Early human development最新文献

{"title":"Characteristics and special challenges of neonatal emergency transports","authors":"S. Schumacher ,&nbsp;B. Mitzlaff ,&nbsp;C. Mohrmann ,&nbsp;K.M. Fiedler ,&nbsp;A. Heep ,&nbsp;F. Beske ,&nbsp;F. Hoffmann ,&nbsp;M. Lange","doi":"10.1016/j.earlhumdev.2024.106012","DOIUrl":"https://doi.org/10.1016/j.earlhumdev.2024.106012","url":null,"abstract":"<div><h3>Background</h3><p>As a rule, newborns do not require special medical care. If unexpected complications occur peripartum or postpartum, support from and transport to specialised neonatal hospitals might be needed.</p></div><div><h3>Methods</h3><p>In a retrospective study, all transport protocols of a supraregional paediatric‑neonatological maximum care hospital in northwestern Germany from 01.10.2018 through 30.09.2021 were analysed. The particular focus was on transports of newborns (&lt;7 days) and the leading symptoms that led to contact.</p></div><div><h3>Results</h3><p>A total of 299 patients were included (average age of 15.4 h, 61.6 % males). The average complete transport time was approximately 2 h. Five leading neonatal diseases (respiratory, infectious, asphyxia, cardiac, haematological) were found to represent the causes of &gt;80 % of transfers. Respiratory adaptation disorders are the main reason for transferring a newborn to a centre, whereas asphyxia is the most severe condition. The various symptoms differ in their time of onset, a factor which must be taken into account in practice. Differences were also found between different types of hospitals: while a large proportion of transports were carried out from maternity hospitals (80.6 %), children transported from children's hospitals were generally more severely ill.</p></div><div><h3>Discussion</h3><p>Transfers of neonates, especially from maternity hospitals to neonatal intensive care units due to special neonatal diseases, are not rare. In times of increasingly scarce resources, the effective care of sick or at-risk neonates is essential. For low-population regions, this means professional cooperation between maximum care providers and smaller children's hospitals and maternity-only hospitals.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"192 ","pages":"Article 106012"},"PeriodicalIF":2.5,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140621758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of music played to new birth mothers on postpartum blues: A randomized controlled trial","authors":"Burcu KÜÇÜKKAYA ,&nbsp;Işıl CAN ,&nbsp;Gamze GÜLER","doi":"10.1016/j.earlhumdev.2024.106013","DOIUrl":"https://doi.org/10.1016/j.earlhumdev.2024.106013","url":null,"abstract":"<div><h3>Background</h3><p>Postpartum blues/postpartum maternal blues is a psychological disorder experienced by mothers with symptoms of postpartum sadness, easy crying, easy anxiety, sensitivity, indecisiveness. The study aimed to examine the effect of music played on newly delivered mothers on postpartum blues.</p></div><div><h3>Methods</h3><p>A prospective, two-arm, randomized controlled study was conducted on <em>n</em> = 82 (41 = control, 41 = music group) mothers who gave birth at term in Trakya University Health Research and Application Center Maternity Service between May and December 2023. The research data were collected through the Personal Information Form, Stein Blues Scale (SBS), and Edinburgh Postpartum Depression Scale (EPDS). The scales used in the study were evaluated four times: postoperative 0–3 h, 12th, 24th, and 36th hours.</p></div><div><h3>Results</h3><p>The postoperative 0–3 h SBS test median of the new mothers in the music group was 19.00, and the 36th hours test median was 2.00, while the postoperative 0–3 h SBS test median of the control group was 21.00, and the 36th hour test median was 13.00. The postoperative 0–3 h EPDS test median of the new mothers in the music group was 22.00, and the 36th hours test median was 0.00, while the postoperative 0–3 h EPDS test median of the control group was 26.00, and the 36th hours test median was 10.00. A significant difference was found in the 12th, 24th, and 36th hours (<em>p</em> &lt; .001). A statistically significant high positive correlation was found between EPDS and SBS in the 12th, 24th, and 36th hours (<em>p</em> &lt; .001).</p></div><div><h3>Conclusions</h3><p>In the study, it was found that music played to newly delivered mothers reduced postpartum blues and depression levels.