Ejso最新文献

{"title":"Salvage abdominoperineal resection for anal squamous cell carcinoma after radiotherapy or chemoradiotherapy: analysis of the French prospective cohort FFCD-ANABASE.","authors":"Clara Naessens, Cécile Evin, Karine Le-Malicot, Claire Lemanski, Magali Rouffiac, David Tougeron, Laurent Quero, Mounira El Demery, Ludovic Evesque, Laurent Alcaraz, Mathieu Minsat, Astrid Lièvre, Franck Drouet, Vincent Hautefeuille, Laurianne Plastaras, Elodie Menager-Tabourel, Nabil Baba-Hamed, Philippe Ronchin, Anne-Agathe Serre, Christophe Locher, Christelle De la Fouchardière, Florence Huguet, Véronique Vendrely","doi":"10.1016/j.ejso.2025.110346","DOIUrl":"10.1016/j.ejso.2025.110346","url":null,"abstract":"<p><strong>Introduction: </strong>Salvage abdominoperineal resection (APR) is indicated for local failure following definitive chemoradiotherapy or radiotherapy for squamous cell carcinoma (SCCA), at the cost of morbidity and reduced quality of life. This study evaluated outcomes after salvage APR.</p><p><strong>Materials and methods: </strong>The FFCD-ANABASE cohort is a prospective multicenter cohort including patients treated for non-metastatic SCCA in France between 2015 and 2020. Among the 1015 patients included in FFCD-ANABASE, 78 underwent salvage APR. After excluding patients with a pathological complete response (pT0N0), the final efficacy analysis cohort comprised 66 patients. We analyzed disease-free survival (DFS), overall survival (OS), locoregional and metastatic relapse rates, post-operative morbidity and prognostic factors in patients who underwent salvage APR for local failure.</p><p><strong>Results: </strong>With a median follow-up of 58.6 months after APR, the locoregional relapse rate was 21.2 % and the metastatic relapse rate was 9.1 %. An R0 resection was achieved in 80.8 % of cases. Five-year DFS and OS rates were 45.8 % [95 %CI: 33.3-57.4], and 50.2 % [95 %CI: 37.1-62.0]. In multivariate analysis, R0 margins (HR: 0.24 [95 %CI: 0.10-0.61]), and tumor size before chemoradiotherapy <4 cm (HR: 0.33 [95 %CI: 0.12-0.91]) were associated with better DFS; whereas no factor was significantly associated with OS. Post-operative morbidity was reported in 65 patients (83.3 %), with 34 of them (52.3 %) experiencing major complications, classified as Clavien-Dindo III-V.</p><p><strong>Conclusions: </strong>Salvage APR results in high post-operative morbidity and poor oncological outcomes. Our study found that complete resection margins was favorable prognostic factor, suggesting the need for additional perioperative treatment.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 10","pages":"110346"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IFC: Advert ESSO-KBCS Minimally Invasive Breast Surgery (MIBS) Masterclass and workshop","authors":"","doi":"10.1016/S0748-7983(25)00889-3","DOIUrl":"10.1016/S0748-7983(25)00889-3","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 10","pages":"Article 110461"},"PeriodicalIF":2.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advert 2025 BASO Annual Scientific Conference","authors":"","doi":"10.1016/j.ejso.2025.110488","DOIUrl":"10.1016/j.ejso.2025.110488","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 10","pages":"Article 110488"},"PeriodicalIF":2.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advert ESSO Course on Basics of Oncology for Surgeons","authors":"","doi":"10.1016/S0748-7983(25)00892-3","DOIUrl":"10.1016/S0748-7983(25)00892-3","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 10","pages":"Article 110464"},"PeriodicalIF":2.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advert ESSO Congress 2025","authors":"","doi":"10.1016/S0748-7983(25)00890-X","DOIUrl":"10.1016/S0748-7983(25)00890-X","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 10","pages":"Article 110462"},"PeriodicalIF":2.