一岁儿童早期甲状腺激素和神经发育评估：DSAN-12m出生队列研究

IF 2 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Early human development Pub Date : 2025-06-15 DOI:10.1016/j.earlhumdev.2025.106320

Nathália Ribeiro dos Santos , Homègnon Antonin Ferréol Bah , Erival Amorim Gomes Júnior , Daisy Oliveira Costa , Victor Otero Martinez , Elis Macedo Pires , Maria Isabel Santos Silveira Souza , Chrissie Ferreira de Carvalho , Nara Côrtes Andrade , José Antonio Menezes Filho

{"title":"一岁儿童早期甲状腺激素和神经发育评估：DSAN-12m出生队列研究","authors":"Nathália Ribeiro dos Santos , Homègnon Antonin Ferréol Bah , Erival Amorim Gomes Júnior , Daisy Oliveira Costa , Victor Otero Martinez , Elis Macedo Pires , Maria Isabel Santos Silveira Souza , Chrissie Ferreira de Carvalho , Nara Côrtes Andrade , José Antonio Menezes Filho","doi":"10.1016/j.earlhumdev.2025.106320","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Maternal thyroid dysfunction during pregnancy has been implicated in adverse infant neurodevelopmental outcomes.</div></div><div><h3>Objective</h3><div>This study investigates the complex interplay between maternal and children's thyroid hormones and neurodevelopmental outcomes in children of the DSAN-12m birth cohort in the Recôncavo Baiano, Brazil.</div></div><div><h3>Methods</h3><div>Thyroid-stimulating hormone (TSH), free thyroxine (FT4), and total triiodothyronine (TT3) levels were measured in serum samples collected during the second trimester of pregnancy and infants at 19 months old. Neurodevelopmental assessment was conducted using the Bayley Scales of Infant and Toddler Development, 3rd edition (BSID-III). A total of 66 mother-infant pairs were evaluated.</div></div><div><h3>Results</h3><div>In general, thyroid hormones were within the reference range for both mothers and infants. However, 79.4 % of children had low FT4 levels. Higher FT4 levels in children were significantly associated with enhanced motor skills, particularly among boys, underlining the gender-specific associations. In pregnant women, TT3 levels were positively associated with language development, while TSH concentrations were negatively associated with the language domain. A non-linear association was observed, indicating better motor development scores with increasing TSH levels, within reference range, in all children. No associations were observed between thyroid hormones and BSID-III scores in girls.</div></div><div><h3>Conclusions</h3><div>This study elucidates the multifaceted relationship between maternal and infant thyroid function, and subsequent neurodevelopmental outcomes. These findings emphasize the importance of thyroid health during pregnancy and infancy, highlighting the need for further research to better understand this relationship.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"208 ","pages":"Article 106320"},"PeriodicalIF":2.0000,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Early-life thyroid hormones and neurodevelopmental assessment in one-year old children: DSAN-12m birth cohort study\",\"authors\":\"Nathália Ribeiro dos Santos , Homègnon Antonin Ferréol Bah , Erival Amorim Gomes Júnior , Daisy Oliveira Costa , Victor Otero Martinez , Elis Macedo Pires , Maria Isabel Santos Silveira Souza , Chrissie Ferreira de Carvalho , Nara Côrtes Andrade , José Antonio Menezes Filho\",\"doi\":\"10.1016/j.earlhumdev.2025.106320\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Maternal thyroid dysfunction during pregnancy has been implicated in adverse infant neurodevelopmental outcomes.</div></div><div><h3>Objective</h3><div>This study investigates the complex interplay between maternal and children's thyroid hormones and neurodevelopmental outcomes in children of the DSAN-12m birth cohort in the Recôncavo Baiano, Brazil.</div></div><div><h3>Methods</h3><div>Thyroid-stimulating hormone (TSH), free thyroxine (FT4), and total triiodothyronine (TT3) levels were measured in serum samples collected during the second trimester of pregnancy and infants at 19 months old. Neurodevelopmental assessment was conducted using the Bayley Scales of Infant and Toddler Development, 3rd edition (BSID-III). A total of 66 mother-infant pairs were evaluated.</div></div><div><h3>Results</h3><div>In general, thyroid hormones were within the reference range for both mothers and infants. However, 79.4 % of children had low FT4 levels. Higher FT4 levels in children were significantly associated with enhanced motor skills, particularly among boys, underlining the gender-specific associations. In pregnant women, TT3 levels were positively associated with language development, while TSH concentrations were negatively associated with the language domain. A non-linear association was observed, indicating better motor development scores with increasing TSH levels, within reference range, in all children. No associations were observed between thyroid hormones and BSID-III scores in girls.</div></div><div><h3>Conclusions</h3><div>This study elucidates the multifaceted relationship between maternal and infant thyroid function, and subsequent neurodevelopmental outcomes. These findings emphasize the importance of thyroid health during pregnancy and infancy, highlighting the need for further research to better understand this relationship.</div></div>\",\"PeriodicalId\":11435,\"journal\":{\"name\":\"Early human development\",\"volume\":\"208 \",\"pages\":\"Article 106320\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-06-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Early human development\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0378378225001306\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Early human development","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0378378225001306","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

