Early human development最新文献_第2页

Self-reported pain sensitivity in adults born extremely preterm compared to term-born controls: A matched cohort study 与足月出生的对照组相比，极度早产成人自我报告的疼痛敏感性：一项匹配的队列研究。

IF 2 3区医学

Early human development Pub Date : 2026-04-01 Epub Date: 2026-01-22 DOI: 10.1016/j.earlhumdev.2026.106492

Julie Vestavik Berge , Silje Nesthus , Merete Røineland Benestad , Geir Egil Eide , Thomas Halvorsen , Bente Johanne Vederhus

{"title":"Self-reported pain sensitivity in adults born extremely preterm compared to term-born controls: A matched cohort study","authors":"Julie Vestavik Berge , Silje Nesthus , Merete Røineland Benestad , Geir Egil Eide , Thomas Halvorsen , Bente Johanne Vederhus","doi":"10.1016/j.earlhumdev.2026.106492","DOIUrl":"10.1016/j.earlhumdev.2026.106492","url":null,"abstract":"<div><h3>Aim</h3><div>To compare self-reported pain sensitivity and the use of pain medication in young adults born extremely preterm (EP) with matched term-born controls.</div></div><div><h3>Methods</h3><div>In this third follow-up of a population-based cohort study of individuals born EP (gestational age ≤28 weeks) in 1991–92, the Pain Sensitivity Questionnaire (PSQ) was administered together with health-related questions. Matched term-born controls served as a comparison group.</div></div><div><h3>Results</h3><div>At 27 years of age, 24 (69%) EP-born and 26 (74%) term-born controls consented to participate. There were no significant differences between groups in PSQ total, moderate, or minor scores, nor in the use of pain medication. No associations were found between the number of painful procedures in the neonatal period and pain sensitivity at 27 years.</div></div><div><h3>Conclusion</h3><div>Self-reported pain sensitivity and use of pain medication at 27 years of age did not differ between adults born extremely preterm and their term-born peers.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"215 ","pages":"Article 106492"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between neonatal hyperglycemia, neonatal illness, and 3-year outcomes in extremely preterm infants 极早产儿新生儿高血糖、新生儿疾病和3年预后之间的关系

IF 2 3区医学

Early human development Pub Date : 2026-04-01 Epub Date: 2026-01-13 DOI: 10.1016/j.earlhumdev.2026.106480

Shin Fujiwara , Ryou Furukawa , Seiko Maeno , Sayaka Fujimura , Hisako Saeki , Chiharu Matubara , Rie Fukuhara

{"title":"The relationship between neonatal hyperglycemia, neonatal illness, and 3-year outcomes in extremely preterm infants","authors":"Shin Fujiwara , Ryou Furukawa , Seiko Maeno , Sayaka Fujimura , Hisako Saeki , Chiharu Matubara , Rie Fukuhara","doi":"10.1016/j.earlhumdev.2026.106480","DOIUrl":"10.1016/j.earlhumdev.2026.106480","url":null,"abstract":"<div><h3>Aim</h3><div>To investigate the association between neonatal hyperglycemia during the first month of life and perinatal characteristics, neonatal morbidities, and developmental outcomes at 3 years of age in extremely preterm (EPT) infants.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included infants born at before 28 weeks of gestation between 2013 and 2020. Infants were categorized into normoglycemia, mild hyperglycemia, and severe hyperglycemia groups based on the frequency of morning blood glucose measurements ≥150 mg/dL and ≥180 mg/dL during the first 28 postnatal days. Perinatal data, clinical outcomes, and neurodevelopmental assessments at 3 years of age using the Kyoto Scale of Psychological Development 2001 (KSPD) were analyzed.</div></div><div><h3>Results</h3><div>Among 195 infants with available glucose data, 151 underwent neurodevelopmental assessment at 3 years of age. Greater degrees of hyperglycemia were associated with lower gestational age (GA) and birth weight. Severe hyperglycemia was significantly associated with increased rates of postnatal steroid use and late-onset circulatory collapse (LCC). Infants with severe hyperglycemia demonstrated significantly lower overall Development Quotient (DQ) and Postural-Motor (P-M) DQ scores in univariate analyses. Similarly, higher mean blood glucose levels were associated with lower scores in these domains. However, after adjustment for birth weight and LCC, these associations were no longer statistically significant.</div></div><div><h3>Conclusion</h3><div>In EPT infants, neonatal hyperglycemia during the first postnatal month was associated with greater immaturity, and did not show an independent association with adverse neurodevelopmental outcomes at 3 years of age.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"215 ","pages":"Article 106480"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Educational value of YouTube videos on exercise during pregnancy: A cross-sectional analysis YouTube孕期运动视频的教育价值：一项横断面分析。

