Early human development最新文献

{"title":"Exploring the burden of preterm infant care in Africa: A comprehensive review of current research","authors":"Mary Mayowa Adetoye ,&nbsp;John Ehi Aboje ,&nbsp;Mercy Chisom Agu ,&nbsp;Praise Oluwatobi Ogunleke ,&nbsp;Eno Abasi Sunday ,&nbsp;Babalola David Olaoluwa ,&nbsp;Alexander Idu Entonu ,&nbsp;Tahav Joshua Kachina ,&nbsp;Gbolahan Olatunji ,&nbsp;Emmanuel Kokori ,&nbsp;Nicholas Aderinto","doi":"10.1016/j.earlhumdev.2025.106464","DOIUrl":"10.1016/j.earlhumdev.2025.106464","url":null,"abstract":"<div><h3>Objective(s)</h3><div>Preterm birth, delivery before 37 weeks of gestation, remains a major contributor to neonatal morbidity and mortality worldwide, with sub-Saharan Africa disproportionately affected. This review aimed to examine the multidimensional burden of caring for preterm infants in African contexts, focusing on economic, psychological, social, and health system challenges experienced by caregivers and healthcare providers.</div></div><div><h3>Study design</h3><div>A narrative review approach was adopted. A comprehensive literature search was conducted across PubMed, Scopus, Web of Science, Google Scholar, and African Journals Online (AJOL), as well as relevant grey literature. Thirty-three studies meeting predefined inclusion criteria were analyzed to identify recurring themes and intervention gaps related to preterm infant care across diverse African settings.</div></div><div><h3>Results</h3><div>The review revealed substantial financial strain on families due to high out-of-pocket expenditures, inadequate insurance coverage, and logistical challenges such as transportation barriers, especially in rural areas. Caregivers frequently experienced anxiety, depression, and social isolation, compounded by poor communication and limited emotional support within health facilities. Health systems were characterized by shortages of essential neonatal equipment, inadequate staffing, inconsistent clinical protocols, and limited training in evidence-based neonatal care. Promising interventions identified included kangaroo mother care, antenatal corticosteroid use, and automated oxygen titration systems.</div></div><div><h3>Conclusion(s)</h3><div>Caring for preterm infants in Africa involves intersecting economic, emotional, and systemic challenges. Strengthening policy and research frameworks, expanding caregiver support, and implementing culturally sensitive, evidence-based interventions are essential to reduce preterm mortality and alleviate caregiver burden across the region.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"214 ","pages":"Article 106464"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parenthood after neonatal care -parenting sense of competence and coparenting three years after discharge","authors":"Christine Persson ,&nbsp;Jenny Ericson ,&nbsp;Mats Eriksson ,&nbsp;Raziye Salari ,&nbsp;Renée Flacking","doi":"10.1016/j.earlhumdev.2025.106462","DOIUrl":"10.1016/j.earlhumdev.2025.106462","url":null,"abstract":"<div><div>Many parents of infants in neonatal intensive care units (NICUs) experience trauma and a loss of their parental role, which may affect their parenting following discharge. This study aimed to compare parenting competence and coparenting between parents of NICU and non-NICU infants three years postpartum. We also examined factors influencing parenting among NICU parents.</div><div>We used a comparative cohort design to collect data from 561 parents who completed a set of questionnaires, including measures of parenting sense of competence, coparenting, dyadic relationship quality, social support, and depressive symptoms.</div><div>Three years postpartum, no differences were found in parenting sense of competence or coparenting between NICU parents and non-NICU parents. For both NICU mothers and fathers, a higher parenting sense of competence in satisfaction and efficacy was associated with a higher quality in the couple relationship. Mothers reported higher parenting satisfaction if they had not experienced a traumatic birth. Fathers reported higher parenting satisfaction if they had no depressive symptoms, and higher parenting efficacy if they had a longer couple relationship, received greater social support, had a shorter infant hospital stay, or were rooming-in with their partner and infant during hospitalization. Factors associated with more coparenting problems among NICU parents included lower couple relationship quality, a 7–14-day hospitalization for mothers, and lower social support for fathers.</div><div>This study highlights that early possibilities for parents to initiate parenthood together and receive adequate mental and social support during and after NICU hospitalization should be a priority for enhancing parents' sense of competence and coparenting.