Early human development最新文献

{"title":"Heart rate variability is associated with self-regulation and stress neurobehavior in preterm infants.","authors":"E L Donnellan, R B Govindan, J Ngwa, N Andescavage, C Limperopoulos, A J du Plessis","doi":"10.1016/j.earlhumdev.2025.106406","DOIUrl":"https://doi.org/10.1016/j.earlhumdev.2025.106406","url":null,"abstract":"<p><strong>Background: </strong>The NICU (neonatal intensive care unit) Network Neurobehavioral Scale (NNNS) quantitatively assesses several distinct neurobehavioral domains. Neurobehavioral states interface with the autonomic nervous system. We sought to determine if autonomic tone, measured by heart rate variability (HRV), is associated with performance on NNNS neurobehavioral subscales.</p><p><strong>Methods: </strong>Using continuous electrocardiogram recordings, we derived the following HRV measures: short (α1), and long-term (α2) fractal scaling exponents and short (RMS1) and long-term (RMS2) root mean square fluctuations. The NNNS was completed around term equivalent age (TEA). Linear mixed effects models tested associations between six NNNS subscales and HRV metrics. Secondary analyses explored the role of postmenstrual age (PMA) on associations between NNNS and HRV. These associations were further tested in the earliest and latest postnatal NICU weeks for each infant.</p><p><strong>Results: </strong>We enrolled 39 premature infants (birth gestational age 23-36 weeks). Several HRV metrics were associated with Self-Regulation and Stress. After controlling for common NICU exposures (i.e. ventilation, steroids, caffeine and antibiotics), self-regulation was positively associated with alpha1 and RMS1 (standardized β = 0.262-0.284). Stress was associated negatively with alpha1 and RMS1 (standardized β = -0.283 to -0.286) and positively with alpha2 (standardized β = 0.245). Associations between Self-Regulation and Stress on RMS1 differed by PMA and NICU week, respectively. α1 and α2 at TEA predicted Stress (AUC = 0.730-0.775).</p><p><strong>Conclusion: </strong>Of the six subscales examined, only Stress and Self-Regulation scores were associated with autonomic metrics in preterm infants. For short-term autonomic fluctuations, PMA and NICU week influenced this relationship. Furthermore, the fractal scaling exponents predict abnormal Stress scores.</p>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"211 ","pages":"106406"},"PeriodicalIF":2.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of children at age 7-8 years after intrauterine exposure to selective serotonin reuptake inhibitors (SSRIs) - Results from the Dutch prospective cohort SMOK study.","authors":"Christine N van der Veere, Anne E den Heijer, Arend F Bos","doi":"10.1016/j.earlhumdev.2025.106405","DOIUrl":"https://doi.org/10.1016/j.earlhumdev.2025.106405","url":null,"abstract":"<p><strong>Introduction: </strong>Selective serotonin reuptake inhibitors (SSRIs) are used by 2-6 % of pregnant women. Safety regarding the neurodevelopment of the child remains unknown.</p><p><strong>Aim: </strong>To determine the effect of prenatal exposure to SSRIs on children's outcome at age 7-8 years, adjusted for maternal depression and anxiety.</p><p><strong>Methods: </strong>This study is part of the Dutch SMOK study. Women (n = 107) were included during pregnancy. At age 7-8 years development of 79 children was examined using tests and questionnaires regarding intellectual ability, executive functioning, attention, social responsiveness, behavior and motor development. Maternal depression and anxiety was determined during pregnancy and at the children's assessment. Differences between SSRI-exposed and non-exposed children were tested using multiple linear regression analyses.</p><p><strong>Results: </strong>All children had lower IQ scores after prenatal exposure to SSRIs but significance was lost after adjustment for maternal psychopathology. No differences in outcome were found on attention and motor development. Boys, not girls, scored significantly lower on Theory of Mind tests when they had been exposed to SSRIs (total norm score 7.9 ± 0.8 vs. 9.6 ± 0.5, p = 0.04; verbal norm score 8.6 ± 0.9 vs. 10.7 ± 0.6, p = 0.02). Scores on the Social Responsiveness Scale measuring social impairment were significantly higher in SSRI-exposed boys (50 ± 2 vs. 45 ± 2, p = 0.03). In girls, outcome on these domains was explained by maternal psychopathology, not by prenatal exposure to SSRIs.