Development最新文献_第8页

Promoting developmental diversity in a changing world. 在不断变化的世界中促进发展多样性。

IF 3.7 2区生物学

Development Pub Date : 2024-10-15 Epub Date: 2024-10-29 DOI: 10.1242/dev.204442

Cassandra Extavour, Liam Dolan, Karen E Sears

引用次数: 0

VitelloTag: a tool for high-throughput cargo delivery into oocytes. VitelloTag：将货物高通量送入卵母细胞的工具。

IF 3.7 2区生物学

Development Pub Date : 2024-10-15 Epub Date: 2024-09-14 DOI: 10.1242/dev.202857

D Nathaniel Clarke, Akshay Kane, Margherita Perillo, Christopher J Lowe, S Zachary Swartz

引用次数: 0

Understanding developmental system drift. 了解发展系统漂移。

IF 3.7 2区生物学

Development Pub Date : 2024-10-15 Epub Date: 2024-10-17 DOI: 10.1242/dev.203054

Áine McColgan, James DiFrisco

引用次数: 0

The case against simplistic genetic explanations of evolution. 反对以简单的基因解释进化论。

IF 3.7 2区生物学

Development Pub Date : 2024-10-15 Epub Date: 2024-10-04 DOI: 10.1242/dev.203077

Kimberly L Cooper

引用次数: 0

Hepatocyte differentiation requires anisotropic expansion of bile canaliculi. 肝细胞分化需要各向异性的胆管扩张。

IF 3.7 2区生物学

Development Pub Date : 2024-10-07 DOI: 10.1242/dev.202777

Maarten Bebelman, Lenka Belicova, Elzbieta Gralinska, Tobias Jumel, Aparajita Lahree, Sarah Sommer, Andrej Shevchenko, Timofei Zatsepin, Yannis Kalaidzidis, Martin Vingron, Marino Zerial

{"title":"Hepatocyte differentiation requires anisotropic expansion of bile canaliculi.","authors":"Maarten Bebelman, Lenka Belicova, Elzbieta Gralinska, Tobias Jumel, Aparajita Lahree, Sarah Sommer, Andrej Shevchenko, Timofei Zatsepin, Yannis Kalaidzidis, Martin Vingron, Marino Zerial","doi":"10.1242/dev.202777","DOIUrl":"https://doi.org/10.1242/dev.202777","url":null,"abstract":"During liver development, bipotential progenitor cells called hepatoblasts differentiate into hepatocytes or cholangiocytes. Hepatocyte differentiation is uniquely associated with multi-axial polarity, enabling the anisotropic expansion of apical lumina between adjacent cells and formation of a three-dimensional network of bile canaliculi (BC). Cholangiocytes, the cells forming the bile ducts, exhibit the vectorial polarity characteristic of epithelial cells. Whether cell polarization feeds back on the gene regulatory pathways governing hepatoblast differentiation is unknown. Here, we used primary hepatoblasts to investigate the contribution of anisotropic apical expansion to hepatocyte differentiation. Silencing of the small GTPase Rab35 caused isotropic lumen expansion and formation of multicellular cysts with the vectorial polarity of cholangiocytes. Gene expression profiling revealed that these cells express reduced levels of hepatocyte markers and upregulate genes associated with cholangiocyte identity. Time-course RNA sequencing demonstrated that loss of lumen anisotropy precedes these transcriptional changes. Independent alterations in apical lumen morphology induced either by modulation of the subapical actomyosin cortex or increased intraluminal pressure caused similar transcriptional changes. These findings suggest that cell polarity and lumen morphogenesis feedback to hepatoblast-to-hepatocyte differentiation.","PeriodicalId":11375,"journal":{"name":"Development","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss of STING impairs lactogenic differentiation. STING 缺失会影响泌乳分化。

IF 3.7 2区生物学

Development Pub Date : 2024-10-01 Epub Date: 2024-10-14 DOI: 10.1242/dev.202998

Ramiah R Vickers, Garhett L Wyatt, Lilia Sanchez, Jordyn J VanPortfliet, A Phillip West, Weston W Porter

{"title":"Loss of STING impairs lactogenic differentiation.","authors":"Ramiah R Vickers, Garhett L Wyatt, Lilia Sanchez, Jordyn J VanPortfliet, A Phillip West, Weston W Porter","doi":"10.1242/dev.202998","DOIUrl":"10.1242/dev.202998","url":null,"abstract":"Heightened energetic and nutrient demand during lactogenic differentiation of the mammary gland elicits upregulation of various stress responses to support cellular homeostasis. Here, we identify the stimulator of interferon genes (STING) as an immune supporter of the functional development of mouse mammary epithelial cells (MECs). An in vitro model of MEC differentiation revealed that STING is activated in a cGAS-independent manner to produce both type I interferons and proinflammatory cytokines in response to the accumulation of mitochondrial reactive oxygen species. Induction of STING activity was found to be dependent on the breast tumor suppressor gene single-minded 2 (SIM2). Using mouse models of lactation, we discovered that loss of STING activity results in early involution of #3 mammary glands, severely impairing lactational performance. Our data suggest that STING is required for successful functional differentiation of the mammary gland and bestows a differential lactogenic phenotype between #3 mammary glands and the traditionally explored inguinal 4|9 pair. These findings affirm unique development of mammary gland pairs that is essential to consider in future investigations into normal development and breast cancer initiation.","PeriodicalId":11375,"journal":{"name":"Development","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The people behind the papers - Isabella Burda and Adrienne Roeder. 报纸背后的人物--伊莎贝拉-布尔达（Isabella Burda）和阿德里安娜-罗德（Adrienne Roeder）。

