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Transitions in development - an interview with Aleksandra Pękowska.
IF 3.7 2区 生物学
Development Pub Date : 2025-02-01 Epub Date: 2025-02-05 DOI: 10.1242/dev.204603
{"title":"Transitions in development - an interview with Aleksandra Pękowska.","authors":"","doi":"10.1242/dev.204603","DOIUrl":"https://doi.org/10.1242/dev.204603","url":null,"abstract":"<p><p>Aleksandra Pękowska leads the Dioscuri Center for Chromatin Biology and Epigenomics at the Nencki Institute of Experimental Biology of the Polish Academy of Sciences in Warsaw, Poland, where she studies the role of astrocytes in brain development. Her research connects astrocyte chromatin architecture to broader questions about how these glial cells have influenced human brain evolution. We met Aleksandra over Zoom to discuss her career path so far. She told us about how she came to work on nervous system development, the interdisciplinary nature of her research group, and how she almost ended up studying law at university.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 3","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conserved roles of ETT and ARF4 in gynoecium development in Brassicaceae with distinct fruit shapes. ETT和ARF4在具有不同果实形状的十字花科植物雌蕊群发育过程中的作用是一致的。
IF 3.7 2区 生物学
Development Pub Date : 2025-02-01 Epub Date: 2025-02-12 DOI: 10.1242/dev.204263
Heather Marie McLaughlin, Tian-Feng Lü, Bhavani Natarajan, Lars Østergaard, Yang Dong
{"title":"Conserved roles of ETT and ARF4 in gynoecium development in Brassicaceae with distinct fruit shapes.","authors":"Heather Marie McLaughlin, Tian-Feng Lü, Bhavani Natarajan, Lars Østergaard, Yang Dong","doi":"10.1242/dev.204263","DOIUrl":"https://doi.org/10.1242/dev.204263","url":null,"abstract":"<p><p>Gynoecium patterning is dependent on the dynamic distribution of auxin, the signalling of which is transduced through several distinct pathways. ETTIN (ETT)-mediated signalling occurs independently of the canonical auxin pathway, and ETT shares partial redundancy with Auxin Response Factor 4 (ARF4) in the gynoecium. ETT and ARF4 were previously hypothesized to translate auxin gradients into patterns of tissue polarity alongside other ARFs. As ARF repressors, ETT/ARF were assumed to antagonistically regulate targets shared with ARF activators of the canonical pathway. Here, comparative transcriptomics identified the distinct and overlapping targets of ETT/ARF4 in the Arabidopsis gynoecium. However, ETT/ARF4 targets with known roles in gynoecium development did not conform to models of A-B ARF antagonism, leaving the relationship with the canonical pathway unclear. Mutants in tir1 afb2 ett were therefore generated in Arabidopsis and Capsella to assess the relationship between the two pathways, and their conservation in species with distinct fruit shapes. The data presented indicate conserved synergism between the two pathways in gynoecium development and suggest a role for ARF4 in the integration of these pathways in Brassicaceae with distinct fruit shapes.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 3","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute inflammation induces acute megakaryopoiesis with impaired platelet production during fetal hematopoiesis. 急性炎症诱导急性巨核生成，胎儿造血过程中血小板生成受损。
IF 3.7 2区 生物学
Development Pub Date : 2025-02-01 Epub Date: 2025-02-05 DOI: 10.1242/dev.204226
Xiaojie Hu, Yirui He, Shengwei Li, Yue Jiang, Renjie Yu, Yi Wu, Xiaoying Fu, Yuanbin Song, Changdong Lin, Jiejun Shi, Hua-Bing Li, Yimeng Gao
{"title":"Acute inflammation induces acute megakaryopoiesis with impaired platelet production during fetal hematopoiesis.","authors":"Xiaojie Hu, Yirui He, Shengwei Li, Yue Jiang, Renjie Yu, Yi Wu, Xiaoying Fu, Yuanbin Song, Changdong Lin, Jiejun Shi, Hua-Bing Li, Yimeng Gao","doi":"10.1242/dev.204226","DOIUrl":"10.1242/dev.204226","url":null,"abstract":"<p><p>Hematopoietic development is tightly regulated by various factors. The role of RNA m6A modification during fetal hematopoiesis, particularly in megakaryopoiesis, remains unclear. Here, we demonstrate that loss of m6A methyltransferase METTL3 induces formation of double-stranded RNAs (dsRNAs) and activates acute inflammation during fetal hematopoiesis in mouse. This dsRNA-mediated inflammation leads to acute megakaryopoiesis, which facilitates the generation of megakaryocyte progenitors but disrupts megakaryocyte maturation and platelet production. The