</p><p><strong>Conclusions: </strong>Prenatal exposure to SSRIs is associated with increased risk of behavioral problems and social impairment associated with autism spectrum disorders only in boys.</p>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"211 ","pages":"106405"},"PeriodicalIF":2.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neopterin as a marker of congenital cytomegalovirus infection.","authors":"Aleksandra Pietrzyk, Justyna Czech-Kowalska, Michał Zarzecki, Agata Leśniewska, Agata Pleskaczyńska, Ewa Kowalska-Ciszek, Katarzyna Patla, Joanna Klimiuk-Balas, Dariusz Gruszfeld","doi":"10.1016/j.earlhumdev.2025.106399","DOIUrl":"https://doi.org/10.1016/j.earlhumdev.2025.106399","url":null,"abstract":"<p><strong>Background and aims: </strong>Neopterin is a marker of cellular immune activation during viral and parasitic infections, with levels typically declining during treatment. Elevated neopterin levels have been observed in the cerebrospinal fluid (CSF) in patients with neuroinfections. This prospective case-control study aimed to evaluate the diagnostic value of neopterin concentrations in body fluids in congenital cytomegalovirus infection (cCMV).</p><p><strong>Methods: </strong>Neopterin concentrations were measured in serum, urine and CSF of neonates with confirmed cCMV and compared with a control group. Clinical and audiological examination, biochemical tests, neuroimaging, viral loud in blood and urine and CMV DNA in CSF were performed at baseline and during treatment.</p><p><strong>Results: </strong>The study group included 58 infants with cCMV (45 (78 %) symptomatic). There were higher baseline neopterin concentrations in the study group than in the control group. Baseline serum neopterin concentrations were higher in infants with intrauterine growth restriction, microcephaly, hepatosplenomegaly, petechiae and with hearing loss. There were higher neopterin concentrations in CSF in infants with clinical symptoms, hearing loss, and those with neuroimaging abnormalities. Neopterin concentrations in body fluids demonstrated good discriminatory ability as a diagnostic marker for cCMV, with an area under the ROC curve (AUC) values of 0. 977 for CSF, 0.895 for serum and 0.87 for urine. Neopterin concentrations were decreasing during treatment.</p><p><strong>Conclusions: </strong>Serum neopterin concentration may serve as an diagnostic marker reflecting disease severity and can be useful for monitoring the effectiveness of the antiviral treatment. Neopterin concentration in CSF indicates the role of the local immune response of CNS injury.</p>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"211 ","pages":"106399"},"PeriodicalIF":2.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of early intervention on early spontaneous movements of infants: a systematic review.","authors":"Dilara Bozgan-Baş, Bilge Nur Yardımcı-Lokmanoğlu, Akmer Mutlu","doi":"10.1016/j.earlhumdev.2025.106403","DOIUrl":"https://doi.org/10.1016/j.earlhumdev.2025.106403","url":null,"abstract":"<p><strong>Background: </strong>Early intervention in infants can impact the process of neural differentiation during the period when the brain is highly plastic. However, it is unclear whether early intervention can similarly affect early spontaneous movements of infants.</p><p><strong>Aim: </strong>To determine the effects of early intervention approaches on early spontaneous movements in infants.</p><p><strong>Methods: </strong>Studies were eligible if they enrolled infants in any early intervention program and assessed early spontaneous movements using a general movements assessment pre- and post-intervention. Five databases were searched and the PRISMA guideline was followed. The Cochrane Risk of Bias Tool-2 and the Risk of Bias in Non-randomized Studies of Interventions were used to identify risk of bias. GRADE approach was used to assess the certainty of the evidence.</p><p><strong>Results: </strong>Ten studies (involving 633 participants) were included. Most of the studies had a high or serious risk of bias, and the certainty of the evidence was low to very low. The studies varied in their intervention approaches, intensity, and inclusion criteria. The most common early intervention methods were motor interventions, such as physiotherapy, or parental involvement. In four out of five studies which showed an improvement, this improvement occurred during the fidgety period.