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"214 ","pages":"Article 106462"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the first months to later ages: Early spontaneous movements and developmental outcomes in extremely low birth weight infants","authors":"Doğan Porsnok ,&nbsp;Bilge Nur Yardımcı-Lokmanoğlu ,&nbsp;Hasan Tolga Çelik ,&nbsp;Akmer Mutlu","doi":"10.1016/j.earlhumdev.2026.106478","DOIUrl":"10.1016/j.earlhumdev.2026.106478","url":null,"abstract":"<div><h3>Background</h3><div>Extremely low birth weight (ELBW; &lt;1000 g) infants are at high-risk for developmental problems; however, no such long-term study has been conducted in this group before in our country. This study aimed to compare the early spontaneous movements and later developmental outcomes of ELBW infants with those of term born normal birth weight (NBW) infants, and to examine the association between the early spontaneous movements and later developmental outcomes at 9-to 12-months of corrected age and at 24-to 42-months in ELBW infants.</div></div><div><h3>Methods</h3><div>Early spontaneous movements of all infants were assessed using the Motor Optimality Score-Revised (MOS-R) at 9-to 20-weeks of corrected age. Developmental outcomes, including cognitive, language and motor domains, were performed using the Bayley Scales of Infant and Toddler Development-Third Edition (Bayley-III) at 9-to 12-months of corrected age in ELBW infants, and at 24-to 42-months of age in both ELBW and term NBW infants.</div></div><div><h3>Results</h3><div>The study included 61 ELBW infants and 50 term NBW infants. ELBW infants had lower MOS-R results (<em>p</em> = 0.017) and lower cognitive (<em>p</em> &lt; 0.001), language (p &lt; 0.001), and motor domains (p &lt; 0.001) outcomes at 24-to 42-months of age compared to term NBW infants. MOS-R and its subcategories were found to be associated with all Bayley-III domains (<em>r</em> = 0.492–0.603, <em>p</em> &lt; 0.05) at both the 9-to 12-months and 24-to 42-months of age.</div></div><div><h3>Conclusions</h3><div>It is highlighted that ELBW infants have lower results than NBW infants, including MOS-R from the early period of life. MOS-R results may serve as a crucial tool to identify ELBW infants who are at higher risk for developmental parameters.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"214 ","pages":"Article 106478"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent short-term and long-term outcomes of massive pulmonary hemorrhage in extremely low birth weight infants: A nationwide cohort study","authors":"Yu Seon Kim ,&nbsp;Eun Yeob Kim ,&nbsp;Hye Jin Cho ,&nbsp;Hye Won Cho ,&nbsp;Eun Hee Lee ,&nbsp;Byung Min Choi","doi":"10.1016/j.earlhumdev.2025.106460","DOIUrl":"10.1016/j.earlhumdev.2025.106460","url":null,"abstract":"<div><h3>Introduction</h3><div>To evaluate the short- and long-term outcomes, particularly neurodevelopment, of extremely low birth weight (ELBW) infants with massive pulmonary hemorrhage, in the context of recent improvements in perinatal and neonatal intensive care.</div></div><div><h3>Study design</h3><div>Data from the prospective registry of the Korean Neonatal Network of ELBW infants born in 69 hospitals across South Korea between 2014 and 2022 were retrospectively analyzed.</div></div><div><h3>Results</h3><div>Seven hundred and eight (11.2 %) of 6344 ELBW infants were diagnosed with MPH and divided into survivors at discharge (<em>n</em> = 253, 35.7 %) and in-hospital deaths (<em>n</em> = 455, 64.3 %). The annual incidence of MPH significantly declined from 13.9 % in 2014 to 7.7 % in 2022, and was accompanied by a similar decrease in in-hospital mortality.</div><div>Surviving infants who experienced MPH had higher rates of in-hospital morbidities. They also showed more adverse neurodevelopmental outcomes than those without MPH. After multivariable adjustment, the risks of cerebral palsy (OR 2.136; 95 % CI 1.253–3.638) and moderate developmental delay on BSID-II/III (OR 2.088; 95 % CI 1.279–3.409) remained significantly higher in MPH survivors.</div></div><div><h3>Conclusion</h3><div>The incidence and in-hospital deaths of massive pulmonary hemorrhage in ELBW infants have decreased in recent years. However, improved survival may be accompanied by increased in-hospital morbidity and adverse neurodevelopmental outcomes, underscoring the need for ongoing monitoring and strategies to mitigate short- and long-term complications in this high-risk population.