Futuristic Biotechnology最新文献

{"title":"The Link Between Chest Infections and Septicemia","authors":"Ahmed B Alwazzan, M. Aslam, S. Khalid, Lahrasab Khan","doi":"10.54393/fbt.v1i02.27","DOIUrl":"https://doi.org/10.54393/fbt.v1i02.27","url":null,"abstract":"Septicemia, also known as sepsis, is a serious and life-threatening condition that can occur when the body's immune system responds uncontrollably to an infection in the chest, such as pneumonia or bronchitis. Chest infections can cause septicemia when the infection spreads from the lungs to other parts of the body, such as the bloodstream. Objective: To explore the link between septicemia and chest infection. Methods: This was a cross-sectional, descriptive study that was conducted at Mayo Hospital in Lahore. The study included 101 patients with septicemia who were admitted to the medical wards and emergency room. Each patient underwent a liver function test, a kidney function test, and a full blood count. The data were analyzed using the latest version of SPSS. Results: Among the 101 patients, 13 patients (8 males and 5 females) were found to have septicemia due to chest infection. The patients had varying levels of bilirubin, blood glucose, blood urea, creatinine, sodium, potassium, ALT, AST, ALP, total protein, albumin, white blood cells, platelets, and hemoglobin. Conclusions: Chest infections such as pneumonia and bronchitis can lead to septicemia, which can be life-threatening. Early detection and treatment of chest infections are important to prevent the development of septicemia. Patients with weakened immune systems or chronic lung disease should be closely monitored for signs of infection. This study provides insight into the characteristics of septicemia due to chest infection, which can help healthcare professionals in the diagnosis and management of this condition.","PeriodicalId":114319,"journal":{"name":"Futuristic Biotechnology","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123147446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dengue: An Overview of Pathogenesis and Analysis of Disease","authors":"Nida Naeem, Muhammad Obaid Tahir, Taha Mobeen, Lahrasb Khan, Amna Mahmood","doi":"10.54393/fbt.v1i02.10","DOIUrl":"https://doi.org/10.54393/fbt.v1i02.10","url":null,"abstract":"Dengue as a viral infection was or is a serious issue. With the time this viral infection changes within it’s environment. Researches are conducted to completely know the genome of dengue as well as it’s long lasting treatment. Both flaviviruses and mammalian cells produce NS1 and induce strong humoral responses in circulation. NS1 levels correlate with viral titer and can be used as a viremia marker. The disappearance of NS1 at high concentrations between low nanograms per milliliter and micrograms per milliliter was determined using numerical ELISA detection. NS1 levels as high as 600 nanograms per milliliter during secondary infection have been found to indicate high levels of severe disease within his first 72 hours of illness","PeriodicalId":114319,"journal":{"name":"Futuristic Biotechnology","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121524671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity and Resistance Pattern of 18 Commercially Available Antibiotics against Pseudomonas Species Isolated from Cloacal Swab of Domestic Pigeons","authors":"A. Azeem, Hafiz Shahzad Muzammil, Hina Asif, S. Sarwar","doi":"10.54393/fbt.v1i02.8","DOIUrl":"https://doi.org/10.54393/fbt.v1i02.8","url":null,"abstract":"Antibiotic resistance is a growing concern globally, leading to increased morbidity and mortality due to bacterial infections. Objective: To determine the sensitivity of pseudomonas species against various antibiotics. Methods: A total of 120 cloacal swab samples were collected from domesticated pigeons in the Narowal district of Pakistan and examined in a laboratory. After that gram staining was performed. Motility test, oxidase, Indole, catalase, coagulation and antibiotic susceptibility test was performed. Results: The results showed that Amikacin, Trimethoprime, and Clarithromycin were the most effective antibiotics against pseudomonas species, with 93.94% sensitivity to each. On the other hand, 54.55% of the pseudomonas strains showed sensitivity to Gentamicin, while 18.18% showed resistance. Conclusion: The domestic pigeons are pseudomonas species carriers and spread the disease to people and other animals via their faeces. The findings highlight the need for ongoing monitoring and research to understand the development