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast sensation following nipple-sparing mastectomy versus breast-conserving surgery: a mixed-methods study.","authors":"Josette Mouawad, James French, Farid Meybodi, Kirsty Stuart, Tim Wang, Jeremy Hsu, Elisabeth Elder","doi":"10.1016/j.ejso.2025.110477","DOIUrl":"https://doi.org/10.1016/j.ejso.2025.110477","url":null,"abstract":"<p><strong>Background: </strong>Nipple-sparing mastectomy (NSM) and breast-conserving surgery (BCS) allow for preservation of the breast or nipple-areolar complex (NAC). However, this does not guarantee retained sensation in these regions. The prevalence of altered post-operative sensation and its importance to patients remains unclear.</p><p><strong>Aims: </strong>This study aims to determine the prevalence of breast and NAC sensation loss in NSM and BCS; to assess its importance to patients; and to compare these outcomes between NSM and BCS.</p><p><strong>Methods: </strong>The BREAST-Q Sensation Module and four study-specific questions were sent to NSM or BCS patients at the Westmead Breast Cancer Institute. Comparisons were made between NSM versus BCS, implant-based versus tissue-based NSM reconstruction, BCS with versus without a formal mammaplasty, and treatment with radiotherapy versus without. Semi-structured interviews were also held.</p><p><strong>Results: </strong>78.8 % and 79.3 % of women experienced breast and/or NAC sensation change, respectively (n = 174). 69.9 % and 44.6 % of NSM patients retained varying levels of breast and NAC sensation, respectively (n = 83). 58.4 % and 60.5 % of BCS patients encountered breast and NAC sensation decrease, respectively (n = 91). Interviews (n = 34) showed that preserved sensation was sometimes of an altered quality and involved neuropathic symptoms. BREAST-Q Sensation scores were worse for NSM than for BCS. NSM reconstruction type did not impact outcomes. NSM patients with radiotherapy had worse BREAST-Q Symptoms scores than those without. BCS mammaplasty status did not influence outcomes, except for patient-reported NAC sensation. Sensation was important to 79.8 % of respondents. NAC sensation was more important to NSM than to BCS patients.</p><p><strong>Conclusion: </strong>Altered sensation is prevalent and significant to both NSM and BCS patients. Future research relating these findings to intraoperative techniques is required.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 12","pages":"110477"},"PeriodicalIF":2.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of extensive surgery in a multidisciplinary approach of parameningeal rhabdomyosarcoma in children, adolescent and young adult population","authors":"Olivier Airaudo ,&nbsp;Romain Luscan ,&nbsp;Jean-François Honart ,&nbsp;Sylvie Helfre ,&nbsp;Stéphanie Bolle ,&nbsp;Daniel Orbach ,&nbsp;Salma Moalla ,&nbsp;Kahina Belhous ,&nbsp;Philippe Drabent ,&nbsp;Hervé Brisse ,&nbsp;Pierre Khneisser ,&nbsp;Kevin Beccaria ,&nbsp;Stephane Temam ,&nbsp;Veronique Minard-Colin ,&nbsp;Vincent Couloigner ,&nbsp;Antoine Moya-Plana","doi":"10.1016/j.ejso.2025.110486","DOIUrl":"10.1016/j.ejso.2025.110486","url":null,"abstract":"<div><h3>Context and objectives</h3><div>Parameningeal (PM) site is a well-known unfavorable site for rhabdomyosarcoma (RMS). PM RMS are usually considered unresectable and treated by radiochemotherapy. This study reviews our experience with a multidisciplinary approach, including extensive surgery.</div></div><div><h3>Method</h3><div>We included all patients treated for PM RMS requiring extensive surgery from January 1992 to December 2021.</div></div><div><h3>Results</h3><div>Thirty-one patients were included with a median age of 6 years (range 6 months–17 years). The primary site was the infratemporal fossa in 81 %, nasopharynx in 13 %, and middle ear/paranasal sinus in one case each. At diagnosis, 23 % had lymph node involvement, and 13 % had distant metastases.