Early human development最新文献

{"title":"Effects of 4 weeks of play in standing and walking on gross motor ability and segmental trunk control in preterm infants using a playpen: A randomized control trial","authors":"Noppharath Sangkarit,&nbsp;Weerasak Tapanya,&nbsp;Chonthicha Panmatchaya,&nbsp;Arpapat Sangpasit,&nbsp;Kanitta Thatawong","doi":"10.1016/j.earlhumdev.2024.106121","DOIUrl":"10.1016/j.earlhumdev.2024.106121","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the effect of computer-based early intervention with a playpen to enhance standing and walking, and to examine the relationship between changes in gross motor percentile and segmental trunk control in preterm infants nine months corrected age.</p></div><div><h3>Methods</h3><p>Forty infants born before 37 weeks of gestation were randomly assigned to either the experimental or control group. The Alberta Infant Motor Scale (AIMS) and the Segmental Assessment of Trunk Control (SATCo) were administered before and after the intervention. The experimental group, consisting of twenty preterm infants, participated in a computer-based early intervention involving 45 min of play in standing and walking positions, five times a week for 4 weeks.</p></div><div><h3>Results</h3><p>There were significant between-group differences in the gross motor percentiles of the AIMS (<em>p</em>-value &lt;0.001). In addition, there was a significant difference in all conditions of the SATCo scores (<em>p</em>-value &lt;0.05) compared with baseline score. The change in percentiles of gross motor development was significantly correlated (r_s = 0.643; p-value &lt;0.001) with reactive SATCo during walking in infants in the experimental group.</p></div><div><h3>Conclusion</h3><p>Early intervention with a playpen in a standing and walking position can be applied to improve changes in gross motor percentiles and segmental trunk control in preterm infants.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"198 ","pages":"Article 106121"},"PeriodicalIF":2.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The androgen receptor gene and criminal offending: Evidence derived from international data","authors":"Lee Ellis ,&nbsp;Anthony Hoskin ,&nbsp;Nicholas Hasan Buker","doi":"10.1016/j.earlhumdev.2024.106113","DOIUrl":"10.1016/j.earlhumdev.2024.106113","url":null,"abstract":"<div><p>Beginning early in fetal development, the androgen receptor (AR) gene helps regulate bodily exposure to testosterone. Most studies of individuals have found an inverse correlation between the number of CAG repeats on this gene and serious forms of physical aggression. This two-phased study was primarily undertaken to determine if a link between AR CAGn and physical aggression also exists at an ecological level of analysis. To make this assessment, we first conducted a bivariate analysis of the average number of AR CAG repeats for a large number of countries and the rates of crime victimization in those same countries. Except for motor vehicle theft, as the national average number of CAG repeats increased, crime victimization rates decreased. This inverse relationship was especially strong for violent offenses. In the second phase of this study, we sought to determine if per capita gross domestic product, pathogen prevalence, and average intelligence might be mediating some of the AR CAG repeats-criminality relationship. Mediation analysis analysis indicated that, once gross domestic product and pathogenic prevalence were controlled, average intelligence was able to eliminate most of the links between CAG repeats and crime victimization rates, especially in the case of violent offenses. These findings suggest that the AR gene is not influencing criminality primarily by altering testosterone brain exposure (as we suspected). Instead, it may affect criminality mainly by affecting cognitive ability. In fact, once average national intelligence is included in the mediation analysis model, direct relationships between CAG repeats and measures of homicide, assault, and robbery were no longer statistically significant. Findings from this two-phased study point toward the AR gene as having multiple effects on brain functioning, particularly regarding intellectual development as hypothesized by Manning [62]. Replication is obviously needed.