Ejso最新文献

{"title":"Perspectives of the medical oncologist regarding adjuvant chemotherapy for pancreatic cancer: An international expert survey and case vignette study.","authors":"N C Biesma, M U J E Graus, G A Cirkel, M G Besselink, J W B de Groot, B Groot Koerkamp, K H Herbschleb, M Los, R C Verdonk, J W Wilmink, A Cervantes, J W Valle, L B J Valkenburg-van Iersel, F E M Froeling, I Q Molenaar, L A Daamen, J de Vos-Geelen, H C van Santvoort","doi":"10.1016/j.ejso.2024.109544","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.109544","url":null,"abstract":"<p><strong>Introduction: </strong>Adjuvant chemotherapy improves survival in patients with resected pancreatic ductal adenocarcinoma (PDAC). The decision to initiate chemotherapy involves both patient and physician factors, decision-specific criteria, and contextual considerations. This study aimed to assess medical oncologists' views on adjuvant chemotherapy following pancreatic resection for PDAC.</p><p><strong>Methods: </strong>An online survey and case vignette study were distributed to medical oncologists via the Dutch Pancreatic Cancer Group (DPCG), International Hepato-Pancreato-Biliary Association (IHPBA) and related networks.</p><p><strong>Results: </strong>A total of 91 oncologists from 14 countries participated, 46 % of whom treated more than 40 new PDAC patients annually, with a median experience of 15 years. Significant discrepancies were noted in their recommendations for adjuvant chemotherapy across case vignettes. In patients over 70, 17 % advised against chemotherapy, while 31 % said age was not a factor. Oncologists with less than 10 years of experience and those in non-academic settings were less likely to recommend adjuvant therapy. While 87 % agreed mFOLFIRINOX is the preferred adjuvant treatment, consensus on individual cases was lacking. The recommended interval between surgery and chemotherapy ranged from 3 to 26 weeks, with varying reasons for withholding treatment, primarily due to postoperative recovery and performance status.</p><p><strong>Conclusions: </strong>Our study revealed substantial variation among oncologists in counseling on adjuvant chemotherapy after PDAC resection. This emphasizes the need for more patient involvement in decision-making and improving shared decision-making.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 3","pages":"109544"},"PeriodicalIF":3.5,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prime suspect or collective responsibility: Impact of specific lymph node station dissection on short- and long-term outcomes among locally advanced gastric cancer patients after neoadjuvant chemotherapy.","authors":"Katarzyna Sędłak, Marcin Kubiak, Zuzanna Pelc, Radosław Mlak, Sebastian Kobiałka, Magdalena Leśniewska, Katarzyna Mielniczek, Katarzyna Chawrylak, Andrew Gumbs, S Vincent Grasso, Timothy M Pawlik, Wojciech P Polkowski, Karol Rawicz-Pruszyński","doi":"10.1016/j.ejso.2024.109545","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.109545","url":null,"abstract":"<p><strong>Background: </strong>Lymphatic route is the main pathway for gastric cancer (GC) spread, and lymph node (LN) involvement is a major prognostic factor after curative resection. The aim of this study was to assess the outcomes of specific LN station dissection.</p><p><strong>Methods: </strong>Patients with locally advanced (cT2-4N0-3M0) GC who underwent multimodal treatment between 2013 and 2023 were included in the study. Patients who had not undergone gastrectomy, had early (cT1) or metastatic GC, who had undergone multiorgan resections, palliative care, had died before the end of curative-intent planned treatment, or had incomplete clinical or pathological information were excluded. The primary endpoint was the development of serious complications, and the secondary outcome was OS.</p><p><strong>Results: </strong>Mulivariable analysis revealed, that among patients who received neoadjuvant chemotherapy (NAC), it was observed that station 10 lymphadenectomy was associated with a higher risk of serious postoperative complications. (27.6 % vs 8.7 %; OR = 3.28) Among the no-NAC group, it was observed that station 13 lymphadenectomy was associated with a higher risk of serious postoperative complications. (57.1 % vs 13.2 %; OR = 6.96). Among the NAC group, a lower risk of death was observed in patients with station 8 (HR = 0.53) or 11 lymphadenectomy (HR = 0.53).</p><p><strong>Conclusion: </strong>While D2 lymphadenectomy remains crucial, particularly in in high-volume, experienced GC centers, the necessity of a more extensive D2+ lymphadenectomy is not supported by our findings. Moreover, we aimed to highlight the importance of tailored surgical approaches and emphasize the significance of LN station dissection in influencing both short-term complications and long-term survival outcomes.