</div><div>Twenty-six patients received neoadjuvant chemotherapy before extensive surgery, while five underwent extensive surgery after radiochemotherapy. Free flap reconstruction was needed for 71 % of patients. Adjuvant radiotherapy (median dose: 50 Gy) was performed in 24 patients, with a median delay of 7.5 weeks post-surgery (range 3-13 weeks).</div><div>Seven recurrences (23 %) were observed: four local relapses, two leptomeningeal spreads, and one distant metastasis. The median follow-up was 81 months (range 16-223 months). The median time to relapse was 12 months (range 6-36 months). Five-year event-free and overall survival rates were both 73.9 %, with a local failure-free survival of 85.7 %.</div></div><div><h3>Conclusion</h3><div>Our study suggests that incorporating extensive surgery in PM RMS treatment improves long-term local control and survival, even in advanced cases with unfavorable features.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 12","pages":"Article 110486"},"PeriodicalIF":2.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk comparison and assessment model of deep vein thrombosis in patients with pituitary adenomas after Surgery:A retrospective cohort study","authors":"Hongyu Wu,&nbsp;Yu Zhang,&nbsp;Xin Ma,&nbsp;Zenghua Mi,&nbsp;Zhijun Yang","doi":"10.1016/j.ejso.2025.110485","DOIUrl":"10.1016/j.ejso.2025.110485","url":null,"abstract":"<div><h3>Background</h3><div>Deep vein thrombosis (DVT), a major component of venous thromboembolism (VTE), is a common postoperative complication. Its occurrence after pituitary adenoma surgery is influenced by multiple factors.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed 1440 pituitary adenoma cases treated at Beijing Tiantan Hospital (2018–2023). The incidence of postoperative DVT was recorded, and logistic regression was used to identify associated risk factors. Differences across pituitary adenoma subtypes were compared. Additionally, Regression and machine learning models were developed to predict DVT.</div></div><div><h3>Results</h3><div>Among 397 patients who underwent postoperative lower limb ultrasound, 104 (7.2 %) developed DVT. Significant risk factors included advanced age, higher body mass index (BMI), intravenous cannulation, prolonged hospital stay, shorter preoperative activated partial thromboplastin time (APTT), longer thrombin time (TT), elevated platelet count, and higher postoperative D-dimer levels. Patients with Cushing's disease exhibited a significantly higher DVT incidence, potentially related to decreased pre- and postoperative APTT and PT/INR values. Conversely, patients with prolactin-secreting adenomas had a lower DVT incidence, possibly due to younger age and higher postoperative PT values. A support vector machine (SVM) model showed strong predictive performance (AUC: 0.82; accuracy: 86.08 %; specificity: 96.72 %).</div></div><div><h3>Conclusion</h3><div>DVT incidence varies by pituitary adenoma subtype. Machine learning enhances predictive models for postoperative DVT in pituitary adenoma patients.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 12","pages":"Article 110485"},"PeriodicalIF":2.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of extensive surgery in a multidisciplinary approach of parameningeal rhabdomyosarcoma in children, adolescent and young adult population","authors":"Olivier Airaudo ,&nbsp;Romain Luscan ,&nbsp;Jean-François Honart ,&nbsp;Sylvie Helfre ,&nbsp;Stéphanie Bolle ,&nbsp;Daniel Orbach ,&nbsp;Salma Moalla ,&nbsp;Kahina Belhous ,&nbsp;Philippe Drabent ,&nbsp;Hervé Brisse ,&nbsp;Pierre Khneisser ,&nbsp;Kevin Beccaria ,&nbsp;Stephane Temam ,&nbsp;Veronique Minard-Colin ,&nbsp;Vincent Couloigner ,&nbsp;Antoine Moya-Plana","doi":"10.1016/j.ejso.2025.110486","DOIUrl":"10.1016/j.ejso.2025.110486","url":null,"abstract":"<div><h3>Context and objectives</h3><div>Parameningeal (PM) site is a well-known unfavorable site for rhabdomyosarcoma (RMS). PM RMS are usually considered unresectable and treated by radiochemotherapy. This study reviews our experience with a multidisciplinary approach, including extensive surgery.