背景：孕妇甲状腺功能障碍与婴儿神经发育不良有关。目的研究巴西Recôncavo Baiano DSAN-12m出生队列儿童甲状腺激素与神经发育结局之间的复杂相互作用。方法测定妊娠中期和19月龄婴儿血清促甲状腺激素（TSH）、游离甲状腺素（FT4）和总三碘甲状腺原氨酸（TT3）水平。神经发育评估采用Bayley婴幼儿发育量表第3版（BSID-III）进行。共对66对母婴进行了评估。结果母婴甲状腺激素水平总体在参考范围内。然而，79.4%的儿童FT4水平较低。儿童中较高的FT4水平与运动技能的增强显著相关，特别是在男孩中，强调了性别特异性关联。在孕妇中，TT3水平与语言发育呈正相关，而TSH浓度与语言域呈负相关。观察到非线性关联，表明在所有儿童中，在参考范围内，随着TSH水平的增加，运动发育评分也随之提高。在女孩中，甲状腺激素和BSID-III评分之间没有关联。结论本研究阐明了母婴甲状腺功能与随后的神经发育结局之间的多方面关系。这些发现强调了孕期和婴儿期甲状腺健康的重要性，强调了进一步研究以更好地理解这种关系的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Early-life thyroid hormones and neurodevelopmental assessment in one-year old children: DSAN-12m birth cohort study

Background

Maternal thyroid dysfunction during pregnancy has been implicated in adverse infant neurodevelopmental outcomes.

Objective

This study investigates the complex interplay between maternal and children's thyroid hormones and neurodevelopmental outcomes in children of the DSAN-12m birth cohort in the Recôncavo Baiano, Brazil.

Methods

Thyroid-stimulating hormone (TSH), free thyroxine (FT4), and total triiodothyronine (TT3) levels were measured in serum samples collected during the second trimester of pregnancy and infants at 19 months old. Neurodevelopmental assessment was conducted using the Bayley Scales of Infant and Toddler Development, 3rd edition (BSID-III). A total of 66 mother-infant pairs were evaluated.

Results

In general, thyroid hormones were within the reference range for both mothers and infants. However, 79.4 % of children had low FT4 levels. Higher FT4 levels in children were significantly associated with enhanced motor skills, particularly among boys, underlining the gender-specific associations. In pregnant women, TT3 levels were positively associated with language development, while TSH concentrations were negatively associated with the language domain. A non-linear association was observed, indicating better motor development scores with increasing TSH levels, within reference range, in all children. No associations were observed between thyroid hormones and BSID-III scores in girls.

Conclusions

This study elucidates the multifaceted relationship between maternal and infant thyroid function, and subsequent neurodevelopmental outcomes. These findings emphasize the importance of thyroid health during pregnancy and infancy, highlighting the need for further research to better understand this relationship.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Early human development 医学-妇产科学

CiteScore

4.40

自引率

4.00%

发文量

100

审稿时长

46 days

期刊介绍： Established as an authoritative, highly cited voice on early human development, Early Human Development provides a unique opportunity for researchers and clinicians to bridge the communication gap between disciplines. Creating a forum for the productive exchange of ideas concerning early human growth and development, the journal publishes original research and clinical papers with particular emphasis on the continuum between fetal life and the perinatal period; aspects of postnatal growth influenced by early events; and the safeguarding of the quality of human survival. The first comprehensive and interdisciplinary journal in this area of growing importance, Early Human Development offers pertinent contributions to the following subject areas: Fetology; perinatology; pediatrics; growth and development; obstetrics; reproduction and fertility; epidemiology; behavioural sciences; nutrition and metabolism; teratology; neurology; brain biology; developmental psychology and screening.