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 3","pages":"109545"},"PeriodicalIF":3.5,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in surgical pathology - Where do we stand, where do we go?","authors":"Chen Sagiv, Ofir Hadar, Abderrahman Najjar, Jens Pahnke","doi":"10.1016/j.ejso.2024.109541","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.109541","url":null,"abstract":"<p><p>Surgical and neuropathologists continuously search for new and disease-specific features, such as independent predictors of tumor prognosis or determinants of tumor entities and sub-entities. This is a task where artificial intelligence (AI)/machine learning (ML) systems could significantly contribute to help with tumor outcome prediction and the search for new diagnostic or treatment stratification biomarkers. AI systems are increasingly integrated into routine pathology workflows to improve accuracy, reproducibility, productivity and to reveal difficult-to-see features in complicated histological slides, including the quantification of important markers for tumor grading and staging. In this article, we review the infrastructure needed to facilitate digital and computational pathology. We address the barriers for its full deployment in the clinical setting and describe the use of AI in intraoperative or postoperative settings were frozen or formalin-fixed, paraffin-embedded materials are used. We also summarize quality assessment issues of slide digitization, new spatial biology approaches, and the determination of specific gene-expression from whole slide images. Finally, we highlight new innovative and future technologies, such as large language models, optical biopsies, and mass spectrometry imaging.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":" ","pages":"109541"},"PeriodicalIF":3.5,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning curve for robot-assisted Mckeown esophagectomy in patients with thoracic esophageal cancer.","authors":"Ligong Yuan, Tianci Zhang, Xianning Wu","doi":"10.1016/j.ejso.2024.109516","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.109516","url":null,"abstract":"<p><strong>Background: </strong>Robot-assisted minimally invasive esophagectomy (RAMIE) is an effective but technically demanding procedure. The learning curve of RAMIE has been studied to help guide training and to ensure its safe implementation.</p><p><strong>Methods: </strong>We retrospectively analyzed the first 83 consecutive patients with thoracic esophageal cancer who underwent robot-assisted minimally invasive Mckeown esophagectomy (RAMIE-MK) between May 2021 and August 2023, all performed by a single surgeon. A cumulative sum (CUSUM) analysis was applied to generate the learning curve of RAMIE-MK, based on total operation time.</p><p><strong>Results: </strong>The learning curve was divided into two phases based on the CUSUM analysis: Phase I, the initial learning phase (cases 1-27) and Phase II, the proficiency phase (cases 28-83). When comparing the proficiency phase with the initial phase, we observed a significant decreased trends in total operation time (329.6 ± 71.0 min vs 221.3 ± 33.5 min, P＜0.001). No significant differences were found in other clinicopathological characteristics.</p><p><strong>Conclusion: </strong>For a surgeon experienced in open and thoracolaparoscopic esophagectomy, and who also received systematic robot-assisted thoracic surgery training on animals, a total of 27 cases were required to gain technical proficiency in RAMIE-MK.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 3","pages":"109516"},"PeriodicalIF":3.5,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the perioperative risks in esophageal resection and reconstruction for esophageal carcinoma among elderly patients: A retrospective propensity score matching analysis.","authors":"Ji Yong Kim, Jae Kwang Yun, Hyeong Ryul Kim, Seung-Il Park, Yong-Hee Kim","doi":"10.1016/j.ejso.2024.109542","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.109542","url":null,"abstract":"<p><strong>Introduction: </strong>With the global aging, the number of elderly candidates for esophageal resection is increasing. However, studies on esophagectomy in elderly patients have yielded conflicting results, and individuals over 75 years old are frequently excluded from studies on esophageal cancer. This study aimed to analyze perioperative and survival outcomes post-esophagectomy in elderly patients using propensity score matching (PSM).</p><p><strong>Materials and methods: </strong>Patients with esophageal carcinoma who underwent esophagectomy (2006-2020) were studied. A 1:2 PSM was performed, with matching variables, including operational approach, type of operation, Charlson Comorbidity Index without age score, clinical stage, and treatment modality. Perioperative and survival outcomes were compared between the age groups.</p><p><strong>Results: </strong>After PSM, 91 elderly and 182 non-elderly patients were analyzed. The postoperative in-hospital mortality rate was identical for both groups at 1.1 %. The non-elderly group had a significantly higher 4-week discharge rate (91.8 % vs. 84.6 %, p = 0.032). There were no significant differences in overall postoperative complications (p = 0.886). Grade III-IV complications occurred in 16.5 % of elderly and 8.8 % of non-elderly patients, with no significant difference (p = 0.092). The 5-year overall survival rate was significantly lower in the elderly group (47.3 % vs. 69.8 %, p = 0.022), while the 5-year recurrence-free survival rate showed no significant difference (45.7 % vs. 63.6 %, p = 0.119).