Ejso最新文献

{"title":"A deep-learning model to predict the completeness of cytoreductive surgery in colorectal cancer with peritoneal metastasis☆","authors":"Qingfeng Lin ,&nbsp;Can Chen ,&nbsp;Kangshun Li ,&nbsp;Wuteng Cao ,&nbsp;Renjie Wang ,&nbsp;Alessandro Fichera ,&nbsp;Shuai Han ,&nbsp;Xiangjun Zou ,&nbsp;Tian Li ,&nbsp;Peiru Zou ,&nbsp;Hui Wang ,&nbsp;Zaisheng Ye ,&nbsp;Zixu Yuan ,&nbsp;Chinese Peritoneal Tumor Collaborative Group (CPTCG)","doi":"10.1016/j.ejso.2025.109760","DOIUrl":"10.1016/j.ejso.2025.109760","url":null,"abstract":"<div><h3>Background</h3><div>Colorectal cancer (CRC) with peritoneal metastasis (PM) is associated with poor prognosis. The Peritoneal Cancer Index (PCI) is used to evaluate the extent of PM and to select Cytoreductive Surgery (CRS). However, PCI score is not accurate to guide patient's selection for CRS.</div></div><div><h3>Objective</h3><div>We have developed a novel AI framework of decoupling feature alignment and fusion (DeAF) by deep learning to aid selection of PM patients and predict surgical completeness of CRS.</div></div><div><h3>Methods</h3><div>186 CRC patients with PM recruited from four tertiary hospitals were enrolled. In the training cohort, deep learning was used to train the DeAF model using Simsiam algorithms by contrast CT images and then fuse clinicopathological parameters to increase performance. The accuracy, sensitivity, specificity, and AUC by ROC were evaluated both in the internal validation cohort and three external cohorts.</div></div><div><h3>Results</h3><div>The DeAF model demonstrated a robust accuracy to predict the completeness of CRS with AUC of 0.9 (95 % CI: 0.793–1.000) in internal validation cohort. The model can guide selection of suitable patients and predict potential benefits from CRS. The high predictive performance in predicting CRS completeness were validated in three external cohorts with AUC values of 0.906(95 % CI: 0.812–1.000), 0.960(95 % CI: 0.885–1.000), and 0.933 (95 % CI: 0.791–1.000), respectively.</div></div><div><h3>Conclusion</h3><div>The novel DeAF framework can aid surgeons to select suitable PM patients for CRS and predict the completeness of CRS. The model can change surgical decision-making and provide potential benefits for PM patients.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 7","pages":"Article 109760"},"PeriodicalIF":3.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to comment on Indocyanine green highlights the lymphatic drainage pathways, enhancing the effectiveness of radical surgery for mid-low rectal cancer: A non-randomized controlled prospective study","authors":"Wenlong Qiu","doi":"10.1016/j.ejso.2025.109744","DOIUrl":"10.1016/j.ejso.2025.109744","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 7","pages":"Article 109744"},"PeriodicalIF":3.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Indocyanine green highlights the lymphatic drainage pathways, enhancing the effectiveness of radical surgery for mid-low rectal cancer: A non-randomized controlled prospective study","authors":"Dimitrios Kehagias ,&nbsp;Charalampos Lampropoulos ,&nbsp;Ioannis Kehagias","doi":"10.1016/j.ejso.2025.109743","DOIUrl":"10.1016/j.ejso.2025.109743","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 7","pages":"Article 109743"},"PeriodicalIF":3.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a simulator for oncoplastic breast conserving surgery","authors":"Laith O.K. Alghazawi ,&nbsp;Stella Mavroveli ,&nbsp;Eleni Anastasiou ,&nbsp;Mohamed Attia ,&nbsp;Natalie Johnson ,&nbsp;Daniel Campioni-Norman ,&nbsp;Dimitri Amiras ,&nbsp;Andreas Ladas ,&nbsp;Michael R. Boland ,&nbsp;George Hanna ,&nbsp;Paul TR. Thiruchelvam ,&nbsp;Daniel R. Leff","doi":"10.1016/j.ejso.2025.109753","DOIUrl":"10.1016/j.ejso.2025.109753","url":null,"abstract":"<div><h3>Background</h3><div>Therapeutic Mammoplasty (TM) is increasingly becoming the standard of care, especially for patients with large tumor-to-breast volume ratios. The wider dissemination of oncoplastic skills warrants systems for the acquisition and assessment of safe skills. To date, TM simulations have not been developed for the acquisition or assessment of oncoplastic skills. This study aimed to design, develop, and validate a synthetic TM simulator for specialist surgical training and assessment.