IF 3.7 2区生物学

Development Pub Date : 2024-10-01 Epub Date: 2024-10-10 DOI: 10.1242/dev.204427

引用次数: 0

Robust organ size in Arabidopsis is primarily governed by cell growth rather than cell division patterns. 拟南芥的器官大小主要受细胞生长而非细胞分裂模式的影响。

IF 3.7 2区生物学

Development Pub Date : 2024-10-01 Epub Date: 2024-10-10 DOI: 10.1242/dev.202531

Isabella Burda, Fridtjof Brauns, Frances K Clark, Chun-Biu Li, Adrienne H K Roeder

{"title":"Robust organ size in Arabidopsis is primarily governed by cell growth rather than cell division patterns.","authors":"Isabella Burda, Fridtjof Brauns, Frances K Clark, Chun-Biu Li, Adrienne H K Roeder","doi":"10.1242/dev.202531","DOIUrl":"10.1242/dev.202531","url":null,"abstract":"Organ sizes and shapes are highly reproducible, or robust, within a species and individuals. Arabidopsis thaliana sepals, which are the leaf-like organs that enclose flower buds, have consistent size and shape, indicating robust development. Cell growth is locally heterogeneous due to intrinsic and extrinsic noise. To achieve robust organ shape, fluctuations in cell growth must average to an even growth rate, which requires that fluctuations are uncorrelated or anti-correlated in time and space. Here, we live image and quantify the development of sepals with an increased or decreased number of cell divisions (lgo mutant and LGO overexpression, respectively), a mutant with altered cell growth variability (ftsh4), and double mutants combining these. Changes in the number of cell divisions do not change the overall growth pattern. By contrast, in ftsh4 mutants, cell growth accumulates in patches of over- and undergrowth owing to correlations that impair averaging, resulting in increased organ shape variability. Thus, we demonstrate in vivo that the number of cell divisions does not affect averaging of cell growth, preserving robust organ morphogenesis, whereas correlated growth fluctuations impair averaging.","PeriodicalId":11375,"journal":{"name":"Development","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11488635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A role for BYN-1/bystin in cellular uptake and clearance of residual bodies in the Caenorhabditis elegans germline. BYN-1/bystin在秀丽隐杆线虫生殖系细胞摄取和清除残留体中的作用

IF 3.7 2区生物学

Development Pub Date : 2024-10-01 Epub Date: 2024-10-08 DOI: 10.1242/dev.202694

Hyemin Min, Emily L Spaulding, Catherine S Sharp, Pankaj Garg, Esther Jeon, Lyn S Miranda Portillo, Noah A Lind, Dustin L Updike

{"title":"A role for BYN-1/bystin in cellular uptake and clearance of residual bodies in the Caenorhabditis elegans germline.","authors":"Hyemin Min, Emily L Spaulding, Catherine S Sharp, Pankaj Garg, Esther Jeon, Lyn S Miranda Portillo, Noah A Lind, Dustin L Updike","doi":"10.1242/dev.202694","DOIUrl":"10.1242/dev.202694","url":null,"abstract":"GLH/Vasa/DDX4 helicases are core germ-granule proteins that promote germline development and fertility. A yeast-two-hybrid screen using Caenorhabditis elegans GLH-1 as bait identified BYN-1, the homolog of human bystin/BYSL. In humans, bystin promotes cell adhesion and invasion in gliomas, and, with its binding partner trophinin, triggers embryonic implantation into the uterine wall. C. elegans embryos do not implant and lack a homolog of trophinin, but both trophinin and GLH-1 contain unique decapeptide phenylalanine-glycine (FG)-repeat domains. In germ cells, we find endogenous BYN-1 in the nucleolus, partitioned away from cytoplasmic germ granules. However, BYN-1 enters the cytoplasm during spermatogenesis to colocalize with GLH-1. Both proteins become deposited in residual bodies (RBs), which are then engulfed and cleared by the somatic gonad. We show that BYN-1 acts upstream of CED-1 to drive RB engulfment, and that removal of the FG-repeat domains from GLH-1 and GLH-2 can partially phenocopy byn-1 defects in RB clearance. These results point to an evolutionarily conserved pathway whereby cellular uptake is triggered by the cytoplasmic mobilization of bystin/BYN-1 to interact with proteins harboring FG-repeats.","PeriodicalId":11375,"journal":{"name":"Development","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11488650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A role for organ level dynamics in morphogenesis of the C. elegans hermaphrodite distal tip cell. 器官水平动力学在秀丽隐杆线虫雌雄同体远端细胞形态发生中的作用

IF 3.7 2区生物学

Development Pub Date : 2024-10-01 Epub Date: 2024-10-09 DOI: 10.1242/dev.203019

Theadora Tolkin, Julia Burnett, E Jane Albert Hubbard

引用次数: 0