</p><p><strong>Conclusions: </strong>Elderly patients undergoing esophagectomy were similar to non-elderly patients in overall complications and in-hospital mortality. Despite a tendency for increased severity of complications and a significantly lower 4-week discharge rate, esophagectomy remains acceptable for elderly patients.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 3","pages":"109542"},"PeriodicalIF":3.5,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of intra-thoracic and intra-abdominal sentinel lymph nodes detected on lymphoscintigraphy in truncal melanoma patients.","authors":"Elan Novis, Ahmad Sulaiman, Jonathan Stretch, David Chung, Kevin London, Terence Wong, Serigne N Lo, Thomas E Pennington, Robyn P M Saw, Sydney Ch'ng, Kerwin F Shannon, Andrew J Spillane, Omgo E Nieweg, John F Thompson, Alexander C J van Akkooi, Michael Rtshiladze","doi":"10.1016/j.ejso.2024.109538","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.109538","url":null,"abstract":"<p><strong>Background: </strong>Although most melanomas drain to the more common major lymph node basins (axilla, groin, neck), rarely they drain to deep SLN locations such as intra-abdominal and intra-thoracic (including intercostal and internal mammary) sites, which pose a higher surgical risk and complexity for procurement. Our study is aimed at determining the rate of positivity and likelihood of recurrence in these nodal sites to guide management decisions for patients with truncal melanomas which drain to these 'deep' SLN locations.</p><p><strong>Methods: </strong>Retrospective data collected between May 2008 and May 2022 including all patients with truncal melanomas who underwent lymphoscintigraphy resulting in the identification of deep SLNs in intra-abdominal and intra-thoracic sites were included. The associations between retrieval of SLNs and recurrence-free survival (RFS) and overall survival (OS) were investigated.</p><p><strong>Results: </strong>74 patients with a total of 91 SLNs located at deep sites were included. 11 (15 %) patients with a total of 12 lymph nodes had SLNB of these deep nodes, all of which were intercostal nodes. Only 1 patient had a positive SLNB. In total, 24 (32 %) patients developed recurrence. However, the remaining patients did not recur at the deep SLN sites. There were no statistically significant associations between retrieval of deep SLNs and RFS or OS. 3-year RFS in the patients who had deep SLNB performed was 62 % compared to 54 % and 50 % in those who had no SLNB or incomplete SLNB, respectively (p = 0.63).</p><p><strong>Conclusion: </strong>In this study omitting procurement of these deep SLNs did not result in reduced RFS or OS.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 2","pages":"109538"},"PeriodicalIF":3.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment-sequencing before and after index hepatectomy with either synchronous or metachronous colorectal liver metastasis: Comparison of recurrence risk, repeat hepatectomy and overall survival in a population-derived cohort.","authors":"Torhild Veen, Arezo Kanani, Claudia Zaharia, Dordi Lea, Kjetil Søreide","doi":"10.1016/j.ejso.2024.109540","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.109540","url":null,"abstract":"<p><strong>Background: </strong>Treatment of colorectal cancer liver metastasis (CRLM) includes several options with impact on the patient journey and may depend on presentation and patient characteristics. The aim of the study was to investigate how treatment sequencing in index hepatectomy for synchronous or metachronous CRLM may potentially impact treatment pathways and oncological outcomes.</p><p><strong>Methods: </strong>An observational cohort study (ACROBATICC; NCT0176813) of patients having surgery for CRLM. Patient and tumour characteristics, treatment and recurrence patterns were recorded. Recurrence-free (RFS) and overall survival (OS) analyzed by Kaplan-Meier method (log-rank test).</p><p><strong>Results: </strong>The study included 132 patients, median age 67 yrs, 69 % men and 55 % had synchronous CRLM. Overall, 65 (50 %) received neoadjuvant chemotherapy, 45 (63 %) in synchronous and 20 (33 %) in metachronous CRLM (odds ratio, OR 0.30 95%CI 0.15-0.62; p < 0.001). Patient- and tumour characteristics did not differ except number of metastases (synchronous CRLM median 2 (range 1-4) vrs metachronous median 1 (1-2), respectively; p < 0.001). Some 99 (75 %) patients relapsed, 38 % had liver-recurrence. Repeat hepatectomy was performed in one-third, with equal rates between synchronous or metachronous CRLM. Median OS of all patients was 68 months, for a difference of 24 months between synchronous and metachronous CRLM (59 and 83 months, respectively; p = 0.334). RFS survival did not differ between groups.</p><p><strong>Conclusion: </strong>Pre-operative chemotherapy was given twice as often for patients with synchronous CRLM who also had more metastases and more frequently rectal primaries. Liver recurrence rates, repeat hepatecomy and overall survival was comparable between groups. Intrinsic cancer biology needs to be better investigated to provide better outcomes.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 2","pages":"109540"},"PeriodicalIF":3.