</p><p><strong>Conclusions: </strong>Early intervention in infants could influence the spontaneous movements, particularly during the fidgety period. The generalizability and comparability of the results are limited due to the heterogeneity of the methods, the low certainty of evidence and the high risk of bias. Future research should investigate the impact of high-level evidence approaches on early spontaneous movements.</p>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"211 ","pages":"106403"},"PeriodicalIF":2.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota as a risk and protective factor in neonatal necrotizing enterocolitis: An integrative review","authors":"Maria Júlia Onofre ,&nbsp;Cesar Augusto Cirino Silva ,&nbsp;Isadora Caixeta da Silveira Ferreira ,&nbsp;Denise Von Dolinger de Brito Röder","doi":"10.1016/j.earlhumdev.2025.106401","DOIUrl":"10.1016/j.earlhumdev.2025.106401","url":null,"abstract":"<div><div>Necrotizing enterocolitis (NEC) is characterized by inflammation of the gastrointestinal tract and intestinal necrosis, primarily affecting premature neonates. It is one of the leading causes of morbidity and mortality in this population. This article aims to analyze, based on recent scientific literature, the relationship between intestinal microbiota and the development of NEC in premature neonates, highlighting the main pathophysiological mechanisms and prevention strategies. We conducted an integrative literature review, with search in the Virtual Health Library (VHL) and Pubmed databases, applying the Patient, Intervention, Comparison and Outcomes (PICO) strategy. A total of 178 articles were initially identified, with the application of validated tools to assess the methodological quality of the studies. The final sample included 13 international articles. The main findings show intestinal dysbiosis, activation of immune pathways and metabolic alterations as key elements in the pathogenesis of NEC. On the other hand, the use of probiotics and enrichment of breast milk were associated with beneficial effects. In conclusion, NEC is a multifactorial disease associated with intestinal dysbiosis, with an increase in pathogenic bacteria and a reduction in beneficial bacteria such as <em>Bifidobacterium</em> spp. The activation of pro-inflammatory TLR4 receptors by bacterial LPS favors intestinal damage. Factors such as prematurity, use of antimicrobials, and changes in the composition of breast milk favor microbiota imbalance. Probiotics and breastfeeding are promising strategies for preventing this situation. Therefore, this article gathers pertinent information that can help in understanding the factors involved in NEC.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"211 ","pages":"Article 106401"},"PeriodicalIF":2.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between cardiorespiratory fitness, activity behavior, physical literacy and parental sports participation in children with a critical congenital heart disease","authors":"J.J. Noordstar ,&nbsp;M.C.A. Sprong ,&nbsp;F.C. Lenderink ,&nbsp;M.G. Slieker ,&nbsp;E.H.J. Hulzebos ,&nbsp;T. Takken","doi":"10.1016/j.earlhumdev.2025.106397","DOIUrl":"10.1016/j.earlhumdev.2025.106397","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated associations between cardiorespiratory fitness (CRF), activity behavior (i.e. physical activity and sports participation), physical literacy (motivation, confidence, knowledge and understanding), and parental sports participation in children with critical congenital heart disease (CCHD), and explore differences in children with a single ventricle physiology (SVP) and children with biventricular physiology (BVP).</div></div><div><h3>Methods</h3><div>Ninety children with CCHD (median age 10.0 [7.0–13.0] years) participated in this prospective observational study. CRF was measured through cardiopulmonary exercise testing (VO₂peak). Activity behavior, physical literacy, and parental sports participation were assessed using validated questionnaires.