</p></div><div><h3>Registration</h3><p>The submission date for a clinical trial protocol is prior to completing participant recruitment and for a systematic review, prior to completing full paper screening. NCT06252155</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"192 ","pages":"Article 106013"},"PeriodicalIF":2.5,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140638741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breastfeeding patterns in one-year-old children was not affected by a breastfeeding support intervention","authors":"Eva-Lotta Funkquist,&nbsp;Paola Oras","doi":"10.1016/j.earlhumdev.2024.106011","DOIUrl":"10.1016/j.earlhumdev.2024.106011","url":null,"abstract":"<div><h3>Background</h3><p>Breastfeeding patterns in 12-month-old children play a central role in the mother-infant dyad, but studies describing the patterns are scarce.</p></div><div><h3>Aim</h3><p>To investigate breastfeeding patterns in 12-month-old infants before and after a breastfeeding support programme.</p></div><div><h3>Study design</h3><p>A baseline/intervention design as part of a larger implementation project aiming to revive the Ten Steps to Successful Breastfeeding programme.</p></div><div><h3>Subjects</h3><p>During a 24-h period, 28 mothers from a baseline group and 24 mothers from an intervention group recorded all breastfeeding sessions on a pen and paper form.</p></div><div><h3>Results</h3><p>The median (range) frequency of breastfeeding sessions was 6 (1−22) in the baseline group and 7 (1−20) times per 24 h in the intervention group. No significant difference was observed in frequencies between the two groups. The majority of children (57 % in the baseline group and 62 % in the intervention group) exhibited a pattern classified as partial breastfeeding, engaging in breastfeeding 6 or more times per 24 h throughout a substantial part of the day. A second pattern was classified as token breastfeeding, with few breastfeeding sessions, suggesting that breastfeeding occurred primarily for comfort.</p></div><div><h3>Conclusion</h3><p>This study illuminates the breastfeeding behaviours of 12-month-old children and can serve to normalise frequent breastfeeding patterns, potentially aiding mothers who wish to continue breastfeeding beyond infancy. The findings indicate no difference between the groups, suggesting that the implemented intervention did not influence maternal breastfeeding practices at one year of age. This underscores the potential necessity for prolonged support for parents throughout the breastfeeding period.</p><p>ISRCTN registry: <span>doi.org/10.1186/ISRCTN91972905</span><svg><path></path></svg>.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"192 ","pages":"Article 106011"},"PeriodicalIF":2.5,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S037837822400080X/pdfft?md5=45b1233326f11c8e04e7e7cd08731a10&pid=1-s2.0-S037837822400080X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140616069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of prenatal maternal distress on offspring brain development: A systematic review","authors":"Sophie Mandl ,&nbsp;Johanna Alexopoulos ,&nbsp;Stephan Doering ,&nbsp;Brigitte Wildner ,&nbsp;Rainer Seidl ,&nbsp;Lisa Bartha-Doering","doi":"10.1016/j.earlhumdev.2024.106009","DOIUrl":"10.1016/j.earlhumdev.2024.106009","url":null,"abstract":"<div><h3>Background</h3><p>Prenatal maternal distress can negatively affect pregnancy outcomes, yet its impact on the offspring's brain structure and function remains unclear. This systematic review summarizes the available literature on the relationship between prenatal maternal distress and brain development in fetuses and infants up to 12 months of age.</p></div><div><h3>Methods</h3><p>We searched Central, Embase, MEDLINE, PsycINFO, and PSYNDEXplus for studies published between database inception and December 2023. Studies were included if prenatal maternal anxiety, stress, and/or depression was assessed, neuroimaging was used to examine the offspring, and the offspring's brain was imaged within the first year of life. The quality of the included studies was evaluated using the Quality Assessment of Diagnostic Accuracy Studies-II.</p></div><div><h3>Results</h3><p>Out of the 1516 studies retrieved, 71 met our inclusion criteria. Although the studies varied greatly in their methodology, the results generally pointed to structural and functional aberrations in the limbic system, prefrontal cortex, and insula in fetuses and infants prenatally exposed to maternal distress.