inflammation and immune response activate the phosphorylation of STAT1 and IRF3, and upregulate downstream interferon-stimulated genes (ISGs). Inflammation inhibits the proliferation rate of hematopoietic progenitors and further skews the cell fate determination toward megakaryocytes rather than toward erythroid from megakaryocyte-erythroid progenitors (MEPs). Transcriptional-wide gene expression analysis identifies IGF1 as a major factor whose reduction is responsible for the inhibition of megakaryopoiesis and thrombopoiesis. Restoration of IGF1 with METTL3-deficient hematopoietic cells significantly increases megakaryocyte maturation. In summary, we elucidate that the loss of RNA m6A modification-induced acute inflammation activates acute megakaryopoiesis, but impairs its final maturation through the inhibition of IGF1 expression during fetal hematopoiesis.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An in vivo CRISPR screen in chick embryos reveals a role for MLLT3 in specification of neural cells from the caudal epiblast. 鸡胚胎的体内CRISPR筛选揭示了MLLT3在尾端外胚层神经细胞分化中的作用。
IF 3.7 2区 生物学
Development Pub Date : 2025-02-01 Epub Date: 2025-02-12 DOI: 10.1242/dev.204591
Ashley R G Libby, Tiago Rito, Arthur Radley, James Briscoe
{"title":"An in vivo CRISPR screen in chick embryos reveals a role for MLLT3 in specification of neural cells from the caudal epiblast.","authors":"Ashley R G Libby, Tiago Rito, Arthur Radley, James Briscoe","doi":"10.1242/dev.204591","DOIUrl":"10.1242/dev.204591","url":null,"abstract":"<p><p>Tissue development relies on the coordinated differentiation of stem cells in dynamically changing environments. The formation of the vertebrate neural tube from stem cells in the caudal lateral epiblast is a well-characterized example. Despite an understanding of the signalling pathways involved, the gene regulatory mechanisms remain poorly defined. To address this, we developed a multiplexed in vivo CRISPR screening approach in chick embryos targeting genes expressed in the caudal epiblast and neural tube. This revealed a role for MLLT3, a component of the super elongation complex, in the specification of neural fate. Perturbation of MLLT3 disrupted neural tube morphology and reduced neural fate acquisition. Mutant forms of retinoic acid receptor A lacking the MLLT3 binding domain similarly reduced neural fate acquisition. Together, these findings validate an in vivo CRISPR screen strategy in chick embryos and identify a previously unreported role for MLLT3 in caudal neural tissue specification.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BMP and STRA8 act collaboratively to ensure correct mitotic-to-meiotic transition in the fetal mouse ovary. BMP和STRA8协同作用，确保胚胎小鼠卵巢中有丝分裂向减数分裂的正确转变。
IF 3.7 2区 生物学
Development Pub Date : 2025-02-01 Epub Date: 2025-02-07 DOI: 10.1242/dev.204227
Fiona K M Cheung, Chun-Wei Allen Feng, Clare Crisp, Yuji Mishina, Cassy M Spiller, Josephine Bowles
{"title":"BMP and STRA8 act collaboratively to ensure correct mitotic-to-meiotic transition in the fetal mouse ovary.","authors":"Fiona K M Cheung, Chun-Wei Allen Feng, Clare Crisp, Yuji Mishina, Cassy M Spiller, Josephine Bowles","doi":"10.1242/dev.204227","DOIUrl":"10.1242/dev.204227","url":null,"abstract":"<p><p>A successful mitosis-to-meiosis transition in germ cells is essential for fertility in sexually reproducing organisms. In mice and humans, it has been established that expression of STRA8 is crucial for meiotic onset in both sexes. Here, we show that BMP signalling is also essential, not for STRA8 induction but for correct meiotic progression in female mouse fetal germ cells. Largely in agreement with evidence from primordial germ cell-like cells (PGCLCs) in vitro, germ cell-specific deletion of BMP receptor 1A (BMPR1A; ALK3) caused aberrant retention of pluripotency marker OCT4 and meiotic progression was compromised; however, the timely onset of Stra8 and STRA8 expression was unaffected. Comparing the transcriptomes of Bmpr1a-cKO and Stra8-null models, we reveal interplay between the effects of BMP signalling and STRA8 function. Our results verify a role for BMP signalling in instructing germ cell meiosis in female mice in vivo, and shed light on the regulatory mechanisms underlying fetal germ cell development.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Planar cell polarity zebrafish models of congenital scoliosis reveal underlying defects in notochord morphogenesis.