IF 2 3区医学

Early human development Pub Date : 2026-04-01 Epub Date: 2026-01-19 DOI: 10.1016/j.earlhumdev.2026.106489

Ugur Sozlu , Rumeysa Barut

{"title":"Educational value of YouTube videos on exercise during pregnancy: A cross-sectional analysis","authors":"Ugur Sozlu , Rumeysa Barut","doi":"10.1016/j.earlhumdev.2026.106489","DOIUrl":"10.1016/j.earlhumdev.2026.106489","url":null,"abstract":"<div><h3>Background</h3><div>Exercise during pregnancy provides significant physical and psychological benefits for both the mother and fetus. However, many women rely on online platforms such as YouTube for guidance, where the accuracy and quality of information can vary widely.</div></div><div><h3>Aim</h3><div>This study aimed to evaluate the educational value of YouTube videos related to exercise during pregnancy.</div></div><div><h3>Methods</h3><div>A systematic search was conducted on YouTube using the keywords “exercise in pregnancy” and “exercise during pregnancy.” A total of 97 videos were analyzed in terms of quality, reliability, and comprehensiveness. The Global Quality Scale (GQS) was used to assess video quality, while reliability was evaluated using the modified DISCERN (mDISCERN) scale. The Exercise Specific Score in Pregnancy (EPSS) was employed to assess the educational content of the videos, and viewer engagement was measured using an interaction index based on likes, comments, and views.</div></div><div><h3>Results</h3><div>Most content was produced by certified pre and postnatal birth coaches (<em>n</em> = 55, 56.7%). Nearly half of the videos were high quality (<em>n</em> = 46, 47.4%), and the majority were reliable (<em>n</em> = 81, 83.5%). Professional organizations mainly produced moderate quality content, whereas health professionals and certified birth coaches generated higher quality videos; in contrast, fitness trainers tended to produce lower quality content. No significant correlations were found between GQS, mDISCERN, EPSS scores, and the interaction index (<em>p</em> > 0.05).</div></div><div><h3>Conclusion</h3><div>The findings suggest that YouTube videos on exercise during pregnancy are generally high-quality and reliable. However, viewer engagement does not align with quality and reliability, indicating a potential risk of pregnant women accessing misleading or inaccurate information.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"215 ","pages":"Article 106489"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146028633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chrononutrition: 24-hour variation in macronutrients in very preterm human milk 时间营养：早产儿母乳中常量营养素的24小时变化

IF 2 3区医学

Early human development Pub Date : 2026-04-01 Epub Date: 2026-01-12 DOI: 10.1016/j.earlhumdev.2026.106481

Alja Bijlsma , Demy van Gilst , Inês Chaves , Irwin K.M. Reiss , Koen F.M. Joosten , Stefanie M.P. Kouwenhoven , Marijn J. Vermeulen , Jorine A. Roelants

{"title":"Chrononutrition: 24-hour variation in macronutrients in very preterm human milk","authors":"Alja Bijlsma , Demy van Gilst , Inês Chaves , Irwin K.M. Reiss , Koen F.M. Joosten , Stefanie M.P. Kouwenhoven , Marijn J. Vermeulen , Jorine A. Roelants","doi":"10.1016/j.earlhumdev.2026.106481","DOIUrl":"10.1016/j.earlhumdev.2026.106481","url":null,"abstract":"<div><h3>Background</h3><div>Human milk composition varies in time to meet the evolving growth and developmental requirements of infants. While 24-hour (diurnal) variations in human milk composition for term-born infants have been reported, evidence concerning diurnal variation of preterm human milk composition remains inconclusive.</div></div><div><h3>Research aim</h3><div>To examine the presence of diurnal variations in macronutrient content in very preterm human milk.</div></div><div><h3>Method</h3><div>Milk samples were donated by mothers of very preterm infants (<30 weeks gestation). Milk series (defined as sequential milk samples collected from one mother) consisted of 13 to 17 (median 15) samples, collected over three consecutive days. Milk macronutrient (fat, true protein and carbohydrates) content were measured using mid-infrared spectrophotometry (Miris HMA™). Rhythmicity analyses and logistic regression analyses were performed to explore associations between macronutrient rhythmicity and pregnancy duration (weeks), infants' sex, and lactational stage).</div></div><div><h3>Results</h3><div>Of the 22 milk series studied, 12 (55%) showed 24-hour rhythmicity in one or more macronutrients. Fat content showed rhythmicity in 41% of the series, with varying peak times. For carbohydrates, protein and calculated energy content, rhythmicity was only identified in 18%, 14% and 27% of the milk series, respectively. Longer pregnancy duration was associated with increased odds of rhythmicity (odds ratio 2.1 (95% confidence interval 1.02–4.21), <em>p</em> = 0.04), but not with sex or stage of lactation.</div></div><div><h3>Conclusions</h3><div>Over half of the preterm human milk samples exhibited diurnal macronutrient rhythmicity, mainly in fat levels. The observed rhythms had varying peak times, suggesting phase differences of the maternal rhythms.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"215 ","pages":"Article 106481"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145957673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digit ratio (2D:4D) and fractional exhaled nitric oxide (FeNO) 数字比率（2D:4D）和呼出一氧化氮分数（FeNO）