</p></div><div><h3>Conclusions</h3><p>The hippocampus, amygdala, and prefrontal cortex have a high density of glucocorticoid receptors, which play a key role in adapting to stressors and maintaining stress-related homeostasis. We thus conclude that in utero exposure to maternal distress prompts these brain regions to adapt by undergoing structural and functional changes, with the consequence that these alterations increase the risk for developing a neuropsychiatric illness later on. Future research should investigate the effect of providing psychological support for pregnant women on the offspring's early brain development.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"192 ","pages":"Article 106009"},"PeriodicalIF":2.5,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0378378224000781/pdfft?md5=51b0dbe736d38d088284c066bc00b50a&pid=1-s2.0-S0378378224000781-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140616075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of proprioceptive neuromuscular facilitation on functional skills, muscle strength, and trunk control in children with cerebral palsy: A randomized controlled trial","authors":"Hatice Adiguzel ,&nbsp;Zekiye Ipek Katirci Kirmaci ,&nbsp;Mehmet Gogremis ,&nbsp;Yusuf Sinasi Kirmaci ,&nbsp;Cengiz Dilber ,&nbsp;Deniz Tuncel Berktas","doi":"10.1016/j.earlhumdev.2024.106010","DOIUrl":"https://doi.org/10.1016/j.earlhumdev.2024.106010","url":null,"abstract":"<div><h3>Background</h3><p>Proprioceptive neuromuscular facilitation (PNF) is generally used for the lower limbs in children with Cerebral Palsy (CP). This study aimed to determine the effect of PNF and Neurodevelopmental Therapy (NDT) on functional abilities, muscle strength, and trunk control in children with CP.</p></div><div><h3>Methods</h3><p>Thirty spastic CP children classified as either level I–II in the Gross Motor Function Classification System (GMFCS) or level I–II in the Manual Ability Classification System (MACS) were included. The PNF (<em>n</em> = 15) and the NDT group (n = 15) had physiotherapy for six weeks. The ABILHAND-Kids scale, the Purdue Pegboard Test (PBPT), the Nine-Hole Peg Test (9-HPT), and the Jebson-Taylor Hand Function Test (JTHFT) were employed. Pinch meters, Jamar handheld dynamometers, and digital muscular strength assessments were used.</p></div><div><h3>Results</h3><p>The PNF group increased shoulder flexion (<em>p</em> &lt; 0.05), adduction (p &lt; 0.05), elevation (p &lt; 0.05), scapular abduction (<em>p</em> &lt; 0.05), elbow extension (right) (<em>p</em> &lt; 0.05), grip (p &lt; 0.05), and pinch strengths (left p &lt; 0.05, right p &lt; 0.05). The PNF group had significantly lower 9-HPT (p &lt; 0.05), JTHFT (card turning), JTHFT (simulated feeding), JTHFT (lifting light cans), and JTHFT (lifting weight cans) durations (<em>p</em> &lt; 0.05), and significantly higher PBPT (right-left) PBPT (bimanual), PBPT (assembly).</p><p>(p &lt; 0.05), ABILHAND (p &lt; 0.05), and TCMS total scores (<em>p</em> &lt; 0.001). While JTHFT (simulated feeding-left), JTHFT (stacking checkers-left), JTHFT (lifting light cans-left), and JTHFT (lifting weight cans-right/left) (p &lt; 0.05) durations decreased in the NDT group, PBPT (right) (p &lt; 0.05) had an increase in duration.</p></div><div><h3>Conclusion</h3><p>PNF improves trunk control, upper extremity functional skills, selective proximal muscle strength, and distal upper extremity muscle and grip strength.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"192 ","pages":"Article 106010"},"PeriodicalIF":2.5,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140638849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability of the Motor Optimality Score Revised (MOS-R) in medically complex infants","authors":"Colleen Peyton ,&nbsp;David Aaby ,&nbsp;Ryan Millman ,&nbsp;Sarah Rodriguez ,&nbsp;Lynn Boswell ,&nbsp;Deborah Gaebler-Spira ,&nbsp;Raye-Ann de Regnier ,&nbsp;Vanessa Maziero Barbosa ,&nbsp;Theresa Sukal-Moulton","doi":"10.1016/j.earlhumdev.2024.106008","DOIUrl":"https://doi.org/10.1016/j.earlhumdev.2024.106008","url":null,"abstract":"<div><h3>Background</h3><p>The Motor Optimality Score-Revised (MOS-R) is a clinical test of infant spontaneous movement at 3–5 months of age and has been associated with neurodevelopmental outcomes in infants with medical complexity. However the stability of the MOS-R tested at different developmental ages is not yet known.