</div></div><div><h3>Method</h3><div>We included all patients treated for PM RMS requiring extensive surgery from January 1992 to December 2021.</div></div><div><h3>Results</h3><div>Thirty-one patients were included with a median age of 6 years (range 6 months–17 years). The primary site was the infratemporal fossa in 81 %, nasopharynx in 13 %, and middle ear/paranasal sinus in one case each. At diagnosis, 23 % had lymph node involvement, and 13 % had distant metastases.</div><div>Twenty-six patients received neoadjuvant chemotherapy before extensive surgery, while five underwent extensive surgery after radiochemotherapy. Free flap reconstruction was needed for 71 % of patients. Adjuvant radiotherapy (median dose: 50 Gy) was performed in 24 patients, with a median delay of 7.5 weeks post-surgery (range 3-13 weeks).</div><div>Seven recurrences (23 %) were observed: four local relapses, two leptomeningeal spreads, and one distant metastasis. The median follow-up was 81 months (range 16-223 months). The median time to relapse was 12 months (range 6-36 months). Five-year event-free and overall survival rates were both 73.9 %, with a local failure-free survival of 85.7 %.</div></div><div><h3>Conclusion</h3><div>Our study suggests that incorporating extensive surgery in PM RMS treatment improves long-term local control and survival, even in advanced cases with unfavorable features.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 12","pages":"Article 110486"},"PeriodicalIF":2.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk comparison and assessment model of deep vein thrombosis in patients with pituitary adenomas after Surgery:A retrospective cohort study","authors":"Hongyu Wu,&nbsp;Yu Zhang,&nbsp;Xin Ma,&nbsp;Zenghua Mi,&nbsp;Zhijun Yang","doi":"10.1016/j.ejso.2025.110485","DOIUrl":"10.1016/j.ejso.2025.110485","url":null,"abstract":"<div><h3>Background</h3><div>Deep vein thrombosis (DVT), a major component of venous thromboembolism (VTE), is a common postoperative complication. Its occurrence after pituitary adenoma surgery is influenced by multiple factors.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed 1440 pituitary adenoma cases treated at Beijing Tiantan Hospital (2018–2023). The incidence of postoperative DVT was recorded, and logistic regression was used to identify associated risk factors. Differences across pituitary adenoma subtypes were compared. Additionally, Regression and machine learning models were developed to predict DVT.</div></div><div><h3>Results</h3><div>Among 397 patients who underwent postoperative lower limb ultrasound, 104 (7.2 %) developed DVT. Significant risk factors included advanced age, higher body mass index (BMI), intravenous cannulation, prolonged hospital stay, shorter preoperative activated partial thromboplastin time (APTT), longer thrombin time (TT), elevated platelet count, and higher postoperative D-dimer levels. Patients with Cushing's disease exhibited a significantly higher DVT incidence, potentially related to decreased pre- and postoperative APTT and PT/INR values. Conversely, patients with prolactin-secreting adenomas had a lower DVT incidence, possibly due to younger age and higher postoperative PT values. A support vector machine (SVM) model showed strong predictive performance (AUC: 0.82; accuracy: 86.08 %; specificity: 96.72 %).</div></div><div><h3>Conclusion</h3><div>DVT incidence varies by pituitary adenoma subtype. Machine learning enhances predictive models for postoperative DVT in pituitary adenoma patients.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 12","pages":"Article 110485"},"PeriodicalIF":2.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}