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"214 ","pages":"Article 106460"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145793563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-reported mental health in adults born extremely preterm. A population based, cross-sectional study","authors":"Åse Margrethe Reed ,&nbsp;Bente Johanne Vederhus ,&nbsp;Geir Egil Eide ,&nbsp;Merete Røineland Benestad","doi":"10.1016/j.earlhumdev.2025.106457","DOIUrl":"10.1016/j.earlhumdev.2025.106457","url":null,"abstract":"<div><h3>Aims</h3><div>The study aims to examine whether self-reported mental health outcomes among adults born extremely preterm differ from those of adults born at term.</div></div><div><h3>Methods</h3><div>A population-based, cross-sectional study was conducted. The study included 48 eligible individuals born between 1982 and 1985 in western Norway with a gestational age ≤ 28 weeks or birth weight ≤ 1000 g, and 46 term-born controls. Mental health was assessed at age 34 years using the Adult Self-Report questionnaire. Data was analysed to compare outcomes between preterm and term-born controls.</div></div><div><h3>Results</h3><div>At age 34 years, 32 (67 %) extremely preterm born and 36 (78 %) term-born participated. The extremely preterm group reported significantly higher scores than the term-born group on the mental health scales for anxious/depressed, withdrawn, somatic complaints, aggressive behaviour, internalizing, and total problems. The extremely preterm group had lower levels of education and employment, and higher rates of disability or unemployment.</div></div><div><h3>Conclusions</h3><div>The findings suggest an association between being born extremely preterm or with extremely low birth weight and poorer self-reported mental health in adulthood compared with term-born controls. Future research should investigate potential underlying causes of this relationship to improve understanding and develop preventive strategies.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"214 ","pages":"Article 106457"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early risk factors related to social functioning in young adults born very preterm","authors":"Sarah C.H. Thompson ,&nbsp;Rheanna M. Mainzer ,&nbsp;Leona Pascoe ,&nbsp;Thi-Nhu-Ngoc Nguyen ,&nbsp;Lauren Pigdon ,&nbsp;Jeanie Cheong ,&nbsp;Terrie E. Inder ,&nbsp;Lex W. Doyle ,&nbsp;Karli Treyvaud ,&nbsp;Peter J. Anderson","doi":"10.1016/j.earlhumdev.2025.106475","DOIUrl":"10.1016/j.earlhumdev.2025.106475","url":null,"abstract":"<div><h3>Background</h3><div>Individuals born very preterm (VPT; &lt;32 weeks' gestation) are at a greater risk of poorer social outcomes than individuals born at term. However, it remains unclear which subgroups of individuals born VPT are at greater risk of lower social functioning later in life. This study aimed to describe the medical, behavioral, emotional, cognitive, and environmental risks in childhood for lower social functioning in early adulthood among young adults born VPT.</div></div><div><h3>Methods</h3><div>Participants were assessed on social functioning domains at age 20 years (<em>N</em> = 123) and risk factors were assessed at birth (<em>N</em> = 224), 2 (<em>N</em> = 219) and 7 (<em>N</em> = 197) years of age in the Victorian Infant Brain Study longitudinal cohort. Differences in mean scores of social functioning outcomes and proportions with lower social functioning at 20 years between risk groups were estimated using generalized linear models. Multiple imputation was used to address missing data.</div></div><div><h3>Results</h3><div>In childhood, greater behavioral and emotional problems, lower cognition, and higher sociodemographic risk were strongly associated with lower social functioning in all domains at age 20. Medical risk was weakly associated with social interaction and social adjustment at age 20.</div></div><div><h3>Conclusions</h3><div>Children born VPT with higher cognitive, behavioral, emotional, and sociodemographic risk have increased likelihood of lower social functioning in early adulthood than those without risk, and could benefit from receiving earlier support to scaffold the development of social skills.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"214 ","pages":"Article 106475"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between parent touch attitudes and experiences with duration of skin-to-skin contact and holding in preterm infants","authors":"Hilde K. Jacobsen ,&nbsp;Bente S. Tandberg ,&nbsp;Nina M. Kynø ,&nbsp;Uta Sailer","doi":"10.1016/j.earlhumdev.2025.106476","DOIUrl":"10.1016/j.earlhumdev.2025.106476","url":null,"abstract":"<div><h3>Background</h3><div>Skin-to-skin contact (SSC) provides extensive benefits for preterm infants and is highly recommended. However, parental SSC duration in Neonatal Intensive Care Units (NICU) varies considerably, with contributing factors poorly understood. Parents' perspectives on, and prior experiences with touch may influence SSC duration.