IF 2 3区医学

Early human development Pub Date : 2026-04-01 Epub Date: 2026-01-29 DOI: 10.1016/j.earlhumdev.2026.106496

Barbara Ślawski , John T. Manning , Bogusław Antoszewski , Anna Elgalal , Anna Kasielska-Trojan

{"title":"Digit ratio (2D:4D) and fractional exhaled nitric oxide (FeNO)","authors":"Barbara Ślawski , John T. Manning , Bogusław Antoszewski , Anna Elgalal , Anna Kasielska-Trojan","doi":"10.1016/j.earlhumdev.2026.106496","DOIUrl":"10.1016/j.earlhumdev.2026.106496","url":null,"abstract":"<div><h3>Background</h3><div>Fractional Exhaled Nitric Oxide (FeNO) is produced in sex-dependent amounts (males>females) by the paranasal sinuses which are formed in utero and which show sex differences in volume (males>females). Digit ratio (2D:4D) is sexually dimorphic (males<females) and is a correlate of prenatal sex steroids.</div></div><div><h3>Aim</h3><div>To investigate the association between 2D:4D and FeNO.</div></div><div><h3>Methods</h3><div>Participants were medical students. Triple measurements of (FeNO) in exhaled air [ppb] were recorded and log transformed means calculated. Digit lengths were measured twice. Sex, age, height, mass and BMI were recorded.</div></div><div><h3>Results</h3><div>There were 159 participants (100 females). Sex differences were present in FeNO, right and left 2D:4D, height, mass and BMI. For females, right and left 2D:4D were negatively related to FeNO with strongest relationship for the former. Mass was positively related to FeNO. Digit ratios remained significant after effect of mass was controlled. For males, seven participants reported allergies and had higher volumes of FeNO than non-allergy subjects. There was a trend for negative relationships between 2D:4D and FeNO but this was not significant.</div></div><div><h3>Conclusion</h3><div>Low 2D:4D is linked to high FeNO volumes in women but further work is needed to clarify this relationship in men. Because 2D:4D ratio is positively related to lactate under anaerobic conditions during exercise, we speculate that 2D:4D may be a biomarker for the interaction between lactate and FeNO during vigorous exercise.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"215 ","pages":"Article 106496"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes in extremely preterm neonates after the introduction of early low-dose hydrocortisone treatment: A retrospective case-control study 引入早期低剂量氢化可的松治疗后极早产儿的结局：一项回顾性病例对照研究。

IF 2 3区医学

Early human development Pub Date : 2026-03-01 Epub Date: 2025-12-18 DOI: 10.1016/j.earlhumdev.2025.106463

