Ejso最新文献

{"title":"Construction of nomogram prognostic model for gastric signet ring cell carcinoma: Signet ring cell proportion influencing prognosis","authors":"Wannian Sui ,&nbsp;Peifeng Chen ,&nbsp;Zhangming Chen,&nbsp;Wenxiu Han","doi":"10.1016/j.ejso.2025.110012","DOIUrl":"10.1016/j.ejso.2025.110012","url":null,"abstract":"<div><h3>Background</h3><div>Signet ring cell (SRC) carcinoma significantly impacts the prognosis of gastric cancer (GC) patients, yet the influence of SRC proportion is often overlooked. This study aims to clarify the relationship between SRC proportion and prognosis and to construct a prognostic prediction model for gastric cancer patients with SRC components (GSRCC).</div></div><div><h3>Methods</h3><div>Clinical data from 628 GSRCC patients who underwent gastrectomy at the First Affiliated Hospital of Anhui Medical University from November 2011 to December 2018 were collected. Patients were randomly divided into a training set (442 patients) and a validation set (186 patients). Prognostic risk factors were identified in the training set, and a nomogram prediction model was established. The internal and external validation were conducted on the training and validation sets.</div></div><div><h3>Results</h3><div>The SRC proportion (hazard ratio [HR]: 9.569, <em>P</em> &lt; 0.001), depth of invasion (HR: 6.838, <em>P</em> = 0.001), tumor size (HR: 1.573, <em>P</em> = 0.044), and N stage (HR: 6.511, <em>P</em> &lt; 0.001) were independent prognostic factors for GSRCC. The nomogram showed excellent performance in predicting 1-year, 3-year, and 5-year overall survival (OS) with AUC values of 0.819, 0.832, and 0.874 in the training set, and of 0.815, 0.847, and 0.876 in the validation set, respectively. Calibration curves indicated good agreement between predicted and actual survival rates.</div></div><div><h3>Conclusions</h3><div>The SRC proportion influences the prognosis of GSRCC patients. The establishment of the prognostic prediction model will provide assistance for clinical decision-making and prognosis assessment.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 8","pages":"Article 110012"},"PeriodicalIF":3.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment outcomes for human papillomavirus negative oropharyngeal cancer: A meta-analysis","authors":"Smriti Panda ,&nbsp;Kurinchi S. Gurusamy ,&nbsp;Alok Thakar ,&nbsp;Sandipta Mitra ,&nbsp;Raghav Dwivedi ,&nbsp;Francesca Angela Chiumenti","doi":"10.1016/j.ejso.2025.110005","DOIUrl":"10.1016/j.ejso.2025.110005","url":null,"abstract":"<div><h3>Background</h3><div>Current treatment guidelines for HPV-negative oropharyngeal squamous cell carcinoma (OPSCC), the predominant form of OPSCC in Asia, are largely extrapolated from the evidence available from HPV-associated OPSCC due to a paucity in the literature in terms of the best treatment option for these cancers.</div></div><div><h3>Methods</h3><div>Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library), MEDLINE, EMBASE and clinical trial registries were searched from January 01, 2009 to June 20, 2023 for studies comparing at least two interventions [randomized (RCT)and non-randomized] performed as primary curative treatment in HPV-negative OPSCC. Random effects model was used for the meta-analysis.</div></div><div><h3>Results</h3><div>Forty-seven studies could be included (randomized controlled trials: 12, 1230 participants; non-randomized cohort studies: 35, 44253 participants). The largest comparison in the non-randomized studies was between upfront surgery and non-surgical intervention [RT/concurrent chemoradiation (CRT)] with 24 studies. The outcomes in the former for overall survival (HR:0.63, 95 %C.I: 0.56, 0.71) and disease-free survival (HR:0.48, 95 %C.I: 0.30, 0.76) were found to be superior (risk of bias: “high” or “serious”). Due to the lack of reporting of treatment-related toxicity and health-related quality of life, meta-analysis could not be performed for these outcomes.</div></div><div><h3>Conclusion</h3><div>and Relevance: Upfront surgery showed superior outcomes in terms of OS and DFS compared with non-surgical modalities in HPV-negative OPSCC, but the observed differences may be due to confounding bias. Toxicity and quality of life reporting was sparse.