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"198 ","pages":"Article 106113"},"PeriodicalIF":2.2,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0378378224001828/pdfft?md5=e3d2198d87124c5d0b255a87cb2f2081&pid=1-s2.0-S0378378224001828-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of early intervention on the mental wellbeing and caregiving practices of preterm infant caregivers","authors":"Eunice Eunhee Jang ,&nbsp;Samantha Burns ,&nbsp;Melissa Hunte ,&nbsp;Megan Vincett ,&nbsp;Lorraine Chiarotto ,&nbsp;Paige T. Church","doi":"10.1016/j.earlhumdev.2024.106112","DOIUrl":"10.1016/j.earlhumdev.2024.106112","url":null,"abstract":"<div><h3>Background</h3><p>The rising incidence of preterm births worldwide presents a pressing public health challenge, affecting both infants and their preterm caregivers. Early Intervention (EI) programs aim to mitigate the negative impacts associated with preterm births on the physical, cognitive, and psychological health of both infants and their caregivers by providing personalized parental support and developmental monitoring. This study addressed the gap in research evaluating the long-term effects of community-based EI programs on the holistic coping mechanisms of families, encompassing mental wellbeing, caregiving competencies, and the transition process from hospital to home care.</p></div><div><h3>Methods</h3><p>This study evaluated the long-term effects of a community-based EI program (in-home only) and the added benefits of earlier Hospital-to-Home (H2H) support, focusing on preterm caregivers' mental wellbeing and caregiving practices.</p></div><div><h3>Results</h3><p>The findings highlight the extended benefits of EI, demonstrating that program duration and intensity significantly benefit families dealing with neonatal intensive care unit stays. For infants requiring extensive medical intervention, EI support markedly enhances caregiver mental wellbeing. Additionally, interventions initiated earlier yield a more substantial positive effect on preterm caregivers' mental wellbeing after discharge compared to those that commence later.</p></div><div><h3>Conclusion</h3><p>These findings suggest the potential role of community-based EI programs and the benefits of supporting preterm caregivers before transitioning home. The study calls for future research to explore the effects of various EI program components to identify which interventions are most effective for addressing preterm infants' specific developmental challenges.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"198 ","pages":"Article 106112"},"PeriodicalIF":2.2,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Best Start Trial: A randomised controlled trial of ultra-early parent-administered physiotherapy for infants at high risk of cerebral palsy or motor delay","authors":"Barbara R. Lucas ,&nbsp;Jenny Bowen ,&nbsp;Catherine Morgan ,&nbsp;Iona Novak ,&nbsp;Nadia Badawi ,&nbsp;Elizabeth Elliott ,&nbsp;Genevieve Dwyer ,&nbsp;Venkatesha Venkatesha ,&nbsp;Lisa A. Harvey","doi":"10.1016/j.earlhumdev.2024.106111","DOIUrl":"10.1016/j.earlhumdev.2024.106111","url":null,"abstract":"<div><h3>Background</h3><p>It is unknown whether ultra-early physiotherapy commenced during neonatal intensive care unit admission is of value for optimising developmental outcomes in preterm/term infants at high-risk of cerebral palsy or motor-delay.</p></div><div><h3>Aims</h3><p>To determine whether ultra-early parent-administered physiotherapy to preterm/term high- risk infants commenced at earliest from 34-weeks post menstrual age, improves motor outcomes at 16-weeks corrected age (CA) compared to usual care.</p></div><div><h3>Methods</h3><p>Single-blind randomised controlled pilot study with 30 infant participants. The primary outcome was the Alberta Infant Motor Scale (AIMS) total score at 16-weeks CA. Secondary outcomes included (i) parent Depression Anxiety and Stress Score and Parent Perceptions Survey at 16-weeks CA; and (ii) Bayley Scales of Infant Development at 12-months CA.