</div></div><div><h3>Methods</h3><div>A prospective, observational, and survey-based study. Breast surgeons collaborated with designers to construct a TM simulator. A modified Delphi approach was used to create a Competency Assessment Tool (CAT). Surgeons with varying operative experience performed simulated vertical scar TM. Procedures were videotaped (blinded, pseudo-anonymized), subsequently reviewed, and independently rated against CAT by three experts. Specimen radiographs and volumetric analysis were performed to assess specimen weight(g), volume(cm³), and adequacy of resection, derived as a percentage of deviation in uniformity around a 10 mm margin.</div></div><div><h3>Results</h3><div>Thirty participants were recruited (10 consultants, 10 senior registrars (ST7-8), and 10 junior registrars (ST3-6)). Video-based rating scores (0-40) were significantly greater in consultants (median(IQR) = 34.0(30.5–38.0)) than in senior registrars (median(IQR) = 30.0(28.0–33.0)) and junior registrars (median(IQR) = 28.0(25.8–30.3)). The CAT scores varied significantly based on operator grade (p &lt; 0.05). The inter-rater reliability showed fair agreement (κ = 0.379). Specimens resected by consultants had significantly greater weight and volume (p &lt; 0.05). The consultants demonstrated the greatest uniformity in resection accuracy (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>A novel oncoplastic simulator was developed to practice and assess TM skills. Video-based ratings and end-product assessments differentiated experts from novice surgeons, suggesting construct validity.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 7","pages":"Article 109753"},"PeriodicalIF":3.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The LyBra score: A risk assessment tool to address targeted prevention against breast cancer – Related lymphedema","authors":"Donato Casella ,&nbsp;Nicola Rocco ,&nbsp;Silvia Sordi ,&nbsp;Giuseppe Catanuto ,&nbsp;Antonio Toesca ,&nbsp;Luca Sanvitale ,&nbsp;Michele Barbiero ,&nbsp;Laura Bergamasco ,&nbsp;Diego Ribuffo ,&nbsp;Pietro Maria Ferrando ,&nbsp;Juste Kaciulyte","doi":"10.1016/j.ejso.2025.109754","DOIUrl":"10.1016/j.ejso.2025.109754","url":null,"abstract":"<div><h3>Introduction</h3><div>Nowadays, physicians have tools to prevent breast cancer-related lymphedema (BCRL) but there is no consensus on when to apply them. The authors analysed patient- and treatment-related risk factors to create the LyBra score, to identify patients that may benefit the most from BCRL preventive interventions.</div></div><div><h3>Materials and methods</h3><div>Patients were selected from cases of breast cancer treated from January 2019 to July 2022. Inclusion criteria were age above 18, breast cancer diagnosis and surgical treatment with lymph-node biopsy or axillary dissection. Recurrent cancers, inflammatory cancer, previous axillary surgery, bilateral cases and patients with primary lymphedema were excluded. Selected cases were assessed with the LyBra Score. Numerosity and distribution of expected BCRL were compared to the BCRL registered during the minimum follow-up of 2 years.</div></div><div><h3>Results</h3><div>During an average 41 months follow-up (range, 24–62), 131 cases (14 %) of BCRL were registered in the total 933 patients included in the study. According to LyBra score, expected BCRL cases were 149 (16 %), slightly higher but with no statistical significance. The major incidence of BCRL (40 cases in 47 patients) was registered in the high-risk group that included 5 % of the study population. A ROC curve was used to determine the diagnostic performance of the LyBra score and the AUC was 0.78 corresponding to a good discriminating ability.