Sensitivity and Resistivity of Various Antibiotics Against of Pseudomonas aeruginosa in Clinical Isolates

Antibiotics are an essential therapy for a variety of bacterial infections, but misuse and overuse of them is encouraging bacterial resistance. Objective: To check different drugs' antibacterial effects on Pseudomonas aeruginosa was the goal. Methods: For this experiment, samples were taken from patients in the pathology division of the Fatima Memorial Hospital in Lahore, Pakistan. From all of the samples gathered, 170 clinical isolates of P. aeruginosa were discovered. To identify bacteria, traditional culture and biochemical techniques were performed. Antibacterial activity was determined by comparing the antibiotic susceptibility patterns of all clinical isolates to commercial antibiotic discs (cefazolin, cefepime, cefixime, cefoxitin, ceftriaxone, ceftazidime, cefuroxime, cephalothin, amikacin, amoxycillin, ampicillin, Augmentin, ciprofloxacin, clindamycin, gentamycin, imipenem. Results: Imipenem (100% sensitivity), Ceftazidime (99%), Linezolid (99%), Clindamycin (99%), Gentamycin (92%), Ciprofloxacin (88%), Levofloxacin (78%), and Cefotaxime (71%), among other antibiotics, shown remarkable sensitivity against Pseudomonas aeruginosa. Conclusions: We came to the conclusion that all clinical isolates of P. aeruginosa exhibited broad resistance to meropenem, ampicillin, cefuroxime, and cefepime. To reduce antibiotic resistance, technical infrastructure must be improved. Appropriate antibiotic selection and advised hand washing are two such measures.