</p></div><div><h3>Results</h3><p>There were no clinically worthwhile effects at 16-weeks CA on the AIMS (mean between-group difference, 95% CI: -0.2, -2.4 to 2.0) or most secondary outcomes. However, the parents' “perception of treatment effectiveness” and “perception of change” favoured the experimental group.</p></div><div><h3>Conclusions</h3><p>In this pilot trial, there was no clinically worthwhile effect of ultra-early parent-administered physiotherapy over usual care on the AIMS. However, the intervention was feasible for infants, acceptable to parents and parents perceived a benefit of treatment. Whilst this trial did not demonstrate treatment effectiveness using the AIMS, these findings should be interpreted cautiously because of the small sample size, the low responsivity of the AIMS to change in motor performance and the heterogeneity of the participants. Therefore, the intervention should not be abandoned on the basis of this trial, but rather further evaluated in a larger trial that addresses some of the learnings from this one.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"198 ","pages":"Article 106111"},"PeriodicalIF":2.2,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142151970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A longitudinal study of breastmilk feeding duration, EEG power and early academic skills","authors":"Syeda Fabeha Husain ,&nbsp;Shuping Lim ,&nbsp;Wei Wei Pang ,&nbsp;Yi Ying Ong ,&nbsp;Doris Fok ,&nbsp;Anne Rifkin-Graboi ,&nbsp;Mary F.-F. Chong ,&nbsp;Yap Seng Chong ,&nbsp;Mei Chien Chua ,&nbsp;L. Mary Daniel ,&nbsp;Mary E. Wlodek ,&nbsp;Evelyn C. Law","doi":"10.1016/j.earlhumdev.2024.106110","DOIUrl":"10.1016/j.earlhumdev.2024.106110","url":null,"abstract":"<div><h3>Background</h3><p>The cognitive benefits of breastfeeding are widely recognized; however, its effects on brain development and later academic skills require further examination. This study aimed to examine the longitudinal relations between breastmilk feeding, neurophysiological changes, and early academic skills.</p></div><div><h3>Methods</h3><p>In the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort, breastmilk feeding practices were collected every 3 months from 3 weeks to 18 months postpartum. Resting electroencephalography (EEG) was recorded at 18 months and power spectral density was derived. The outcomes were a set of early academic assessments administered at age 4 (<em>n</em> = 810). Structural equation modelling was used to investigate EEG power as a mediator between breastmilk duration and early academic skills.</p></div><div><h3>Results</h3><p>Breastmilk feeding for ≥12 months was associated with better general knowledge, numeracy, and language at age 4 compared to shorter durations of breastmilk feeding (Cohen's <em>d</em>: 1.53–17.44). Linear regression showed that breastmilk duration was negatively and positively associated with low- (i.e., delta, theta) and high-frequency power (i.e., gamma), respectively (Cohen's <em>f</em>²: 0.03–0.09). After adjusting for demographic and child baseline covariates, a decrease in absolute and relative delta, as well as relative theta was associated with better general knowledge and numeracy (Cohen's <em>f</em>²: 0.16–0.25). Relative delta power provided an indirect path between breastmilk duration and early academic skills (<em>x</em>²: 18.390, <em>p</em> = 0.010; CFI: 0.978; TLI: 0.954; RMSEA: 0.040).</p></div><div><h3>Conclusions</h3><p>Extended breastmilk feeding is associated with reduced low-frequency power and better early academic skills, suggesting benefits to brain development. Additional research to confirm this finding is warranted.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"198 ","pages":"Article 106110"},"PeriodicalIF":2.2,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0378378224001798/pdfft?md5=a7ca88665a1070b452f2daeaa90b23b2&pid=1-s2.0-S0378378224001798-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into neurosonographic indicators for prenatal diagnosis of fetal neurological anomalies and cortical development: A systematic review of the literature","authors":"Carmen Vargas-Rodríguez ,&nbsp;Angel Chimenea ,&nbsp;Guillermo Antiñolo ,&nbsp;Lutgardo García-Díaz","doi":"10.1016/j.earlhumdev.2024.106109","DOIUrl":"10.1016/j.earlhumdev.2024.106109","url":null,"abstract":"<div><h3>Background</h3><p>Congenital