Ellie Purcell , Pooja Sachdev , Dushyant Batra

{"title":"Outcomes in extremely preterm neonates after the introduction of early low-dose hydrocortisone treatment: A retrospective case-control study","authors":"Ellie Purcell , Pooja Sachdev , Dushyant Batra","doi":"10.1016/j.earlhumdev.2025.106463","DOIUrl":"10.1016/j.earlhumdev.2025.106463","url":null,"abstract":"<div><h3>Objective</h3><div>Assess the association between use of early low-dose hydrocortisone (ELDH) in extremely preterm neonates, and bronchopulmonary dysplasia (BPD)-free survival at 36 weeks completed gestational age (CGA), as well as additional secondary outcomes.</div></div><div><h3>Design</h3><div>Retrospective, matched, case-control study.</div></div><div><h3>Setting</h3><div>Tertiary neonatal intensive care units in Nottingham University Hospitals NHS Trust (Queens Medical Centre and Nottingham City Hospital).</div></div><div><h3>Patients</h3><div>188 extremely preterm neonates. 94 historical controls born between 1 October 2017 and 30 September 2019. 94 cases born between 1 January 2020 and 31 December 2021.</div></div><div><h3>Interventions</h3><div>ELDH using the published PREMILOC study protocol (total dose of 8.5 mg/kg over 10 days) initiated within the first 24 h of life.</div></div><div><h3>Primary outcome measure</h3><div>Survival without BPD at 36 weeks CGA.</div></div><div><h3>Results</h3><div>There were no statistically significant associations between the sex, gestational age or birthweight of the groups. There was no significant association between the use of ELDH and increased survival without BPD at 36 weeks CGA (<em>p</em> = 0.153) or reduction in mortality (<em>p</em> = 0.814). Using ELDH was significantly associated with an increased incidence of culture positive late-onset sepsis (<em>p</em> = 0.006), higher non-invasive respiratory support days (<em>p</em> = 0.032) and a longer total length of stay (<em>p</em> = 0.004).</div></div><div><h3>Conclusions</h3><div>ELDH use was not associated with an improvement in BPD free survival in extremely preterm neonates. The cases had a higher incidence of culture positive late-onset sepsis and longer duration of respiratory support. Further research exploring stratification of preterm neonates that will benefit from ELDH is needed.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"214 ","pages":"Article 106463"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucose-to-lactate ratio in infants with hypoxic-ischemic encephalopathy treated with hypothermia 低体温治疗婴儿缺氧缺血性脑病的血糖与乳酸比值

IF 2 3区医学

Early human development Pub Date : 2026-03-01 Epub Date: 2025-12-09 DOI: 10.1016/j.earlhumdev.2025.106458

Carlo Dani , Giulia Remaschi , Elia Benelli , Alessandra Cecchi , Clara Lunardi , Camilla Fazi , Andrea Bianchi , Elisa Scola , Enrico Fainardi , Vittorio Miele , Caterina Coviello

{"title":"Glucose-to-lactate ratio in infants with hypoxic-ischemic encephalopathy treated with hypothermia","authors":"Carlo Dani , Giulia Remaschi , Elia Benelli , Alessandra Cecchi , Clara Lunardi , Camilla Fazi , Andrea Bianchi , Elisa Scola , Enrico Fainardi , Vittorio Miele , Caterina Coviello","doi":"10.1016/j.earlhumdev.2025.106458","DOIUrl":"10.1016/j.earlhumdev.2025.106458","url":null,"abstract":"<div><h3>Background</h3><div>Glucose-to-lactate ratio and abnormal values of glucose and lactate blood values, as well as neuroimaging, have been reported to predict neurodevelopmental outcome in infants with hypoxic–ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH). Our aim was to confirm or confute these correlations.</div></div><div><h3>Methods</h3><div>We retrospectively studied 48 late preterm and term infants, 31 with favourable and 17 with unfavourable outcome. Glucose-to-lactate ratio, glucose and lactate values were recorded before and during TH. They were studied with aEEG, cerebral magnetic resonance imaging (MRI), and the Bayley-III scales for assessing psychomotor development at 24 ± 2 months corrected age.</div></div><div><h3>Results</h3><div>Logistic regression analysis demonstrated that glucose (OR 30.219, 95 % Cl 1.473–62.069, <em>P</em> = 0.027) and lactate (OR 1.923, 95 % Cl 1.027–3.601, <em>P</em> = 0.041) blood level at 24 h of TH and MRI score (OR 2.668 95 % Cl 1.060–6.713. <em>P</em> = 0.037) were positively correlated with unfavourable outcome.</div></div><div><h3>Conclusions</h3><div>Glucose-to-lactate ratio did not predict neurodevelopmental outcome in infants with HIE treated with TH. Further investigation is needed to explore the prognostic significance of this biomarker. Glycemia and lactate blood levels measured at 24 h of TH, as well as cerebral MRI, are positively correlated with an increasing risk of unfavourable outcome.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"214 ","pages":"Article 106458"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145735975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digit ratio (2D:4D) and neonatal head circumference: Evidence for oestrogenization in human brain evolution? 手指比例（2D:4D）和新生儿头围：人类大脑进化中雌激素发生的证据？

IF 2 3区医学

Early human development Pub Date : 2026-03-01 Epub Date: 2026-01-10 DOI: 10.1016/j.earlhumdev.2026.106479