</div></div><div><h3>Conclusion</h3><div>By sorting patients into risk groups, the LyBra score offers a solution to the actual dilemma of timing and indication of the modern preventive-BCRL microsurgeries.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 7","pages":"Article 109754"},"PeriodicalIF":3.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia is a negative prognostic factor in localized extremities/trunk wall soft tissue sarcomas","authors":"Tiziana Robba ,&nbsp;Vito Chianca ,&nbsp;Martina Rabino ,&nbsp;Edoardo Cesaro ,&nbsp;Francesca Molea ,&nbsp;Antonella Boglione ,&nbsp;Gian Luca Desi ,&nbsp;Pietro Pellegrino ,&nbsp;Michele Boffano ,&nbsp;Simone De Meo ,&nbsp;Alessandra Merlini ,&nbsp;Federica Santoro ,&nbsp;Alessandra Linari ,&nbsp;Mario Levis ,&nbsp;Sergio Sandrucci ,&nbsp;Alessandro Comandone ,&nbsp;Giovanni Grignani ,&nbsp;Raimondo Piana ,&nbsp;Lorenzo D'Ambrosio","doi":"10.1016/j.ejso.2025.109746","DOIUrl":"10.1016/j.ejso.2025.109746","url":null,"abstract":"<div><h3>Objective</h3><div>Sarcopenia is an emerging determinant of oncologic patients’ prognosis, but few data are available in extremities and trunk wall soft tissue sarcomas (ESTS). The aim was to evaluate sarcopenia impact on outcomes of patients affected by ESTS.</div></div><div><h3>Methods</h3><div>Through SliceOMatic software we selected cross-sectional skeletal muscle area (SMA), subcutaneous fat area (SFA) and visceral fat area (VFA) on a basal CT-slice at level of the third lumbar vertebra. Muscle density (MD) was computed in Hounsfield units (HU).</div><div>Skeletal mass index (SMI, cm²/m²) was computed by normalizing SMA for the square of patient's height. Cut-offs for SMI were 52 and 39 cm²/m² for men and women, respectively, while we used median values for MD, SFA and VFA. We explored the correlation of the different parameters with post-surgical complications and survival outcomes (Kaplan-Meier method).</div></div><div><h3>Results</h3><div>268 patients were included. Median SMAs, SMIs and MD were 155.7 cm², 51.2 cm²/m², and 33.8 HU for men, 91.4 cm², 39.2 cm²/m², and 30.4 HU for women. Sarcopenia rate was not significantly higher in patients ≥65 years nor according to baseline prognostic factors (Sarculator app). Overall survival (OS) was significantly worse for sarcopenic patients: median OS 111.7 months (95%CI 72.8–150.6) vs not reached (NR; HR = 1.55, 95%CI:1.00–2.41, p = 0.049) for low-vs high-SMI; median OS 79.6 months (38.6–120.6) vs NR (HR 2.11, 1.34–3.34, p = 0.001) for low-vs high-MD, respectively. Sarcopenic patients showed increased post-surgical complications (30.5 % vs 17.0 %, p = 0.073).</div></div><div><h3>Conclusion</h3><div>Although retrospective, our study suggests to further explore sarcopenia as a negative prognostic factor in ESTS patients.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 7","pages":"Article 109746"},"PeriodicalIF":3.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The survival and prognostic factors of head and neck cancer patients over the age of 80 in comparison to their younger counterparts: Cohort study","authors":"Adrien Masseron ,&nbsp;Demah AlAyadhi ,&nbsp;Jacques Blanc ,&nbsp;Carine Fuchsmann ,&nbsp;Ariane Lapierre ,&nbsp;Philippe Ceruse ,&nbsp;Pierre Philouze","doi":"10.1016/j.ejso.2025.109755","DOIUrl":"10.1016/j.ejso.2025.109755","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to compare the overall survival and prognostic factors of patients ≥80 years old with those of patients aged 70–79 years who were diagnosed with head and neck squamous cell carcinoma.</div></div><div><h3>Materials and methods</h3><div>A retrospective study was conducted between 2013 and 2021. Patients were divided into two groups: group-1, aged ≥80 years, and group-2, aged between 70 and 79 years; all patients were diagnosed with squamous cell carcinoma of the head and neck and treated with curative intent.