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes after postponing surgery to optimise patients with acute right-sided obstructing colon cancer.","authors":"Elize W Lockhorst, Jeske R E Boeding, Lissa Wullaert, Robert R J Coebergh van den Braak, Arjen M Rijken, Cornelis Verhoef, Paul D Gobardhan, Jennifer M J Schreinemakers","doi":"10.1016/j.ejso.2024.109521","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.109521","url":null,"abstract":"<p><strong>Aim: </strong>To retrospectively analyse the short- and long-term oncological, morbidity and mortality outcomes in patients diagnosed with acute right-sided obstructing colon cancer. Patients who underwent pre-optimisation prior to the oncological resection were compared to patients who did not undergo pre-optimisation.</p><p><strong>Methods: </strong>All consecutive patients with right-sided obstructing colon cancer, either with a high clinical suspicion or confirmed diagnosis by histological analysis, who underwent curative-intent treatment between March 2013 and December 2020 were included. Patients were divided into two groups: an optimised group and a non-optimised group. Preoperative optimisation included additional nutrition, physiotherapy, and, if needed, bowel decompression. Data about disease-free survival and mortality were collected up to three years after surgery.</p><p><strong>Results: </strong>Sixty-two patients were included. Thirty patients underwent the optimisation protocol before postponed surgery, and 32 patients received emergency surgery, without optimisation (surgery performed with a median of 9.6 days versus 22 h after admission). The postoperative complication rate was significantly lower in the optimisation group (50 % vs 78 %, p = 0.033). No significant differences were found in the 90-day mortality rate (7 % vs 13 %, p = 0.672) and three-year overall survival rate (43 % vs 56 %, p = 0.49). After three years, sixteen (53 %) patients in the optimised group and twenty (63 %) in the non-optimised were deceased (p = 0.672).</p><p><strong>Conclusion: </strong>Postponing the surgery with preoperative optimisation in patients with obstructing right-sided colon cancer results in a significantly lower 90-day complication rate and suggests no negative effect on survival rates compared to an acute resection. Although, further research with a larger sample size is needed.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 2","pages":"109521"},"PeriodicalIF":3.5,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Factors associated with leakage after reversal of protective stoma in patients with locally advanced rectal cancer following curative resection and anastomosis\".","authors":"Youchang Sun, Sheng Li","doi":"10.1016/j.ejso.2024.109508","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.109508","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":" ","pages":"109508"},"PeriodicalIF":3.5,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which surrogate endpoint best predict survival in locally advanced gastric cancer patients undergoing neoadjuvant chemoimmunotherapy followed by surgery? A multicenter retrospective study.","authors":"Xiong Sun, Xuanfei Li, Shijun Zhao, Chengguo Li, Yao Lin, Qian Shen, Jianing Ding, Tianhao Li, Yuping Yin, Kaixiong Tao","doi":"10.1016/j.ejso.2024.109517","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.109517","url":null,"abstract":"<p><strong>Introduction: </strong>Recent clinical researches have reported that neoadjuvant chemoimmunotherapy (NCIT) significantly improve the pathological complete response (pCR) and major pathological response (MPR) rates. However, surrogate endpoints for survival remains controversy for locally advanced gastric cancer (LAGC) after NCIT.</p><p><strong>Methods: </strong>A retrospective analysis was performed on 84 patients with LAGC who had undergone NCIT following radical resection in three medical centers in China, between July 2020 and September 2023. Survival curves for event-free survival (EFS) and overall survival (OS) were estimated using the Kaplan-Meier method, and the log-rank test was used to compare survival outcomes. Univariate and multivariate analyses for prognostic factors were based on Cox regression analysis.</p><p><strong>Results: </strong>The rates of ypN0, pCR and MPR were 60.7 % (51/84), 26.2 % (22/84) and 39.3 %(33/84),respectively. Patients with ypN0 had better EFS and OS than those with ypN+ (all p < 0.05). Survival was equivalent between pCR and non-pCR group (all p > 0.05). while patients with MPR had better EFS than those with non-MPR (p = 0.028). Furthermore, a multivariate analysis revealed that the lymph nodes(LNs) status was an independent prognostic factor for the EFS (hazard ratio [HR] 5.533, 95 % confidence interval [CI] 1.186-25.804, p = 0.029) and OS (HR 5.116, 95 % CI 1.357-19.281, p = 0.016), but not pCR and MPR (all p > 0.05). Based on the status of pathologic LNs, ypN0 group showed lower depth of tumor invasion, and lower rate of perineural and vascular invasion (all p < 0.05).</p><p><strong>Conclusion: </strong>These findings demonstrated that ypN0 may be important as a surrogate of favorable clinical outcome in LAGC patients who received NCIT plus curative surgery.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 2","pages":"109517"},"PeriodicalIF":3.5,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}