肌肉质量对新生儿神经精神运动发育的影响：早产儿和足月婴儿的比较分析

IF 2.2 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Early human development Pub Date : 2025-04-16 DOI:10.1016/j.earlhumdev.2025.106267

Carolina Cristina dos Santos Camargo , Débora Nunes Prata Anjos , Etiene Farah Teixeira de Carvalho , Eneida Yuri Suda , Evelim Leal de Freitas Dantas Gomes

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引用次数: 0

摘要

早产儿在发育的关键时期导致多个系统的结构和功能重塑。胎龄与神经发育障碍以及心血管、代谢和呼吸系统疾病的风险成反比关系。早产新生儿在宫外生命的最初几周表现出出生后生长迟缓。最近的研究表明，一段时间的快速增长会对长期健康产生重大影响，而瘦体重的不成比例增长是一个因素。目的探讨早产儿和足月儿骨骼肌大小和质量对运动能力的影响。方法在某公立医院新生儿病房进行横断面研究。对94例新生儿进行评估并分为两组：早产儿（PTNB, n = 47）和足月新生儿（FTNB, n = 47）。采用运动学超声评估股骨直肌、胫骨前肌和肱二头肌的骨骼肌厚度、横截面积和穿刺角。采用婴儿运动表现测试（TIMP）量表评估神经精神运动表现。结果FTNB组患者下肢肌肉大小与TIMP评分显著相关。相反，在PTNB组中，下肢和上肢肌肉的大小都影响TIMP评分。PTNB组表现出较低的人体测量值，并表现出较低的TIMP分数和z分数所显示的神经精神运动发育延迟。结论除早产儿外，骨骼肌大小对新生儿运动能力也有重要影响。

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Effect of muscle mass on neuropsychomotor development in newborns: A comparative analysis between preterm and full-term infants

Introduction

Premature birth leads to structural and functional remodeling of multiple systems during a critical developmental period. There is an inversely proportional relationship between gestational age and the risk of neurodevelopmental impairment, as well as cardiovascular, metabolic, and respiratory diseases. Premature newborns exhibit delayed postnatal growth in the initial weeks of extrauterine life. Recent studies have shown that a period of rapid growth can significantly impact long-term health, with the disproportionate growth of lean mass being a contributing factor.

Objective

This study aims to correlate and assess the effect of skeletal muscle size and quality on motor performance in preterm newborns compared to full-term infants.

Methods

A cross-sectional study was conducted at the neonatal unit of a public hospital. Ninety-four newborns were evaluated and divided into two groups: preterm newborns (PTNB, n = 47) and full-term newborns (FTNB, n = 47). Skeletal muscle thickness, cross-sectional area, and pennation angle of the rectus femoris, tibialis anterior, and biceps brachii were assessed using kinesiological ultrasound. Neuropsychomotor performance was evaluated using the Test of Infant Motor Performance (TIMP) scale.

Results

In the FTNB group, the size of the lower limb muscles was significantly correlated with the TIMP score. In contrast, in the PTNB group, the size of both lower and upper limb muscles influenced the TIMP score. The PTNB group exhibited lower anthropometric measurements and showed delayed neuropsychomotor development as indicated by lower TIMP scores and Z-scores.

Conclusion

These findings demonstrate that, in addition to prematurity, skeletal muscle size plays a significant role in influencing motor performance in newborns.

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来源期刊

Early human development 医学-妇产科学

CiteScore

4.40

自引率

4.00%

发文量

100

审稿时长

46 days

期刊介绍： Established as an authoritative, highly cited voice on early human development, Early Human Development provides a unique opportunity for researchers and clinicians to bridge the communication gap between disciplines. Creating a forum for the productive exchange of ideas concerning early human growth and development, the journal publishes original research and clinical papers with particular emphasis on the continuum between fetal life and the perinatal period; aspects of postnatal growth influenced by early events; and the safeguarding of the quality of human survival. The first comprehensive and interdisciplinary journal in this area of growing importance, Early Human Development offers pertinent contributions to the following subject areas: Fetology; perinatology; pediatrics; growth and development; obstetrics; reproduction and fertility; epidemiology; behavioural sciences; nutrition and metabolism; teratology; neurology; brain biology; developmental psychology and screening.