</p></div><div><h3>Aim</h3><p>To determine if the repeated scoring of the MOS-R remained consistent when tested at two developmental ages in young infants.</p></div><div><h3>Study design</h3><p>In this prospective cohort study, infants were tested twice with the MOS-R between 12 and 13 weeks corrected age (CA) and 14–16 weeks CA. Bland Altman Plots were used to calculate agreement between the scores. Infants were grouped as having higher or lower medical complexity. MOS-R threshold scores were analyzed to assess changes over time within each group using Fisher's exact test.</p></div><div><h3>Subjects</h3><p>85 infants with history of hospitalization in a neonatal intensive care unit (NICU).</p></div><div><h3>Results</h3><p>The MOS-R scores had a high agreement with negligible bias (0.058) between timepoints (95 % CI -1.10, 1.22). Using a MOS-R cut point of 19, infants with higher medical complexity were more likely to change groups between timepoints than infants with lower medical complexity (<em>p</em> = 0.008), but this was not significantly different using cut points of 20 or 21.</p></div><div><h3>Conclusion</h3><p>The MOS-R scores were stable when measured repeatedly in infants who were hospitalized in a NICU. Infants with high medical complexity had less stable MOS-R scores using certain cut points than infants with lower medical complexity.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"192 ","pages":"Article 106008"},"PeriodicalIF":2.5,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140554873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between early infant motor repertoire and neurodevelopment on the hammersmith infant neurological examination in a developmentally vulnerable First Nations cohort","authors":"Carly Luke ,&nbsp;Leeann Mick-Ramsamy ,&nbsp;Arend F. Bos ,&nbsp;Katherine A. Benfer ,&nbsp;Margot Bosanquet ,&nbsp;Anya Gordon ,&nbsp;Hailey Williams ,&nbsp;Chloe Taifalos ,&nbsp;Maria Smith ,&nbsp;Shaneen Leishman ,&nbsp;Ellena Oakes ,&nbsp;Megan Kentish ,&nbsp;Lynda McNamara ,&nbsp;Robert S. Ware ,&nbsp;Roslyn N. Boyd","doi":"10.1016/j.earlhumdev.2024.106004","DOIUrl":"https://doi.org/10.1016/j.earlhumdev.2024.106004","url":null,"abstract":"<div><h3>Aim</h3><p>To implement a culturally-adapted screening program aimed to determine the ability of infant motor repertoire to predict early neurodevelopment on the Hammersmith Infant Neurological Examination (HINE) and improve Australian First Nations families' engagement with neonatal screening.</p></div><div><h3>Methods</h3><p>A prospective cohort of 156 infants (55 % male, mean (standard deviation [SD]) gestational age 33.8 (4.6) weeks) with early life risk factors for adverse neurodevelopmental outcomes (ad-NDO) participated in a culturally-adapted screening program. Infant motor repertoire was assessed using Motor Optimality Score-revised (MOS-R), captured over two videos, 11–13⁺⁶ weeks (V1; &lt;14 weeks) and 14–18 weeks (V2; ≥14 weeks) corrected age (CA). At 4–9 months CA neurodevelopment was assessed on the HINE and classified according to age-specific cut-off and optimality scores as; developmentally ‘on track’ or high chance of either adverse neurodevelopmental outcome (ad-NDO) or cerebral palsy (CP).</p></div><div><h3>Results</h3><p>Families were highly engaged, 139/148 (94 %) eligible infants completing MOS-R, 136/150 (91 %), HINE and 123 (83 %) both. Lower MOS-R at V2 was associated with reduced HINE scores (β = 1.73, 95 % confidence interval [CI] = 1.03–2.42) and high chance of CP (OR = 2.63, 95%CI = 1.21–5.69) or ad-NDO (OR = 1.38, 95%CI = 1.10–1.74). The MOS-R sub-category ‘observed movement patterns’ best predicted HINE, infants who score ‘4’ had mean HINE 19.4 points higher than score ‘1’ (95%CI = 12.0–26.9). Receiver-operator curve analyses determined a MOS-R cut-off of &lt;23 was best for identifying mild to severely reduced HINE scores, with diagnostic accuracy 0.69 (sensitivity 0.86, 95%CI 0.76–0.94 and specificity 0.40, 95 % CI 0.25–0.57). A trajectory of improvement on MOS-R (≥2 point increase in MOS-R from 1st to 2nd video) significantly increased odds of scoring optimally on HINE (OR = 5.91, 95%CI 1.16–29.89) and may be a key biomarker of ‘on track’ development.</p></div><div><h3>Interpretation</h3><p>Implementation of a culturally-adapted program using evidence-based assessments demonstrates high retention. Infant motor repertoire is associated with HINE scores and the early neurodevelopmental status of developmentally vulnerable First Nations infants.