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 8","pages":"Article 110005"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical strategy and outcomes of penoscrotal Paget's disease: A large retrospective cohort study in a Chinese tertiary center","authors":"Xiang Wan ,&nbsp;Dachao Zheng ,&nbsp;Dajun Gao ,&nbsp;Minkai Xie,&nbsp;Jianshu Ni,&nbsp;Bin Xu,&nbsp;Haijun Yao","doi":"10.1016/j.ejso.2025.110004","DOIUrl":"10.1016/j.ejso.2025.110004","url":null,"abstract":"<div><h3>Background</h3><div>Penoscrotal Paget's disease (PPD) is a rare malignant skin tumor, and consensus on reconstruction, treatment strategies, and prognosis remains elusive. We aimed to elucidate the clinical features, surgical outcomes, and prognosis, proposing a tailored Perineal Reconstruction (PR) strategy.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study using pathologically confirmed 233 PPD cases from a large tertiary hospital pathology registry between May 2004 and February 2021. Clinical features, surgical treatment patterns, sexual function, and prognosis were analyzed. Kaplan-Meier analysis, univariate and multivariate Cox regression were performed to identify prognostic factors.</div></div><div><h3>Results</h3><div>PR strategy-based reconstruction was applied on all postsurgical defects. Kaplan-Meier analysis indicated worse disease free-survival (DFS) in the high-PR score (≥4) group compared to the low-PR score (≤3) group. Age, tumor thickness, and lymph node invasion emerged as independent predictors of overall survival (OS).</div></div><div><h3>Conclusions</h3><div>Early evaluation and intervention are crucial to prevent vertical and lymph node invasion. Wide local excision provides low recurrence, high overall survival rates, and acceptable sexual function. The PR strategy serves as a promising approach to assess lesions, guide reconstruction, and predict prognosis, potentially improving treatment and management of this rare malignancy.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 8","pages":"Article 110004"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of parathyroid autotransplantation during total thyroidectomy and functional recovery post-operation: A retrospective study","authors":"Guannan Ge ,&nbsp;Ying Lu ,&nbsp;Hua Huang ,&nbsp;Zifeng Kuang ,&nbsp;Hao Zhao ,&nbsp;Yue Cao ,&nbsp;Yu Xia ,&nbsp;Xiaoyi Li","doi":"10.1016/j.ejso.2025.110007","DOIUrl":"10.1016/j.ejso.2025.110007","url":null,"abstract":"<div><h3>Introduction</h3><div>Thyroid carcinoma is the most common endocrine malignancy, with total thyroidectomy being a standard treatment. However, this procedure carries a risk of hypoparathyroidism. Parathyroid autotransplantation (PAT) is recommended to prevent postoperative hypoparathyroidism, though its effectiveness and the recovery of parathyroid function remain poorly understood.</div></div><div><h3>Methods</h3><div>A retrospective study was conducted on patients who underwent total thyroidectomy with four-gland PAT at Peking Union Medical College Hospital between April 2012 and February 2024. Exclusion criteria included postoperative serum calcium levels &gt;2.11 mmol/L without supplementation within 48 h and inadequate follow-up. Preoperative and postoperative serum calcium and parathyroid hormone (PTH) levels were analysed at multiple time points to assess parathyroid function recovery and the effectiveness of PAT. Patients were divided into an immediate transplantation group and a non-immediate transplantation group based on the timing of parathyroid gland transplantation. Serum calcium levels were compared between the groups at various time points.</div></div><div><h3>Results</h3><div>This study included 142 patients. Compared with preoperative levels, the mean of serum calcium and PTH levels significantly decreased at 24 h, 48 h and 1week postoperatively. From 1 month post-surgery serum calcium and PTH levels showed no significant difference compared with preoperative levels. The immediate transplantation group had higher serum calcium levels within the first month compared to the non-immediate group, but no significant difference was observed at later time points. Permanent hypoparathyroidism occurred in 1.4 % (2/142) of patients.</div></div><div><h3>Conclusion</h3><div>PAT is effectively restores and maintains parathyroid function following total thyroidectomy. Functional recovery begins 1 week post-PAT and is complete in 1 month with stable function thereafter. Minimising in vitro parathyroid gland manipulation and performing PAT immediately can enhance early recovery of parathyroid function.