</div></div><div><h3>Results</h3><div>A total of 346 patients were included, and 162 were aged older than 80 years. There was no difference in overall survival between the two groups, with a median of 39 months (95 % CI: 24–47) for those aged &gt;80 years and 41 months (95 % CI: 31–67) for those aged 70–79 years. The same finding was observed for recurrence-free survival, with a median of 33 months (95 % CI 21–45) for patients in group-1and 34 months (95 % CI 29–39) for patients in group-2. Stratified analyses revealed a poorer prognosis for patients with locally advanced disease and combined treatment with surgery and radiotherapy for overall survival. A locally advanced stage was the only factor impacting recurrence-free survival. Furthermore, age was not considered a prognostic factor for overall or recurrence-free survival. On the other hand, the PS score, ASA score, and G8 score were significant factors.</div></div><div><h3>Conclusion</h3><div>This study revealed that advanced age was not an independent risk factor for survival and should not justify suboptimal treatment for elderly patients aged 80 years or older. Certain scores, such as the PS and G8 score, appear to be more reliable prognostic factors for oncological outcomes after treatment.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 7","pages":"Article 109755"},"PeriodicalIF":3.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and distribution of neck node metastases in hereditary vs. sporadic medullary thyroid cancer at basal calcitonin serum levels ≤100 pg/ml: 30-year experience","authors":"Andreas Machens ,&nbsp;Kerstin Lorenz ,&nbsp;Frank Weber ,&nbsp;Henning Dralle","doi":"10.1016/j.ejso.2025.109756","DOIUrl":"10.1016/j.ejso.2025.109756","url":null,"abstract":"<div><h3>Background</h3><div>The frequency and distribution of neck node metastases are ill-defined for the growing subset of patients with hereditary and sporadic medullary thyroid cancer (MTC) who present with preoperative basal calcitonin serum levels ≤100 pg/ml.</div></div><div><h3>Methods</h3><div>This study, evaluating 30-year data from a tertiary surgical center, aimed to provide that information.</div></div><div><h3>Results</h3><div>Included were 256 previously untreated patients with basal calcitonin levels ≤100 pg/ml: 125 patients with hereditary MTC, 9 (7.2 %) of whom harbored node metastases; and 131 patients with sporadic MTC, 17 (13.0 %) of whom revealed node metastases (<em>P</em> = 0.150).</div><div>With basal calcitonin levels ≤40 pg/ml, node metastases were less frequent (5 % [5 of 97 patients] for hereditary MTC; 9 % [6 of 69 patients] for sporadic MTC) than above that mark (14 % [4 of 28 patients] for hereditary MTC; and 18 % [11 of 62 patients] for sporadic MTC).</div><div>Node metastases limited to the ipsilateral lateral neck, sparing the central neck, were found in 2 (22 %) of 9 node-positive patients with hereditary MTC and 5 (29 %) of 17 node-positive patients with sporadic MTC.</div><div>The lowest basal calcitonin levels associated with nodal disease were 15.7 pg/ml in a 24-year-old male non-index patient with hereditary MTC, and 14.1 pg/ml and 14.3 pg/ml in two 46- and 68-year-old female patients with sporadic MTC.</div></div><div><h3>Conclusion</h3><div>Central node dissection at the time of thyroidectomy may be beneficial in experienced hands at increased basal calcitonin levels ≤100 pg/ml. When preoperatively increased calcitonin levels persist after central neck dissection, exploration of the ipsilateral lateral neck may be worthwhile.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 7","pages":"Article 109756"},"PeriodicalIF":3.