The people behind the papers - Xueqi Jia and Ryoichiro Kageyama.

IF 3.6 2区生物学 Q1 DEVELOPMENTAL BIOLOGY

Development Pub Date : 2025-09-01 Epub Date: 2025-09-15 DOI:10.1242/dev.205200

引用次数: 0

Abstract

Temporal-spatial regulation of somite formation is controlled by the oscillating signals of the segmentation clock, such as Hes7, but how these signals are themselves coordinated remain unclear. In their latest study, Kageyama and colleagues identify Cdh2 as a previously unreported downstream target of Hes7 that is functionally important for the timing of somite formation by both synchronising the oscillations of Hes7 and modulating the oscillations of fellow clock component ppERK. To find out more about the researchers behind the paper and how this story developed, we spoke to first author Xueqi Jia and corresponding author Ryoichiro Kageyama, Director of the RIKEN Center for Biosystems Dynamics Research.

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文件背后的人——贾学圻和鹿山良一郎。

体体形成的时空调控是由分割时钟的振荡信号控制的，如Hes7，但这些信号本身是如何协调的尚不清楚。在他们最新的研究中，Kageyama和他的同事们发现Cdh2是Hes7的一个以前未被报道的下游靶标，它通过同步Hes7的振荡和调节其他时钟成分ppERK的振荡，对体形成的时间具有重要的功能。为了了解更多关于这篇论文背后的研究人员以及这个故事是如何发展的，我们采访了第一作者Xueqi Jia和通讯作者RIKEN生物系统动力学研究中心主任Ryoichiro Kageyama。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Development 生物-发育生物学

CiteScore

6.70

自引率

4.30%

发文量

433

审稿时长

3 months

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