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 7","pages":"Article 110007"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nodal status in major salivary gland cancer: External validation of a novel N- classification","authors":"Davide Lombardi ,&nbsp;Michele Tomasoni ,&nbsp;Francesco Missale ,&nbsp;Ludwig E. Smeele ,&nbsp;Charlotte Van Lierde ,&nbsp;Matthieu Van Eecke ,&nbsp;Raul Pellini ,&nbsp;Francesco Mazzola ,&nbsp;Marco Ravanelli ,&nbsp;Davide Farina ,&nbsp;Jonathan Clark ,&nbsp;Tsui-Hui (Hubert) Low ,&nbsp;Ruta Gupta ,&nbsp;Jason C. Fleming ,&nbsp;Randa Ghazal-Asswad ,&nbsp;Laura Locati ,&nbsp;Marta Filauro ,&nbsp;Giorgio Peretti ,&nbsp;Snehal Patel ,&nbsp;Laura Gagliardini ,&nbsp;Cesare Piazza","doi":"10.1016/j.ejso.2025.110006","DOIUrl":"10.1016/j.ejso.2025.110006","url":null,"abstract":"<div><h3>Background</h3><div>Nodal status has been considered an important prognosticator when dealing with MSGC. Since current TNM N-categories do not accurately stratify patients, alternative nodal staging systems have been advocated. Our group has previously proposed 3 novel N-classification models according to number of metastatic nodes, largest diameter of metastatic nodes, and a combination of these two parameters.</div></div><div><h3>Aim of the study</h3><div>Through an external validation in a new multicentric cohort, the present study aims to confirm the superiority of the previously proposed models over the 8th TNM and to assess which of the models is the most reliable.</div></div><div><h3>Material and methods</h3><div>The 3 novel N-classification systems were applied to the validation dataset. Significance of observed differences between primary and validation datasets was assessed using Fisher, chi-squared, and Mann-Whitney tests. Oncological outcomes were overall survival (OS) and recurrence free survival (RFS). Survival estimates were obtained through Kaplan-Meier method. The significance of observed differences in survival and hazard ratios (HRs) according to the levels of each N-classification system was estimated through log-rank test and Cox proportional hazard model, respectively.</div></div><div><h3>Results</h3><div>N-classification considering number of metastatic nodes showed the best prognostic stratification, with significant differences among pN0, pN1 (number of NM &lt; 4), and pN2 (number of NM ≥ 4) for both survival outcomes. This model confirmed to be superior to current TNM N-categories.</div></div><div><h3>Conclusions</h3><div>In patients with MSGC, overall number of involved lymph nodes is the most important prognostic factor, providing a more accurate risk stratification than that obtained using the current TNM classification.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 8","pages":"Article 110006"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Long-term outcome for neoadjuvant versus adjuvant chemotherapy in early breast cancer and the prognostic impact of nodal therapy response: A population-based study”","authors":"Wei Zhang","doi":"10.1016/j.ejso.2025.110002","DOIUrl":"10.1016/j.ejso.2025.110002","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 8","pages":"Article 110002"},"PeriodicalIF":3.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surveillance frequency in resected esophageal cancer: Towards personalization of follow-up","authors":"Jarlath C. Bolger ,&nbsp;Karren Xiao ,&nbsp;Ivan Ristic ,&nbsp;Gail E. Darling ,&nbsp;Elliot Wakeam ,&nbsp;Jonathan C. Yeung","doi":"10.1016/j.ejso.2025.110001","DOIUrl":"10.1016/j.ejso.2025.110001","url":null,"abstract":"<div><h3>Introduction</h3><div>In spite of advances in curative management of esophageal cancer, a significant proportion of patients have early recurrence following resection. The role of CT-guided surveillance remains undefined. This study aims to determine if follow-up can be personalised, to allow detection of clinically relevant recurrence, while reducing low-yield surveillance for patients.</div></div><div><h3>Methods</h3><div>A retrospective review was conducted encompassing patients undergoing esophagectomy with curative intent from 1st March 2018–31st May 2022. Routine 3-monthly CT scanning was conducted for 2 years, followed by 6-monthly surveillance for 1 year, and annual surveillance to 5 years. Disease characteristics, time to recurrence and time to death were recorded and interrogated to determine their impact on recurrence and personalization of surveillance.