IF 3.7 2区 生物学
Development Pub Date : 2025-02-01 Epub Date: 2025-02-06 DOI: 10.1242/dev.204656
Mingqin Wang, Sen Zhao, Chenjun Shi, Marie-Claude Guyot, Meijiang Liao, Josephine T Tauer, Bettina M Willie, Nikita Cobetto, Carl-Éric Aubin, Elke Küster-Schöck, Pierre Drapeau, Jitao Zhang, Nan Wu, Zoha Kibar
{"title":"Correction: Planar cell polarity zebrafish models of congenital scoliosis reveal underlying defects in notochord morphogenesis.","authors":"Mingqin Wang, Sen Zhao, Chenjun Shi, Marie-Claude Guyot, Meijiang Liao, Josephine T Tauer, Bettina M Willie, Nikita Cobetto, Carl-Éric Aubin, Elke Küster-Schöck, Pierre Drapeau, Jitao Zhang, Nan Wu, Zoha Kibar","doi":"10.1242/dev.204656","DOIUrl":"https://doi.org/10.1242/dev.204656","url":null,"abstract":"","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 3","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ear pinna growth and differentiation is conserved in murids and requires BMP signaling for chondrocyte proliferation.
IF 3.7 2区 生物学
Development Pub Date : 2025-02-01 Epub Date: 2025-02-13 DOI: 10.1242/dev.204560
Robyn S Allen, Shishir K Biswas, Ashley W Seifert
{"title":"Ear pinna growth and differentiation is conserved in murids and requires BMP signaling for chondrocyte proliferation.","authors":"Robyn S Allen, Shishir K Biswas, Ashley W Seifert","doi":"10.1242/dev.204560","DOIUrl":"10.1242/dev.204560","url":null,"abstract":"<p><p>Despite being a major target of reconstructive surgery, development of the ear pinna remains poorly studied. Here, we provide a cellular characterization of late gestational and postnatal ear pinna development in two rodents and investigate the role of BMP5 in expansion and differentiation of auricular elastic cartilage. We find that ear pinna development is largely conserved between Mus musculus and the highly regenerative Acomys dimidiatus. The pattern of pre-cartilaginous cells is established early in development. These cells are specified into chondroblasts before ear unfolding and then undergo extensive proliferation before maturation. The elastic cartilage, connective tissue fibroblasts, dermal papilla and sheath cells, and adipocytes in the adult pinna are derived from cranial neural crest. Cellular analysis using the naturally occurring short ear mouse mutant shows that loss of BMP5 does not prevent specification of chondroblasts, but does impair chondroblast proliferation. Finally, chondroblast proliferation remains impaired in the adult mid-distal ear pinna of these mutants. Together, these data establish the developmental basis for differentiation of ear pinna tissues.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The dynamics of tubulogenesis in development and disease.
