Development最新文献_第9页

Transitions in development - an interview with Fan Zhou. 发展中的过渡--周凡访谈录。

IF 3.7 2区生物学

Development Pub Date : 2024-10-01 Epub Date: 2024-09-30 DOI: 10.1242/dev.204377

引用次数: 0

Retinoic acid, an essential component of the roof plate organizer, promotes the spatiotemporal segregation of dorsal neural fates. 视黄酸是顶板组织器的重要组成部分，能促进背侧神经命运的时空分离。

IF 3.7 2区生物学

Development Pub Date : 2024-10-01 Epub Date: 2024-09-30 DOI: 10.1242/dev.202973

Dina Rekler, Shai Ofek, Sarah Kagan, Gilgi Friedlander, Chaya Kalcheim

{"title":"Retinoic acid, an essential component of the roof plate organizer, promotes the spatiotemporal segregation of dorsal neural fates.","authors":"Dina Rekler, Shai Ofek, Sarah Kagan, Gilgi Friedlander, Chaya Kalcheim","doi":"10.1242/dev.202973","DOIUrl":"10.1242/dev.202973","url":null,"abstract":"Dorsal neural tube-derived retinoic acid promotes the end of neural crest production and transition into a definitive roof plate. Here, we analyze how this impacts the segregation of central and peripheral lineages, a process essential for tissue patterning and function. Localized in ovo inhibition in quail embryos of retinoic acid activity followed by single-cell transcriptomics unraveled a comprehensive list of differentially expressed genes relevant to these processes. Importantly, progenitors co-expressed neural crest, roof plate and dI1 interneuron markers, indicating a failure in proper lineage segregation. Furthermore, separation between roof plate and dI1 interneurons is mediated by Notch activity downstream of retinoic acid, highlighting their crucial role in establishing the roof plate-dI1 boundary. Within the peripheral branch, where absence of retinoic acid resulted in neural crest production and emigration extending into the roof plate stage, sensory progenitors failed to separate from melanocytes, leading to formation of a common glia-melanocyte cell with aberrant migratory patterns. In summary, the implementation of single-cell RNA sequencing facilitated the discovery and characterization of a molecular mechanism responsible for the segregation of dorsal neural fates during development.","PeriodicalId":11375,"journal":{"name":"Development","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linkage between Fuz and Gpr161 genes regulates sonic hedgehog signaling during mouse neural tube development. Fuz和Gpr161基因之间的联系调控了小鼠神经管发育过程中的声刺猬信号传导。

IF 3.7 2区生物学

Development Pub Date : 2024-10-01 Epub Date: 2024-10-04 DOI: 10.1242/dev.202705

Sung-Eun Kim, Hyun-Yi Kim, Bogdan J Wlodarczyk, Richard H Finnell

{"title":"Linkage between Fuz and Gpr161 genes regulates sonic hedgehog signaling during mouse neural tube development.","authors":"Sung-Eun Kim, Hyun-Yi Kim, Bogdan J Wlodarczyk, Richard H Finnell","doi":"10.1242/dev.202705","DOIUrl":"10.1242/dev.202705","url":null,"abstract":"Sonic hedgehog (Shh) signaling regulates embryonic morphogenesis utilizing the primary cilium, the cell's antenna, which acts as a signaling hub. Fuz, an effector of planar cell polarity signaling, regulates Shh signaling by facilitating cilia formation, and the G protein-coupled receptor 161 (Gpr161) is a negative regulator of Shh signaling. The range of phenotypic malformations observed in mice bearing mutations in either of the genes encoding these proteins is similar; however, their functional relationship has not been previously explored. This study identified the genetic and biochemical linkage between Fuz and Gpr161 in mouse neural tube development. Fuz was found to be genetically epistatic to Gpr161 with respect to regulation of Shh signaling in mouse neural tube development. The Fuz protein biochemically interacts with Gpr161, and Fuz regulates Gpr161-mediated ciliary localization, a process that might utilize β-arrestin 2. Our study characterizes a previously unappreciated Gpr161-Fuz axis that regulates Shh signaling during mouse neural tube development.","PeriodicalId":11375,"journal":{"name":"Development","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Manipulating cell fate through reprogramming: approaches and applications. 通过重编程操纵细胞命运：方法与应用。

IF 3.7 2区生物学

Development Pub Date : 2024-10-01 Epub Date: 2024-09-30 DOI: 10.1242/dev.203090

Masaki Yagi, Joy E Horng, Konrad Hochedlinger

引用次数: 0

Pathway to independence: perspectives on the future. 独立之路：对未来的展望。

IF 3.7 2区生物学

Development Pub Date : 2024-10-01 Epub Date: 2024-10-04 DOI: 10.1242/dev.204366

Marcella Birtele, Martina Cerise, Lydia Djenoune, Girish Kale, Eirini Maniou, Louis S Prahl, Keaton Schuster, Clementine Villeneuve