</div></div><div><h3>Results</h3><div>In total, 190 patients underwent surveillance. Seventy-one (37 %) developed recurrence, with most in the first two years. Those who recurred were younger (63 vs 67, <em>p</em> &lt; 0.001), had higher pathologic staging (<em>p</em> &lt; 0.001), higher tumour regression grade (<em>p</em> = 0.005), higher lymph node ratio (<em>p</em> &lt; 0.001) and high-risk histology (<em>p</em> &lt; 0.001). Most recurrences detected were asymptomatic (94 %). A personalised surveillance score was devised. With strict criteria, 12 % of patients could be excluded from surveillance without compromising detection of asymptomatic recurrence. By broadening criteria, a larger portion of patients could avoid imaging, with a small number of asymptomatic recurrences missed. This would require significant balancing of the risk-benefit ratio for individuals.</div></div><div><h3>Conclusion</h3><div>Intensive surveillance post-resection of esophageal cancer will detect most recurrences while asymptomatic, potentially facilitating intervention. In select patients, routine surveillance could be excluded without compromising oncologic or patient outcomes.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 7","pages":"Article 110001"},"PeriodicalIF":3.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined peritoneal and liver metastases in colorectal cancer: A Dutch nationwide population-based analysis of incidence, treatment and survival","authors":"Eline H.E. van Gansewinkel ,&nbsp;Teun B.M. van den Heuvel ,&nbsp;Felice N. van Erning ,&nbsp;Ignace H.J.T. De Hingh ,&nbsp;Stefan A.W. Bouwense ,&nbsp;Geert A. Simkens","doi":"10.1016/j.ejso.2025.109999","DOIUrl":"10.1016/j.ejso.2025.109999","url":null,"abstract":"<div><h3>Introduction</h3><div>The aim of this study was to determine the incidence, treatment patterns, survival and factors associated with curative treatment in colorectal cancer patients with combined liver and peritoneal metastases using Dutch population-based data.</div></div><div><h3>Materials and methods</h3><div>Data from the Netherlands Cancer Registry were used. All patients diagnosed with synchronous isolated peritoneal and liver metastasized colorectal adenocarcinoma between January 1, 2015 and December 31, 2021 were included. Multivariable regression analyses were performed to identify factors associated with receiving curative treatment. Survival rates were calculated for patients undergoing palliative and curative treatment separately.</div></div><div><h3>Results</h3><div>Of 14627 patients with colorectal adenocarcinoma in the study period, 927 patients (6.3 %) had isolated liver and peritoneal metastases and were evaluated in this study. Mean age was 66.9 years, non-mucinous and non-signet-ring cell adenocarcinomas were most prevalent (89.0 %) and tumors were mostly located in the colon (92.1 %). Patients were treated with best supportive care (n = 254, 27,4 %), palliative treatment (n = 618, 66,7 %) or curative treatment (n = 55, 5,9 %). Median OS was 1.5 months, 11.3 months, and 32.6 months, respectively. Multivariable analysis showed that younger age (OR 0.95, p &lt; 0.001) and up to 3 liver metastases (OR 0.13, p &lt; 0.001) are positively associated with receiving curative treatment.</div></div><div><h3>Conclusion</h3><div>This population-based study provides a comprehensive overview of the incidence and treatment of patients with synchronous colorectal liver and peritoneal metastases. It shows that in a highly selected group of patients, curative treatment is associated with better overall survival.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 7","pages":"Article 109999"},"PeriodicalIF":3.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical resection for small (≤2 cm) gastric gastrointestinal stromal tumor","authors":"Siyu Tan,&nbsp;Guowang Yang","doi":"10.1016/j.ejso.2025.109998","DOIUrl":"10.1016/j.ejso.2025.109998","url":null,"abstract":"<div><h3>Background</h3><div>It is unclear whether surgical excision is the best course of treatment for small gastric gastrointestinal stromal tumor (GIST) ≤2 cm. The aim of this study was to evaluate the long-term survival results of surgical and non-surgical treatment for small gastric GIST.