IF 3.7 2区 生物学
Development Pub Date : 2025-02-01 Epub Date: 2025-02-17 DOI: 10.1242/dev.202820
Adrian Romero, Brandy L Walker, Vanja Krneta-Stankic, Kamryn Gerner-Mauro, Lydia Youmans, Rachel K Miller
{"title":"The dynamics of tubulogenesis in development and disease.","authors":"Adrian Romero, Brandy L Walker, Vanja Krneta-Stankic, Kamryn Gerner-Mauro, Lydia Youmans, Rachel K Miller","doi":"10.1242/dev.202820","DOIUrl":"https://doi.org/10.1242/dev.202820","url":null,"abstract":"<p><p>Tubes are crucial for the function of many organs in animals given their fundamental roles in transporting and exchanging substances to maintain homeostasis within an organism. Therefore, the development and maintenance of these tube-like structures within organs is a vital process. Tubes can form in diverse ways, and advances in our understanding of the molecular and cellular mechanisms underpinning these different modes of tubulogenesis have significant impacts in many biological contexts, including development and disease. This Review discusses recent progress in understanding developmental mechanisms underlying tube formation.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 3","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Transcriptional dynamics during karyogamy in rice zygotes.
IF 3.7 2区 生物学
Development Pub Date : 2025-02-01 Epub Date: 2025-02-11 DOI: 10.1242/dev.204691
Erika Toda, Shizuka Koshimizu, Atsuko Kinoshita, Tetsuya Higashiyama, Takeshi Izawa, Kentaro Yano, Takashi Okamoto
{"title":"Correction: Transcriptional dynamics during karyogamy in rice zygotes.","authors":"Erika Toda, Shizuka Koshimizu, Atsuko Kinoshita, Tetsuya Higashiyama, Takeshi Izawa, Kentaro Yano, Takashi Okamoto","doi":"10.1242/dev.204691","DOIUrl":"10.1242/dev.204691","url":null,"abstract":"","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 3","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interplay of SHH, WNT and BMP4 signaling regulates the development of the lamina propria in the murine ureter. SHH、WNT和BMP4信号的相互作用调节小鼠输尿管固有层的发育。
IF 3.7 2区 生物学
Development Pub Date : 2025-02-01 Epub Date: 2025-02-06 DOI: 10.1242/dev.204214
Philipp Straube, Anja Beckers, Ulrich W H Jany, Florian Bergmann, Timo H-W Lüdtke, Carsten Rudat, Mark-Oliver Trowe, Imke Peters, Maximilian G Klopf, Tamrat M Mamo, Andreas Kispert
{"title":"Interplay of SHH, WNT and BMP4 signaling regulates the development of the lamina propria in the murine ureter.","authors":"Philipp Straube, Anja Beckers, Ulrich W H Jany, Florian Bergmann, Timo H-W Lüdtke, Carsten Rudat, Mark-Oliver Trowe, Imke Peters, Maximilian G Klopf, Tamrat M Mamo, Andreas Kispert","doi":"10.1242/dev.204214","DOIUrl":"10.1242/dev.204214","url":null,"abstract":"<p><p>In mammalian ureters, the lamina propria presents as a prominent layer of connective tissue underneath the urothelium. Despite its important structural and signaling functions, little is known how the lamina propria develops. Here, we show that in the murine ureter the lamina propria arises at late fetal stages and massively increases by fibrocyte proliferation and collagen deposition after birth. WNT, SHH, BMP4 and retinoic acid signaling are all active in the common mesenchymal progenitor of smooth muscle cells and lamina propria fibrocytes. However, around birth, the lamina propria becomes a target for epithelial WNT and SHH signals and a source of BMP4 and retinoic acid. SHH and WNT signaling promote lamina propria and smooth muscle cell differentiation and proliferation at fetal and early postnatal stages, whereas BMP4 signaling is required for early smooth muscle cell differentiation but not for its later maintenance. Our findings suggest that, in the presence of SHH and WNT signaling, it is the modulation of BMP4 signaling which is the major determinant for the segregation of lamina propria and smooth muscle cells.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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