IF 3.5 2区医学

Ejso Pub Date : 2025-03-01 DOI: 10.1016/j.ejso.2024.108776

Hanzala Ahmed Farooqi, Hamza Bin Ahmed, Rayyan Nabi

引用次数: 0

Surgical outcomes and morbidity in open and videoendoscopic inguinal lymphadenectomy in vulvar cancer: A systematic review and metanalysis” 外阴癌开放式和视频内窥镜腹股沟淋巴结切除术的手术效果和发病率：系统回顾和荟萃分析"。

IF 3.5 2区医学

Ejso Pub Date : 2025-03-01 DOI: 10.1016/j.ejso.2024.108744

Mariano Catello Di Donna , Giuseppe Cucinella , Vincenzo Giallombardo , Giuseppina Lo Balbo , Vito Andrea Capozzi , Giulio Sozzi , Natalina Buono , Letizia Borsellino , Andrea Giannini , Antonio Simone Laganà , Giovanni Scambia , Vito Chiantera

{"title":"Surgical outcomes and morbidity in open and videoendoscopic inguinal lymphadenectomy in vulvar cancer: A systematic review and metanalysis”","authors":"Mariano Catello Di Donna , Giuseppe Cucinella , Vincenzo Giallombardo , Giuseppina Lo Balbo , Vito Andrea Capozzi , Giulio Sozzi , Natalina Buono , Letizia Borsellino , Andrea Giannini , Antonio Simone Laganà , Giovanni Scambia , Vito Chiantera","doi":"10.1016/j.ejso.2024.108744","DOIUrl":"10.1016/j.ejso.2024.108744","url":null,"abstract":"<div><h3>Introduction</h3><div>Surgical evaluation of inguinal lymph nodes is essential to correctly guide the adjuvant treatment of vulvar cancer patients. Open inguinal lymphadenectomy (OIL) approach is the preferred route, while the videoendoscopic inguinal lymphadenectomy (VEIL) seems to be associated with better results. This meta-analysis aimed to compare the surgical outcomes of OIL vs VEIL in vulvar cancer.</div></div><div><h3>Methods</h3><div>The meta-analysis was conducted according to the PRISMA guideline. The search string included the following keywords: “(vulvar cancer) AND ((inguinal) OR (femoral)) AND ((lymph node dissection) OR (lymphadenectomy))”. Three double-blind researchers independently extracted data.</div></div><div><h3>Results</h3><div>Seventeen studies were considered eligible for the analysis. Seven studies were included in the OIL group and ten studies in the VEIL group. A total of 372 groins were included in OIL group and 197 groins in VEIL group. 153 groins (41.1 %) in the OIL group and 25 groins (12.6 %) in the VEIL group developed major complications. The analysis of all lymphatic and wound complications showed that VEIL had a lower rate of lymphatic and wound complications. Estimated blood loss (p = 0.4), hospital stay (p = 0.18), time of drainage (p = 0.74), number of lymph node excised (p = 0.74) did not show significant difference between the two approaches.</div></div><div><h3>Conclusions</h3><div>VEIL route may be a valid alternative to OIL route with no differences in terms of surgical outcomes, except for operative time that is shorter for OIL. Future analysis of randomized controlled trials in this specific patient population are warranted to confirm these results.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 3","pages":"Article 108744"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Appendiceal adenocarcinoma-patterns of tumor spread and prognosis 阑尾腺癌--肿瘤扩散模式和预后。