</div></div><div><h3>Results</h3><div>CRF was moderately associated with physical activity (<em>r</em> = 0.36, <em>p</em> &lt; .001) and weakly associated with motivation and confidence (<em>r</em> = 0.25, <em>p</em> = .019). No association was found between CRF and sports participation. Children's sports participation was positively associated with maternal (<em>r</em> = 0.23, <em>p</em> = .034) and paternal (r = 0.23, <em>p</em> = .042) sports participation, as well as with motivation and confidence (<em>r</em> = 0.28, <em>p</em> = .009). Children with a SVP (<em>n</em> = 11) had significantly lower CRF than those with BVP (<em>n</em> = 79) (<em>p</em> &lt; .001). No other differences were found between children with a SVP and children with a BVP.</div></div><div><h3>Conclusion</h3><div>CRF is positively associated with physical activity, motivation and confidence in children with CCHD. Additionally, parental sports participation is associated with children's sports participation. These findings suggest integrating a physical literacy and family-centered approach in interventions aimed to enhance CRF in children with CCHD.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"211 ","pages":"Article 106397"},"PeriodicalIF":2.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying cognitive vulnerability in school-aged children born preterm: The role of neonatal and early-life factors","authors":"Symeon Dimitrios Daskalou ,&nbsp;Nikolaos Gerosideris ,&nbsp;Georgia Tsakni ,&nbsp;Pinelopi Vlotinou ,&nbsp;Georgios Bablekos ,&nbsp;Ioanna Giannoula Katsouri","doi":"10.1016/j.earlhumdev.2025.106396","DOIUrl":"10.1016/j.earlhumdev.2025.106396","url":null,"abstract":"<div><h3>Background</h3><div>Children born preterm are at increased risk for cognitive difficulties. While gestational age is a known predictor, the combined influence of early-life variables such as breastfeeding, NICU stay, and birth weight on later cognitive outcomes remains less understood.</div></div><div><h3>Objective</h3><div>To compare cognitive performance between preterm and non preterm school-aged children and identify neonatal and postnatal predictors of verbal and non verbal intelligence.</div></div><div><h3>Methods</h3><div>A total of 140 children aged 6–12 years (70 preterm, 70 non preterm) were assessed using Raven's Coloured Progressive Matrices (CPM) and Crichton Vocabulary Scale (CVS). Mann–Whitney <em>U</em> tests and multiple linear regressions were used to examine group differences and predictors of cognitive scores. Predictors included gestational age, NICU stay, socioeconomic status (SES), breastfeeding, birth weight, age, and sex. VIF values were used to assess multicollinearity.</div></div><div><h3>Results</h3><div>Preterm children scored significantly lower than non preterm peers on both CPM (<em>p</em> &lt; 0.001, <em>r</em> = − 0.27) and CVS (p &lt; 0.001, <em>r</em> = − 0.43). Regression models showed that gestational age was a consistent predictor across both scales. Breastfeeding and higher SES were associated with higher CPM and CVS scores, while prolonged NICU stay negatively impacted CVS performance. No multicollinearity issues were detected (VIF &lt; 2.6).</div></div><div><h3>Conclusion</h3><div>Preterm birth is linked to reduced cognitive performance during middle childhood, especially in verbal reasoning. Breastfeeding and shorter NICU stay may offer protective benefits. These findings highlight the importance of early-life factors and support targeted developmental surveillance and interventions for preterm populations.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"211 ","pages":"Article 106396"},"PeriodicalIF":2.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145099985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of internalising trajectories in adult wealth and social relationships following very preterm birth/very low birth weight","authors":"Yanlin Zhou ,&nbsp;Elif Gonen ,&nbsp;Peter Bartmann ,&nbsp;Dieter Wolke","doi":"10.1016/j.earlhumdev.2025.106395","DOIUrl":"10.1016/j.earlhumdev.2025.106395","url":null,"abstract":"<div><h3>Background</h3><div>Individuals born very preterm (VPT; &lt;32 weeks) and/or with very low birth weight (VLBW; &lt;1500 g) are at higher risk for internalising problems and adulthood difficulties. However, internalising symptoms fluctuate over time, and it remains unclear how these patterns of change relate to adult outcomes after VPT/VLBW birth.