and spread of antibiotic resistance and to ensure the effective treatment of bacterial infections.","PeriodicalId":114319,"journal":{"name":"Futuristic Biotechnology","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134486117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Septicemia in Patients Admitted at Mayo Hospital due to Wound Infection","authors":"Z. Manzoor, Muhammad Azhar, I. Tanvir","doi":"10.54393/fbt.v1i02.25","DOIUrl":"https://doi.org/10.54393/fbt.v1i02.25","url":null,"abstract":"Septicemia may result due to invasive procedures undertaking in medical sections. Patients are more likely to experience septicemia after endoscopic biliary drainage/stenting. Objectives: To find septicemia in patients admitted at Mayo hospital due to wound infection. Method: In a tertiary care hospital in Lahore, 101 confirmed cases of septicemia were the subject of an observational cross-sectional study. Any case of septicemia, whether it developed before or during a hospital stay, is included in the study. All patients' test results were collected between 24 hours of admission. Patients of both sexes were included, and their ages were broken down into three ranges: 30–50, 51–70, and 71–90. Results: Septicemia due to wound infection was seen in 8 patients out of which 5 were males and 3 were females. Bilirubin was high in 3/5 males but normal in 3/3 females. Blood glucose was high in 4/5 males and normal in 2/3 females. Blood urea was high in 4/5 males and 3/3 females. Creatinine was high in 7/8 patients. \u0000Conclusion: Major causes of septicemia were wound infection. Septicemia due to wound infection was seen in majority of patients. ALT, AST and  ALP was high while total protein was normal in septicemia due to wound infection","PeriodicalId":114319,"journal":{"name":"Futuristic Biotechnology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128439795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Tuberculosis on Culture, Comparison of Findings with Fluorescence Microscopy and GeneXpert","authors":"Asmat Amjad, Zeeshan Yousuf, Hafiz Shehzad Muzammil","doi":"10.54393/fbt.v1i01.6","DOIUrl":"https://doi.org/10.54393/fbt.v1i01.6","url":null,"abstract":"The GeneXpert MTB/RIF technique is used for the identification of tuberculosis and rifampicin (RIF) resistance. Xpert MTB / RIF provides patients with distinct advantages such as early diagnosis. Objectives: To compared the performance of fluorescence microscopy and GeneXpert with culture in TB samples from Narowal, Pakistan. Methods: A total of 299 TB positive specimens were obtained. Among these 54% (n = 160) were categorized to be obtained from male and 46% (n = 139) from female population. The sensitivity and specificity of fluorescence microscopy, GeneXpert and culture of TB samples were done. Results: The parameters including sensitivity and specificity calculated for GeneXpert were 73% and 100%, respectively, while the sensitivity and specificity calculated for culture was 100% and the sensitivity and specificity for FM microscope were 43% and 100%, respectively. Conclusions: We conclude that the GeneXpert is more sensitive than FM considering culture as a gold standard. Although the GeneXpert assay was also shown to be able to detect a limited number of bacillus from samples, the culture's sensitivity and specificity were both 100%.","PeriodicalId":114319,"journal":{"name":"Futuristic Biotechnology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125298008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity and Resistivity of Various Antibiotics Against of Pseudomonas aeruginosa in Clinical Isolates","authors":"Arwa Saud Abbas, Lahraseb Khan, Hafiz Shehzad Muzammil, Muhammad Mohsin Aftab","doi":"10.54393/fbt.v1i01.7","DOIUrl":"https://doi.org/10.54393/fbt.v1i01.7","url":null,"abstract":"Antibiotics are an essential therapy for a variety of bacterial infections, but misuse and overuse of them is encouraging bacterial resistance. Objective: To check different drugs' antibacterial effects on Pseudomonas aeruginosa was the goal. Methods: For this experiment, samples were taken from patients in the pathology division of the Fatima Memorial Hospital in Lahore, Pakistan. From all of the samples gathered, 170 clinical isolates of P. aeruginosa were discovered. To identify bacteria, traditional culture and biochemical techniques were performed. Antibacterial activity was determined by comparing the antibiotic susceptibility patterns of all clinical isolates to commercial antibiotic discs (cefazolin, cefepime, cefixime, cefoxitin, ceftriaxone, ceftazidime, cefuroxime, cephalothin, amikacin, amoxycillin, ampicillin, Augmentin, ciprofloxacin, clindamycin, gentamycin, imipenem. Results: Imipenem (100% sensitivity), Ceftazidime (99%), Linezolid (99%), Clindamycin (99%), Gentamycin (92%), Ciprofloxacin (88%), Levofloxacin (78%), and Cefotaxime (71%), among other antibiotics, shown remarkable sensitivity against Pseudomonas aeruginosa. Conclusions: We came to the conclusion that all clinical isolates of P. aeruginosa exhibited broad resistance to meropenem, ampicillin, cefuroxime, and cefepime. To reduce antibiotic resistance, technical infrastructure must be improved. Appropriate antibiotic selection and advised hand washing are two such measures.","PeriodicalId":114319,"journal":{"name":"Futuristic Biotechnology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115908128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Different Media Types on In Vitro Wheat Germination","authors":"Maleeha Anjum, M. Aslam","doi":"10.54393/fbt.v1i01.2","DOIUrl":"https://doi.org/10.54393/fbt.v1i01.2","url":null,"abstract":"Wheat is a very crucial cereal for us as we highly depend on it and in Pakistan it is a crop which is mostly consumed. Wheat prevents colon cancer as it is a good source of dietary fiber. In vitro plant tissue culture is an alternative way to produce high yielding crops. Therefore, through the in vitro propagation of the wheat we can produce wheat with better quality and high nutritional value. Objective: To determine the rate of germination of the seeds of a wheat cultivar on different types of nutrient media.  Methods: In the current study, two different types of media containing different hormones were used to investigate their effect on seed germination. For this purpose, M1 media with 2,4-D and M2 media with a combination of 2,4-D and BAP was used. Plant growth regulators were added in order to induce the germination process. The wheat cultivar Galaxy-2013 was used where 60 seeds were used for each medium. Results: The germination frequency on M1 was 41.66% while the germination frequency on M2 media was 61.66%.  Conclusions: Hence, the results indicate that the combination of the PGRs showed better germination on MS media. This experiment could help in the selection of media which have a better germination capability for future research.","PeriodicalId":114319,"journal":{"name":"Futuristic Biotechnology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124604159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Gene Expression of TNF-α in Healthy Subjects","authors":"Samra Anees, S. Sharif, Muhammad Roman, S. Jahan","doi":"10.54393/fbt.v1i01.15","DOIUrl":"https://doi.org/10.54393/fbt.v1i01.15","url":null,"abstract":"Tumor necrosis factor-alpha (TNF-α) is a cytokine involved in the immune response, inflammation, and apoptosis. Dysregulation of TNF-α expression has been associated with various diseases, including autoimmune disorders, cancer, and chronic inflammatory conditions. Understanding the regulation of TNF-α expression in healthy individuals can help identify potential therapeutic targets for these diseases. Objective: To evaluate of gene expression of TNF-α in healthy subjects. Methods: The cross-sectional study conducted on 40 individuals on healthy individuals. RNA was extracted and TNF-α gene expression was evaluated using PCR and statistical analysis was done using SPSS software. Results: The evaluation of TNF-α gene expression in healthy individuals has also led to the identification of potential biomarkers of disease and new therapeutic targets. Conclusion: In conclusion, the evaluation of TNF-α gene expression in healthy individuals is an important tool for identifying potential biomarkers of disease and understanding the physiological role of this cytokine.","PeriodicalId":114319,"journal":{"name":"Futuristic Biotechnology","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126737400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vitro Propagation of Pharmacologically Important Medicinally Plants Producing Bioactive Compounds","authors":"Syeda Safina Zanib, M. I. U. Hyul Qayoom, A. Anwar, Eman Anwar, M. Aslam","doi":"10.54393/fbt.v1i01.3","DOIUrl":"https://doi.org/10.54393/fbt.v1i01.3","url":null,"abstract":"In-vitro plant propagation is one of the promising strategies for sustainable production of medicinal plants. Plant tissue culture involves in-vitro propagation of plant parts under controlled conditions. It is a very useful technique for fundamental and applied research