IF 3.5 2区医学

Ejso Pub Date : 2025-03-01 DOI: 10.1016/j.ejso.2024.108755

D. Madonia , P. Cashin , W. Graf , L. Ghanipour

{"title":"Appendiceal adenocarcinoma-patterns of tumor spread and prognosis","authors":"D. Madonia , P. Cashin , W. Graf , L. Ghanipour","doi":"10.1016/j.ejso.2024.108755","DOIUrl":"10.1016/j.ejso.2024.108755","url":null,"abstract":"<div><h3>Introduction</h3><div>Appendiceal adenocarcinoma represents a diagnostic and therapeutic challenge since it is prone to early lymphatic and peritoneal spread. We aimed to analyze the proportion of lymph node metastases in completion right hemicolectomy specimens, risk factors for peritoneal metastases (PM), and prognosis after definitive treatment.</div></div><div><h3>Methods</h3><div>Ninety-three patients with appendiceal adenocarcinoma scheduled for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) in Uppsala 2004–2020 were identified from a prospectively maintained registry. Risk factors for PM were assessed based on the presence (CT + group, n = 55) or absence (CT – group, n = 37) of visible PM at baseline CT scan. Prognostic factors were analyzed based on the actual presence (PM group, n = 66) or absence (no PM group, n = 27) of PM.</div></div><div><h3>Results</h3><div>The median age was 60 (26–78). Forty-eight patients were women. Resection of PM at initial surgery indicated an 80 % risk of finding PM at a follow-up exploration. R1 appendectomy and perforated appendix had a similar risk for PM (24 %,26 %) which increased to 38 % if both were present.</div><div>Regional lymph node metastases occurred in 31 % in the CT + group vs. 14 % in the CT − group (p = 0.005) and was associated with poor survival HR 5.16 (1.49–17.81).</div><div>The 5-year OS and DFS rates were 54 % and 29 % in the PM group.</div></div><div><h3>Conclusions</h3><div>Patients with certain risk factors have a high likelihood of PM despite a normal CT scan, which justifies selective exploration at a HIPEC center. Regional lymph node spread supports the current practice of completion right hemicolectomy and is a significant prognostic factor.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 3","pages":"Article 108755"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142516356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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IF 3.5 2区医学

Ejso Pub Date : 2025-03-01 DOI: 10.1016/S0748-7983(25)00095-2

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IF 3.5 2区医学

Ejso Pub Date : 2025-03-01 DOI: 10.1016/S0748-7983(25)00089-7

引用次数: 0

The impact of preoperative skeletal muscle mass index-defined sarcopenia on postoperative complications and survival in gastric cancer: An updated meta-analysis 术前骨骼肌质量指数定义的肌肉减少症对胃癌术后并发症和生存的影响：一项最新的荟萃分析。

IF 3.5 2区医学

Ejso Pub Date : 2025-03-01 DOI: 10.1016/j.ejso.2024.109569

Chengcong Liu , Yueping Li , Yongjing Xu , Hong Hou

{"title":"The impact of preoperative skeletal muscle mass index-defined sarcopenia on postoperative complications and survival in gastric cancer: An updated meta-analysis","authors":"Chengcong Liu , Yueping Li , Yongjing Xu , Hong Hou","doi":"10.1016/j.ejso.2024.109569","DOIUrl":"10.1016/j.ejso.2024.109569","url":null,"abstract":"<div><h3>Background</h3><div>The impact of preoperative sarcopenia on postoperative outcomes in gastric cancer remains debated. This study aims to perform an in-depth meta-analysis and comprehensive review of the relationship between preoperative sarcopenia, as assessed by the Skeletal Muscle Mass Index (SMI), and postoperative complications and survival metrics in gastric cancer patients, to offer new insights into this issue.</div></div><div><h3>Methods</h3><div>We conducted a systematic search of primary studies in databases such as Embase, PubMed, and Web of Science, up to July 2024. Our analysis focused on comparing postoperative readmission and mortality rates, overall and severe complication rates, incidence of specific complications, as well as overall survival (OS) and disease-free survival (DFS) between groups with and without preoperative sarcopenia.</div></div><div><h3>Results</h3><div>Our review included 42 studies with a total of 11,981 patients. Findings revealed that patients with sarcopenia had significantly higher rates of overall postoperative complications, severe complications, mortality, and readmissions compared to those without sarcopenia (all P < 0.001). A detailed examination showed that sarcopenic patients had notably higher incidences of pulmonary complications, bowel obstruction, and pancreatic fistulas. Additionally, the OS (P < 0.001) and DFS (P = 0.003) rates were considerably lower in the sarcopenia group.</div></div><div><h3>Conclusions</h3><div>Preoperative sarcopenia is associated with an increased risk of postoperative complications and poorer survival outcomes in gastric cancer patients. Given these associations, it is recommended to incorporate routine screening for sarcopenia using SMI before surgery, where feasible, to enhance patient risk assessment and customize treatment approaches.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"51 3","pages":"Article 109569"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgery vs. non-surgery for liver metastases from primary breast cancer 原发性乳腺癌肝转移的手术与非手术治疗。

IF 3.5 2区医学

Ejso Pub Date : 2025-03-01 DOI: 10.1016/j.ejso.2024.108445

Wei Han , Chun-tao Shi , Hao-nan Wang

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IF 3.5 2区医学

Ejso Pub Date : 2025-03-01 DOI: 10.1016/S0748-7983(25)00087-3

引用次数: 0

Reply to: Surgery vs. non-surgery for liver metastases from primary breast cancer 回复：原发性乳腺癌肝转移的手术与非手术治疗。

IF 3.5 2区医学