defects of the central nervous system are the second cause of disability in childhood, representing up to 20 % of structural malformations diagnosed prenatally. The accurate prenatal diagnosis of fetal neurological anomalies and the assessment of cortical development are critical for early intervention and improved long-term outcomes. Neurosonography plays a vital role in this process, providing detailed insights into the structural and functional development of the fetal brain. This systematic review aims to synthesize current knowledge on neurosonographic indicators for prenatal diagnosis, with a special focus on cortical development and its impact in cases of fetal growth defects.</p></div><div><h3>Material and methods</h3><p>We conducted a comprehensive search for primary literature in PubMed database were searched for English and Spanish-language, peer-reviewed literature published in the last 15 years. Additional articles were identified by scrutinizing others search platforms (Cochrane Library, UpToDate). Inclusion criteria were single pregnancy and no known feto-maternal pathologies at the beginning of the study.</p></div><div><h3>Results</h3><p>Of the 361 published abstracts identified, 35 met criteria for inclusion. The review highlighted the importance of detailed neurosonographic assessments, including the evaluation of cerebral fissures such as the Sylvian fissure, parieto-occipital fissure, and calcarine fissure. Targeted ultrasound techniques were found to provide comprehensive insights comparable to fetal magnetic resonance imaging. We underscored the significant impact of intrauterine growth restriction on cortical development, with early intervention being crucial. Genetic and congenital infection screenings were emphasized as essential components of prenatal assessment.</p></div><div><h3>Conclusion</h3><p>The assessment of fetal brain maturation patterns according to gestational age allows us to rule out a delay in cortical development. The heterogeneity of methods and evaluable parameters in fetal neurodevelopment makes it necessary to standardize the evaluation of the main structures of interest both for screening and for the diagnosis of cortical development anomalies, even with the aim of trying to improve upgrade prognostic advice.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"197 ","pages":"Article 106109"},"PeriodicalIF":2.2,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142088246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal chorioamnionitis and the risk for necrotizing enterocolitis in the United States: A national cohort study","authors":"Mohsen A.A. Farghaly ,&nbsp;Sarah Alzayyat ,&nbsp;Daliah Kassim ,&nbsp;Sherin A. Taha ,&nbsp;Hany Aly ,&nbsp;Mohamed A. Mohamed","doi":"10.1016/j.earlhumdev.2024.106108","DOIUrl":"10.1016/j.earlhumdev.2024.106108","url":null,"abstract":"<div><h3>Background</h3><p>Necrotizing enterocolitis (NEC) is a major cause for morbidity and mortality among newborn infants. Chorioamnionitis is a perinatal complication that is associated with preterm delivery. Few reports have studied chorioamnionitis as a possible risk factor for NEC. Further investigation is needed to fully understand this association.</p></div><div><h3>Objective</h3><p>To examine the association of chorioamnionitis with NEC in newborn infants.</p></div><div><h3>Methods</h3><p>We used National Inpatient Sample (NIS) datasets produced by the federal Healthcare Cost and Utilization Project (HCUP). We identified infants born to mothers diagnosed with chorioamnionitis and infants born to mothers who did not have chorioamnionitis. The odds ratios (OR) to develop NEC in infants born to mothers affected by chorioamnionitis were calculated using chi square and Fisher Exact tests in the overall sample and in subgroups of different birthweight (BW) categories. The association was re-evaluated using logistic regression models to control for confounding variables.