</div></div><div><h3>Aims</h3><div>To investigate how parental attitudes toward and experiences with touch relate to SSC and holding durations, and to explore how these durations vary by relationship (mother/father), infant gestational age (GA) and parents' level of education.</div></div><div><h3>Study design</h3><div>Observational Study.</div></div><div><h3>Subjects</h3><div>Parents (<em>n</em> = 123) of preterm infants (<em>n</em> = 69), GA 27⁰–36⁶, admitted to a Norwegian family-centered care NICU providing 24/7 parental presence, participated.</div></div><div><h3>Outcome measures</h3><div>Daily parental SSC and holding durations (one week), video-evaluation of occurrence of slow, gentle and faster stroking, and Touch Experiences and Attitudes Questionnaire.</div></div><div><h3>Results</h3><div>Mothers provided significantly more SSC (<em>p</em> = .024) and holding (<em>p</em> = .005) than fathers. Parents provided significantly more SSC for infants at GA 27–30 (<em>p</em> = .029) and GA 31–33 (<em>p</em> = .036) than for GA 34–36, while significantly more holding for GA 31–33 (<em>p</em> = .022) and GA 34–36 (<em>p</em> = .001) than GA 27–30. No relation between parents' touch attitudes and experiences, affective touch awareness, or education, and SSC and holding duration was observed.</div></div><div><h3>Conclusion</h3><div>Maternal status and GA predicted SSC and holding duration yet explained the variance only partially. Parents' touch attitudes and experiences showed no association. This suggests that contextual, clinical or systemic factors may predominantly determine SSC and holding provision.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"214 ","pages":"Article 106476"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The motor optimality of infants who have had Meningitis in the first months of life: A retrospective study","authors":"Sophie Dixon ,&nbsp;Samantha Ashby ,&nbsp;Caroline Kuhne ,&nbsp;Karen Ray ,&nbsp;Larissa Korostenski ,&nbsp;Katya Zawada ,&nbsp;Anna Mistry ,&nbsp;Rosemary Day ,&nbsp;Michelle Jackman","doi":"10.1016/j.earlhumdev.2025.106477","DOIUrl":"10.1016/j.earlhumdev.2025.106477","url":null,"abstract":"<div><h3>Background</h3><div>Infants who have meningitis are at increased risk of adverse neurodevelopmental outcomes. Early screening tools can add value in identifying infants who may benefit from early intervention supports. The Motor Optimality Score Revised (MOS-R) is a relatively new tool used between 3 and 5 months of age that may have predictive value.</div></div><div><h3>Aim</h3><div>To describe the motor optimality of infants diagnosed with meningitis and determine whether the MOS-R is associated with development at 12 months of age.</div></div><div><h3>Study design</h3><div>A retrospective, single-center, cohort study from 2011 to 2023. The MOS-R was taken at 3–4 months corrected gestational age and development was assessed using the Bayley Scales of Infant and Toddler Development (Bayley) III/IV at 12 or 24 months of age.</div></div><div><h3>Subjects</h3><div>Participants included 73 infants (mean gestational age 37 + 3), admitted to hospital with meningitis before 4 months of age, who had a general movements assessment.</div></div><div><h3>Results</h3><div>Infants had a mean MOS-R of 22.3 (SD 3.29), with most infants <del>in the study</del> having MOS-R scores indicating mildly reduced optimality (78.8 %). Significant positive correlations were found between MOS-R total scores and the receptive language, expressive language and gross motor domains of the Bayley III/IV. Infants with MOS-R scores &lt;21 were more likely to show developmental delays in cognition, expressive language and receptive language.</div></div><div><h3>Conclusion</h3><div>For infants who had meningitis, MOS-R scores were associated with development at 12 months of age. The MOS-R, used in addition to GMA may have the potential to identify infants who would benefit from early intervention to support their development. Further research is needed to understand the use of the MOS-R, alongside other screening tools for populations at risk of adverse neurodevelopmental outcomes.