025.110190","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 9","pages":"Article 110190"},"PeriodicalIF":3.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of cul-de-sac seeding with intraperitoneal tumor burden in advanced ovarian cancer (CIEL, KGOG 4003)","authors":"Min Kyung Kim ,&nbsp;Seung Yeon Pyeon ,&nbsp;Sung Il Hwang ,&nbsp;Banghyun Lee ,&nbsp;Yong Beom Kim ,&nbsp;Dong Hoon Suh ,&nbsp;Kidong Kim","doi":"10.1016/j.ejso.2025.110231","DOIUrl":"10.1016/j.ejso.2025.110231","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the relationship between tumor seeding in the cul-de-sac, assessed by transvaginal or transrectal ultrasound, and intraperitoneal tumor burden in advanced ovarian cancer.</div></div><div><h3>Methods</h3><div>We prospectively enrolled 101 patients scheduled for surgery due to suspected or newly diagnosed ovarian, fallopian tube, or peritoneal cancer at three hospitals in Korea (Feb 2022–Dec 2023). Five were excluded for missing ultrasound or surgery, and eleven for benign or other malignancies. Preoperative ultrasound was used to assess cul-de-sac tumor seeding, categorized as no seeding, reticulonodular, serosal, or mass seeding. Intraperitoneal tumor burden was evaluated using the Peritoneal Cancer Index (PCI) and Fagotti score. Associations with bowel surgery and residual tumors &gt;1 cm were also analyzed.</div></div><div><h3>Results</h3><div>Eighty-five patients were included; 28 received neoadjuvant chemotherapy. Cul-de-sac seeding was classified as no seeding (42 %), reticulonodular (14 %), serosal (18 %), or mass (26 %). Higher PCI and Fagotti scores correlated with more severe seeding. Intraoperative confirmation of seeding was seen in 69 % of cases. Bowel surgery was less frequent in patients without seeding. No significant differences were found in residual tumors &gt;1 cm between groups.</div></div><div><h3>Conclusion</h3><div>Cul-de-sac tumor seeding identified by transvaginal or transrectal ultrasound may reflect intraperitoneal tumor burden and could help predict surgical complexity in advanced ovarian cancer.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 9","pages":"Article 110231"},"PeriodicalIF":3.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors of sentinel lymph node mapping failure in cervical cancer: A systematic review and meta-analysis","authors":"Miao Ao ,&nbsp;Anqi Zhao ,&nbsp;You Wu,&nbsp;He Zhang,&nbsp;Wei Mao,&nbsp;Zhiping Huo,&nbsp;Bin Li","doi":"10.1016/j.ejso.2025.110230","DOIUrl":"10.1016/j.ejso.2025.110230","url":null,"abstract":"<div><h3>Background</h3><div>Sentinel lymph node (SLN) mapping is crucial in cervical cancer, helping to assess lymph node status while reducing unnecessary systemic lymph node dissection. However, bilateral SLN mapping fails in 5 %–20 % of cases, with various contributing factors. This meta-analysis aims to identify predictive factors associated with SLN mapping failure in cervical cancer.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted across Cochrane, MEDLINE, Embase, PubMed, Web of Science, CBM, CNKI, WFDB, and VIP from inception to July 2024. Additional data were obtained from SRCTN, Physicians Data Query, ClinicalTrials, and the International Clinical Trials Registry Platform. Two independent researchers screened studies, assessed quality, and extracted data. The associations between predictive factors and SLN mapping failure were evaluated using odds ratios (ORs) with 95 % confidence intervals (CIs).</div></div><div><h3>Results</h3><div>A total of 27 observational studies comprising 4059 patients were included. Significant predictive factors for SLN mapping failure included tumor size ≥2 cm [OR = 1.35, 95 % CI (1.05, 1.74), P = 0.018], age ≥50 years [OR = 2.71, 95 % CI (1.85, 3.97), P ≤ 0.001], FIGO stages II-IV [OR = 2.11, 95 % CI (1.20, 3.72), P = 0.009], pelvic lymph node metastasis [OR = 2.15, 95 % CI (1.10, 4.20), P = 0.025], and neoadjuvant chemotherapy (NACT) [OR = 1.44, 95 % CI (1.09, 1.90), P = 0.010]. Other factors including obesity, surgical approach, cervical conization, tumor differentiation, lymphovascular space invasion (LVSI), and histologic type were not associated with SLN mapping failure.</div></div><div><h3>Conclusions</h3><div>Larger tumor, older age, advanced FIGO stage, pelvic lymph node metastasis, and NACT are predictive factors for SLN mapping failure. These findings highlight the importance of preoperative assessment before SLN mapping.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 9","pages":"Article 110230"},"PeriodicalIF":3.