</p></div><div><h3>Results</h3><p>The study identified 18,973,800 newborn infants admitted during the years 2016–2020. Among infants born to mothers with chorioamnionitis, NEC occurred in 0.9 % compared to 0.1 % in infants born to mothers without chorioamnionitis, (adjusted OR = 1.12, CI:1.02–1.15, <em>p</em> = 0.01). The prevalence of NEC in infants born to mothers with chorioamnionitis varied by the birth weight category, mainly for BW category 2500-4499 g (aOR = 1.61, CI:1.44–1.80, <em>p</em> &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>Maternal chorioamnionitis is associated with increased incidence of NEC, particularly in the BW category 2500-4499 g. Further studies are needed to examine the pathophysiological factors underlying this association.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"197 ","pages":"Article 106108"},"PeriodicalIF":2.2,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0378378224001774/pdfft?md5=1fa0ed9765e26538ba486901b2c7c5b0&pid=1-s2.0-S0378378224001774-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142045015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged oligohydramnios and the adverse composite outcome of death or severe neurodevelopmental impairment at 3 years of age in infants born at 22–29 gestational weeks","authors":"Mitsuhiro Haga ,&nbsp;Eri Nishimura ,&nbsp;Ayumi Oshima ,&nbsp;Naoyuki Miyahara ,&nbsp;Shuntaro Oka ,&nbsp;Yukiko Motojima ,&nbsp;Kana Saito ,&nbsp;Kanako Itoh ,&nbsp;Masayo Kanai ,&nbsp;Kazuhiko Kabe ,&nbsp;Sumiko Era ,&nbsp;Shinichiro Yabe ,&nbsp;Akihiko Kikuchi ,&nbsp;Fumihiko Namba","doi":"10.1016/j.earlhumdev.2024.106100","DOIUrl":"10.1016/j.earlhumdev.2024.106100","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the association between prolonged oligohydramnios and a composite outcome of death or severe neurodevelopmental impairment (NDI) at 3 years of age.</p></div><div><h3>Methods</h3><p>This single-center retrospective cohort study enrolled infants born at 22–29 weeks of gestational age without major congenital anomalies. The patients were classified into three groups depending on the existence and duration of oligohydramnios: no/non-prolonged oligohydramnios (no or 0–7 days of oligohydramnios), prolonged oligohydramnios (8–14 days), and very prolonged oligohydramnios (&gt; 14 days). The primary outcome was a composite of death or severe NDI, which was defined as severe cerebral palsy, developmental delay, severe visual impairment, or deafness at age 3.</p></div><div><h3>Results</h3><p>Out of the 843 patients, 784 (93 %), 30 (3.6 %), and 29 (3.4 %) were classified into the no/non-prolonged, prolonged, and very prolonged oligohydramnios groups, respectively. After excluding patients lost to follow-up, the adverse composite outcome at 3 years of age was observed in 194/662 (29 %), 7/26 (27 %), and 8/23 (35 %) in the corresponding groups. The composite outcome showed no significant trend with the duration of oligohydramnios (<em>P</em> = 0.70). In a logistic regression model controlling the known predictors of gestational age, birth weight, small-for-gestational-age, male sex, multiple pregnancy, hypertensive disorders of pregnancy, antenatal corticosteroids, and the number of family–social risk factors, the duration of oligohydramnios was not independently associated with the composite outcome; odds ratio 1.3 (95 % confidence interval, 0.78–2.0).</p></div><div><h3>Conclusion</h3><p>Prolonged oligohydramnios was not associated with the composite outcome of death or severe NDI at 3 years of age.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"197 ","pages":"Article 106100"},"PeriodicalIF":2.2,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142050209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct breastfeeding: Predictive factors and possible effects on neurodevelopment in very preterm infants","authors":"Carlo Dani ,&nbsp;Caterina Coviello ,&nbsp;Martina Ciarcià ,&nbsp;Monica Fusco ,&nbsp;Clara Lunardi ,&nbsp;Giulia Remaschi ,&nbsp;Davide Sarcina ,&nbsp;Giovanni Sassudelli ,&nbsp;Simone Pratesi ,&nbsp;Silvia Perugi ,&nbsp;PROBREAST Study Group","doi":"10.1016/j.earlhumdev.2024.106099","DOIUrl":"10.1016/j.earlhumdev.2024.106099","url":null,"abstract":"<div><h3>Background</h3><p>the importance of sucking milk directly at the mother's breast is often underestimated and many aspects of direct breastfeeding of very preterm infants are not investigated.