</div></div><div><h3>Objective</h3><div>To examine whether internalising trajectories from childhood to early adulthood mediate or moderate the association between VPT/VLBW birth and adult wealth and social relationship difficulties.</div></div><div><h3>Methods</h3><div>Data were drawn from the Bavarian Longitudinal Study (252 VPT/VLBW, 228 term-born), followed from birth to 34 years. Internalising symptoms were parent-reported at four waves (ages 6, 8, 13 and 26 years) and modelled into trajectories. Path analysis tested direct and indirect effects of VPT/VLBW status on outcomes at 34 years via these trajectories. Moderation was tested using analysis of variance. Covariates included sex, socioeconomic status (SES) at birth, and neurosensory impairments (NSI).</div></div><div><h3>Results</h3><div>Three internalising trajectories emerged: consistently low (70.4 %), decreasing (15 %), and increasing (14.6 %). The increasing trajectory mediated the association between VPT/VLBW birth and both lower wealth and greater social relationship difficulties. After adjusting for sex, SES, and NSI, only the mediation effect on wealth remained significant. Indirect effects accounted for approximately 15–18 % of the total effects. Interactions between birth group (VPT/VLBW vs. term-born) and internalising trajectory on adult outcomes were non-significant.</div></div><div><h3>Conclusions</h3><div>Increasing internalising symptoms partially mediate the impact of VPT/VLBW birth on adult wealth and social relationships. Findings highlight the value of continuing mental health support, particularly for those born VPT/VLBW.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"211 ","pages":"Article 106395"},"PeriodicalIF":2.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental satisfaction on moving from open bay to single-family rooms neonatal intensive care unit","authors":"Wielenga Joke ,&nbsp;Pascual April ,&nbsp;Ruhe Kiki ,&nbsp;de Ligt Chantal ,&nbsp;van Kaam Anton","doi":"10.1016/j.earlhumdev.2025.106394","DOIUrl":"10.1016/j.earlhumdev.2025.106394","url":null,"abstract":"<div><div>The purpose of the study was to assess the impact of moving from open bay units (OBU) to single-family rooms (SFR) on parental satisfaction in the Neonatal Intensive Care Unit (NICU) An observational longitudinal cohort study was conducted between February 2021 until January 2024, during which time the setting changed from OBU to SFR with a mixed transitional phase in between. All parents of infants admitted were eligible for inclusion. The Empathic-N was used to measure parental satisfaction. The Empathic-N was filled out by 110 mothers and 76 partners of 148 infants. The overall satisfaction when moving from an OBU and SFRs showed no statistical significant increase for both parents. Partners showed a statistically significant increase in the domains Communication and information (<em>p</em> = .012) and Organization (p = .012) after moving to SFRs. For mothers, only several statements within these domains showed a significant increase after transitioning to SFRs. In conclusion, parental satisfaction increased in specific domains after the transition from an OBU to SFR environment in a level III NICU. However, this improvement was modest and differed between mothers and partners. In case of pre-existing high parental satisfaction rates moving from OBU to SFR is not an important contributor to parental satisfaction.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"211 ","pages":"Article 106394"},"PeriodicalIF":2.0,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden placental damage in stillbirths with idiopathic polyhydramnios","authors":"Laura Avagliano ,&nbsp;Martina Benuzzi ,&nbsp;Francesca Monari ,&nbsp;Gaetano Bulfamante","doi":"10.1016/j.earlhumdev.2025.106393","DOIUrl":"10.1016/j.earlhumdev.2025.106393","url":null,"abstract":"<div><div>Idiopathic polyhydramnios is clinically linked to stillbirth; however, its placental histopathology remains poorly characterized. This is the first study analyzing placentas from stillbirths with idiopathic polyhydramnios, revealing frequent lesions of fetal and maternal vascular malperfusion. Findings support a previously unrecognized role of placental dysfunction in fetal compromise.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"211 ","pages":"Article 106393"},"PeriodicalIF":2.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145099984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}