</div></div><div><h3>Methods</h3><div>Between 2000 and 2021, patients with small gastric GIST were chosen from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was used to mitigate selection bias in the comparison process. Kaplan-Meier analysis and multivariate Cox model were used to assess the effects of demographic and clinical characteristics on overall survival (OS) and cancer-specific survival (CSS).</div></div><div><h3>Results</h3><div>A total of 1229 patients with gastric GIST (≤2 cm) were included, including 1004 (81.69 %) patients who underwent operative management and 225 (18.31 %) who received non-operative management. The 5-year OS and CSS rates were compared between the two groups before PSM [5-year OS (83.51 % vs. 79.53 %, P &lt; 0.001), 5-year CSS (96.96 % vs. 91.81 %, P = 0.017)]; after PSM [5-year OS (82.79 % vs. 80.00 %, P = 0.039), and 5-year CSS (94.88 % vs. 94.42 %, P = 0.398)]. Furthermore, after correcting for covariates, operative management was associated with a significant improvement in OS (HR = 0.62, 95 % CI 0.40–0.97, P = 0.037), while no significant effect on CSS was observed (HR = 0.85, 95 % CI 0.43–1.70, P = 0.643).</div></div><div><h3>Conclusions</h3><div>Our analysis demonstrated a statistically significant association between operative management and improved OS for small gastric GIST (≤2 cm).</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 7","pages":"Article 109998"},"PeriodicalIF":3.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and survival of rare female genital tract cancers in Europe: The EUROCARE-6 study.","authors":"Gemma Gatta, Jean Calleja-Agius, Sergio Sandrucci, Miriam Azzopardi, Riccardo Capocaccia, M Hackl","doi":"10.1016/j.ejso.2025.109996","DOIUrl":"https://doi.org/10.1016/j.ejso.2025.109996","url":null,"abstract":"<p><p>Cancers of female genital tract (FGTC) account in Europe for 14 % of all female malignancies, and many of them are rare. FGTC epidemiological indicators are usually reported by anatomical site, but they are a heterogeneous group of diseases in terms of morphological characteristics and clinical management. We show incidence and survival population-based estimates and time trends in the European population for FGTC, defined combining topography and morphology codes. We analyzed data of females aged 15 years or more diagnosed with 25 FGTC of which 23 rare. Data were provided by 100 European population-based cancer registries to the EUROCARE-6 project. Incidence was estimated for the period of diagnosis 2001-2013 in terms of both crude and age-adjusted rates. Observed and relative survival was estimated with the complete approach for the period of diagnosis 2008-2013 and with the period approach for trends, considering years of follow-up from 2001 to 2014. Over a total of 793,715 considered diagnoses of FGTC, 279,667 were classified as rare entities. Their crude incidence rate per 100,000 largely varied from almost zero for adenoid cystic carcinoma of corpus uteri to 5.9 for squamous cell carcinoma of cervix uteri. During the period 2001-13, a significant increment was reported for clear cell adenocarcinoma, Mullerian mixed tumor and serous/papillary carcinoma of corpus uteri, for the Mullerian mixed tumor, adenocarcinoma of fallopian tube, and primary peritoneal serous/papillary carcinoma, and malignant/immature teratoma of ovary. Incidence rates significantly reduced for squamous cell carcinoma of cervix uteri, mucinous adenocarcinoma and sex cord tumor of ovary. Five-year relative survival was >84 % for all the non-epithelial tumors of ovary and for choriocarcinoma of placenta. Survival under 40 % was estimated for Mullerian mixed tumors and undifferentiated carcinomas of all the considered sites. Major survival improvements were observed for placenta choriocarcinoma, sex cord tumor, malignant/immature teratoma and mucinous adenocarcinoma of ovary, in adenocarcinoma of fallopian tube and in serous/papillary carcinoma of corpus uteri. Relative survival significantly reduced in squamous cell carcinoma of corpus uteri. The increasing incidence and survival of many rare FGTC can be in part attributed to better diagnostic ability and to a better organisation of care of patients with rare tumors. The epidemiological indicators here provided can be taken as a starting point to evaluate the effectiveness of the future activities of the European Rare Cancers Networks.</p>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":" ","pages":"109996"},"PeriodicalIF":3.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}