and has many commercial uses. Medicinal plants have been used to treat many diseases since decades. They are enriched with pharmacologically important bio-active compounds. These bio-active compounds can be used to treat different human ailments. Because of over-exploitation of these medicinal plants, there is a need to sustain their production. The most commonly used medicinal plants are Aconite, Alfa Alfa , Aloe Vera, Borage, Comfrey, Ephedra, Germander, Ginkgo biloba, Neem, Licorice, Isapghul, Sassafras, Senna, St. John’s wort ,Neem ,Tulsi. The current review gives insights into important compounds produced by popular medicinal plants. Some of the important bioactive compounds are taxol, methane, acetic acid, carotenoids, flavonoids, carnitine, choline, dithiolthiones, phytosterols, phytoestrogens, glucosinolates, polyphenols, and taurine. The review also focuses on in-vitro propagation of medicinally important plants to ensure their availability irrespective of seasonal and geographical constraints.","PeriodicalId":114319,"journal":{"name":"Futuristic Biotechnology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126041581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inaugural Message from Editor-in-Chief","authors":"R. Mehboob","doi":"10.54393/fbt.v1i01.4","DOIUrl":"https://doi.org/10.54393/fbt.v1i01.4","url":null,"abstract":"There could not possibly be a better or more appropriate time to introduce the journal Futuristic Biotechnology (FBT) given the extraordinary advancements made over the past few decades in science and medicine. We have had the good fortune to watch as numerous scientific and medical advancements have been combined to push the boundaries of disease detection and treatment that can affect any part of the body. As a result, numerous cutting-edge therapeutic approaches are currently being developed to address diseases for which there are few effective treatments.\u0000Although at first glance these therapeutic approaches seem disparate, closer examination reveals that they all rely on a \"shared signalling platform\" that is closely linked through biological pathways and has a major impact on patient clinical outcomes. It is evident that cellular and genetic targets have a straightforward effect on numerous disease entities. For many disorders, the conversion of these pathways into useful clinical treatments can be fruitful. FBT was designed with this notion in mind. FBT is an open access, peer-reviewed international journal that publishes broad-spectrum researches with close connection to experimental activity related to biology and biotechnology. FBT is intended for exploring the molecular mechanisms that support key biological processes in biochemistry, cellular biosciences, molecular biology, plant biotechnology, genetic engineering, nanotechnology, regenerative medicine and bioinformatics. Furthermore, it also covers topics related to immunology, antibody production, protein purification studies, primer synthesis, DNA sequencing, production of transgenic animal models, insect resistant crop varieties and edible and ornamental plant varieties.\u0000FBT will give the scientific and medical communities an international venue to translate basic and clinical research investigations into clinical therapeutics, as well as to report on prognostics, new therapeutic approaches, and the development of biomarkers. As original research papers, review articles, clinical studies, expert opinion, systematic reviews, meta-analysis, commentaries, and letters to the editor, FBT will provide a variety of platforms for authors to share their ideas and discoveries.\u0000In the end, FBT will encourage a thorough, impartial, and helpful appraisal of every paper submitted. All authors will be able to track the development of their papers throughout the phases of evaluation, copyediting, and publication because articles will be processed in a very timely manner. With the debut of FBT, we are incredibly enthusiastic and certain that the journal will significantly fill a gap in the reporting of recent scientific and medical advancements. FBT will act as a global platform for the highest level of scholarship in the scientific and clinical sectors to convert ground-breaking \"bench to bedside\" innovations into effective treatment procedures. On behalf of the Editorial Team and the Editorial B","PeriodicalId":114319,"journal":{"name":"Futuristic Biotechnology","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127105981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}