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"192 ","pages":"Article 106004"},"PeriodicalIF":2.5,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0378378224000732/pdfft?md5=d08d380ed12a338d0e91d9867a6652ac&pid=1-s2.0-S0378378224000732-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140606873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The long-term developmental outcomes of children born to mothers with systemic lupus erythematosus at different parities","authors":"Shuming Shao ,&nbsp;Yimin Zhang ,&nbsp;Jie Liu ,&nbsp;Zheng Liu ,&nbsp;Xiaorui Zhang","doi":"10.1016/j.earlhumdev.2024.106007","DOIUrl":"https://doi.org/10.1016/j.earlhumdev.2024.106007","url":null,"abstract":"<div><h3>Background</h3><p>In recent years, China has adjusted its fertility policies to optimize the population structure by implementing the two-child and three-child policies. Some patients with systemic lupus erythematosus (SLE) are considering the possibility of having a second child. The issue is whether the offspring from the second childbirth will have favorable long-term developmental outcomes.</p></div><div><h3>Objective</h3><p>The research aims to investigate the long-term physical, neurological, and social-emotional development outcomes of children born to mothers with SLE at different parities. This study aims to offer valuable insights and references for SLE patients who are considering subsequent pregnancies and require information about potential developmental outcomes for their future children.</p></div><div><h3>Methods</h3><p>The study conducted a follow-up of children born to SLE mothers who were admitted to the obstetrics department between January 1, 2016, and September 30, 2021. The SLE patients were categorized into two groups based on their history of live delivery: the primiparity group and the multiparity group. The physical development status, including weight, height (length), and other relevant factors, was evaluated in both groups. The Ages and Stages Questionnaires, Third Edition (ASQ-3) was utilized to assess the neurological development in five domains, encompassing communication, gross motor, fine motor, problem solving and personal-social. Social-emotional development was assessed using the Ages and Stages Questionnaires: Social-Emotional (ASQ:SE). The weight, height (length), body mass index, and ASQ-3 domain scores were standardized into <em>Z</em>-scores to enable comparison across various ages and genders.</p></div><div><h3>Results</h3><p>The study revealed that the weight Z-score and BMI Z-score of the children in the multiparity group were significantly higher compared to those in the primiparity group. However, there were no statistically significant differences in the proportions of overweight and obesity between the two groups. In terms of neurological developmental outcomes, the <em>Z</em>-scores of the communication and gross motor domains in the ASQ-3 assessment were significantly higher in the multiparity group compared to those in the primiparity group. The proportion of abnormal screening for social and emotional development in the children of the multiparity group was lower than that of the primiparity group, although this difference did not reach statistical significance.</p></div><div><h3>Conclusions</h3><p>The long-term weight development, communication and gross motor development of children born to SLE patients in the multiparity group were better than those in the primiparity group. However, there was no significant difference in social-emotional development between the two groups.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"192 ","pages":"Article 106007"},"PeriodicalIF":2.5,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140545912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal cardiac functional changes in pregnancies with Behcet's disease: A case-control study","authors":"Dilek Menekse Beser ,&nbsp;Deniz Oluklu ,&nbsp;Derya Uyan Hendem ,&nbsp;Muradiye Yildirim ,&nbsp;Bergen Laleli Koc ,&nbsp;Dilek Sahin","doi":"10.1016/j.earlhumdev.2024.106006","DOIUrl":"https://doi.org/10.1016/j.earlhumdev.2024.106006","url":null,"abstract":"<div><h3>Background</h3><p>Behcet's disease usually progresses with remission during pregnancy, but early subtle changes might be detected in the heart of these fetuses due to inflammation.