引用次数: 0

Myonuclear position and blood vessel organization during skeletal muscle postnatal development. 骨骼肌产后发育过程中的肌核位置和血管组织

IF 4.6 2区生物学

Development Pub Date : 2024-09-17 DOI: 10.1242/dev.202548

Catarina Sequeira,Lou Martha Wackerbarth,Andreia Pena,Mafalda Sá-Pereira,Cláudio A Franco,Edgar R Gomes

引用次数: 0

EnhancerNet: A predictive model of cell identity dynamics through enhancer selection. 增强子网络：通过增强子选择预测细胞特征动态的模型

IF 4.6 2区生物学

Development Pub Date : 2024-09-17 DOI: 10.1242/dev.202997

Omer Karin

引用次数: 0

In preprints: keeping endothelial cell specification and vascular development in check. 预印本：控制内皮细胞规格和血管发育。

IF 4.6 2区生物学

Development Pub Date : 2024-09-17 DOI: 10.1242/dev.204338

Tim Petzold,Holger Gerhardt

引用次数: 0

bHLH family proteins control the timing and completion of transition from neuroepithelial cells into neural stem cells. bHLH 家族蛋白控制着神经上皮细胞向神经干细胞过渡的时间和完成。

IF 3.7 2区生物学

Development Pub Date : 2024-09-15 Epub Date: 2024-09-16 DOI: 10.1242/dev.202630

Chika Akiba, Aya Takezawa, Yuanchang Tsai, Mire Hirose, Takumi Suzuki

{"title":"bHLH family proteins control the timing and completion of transition from neuroepithelial cells into neural stem cells.","authors":"Chika Akiba, Aya Takezawa, Yuanchang Tsai, Mire Hirose, Takumi Suzuki","doi":"10.1242/dev.202630","DOIUrl":"https://doi.org/10.1242/dev.202630","url":null,"abstract":"The number of neural stem cells reflects the total number of neurons in the mature brain. As neural stem cells arise from neuroepithelial cells, the neuroepithelial cell population must be expanded to secure a sufficient number of neural stem cells. However, molecular mechanisms that regulate timely differentiation from neuroepithelial to neural stem cells are largely unclear. Here, we show that TCF4/Daughterless is a key factor that determines the timing of the differentiation in Drosophila. The neuroepithelial cells initiated but never completed the differentiation in the absence of TCF4/Daughterless. We also found that TCF4/Daughterless binds to the Notch locus, suggesting that Notch is one of its downstream candidate genes. Consistently, Notch expression was ectopically induced in the absence of TCF4/Daughterless. Furthermore, ectopic activation of Notch signaling phenocopied loss of TCF4/Daughterless. Our findings demonstrate that TCF4/Daughterless directly inactivates Notch signaling pathway, resulting in completion of the differentiation from neuroepithelial cells into neural stem cells with optimal timing. Thus, the present results suggest that TCF4/Daughterless is essential for determining whether to move to the next state or stay in the current state in differentiating neuroepithelial cells.","PeriodicalId":11375,"journal":{"name":"Development","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphogens in the evolution of size, shape and patterning. 大小、形状和图案进化过程中的形态发生器

IF 3.7 2区生物学

Development Pub Date : 2024-09-15 Epub Date: 2024-09-18 DOI: 10.1242/dev.202412

Lewis S Mosby, Amy E Bowen, Zena Hadjivasiliou

{"title":"Morphogens in the evolution of size, shape and patterning.","authors":"Lewis S Mosby, Amy E Bowen, Zena Hadjivasiliou","doi":"10.1242/dev.202412","DOIUrl":"10.1242/dev.202412","url":null,"abstract":"Much of the striking diversity of life on Earth has arisen from variations in the way that the same molecules and networks operate during development to shape and pattern tissues and organs into different morphologies. However, we still understand very little about the potential for diversification exhibited by different, highly conserved mechanisms during evolution, or, conversely, the constraints that they place on evolution. With the aim of steering the field in new directions, we focus on morphogen-mediated patterning and growth as a case study to demonstrate how conserved developmental mechanisms can adapt during evolution to drive morphological diversification and optimise functionality, and to illustrate how evolution algorithms and computational tools can be used alongside experiments to provide insights into how these conserved mechanisms can evolve. We first introduce key conserved properties of morphogen-driven patterning mechanisms, before summarising comparative studies that exemplify how changes in the spatiotemporal expression and signalling levels of morphogens impact the diversification of organ size, shape and patterning in nature. Finally, we detail how theoretical frameworks can be used in conjunction with experiments to probe the role of morphogen-driven patterning mechanisms in evolution. We conclude that morphogen-mediated patterning is an excellent model system and offers a generally applicable framework to investigate the evolution of developmental mechanisms.","PeriodicalId":11375,"journal":{"name":"Development","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7616732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0