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SLYMEC II study: Overall survival analysis of the impact of LVSI in apparent early stage endometrioid endometrial cancer","authors":"Jessica Mauro ,&nbsp;Michael Mueller ,&nbsp;Emanuele Perrone ,&nbsp;Valentina Bruno ,&nbsp;Stefano Restaino ,&nbsp;Elena De Ponti ,&nbsp;Sara Imboden ,&nbsp;Virginia Garcia-Pineda ,&nbsp;Salih Taskin ,&nbsp;Tommaso Grassi ,&nbsp;Franziska Siegenthaler ,&nbsp;Jvan Casarin ,&nbsp;Diego Raimondo ,&nbsp;Vito Andrea Capozzi ,&nbsp;Dogan Vatansever ,&nbsp;Ilaria Capasso ,&nbsp;Enrico Vizza ,&nbsp;Mete Gungor ,&nbsp;Ignacio Zapardiel ,&nbsp;Andrea Papadia ,&nbsp;Alessandro Buda","doi":"10.1016/j.ejso.2025.109750","DOIUrl":"10.1016/j.ejso.2025.109750","url":null,"abstract":"<div><div>In our initial report of the SLYMEC study we published the results evaluated the prognostic impact of substantial lymphovascular space invasion (LVSI) on the sentinel lymph node status and the impact of the different types of LVSI on 3-year disease-free survival.</div><div>The aim of the SLYMEC II study was to assess the impact of focal and substantial lymphovascular space invasion on 5-years overall survival in the subgroup of patients with endometrioid endometrial cancer. A total of 2030 patients were included in the analysis from the original data set. Focal LVSI were identified in 131 patients (6.4 %), whereas 319 patients (15.7 %) showed substantial LVSI at final pathology. Among 1876 patients who underwent minimally invasive surgery (92.6 %), 442 patents (21.8 %) underwent robotic assisted surgery, whereas and 150 patients (7.6 %) patients underwent open surgery. Rate of overall survival at 5 years was 83.6 % versus 100 % for substantial and focal LVSI groups, respectively (HR for death = 2.1 [95 % CI, 1.4 to 3.2]; P &lt; 0.0001). Patients with endometrioid endometrial cancer having substantial LVSI after surgery showed an increased risk of death in the after 5-years overall survival when compared to patients with negative, or focal LVSI. The presence of positive LVSI in patients with positive sentinel nodes showed a trend toward reduced 5-year overall survival compared to SLN-negative patients, although it did not reach statistical significance.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 7","pages":"Article 109750"},"PeriodicalIF":3.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colorectal liver metastasis resection results in excellent long-term quality of life and low symptom burden","authors":"Nazim Bhimani ,&nbsp;Mbathio Dieng ,&nbsp;Patrick J. Kelly ,&nbsp;Thomas J. Hugh","doi":"10.1016/j.ejso.2025.109751","DOIUrl":"10.1016/j.ejso.2025.109751","url":null,"abstract":"<div><h3>Introduction</h3><div>Prognostic factors in patients who undergo liver resection for colorectal liver metastases (CRLM) have been investigated, but limited research exists on health-related quality of life (HRQoL), functional status, and ongoing symptoms. This study aimed to assess the long-term HRQoL of life and examine the factors associated with HRQoL, functional status, and ongoing symptoms.</div></div><div><h3>Materials and methods</h3><div>This was a cross-sectional study of patients who had curative resection between 2010 and June 2021. Patients completed the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 (a generic questionnaire) and QLQ-LMC21 (CRLM-specific) questionnaires.</div></div><div><h3>Results</h3><div>In total, 121 patients underwent liver resection, of which 85 were alive. There was a 61 % response rate (n = 52). The median postoperative time when the survey was completed was 4.0 years (1–13.1). Overall, most patients were doing well, with a median global HRQoL score of 83 and scores &gt;80 in all domains. Most symptoms were assigned a median score of “0”. There were no clinical factors that significantly impacted HRQoL and only trivial differences in relation to physical symptoms.</div></div><div><h3>Conclusion</h3><div>This study demonstrates excellent long-term HRQoL and functional status in patients who undergo liver resection for CRLM and have long-term survival.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 7","pages":"Article 109751"},"PeriodicalIF":3.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}