</p></div><div><h3>Aim</h3><p>The primary endpoint of the study was to identify maternal and infant clinical predictors of direct breastfeeding in a cohort of infants born at &lt;32 weeks of gestation or weighing &lt;1500 g. The secondary endpoint was to evaluate the possible effects of direct breastfeeding on infant neurodevelopment.</p></div><div><h3>Study design</h3><p>Seventy-two infants born between July 2018 and December 2019 were divided into the subgroup that were directly breastfed (<em>n</em> = 42) and not directly breastfed (<em>n</em> = 30) at discharge. Maternal and infant characteristics were compared, and differences were analysed.</p></div><div><h3>Results</h3><p>Logistic regression analysis demonstrated that the percentage of maternal milk taken during hospitalization, maternal age, and weight (z-score) at discharge were positively correlated with the likelihood of direct breastfeeding at discharge. Direct breastfeeding was not correlated with the cognitive score at 24 months corrected age.</p></div><div><h3>Conclusions</h3><p>Direct breastfeeding at discharge is more probable in infants of older mothers who receive more breastmilk and who experience greater weight gain. Direct breastfeeding is not correlated with the cognitive score at 24 months corrected age.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"197 ","pages":"Article 106099"},"PeriodicalIF":2.2,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive validity of the Standardized Infant NeuroDevelopmental Assessment (SINDA) to identify 4–5 year-old children at risk of developmental delay in a low-risk sample","authors":"Selena J. Rosinda ,&nbsp;Pieter J. Hoekstra ,&nbsp;Mijna Hadders-Algra ,&nbsp;Annelies de Bildt ,&nbsp;Kirsten R. Heineman","doi":"10.1016/j.earlhumdev.2024.106097","DOIUrl":"10.1016/j.earlhumdev.2024.106097","url":null,"abstract":"<div><h3>Background</h3><p>Early detection of developmental problems is important as it allows for early intervention. Previous studies, in high-risk infants, found high predictive values of atypical scores on the Standardized Infant NeuroDevelopmental Assessment (SINDA) for later neurodevelopmental disorders (i.e., cerebral palsy, intellectual disability).</p></div><div><h3>Aims</h3><p>The present study explored SINDA's predictive values to identify risk of developmental delay at 4–5 years.</p></div><div><h3>Study design</h3><p>Cohort study.</p></div><div><h3>Subjects</h3><p>786 low-risk Dutch children (367 boys; median gestational age: 40 (27–42) weeks; mean birth weight: 3455 (SD 577) grams).</p></div><div><h3>Outcome measures</h3><p>The SINDA was assessed at 2–12 months and risk of developmental delay was assessed using the Ages and Stages Questionnaire (ASQ) at 4–5 years. SINDA's predictive values were determined for five ASQ domains and the total ASQ score for children at risk of marked (all ASQ domains deviant) and any (one or more ASQ domains deviant) developmental delay.</p></div><div><h3>Results</h3><p>Presence of one atypical SINDA scale score showed low to moderate sensitivities (12–88 %, depending on the SINDA scale and ASQ domain involved), moderate to high specificities (66–94 %), low positive predictive values (PPVs; 3–16 %), and high negative predictive values (NPVs; 95–100 %) for children at risk of marked and any developmental. Presence of multiple atypical SINDA scale scores predicted deviant ASQ domains slightly better (sensitivities = 11–62 %, specificities = 90–98 %, PPVs = 6–30 %, and NPVs = 95–100 %).</p></div><div><h3>Conclusions</h3><p>In low-risk infants, SINDA's predictive value is low for detecting children at risk of marked and any developmental delay at 4–5 years, as reflected by the low sensitivities. One of the explanations is the relatively low prevalence of developmental delay in low-risk populations. This might have consequences for the application of the SINDA in general healthcare settings (e.g. child health clinics), but further studies are needed to draw this conclusion.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"196 ","pages":"Article 106097"},"PeriodicalIF":2.2,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S037837822400166X/pdfft?md5=e38434e5ba6a072f341a2201a5594648&pid=1-s2.0-S037837822400166X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}