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle-specific strength is an alternative to muscle mass and grip strength for predicting outcomes in patients with gastric cancer","authors":"Su-Lin Wang ,&nbsp;Chen-Bin Chen ,&nbsp;Yun-Shi Huang ,&nbsp;Xiao-Jiao Ruan ,&nbsp;Jun Cheng ,&nbsp;Xian Shen ,&nbsp;Qian-Tong Dong","doi":"10.1016/j.ejso.2025.110229","DOIUrl":"10.1016/j.ejso.2025.110229","url":null,"abstract":"<div><h3>Background</h3><div>Muscle-specific strength is a newly proposed indicator for assessing muscle quality. Its prognostic value in patients undergoing cancer surgery remains unclear. This study aims to evaluate the impact of low muscle-specific strength on short- and long-term outcomes in patients with resectable gastric cancer.</div></div><div><h3>Methods</h3><div>Patient data were prospectively collected from 2013 to 2019 for individuals diagnosed with gastric cancer. Muscle-specific strength was determined by calculating the ratio of grip strength to skeletal muscle area. Reference values for low muscle-specific strength were calculated using optimal stratification with X-tile software. Survival outcomes were analyzed using Kaplan-Meier survival curves and multivariate Cox proportional hazards models.</div></div><div><h3>Results</h3><div>A total of 1404 patients were included, comprising 1030 males (73.4 %) and 374 females (26.6 %) with a median age of 66 years. Low muscle-specific strength was identified as an independent risk factor for severe postoperative complications (OR = 2.026, 95 % CI = 1.115–3.684, <em>P</em> = 0.021) and overall survival (HR = 1.385, 95 % CI = 1.072–1.789, <em>P</em> = 0.013). In the subgroup analysis, low muscle-specific strength emerged as an independent risk factor for both postoperative severe complications (HR = 1.938, 95 % CI = 1.024–3.668, <em>P</em> = 0.042) and overall survival (HR = 1.359, 95 % CI = 1.017–1.816, <em>P</em> = 0.038) in males, but not in females. A combination of low muscle strength, low muscle-specific strength, and low muscle mass exhibited a better prognostic value for mortality risk than any two-factor combination or individual indicator.</div></div><div><h3>Conclusions</h3><div>Muscle-specific strength may serve as a reliable alternative to traditional sarcopenia criteria in predicting the prognosis of surgical oncology patients. The integration of multiple muscle-related indicators can further enhance risk stratification for adverse outcomes.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 9","pages":"Article 110229"},"PeriodicalIF":3.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate or delayed contralateral symmetrisation in therapeutic mammoplasty–A systematic review","authors":"Anabelle Permutt ,&nbsp;Ronak Patel ,&nbsp;Paul TR. Thiruchelvam ,&nbsp;Daniel R. Leff","doi":"10.1016/j.ejso.2025.110226","DOIUrl":"10.1016/j.ejso.2025.110226","url":null,"abstract":"<div><h3>Background</h3><div>For patients undergoing unilateral therapeutic mammoplasty for breast cancer, the timing of contralateral symmetrisation to achieve optimal outcomes is unclear. This review aims to evaluate studies examining outcomes following immediate or delayed symmetrisation.</div></div><div><h3>Methods</h3><div>A literature search of four databases (MEDLINE, EMBASE, Web of Science and Scopus) yielded 1077 papers. Thirty-five articles encompassing 2297 patients met the inclusion criteria for systematic review. The primary outcome was patient reported outcome measures (PROMs) and secondary outcomes included cosmesis, cost-effectiveness and complications.</div></div><div><h3>Results</h3><div>Two studies directly compared immediate and delayed contralateral symmetrisation, 17 studies focused only on immediate and six on delayed symmetrisation. PROMs were reported in 13 immediate symmetrisation studies describing high-levels of patient satisfaction (range of satisfaction with breasts = 68.6–81.5). Cosmesis was reported in 13 immediate and two delayed studies. Delayed symmetrisation was associated with inferior results (50 % described “unfair” outcomes in delayed studies vs. 89 % “fair”, “good” or excellent” cosmetic outcomes in immediate studies). Complications across 34 studies were similar regardless of whether symmetrisation was immediate or delayed. Cost-effectiveness was reported in one study and observed significantly greater costs associated with delayed procedures [median (range) costs: immediate = €4696 (€2724–6745); delayed = €9368 (€6982–11 646)].</div></div><div><h3>Conclusion</h3><div>High levels of patient satisfaction are reported with immediate symmetrisation, but comparisons with delayed mammoplasty is lacking. Patients receiving immediate symmetrisation report superior cosmesis and financial outcomes, with no additional increase in complications. Further research is required to directly compare PROMs and aesthetic outcomes of immediate and delayed symmetrisation.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 9","pages":"Article 110226"},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}