</p></div><div><h3>Aims</h3><p>We aimed to evaluate the cardiac functions in fetuses of pregnant women with Behcet's disease (BD).</p></div><div><h3>Study design</h3><p>Prospective case-control study.</p></div><div><h3>Subjects</h3><p>This prospective study enrolled pregnant women diagnosed with Behcet's disease before pregnancy. Twenty-four pregnancies with Behcet's disease and 48 healthy pregnancies were included at 32–34 gestational weeks.</p></div><div><h3>Outcome measures</h3><p>Pulsed-wave Doppler and tissue Doppler imaging (TDI) were used to assess cardiac functions.</p></div><div><h3>Results</h3><p>Right ventricle (RV) E (early) wave and left ventricle (LV) E were significantly increased in pregnancies with BD (<em>p</em> = .008, <em>p</em> = .041, respectively). Decreased right ventricle E' (peak systolic velocity) was detected with TDI in the case group (6.2 ± 0.5, <em>p</em> &lt; .001). E/E' ratios for RV and LV were significantly increased in the case group (p &lt; .001, <em>p</em> = .001, respectively). The correlation between the duration of the disease and fetal cardiac functions was also evaluated. For RV, E (<em>r</em> = 0.735, <em>p</em> &lt; .001), E' (<em>r</em> = −0.735, p &lt; .001), E/E' (<em>r</em> = 0.894, p &lt; .001), were strongly correlated with the disease duration. The study also showed the correlation between disease duration and LV E' (r = −0.735, <em>p</em> = .005), LV E (<em>r</em> = 0.750, p &lt; .001), and LV E/E' (<em>r</em> = 0.820, p &lt; .001).</p></div><div><h3>Conclusion</h3><p>This is the first study to evaluate the fetal cardiac functions in fetuses of pregnancies with BD. Although BD usually progresses with remission during pregnancy, early subclinical diastolic changes might occur in the heart of these fetuses due to inflammation.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"192 ","pages":"Article 106006"},"PeriodicalIF":2.5,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140535043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feeding practices and anthropometric classification of nutritional status in low-birth-weight infants at term. A prospective cohort study","authors":"Carlos Javier Avendaño-Vásquez ,&nbsp;Magda Liliana Villamizar-Osorio ,&nbsp;Claudia Jazmín Niño Peñaranda ,&nbsp;Judith Medellín Olaya ,&nbsp;Nadia Carolina Reina Gamba","doi":"10.1016/j.earlhumdev.2024.106005","DOIUrl":"https://doi.org/10.1016/j.earlhumdev.2024.106005","url":null,"abstract":"<div><h3>Background</h3><p>About 50 % of LBW occurs in term newborns, which is associated with higher infant mortality rates compared to infants of average birth weight. Analysis of feeding practices in at-risk groups is essential to address malnutrition and stunting in infancy.</p></div><div><h3>Aim</h3><p>To identify feeding practices and anthropometric classification of nutritional status in a cohort of low-birth-weight term infants.</p></div><div><h3>Methods</h3><p>Methods: Cohort study. A prospective follow-up of 73 term newborns with low birth weight up to six months of age was performed. Feeding practices and anthropometric classification of nutritional were analysed. Data were processed by univariate analysis and multivariate linear regression.</p></div><div><h3>Results</h3><p>The most common feeding practice was exclusive breastfeeding. Breast milk substitutes are frequent in this population group. The risk of undernutrition ranged from 2.7 % to 19.2 % and of overweight from 4.1 % to 11.0 % during the first six months of life. Low height-for-age risk was the most frequent anthropometric classification during the follow-up period. Average head circumference was consistent in infants with low birth weight. Gestational risk classification, breastfeeding during the first hour of life, and sex of the newborn were predictors of variations in anthropometric indicators.</p></div><div><h3>Conclusions</h3><p>Exclusive breastfeeding is the most common feeding practice in the population group studied, but using breast milk substitutes is also prevalent. Low height-for-age is the most frequent anthropometric classification. The weight growth rate seems reasonable, but further studies are needed based on gender differences, analysis of the composition of breast milk, and socio-environmental factors involved in growth.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"192 ","pages":"Article 106005"},"PeriodicalIF":2.5,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140344582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}