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"214 ","pages":"Article 106477"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effects of maternal diabetes on early infant neurodevelopment with a novel combination of four neurodevelopmental tools","authors":"Alexa Escapita ,&nbsp;Alexandra Glatter ,&nbsp;Eric Siegel ,&nbsp;Tara Johnson ,&nbsp;Hari Eswaran ,&nbsp;Diana Escalona-Vargas","doi":"10.1016/j.earlhumdev.2025.106461","DOIUrl":"10.1016/j.earlhumdev.2025.106461","url":null,"abstract":"<div><div>There are associations between maternal diabetes and neurodevelopmental disorders, such as autism spectrum disorders, attention-deficit/hyperactivity disorder, and intellectual disabilities. Using this knowledge, our objective is to characterize the effects of type 1 (T1DM) and type 2 diabetes mellitus (T2DM) on the neurodevelopment of infants.</div><div>We performed a prospective study on 54 infants of mothers with T1DM (<em>n</em> = 10), T2DM (<em>n</em> = 24), and non-diabetic controls (<em>n</em> = 20). To evaluate their neurodevelopment in multiple developmental domains, we used four assessments on 1–2-month-old infants: The Hammersmith Neonatal Neurological Examination (HNNE), The Dubowitz exam, The Capute Scales, and The General Movement Assessment (GMA).</div><div>Differences in neurodevelopmental outcomes did not reach statistical significance in any of the four assessments, individually or combined. However, we note the following trends: 20 infants had suboptimal neuromotor development (HNNE score &lt; 30.5). T1DM group infants had lower mean language scores (83.7 vs 105.85) when compared to the control group. Using GMA, T2DM group infants had more abnormal writhing movements when compared to the other groups.</div><div>Our overall findings suggest that the T1DM group had lower language scores and the T2DM group had lower visual-motor (cognitive) scores which may indicate developmental delays. Further research is needed to confirm these findings. We suggest that these infant's parents consider developmental therapy, to promote early identification and treatment of potential developmental delays. To our knowledge this study would be the first to use the combination of these assessments to evaluate 1-month-olds in this patient population. Given the small sample size, these findings should be interpreted with caution.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"214 ","pages":"Article 106461"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145780545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental vascular abnormality is associated with worse neurodevelopmental outcomes for infants with congenital heart disease and genetic abnormality","authors":"Kelly L. Meyer ,&nbsp;Clare O'Hare ,&nbsp;Mai He ,&nbsp;Gillian Mayersohn ,&nbsp;Avihu Z. Gazit ,&nbsp;Anthony Odibo ,&nbsp;Jinli Wang ,&nbsp;Cynthia M. Ortinau","doi":"10.1016/j.earlhumdev.2025.106456","DOIUrl":"10.1016/j.earlhumdev.2025.106456","url":null,"abstract":"<div><h3>Objective</h3><div>Determine the association of placental vascular abnormality with neurodevelopment (ND) in toddlers with congenital heart disease (CHD) requiring intervention with cardiopulmonary bypass (CPB) in the first year of life.</div></div><div><h3>Study design</h3><div>This single center retrospective cohort study included 69 singleton, term-born infants with prenatally diagnosed CHD requiring CPB in infancy who had placental pathology data and underwent ND follow-up assessment with the Bayley Scales of Infant and Toddler Development (Bayley). Infants with a clinically diagnosed genetic abnormality were included. Placental vascular abnormality was defined as maternal vascular malperfusion, fetal vascular malperfusion, or delayed villous maturation. Multivariable regression models were used to assess the association between placental vascular abnormality and Bayley scores.</div></div><div><h3>Results</h3><div>Placental vascular abnormality was present in 43 % (30/69) of the cohort and was associated with lower Bayley language and motor scores on univariate analysis. A significant interaction was identified between placental vascular abnormality and genetic abnormality, which occurred in 26 % (18/69) of the cohort. In multivariable models, compared to infants with genetic abnormality alone, infants with placental vascular abnormality and genetic abnormality had lower cognitive (group difference –18.4, 95 % CI –30.7, −6.1), language (group difference –27.5, 95 % CI –41.2, −13.9), and motor (group difference –27.6, 95 % CI –40.9, −14.2) composite scores. There was no association of placental vascular abnormality with ND scores for infants without genetic abnormality in multivariable models.</div></div><div><h3>Conclusion</h3><div>Placental vascular abnormalities are associated with worse ND outcomes in infants with CHD when a genetic abnormality is also present.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"213 ","pages":"Article 106456"},"PeriodicalIF":2.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145690754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}