Barış Özener , John T. Manning , Berna Ertuğrul , Fatih Aydık

{"title":"Digit ratio (2D:4D) and neonatal head circumference: Evidence for oestrogenization in human brain evolution?","authors":"Barış Özener , John T. Manning , Berna Ertuğrul , Fatih Aydık","doi":"10.1016/j.earlhumdev.2026.106479","DOIUrl":"10.1016/j.earlhumdev.2026.106479","url":null,"abstract":"<div><h3>Objectives</h3><div>The second-to-fourth digit ratio (2D:4D) is widely thought to be a correlate of first trimester sex steroids, such that it is negatively correlated to testosterone and positively correlated to oestrogen. The 2D:4D has been linked to many physical and behavioural traits, including intelligence. However, little attention has been paid to its association with neonatal characteristics. Here we focus on associations between neonatal 2D:4D and head circumference as the latter variable is correlated with intelligence.</div></div><div><h3>Material and methods</h3><div>Our sample was 225 full-term (37–41 weeks) newborns comprising 125 girls and 100 boys. Recumbent length, weight, head circumference and right and left second and fourth digit lengths were measured. In addition to biological measures, maternal education was recorded as a proxy for sociodemographic status. Hierarchical multiple linear regression analyses were conducted separately for each sex to assess associations.</div></div><div><h3>Results</h3><div>For males, recumbent length and right 2D:4D were significantly positively associated with head circumference. Mother's education level was not related to head circumference. For females, recumbent length and birth weight were significant positive predictors of head circumference, digit ratios and mother's education showed no association. The independent variables accounted for more variance in head circumference for male newborns than for females.</div></div><div><h3>Conclusions</h3><div>We have found that right 2D:4D of newborns is positively correlated to head circumference, the effect was strongest for boys and independent of recumbent length and weight. High 2D:4D is associated with high prenatal oestrogen and head circumference is positively linked to intelligence. We discuss our findings in the context of oestrogenization in human brain evolution.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"214 ","pages":"Article 106479"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Effectiveness of an oral-motor intervention for premature infants: Feeding and maternal self-efficacy” [Early Human Development 210 (2025) 106382] “早产儿口腔运动干预的有效性：喂养和母亲自我效能”的更正[早期人类发展210(2025)106382]。

IF 2 3区医学

Early human development Pub Date : 2026-03-01 Epub Date: 2025-09-05 DOI: 10.1016/j.earlhumdev.2025.106390

Zohar Meroz , Jennifer R. Budman , Aviva Yochman , Alona Bin-Nun , Anat Golos

引用次数: 0

Associations between parental stress, parent-infant bonding, and infant neuromotor functioning 父母压力、亲子关系和婴儿神经运动功能之间的关系。

IF 2 3区医学

Early human development Pub Date : 2026-03-01 Epub Date: 2025-12-11 DOI: 10.1016/j.earlhumdev.2025.106459

L.C. Span , E.M. Rodenboog , N.H. van Dokkum , A.F. Bos , C.A. Hartman

{"title":"Associations between parental stress, parent-infant bonding, and infant neuromotor functioning","authors":"L.C. Span , E.M. Rodenboog , N.H. van Dokkum , A.F. Bos , C.A. Hartman","doi":"10.1016/j.earlhumdev.2025.106459","DOIUrl":"10.1016/j.earlhumdev.2025.106459","url":null,"abstract":"<div><h3>Aim</h3><div>The young developing brain is very sensitive to many environmental influences, both positive and negative. Parental stress and parent-infant bonding have been shown to be associated with neurodevelopmental delays in toddlers. However, it is not known at what age these associations become relevant which we aim to study as early as three-months of age, paving the way for new intervention strategies.</div></div><div><h3>Methods</h3><div>This study included 339 parent-infant dyads or triads from the Dutch TRAILS-NEXT cohort. Parental stress and parent-infant bonding were assessed at three months of age using the ‘Nijmeegse Ouderlijke Stress Index – Korte versie’ (NOSI-K) and Postpartum Bonding Questionnaire (PBQ), respectively. Infant neurodevelopment was assessed using the General Movement Assessment (GMA), including the Motor Optimality score – Revised (MOS-R). Perinatal risk factors with known associations with infant neurodevelopment were included as potential confounders.</div></div><div><h3>Results</h3><div>210 infant-mother dyads and 147 infant-partner dyads were included in the main analysis. Parental stress levels were elevated in 7 % of mothers and 18 % of partners, but no significant correlations were found between parental stress, bonding, and MOS-R scores. After adjustments for confounders, neither parental bonding nor stress showed significant relationships with general movement characteristics in regression analyses, suggesting that other factors may influence individual differences in early motor development.</div></div><div><h3>Conclusion</h3><div>Parental stress and parent-infant bonding were not associated with infant neurodevelopment at age of three months, suggesting a wider window of opportunity to intervene in case of parental stress or suboptimal parent-infant bonding.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"214 ","pages":"Article 106459"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0