Diabetology International最新文献

{"title":"Premature mortality due to diabetes in Japan: a nationwide analysis from 2000 to 2020.","authors":"Duc-Cuong Le, Truong-Minh Pham, Pham Nguyen Quy, Aki Kondo, Thi Thu Huong Le, Alysha Crocker, Narender Singh, Tatsuhiko Kubo, Yoshihisa Fujino, Shinya Matsuda","doi":"10.1007/s13340-025-00801-5","DOIUrl":"10.1007/s13340-025-00801-5","url":null,"abstract":"<p><strong>Aims: </strong>We examined if there has been improvements in the lifespan of people who died from diabetes in Japan between 2000 and 2020 using the novel average lifespan shortened (ALSS) measure.</p><p><strong>Methods: </strong>The number of deaths due to diabetes in Japan were obtained from the World Health Organization mortality database. We calculated age standardized rates (ASR) using direct method adjusted to the World Standard Population. Years of life lost (YLL) due to diabetes was calculated using Japanese life tables. ALSS measure was calculated as a ratio of YLL to the expected lifespan. We used the bootstrap method to calculate 95% confidence interval (95% CI) for the ALSS measure.</p><p><strong>Results: </strong>The ASR of deaths due to diabetes decreased from 5.5 to 3.7 deaths per 100,000 people in men, and from 2.9 to 1.5 deaths in women over the study period. The ALSS results show that men with diabetes lost 18.0% (95% CI 17.7-18.3) of their lifespan at the beginning of the study period, but only 14.3% (95% CI 14.1-14.6) of their lifespan at the end of the study period. Similarly, the ALSS values for women decreased from 15.0% (95% CI 14.7-15.2) of their lifespan to 12.1% (95% CI 11.9-12.3) at the end of the study period.</p><p><strong>Conclusion: </strong>Results from the new ALSS measure show lifespan of people who died from diabetes prolonged by about 4 and 3 percentage points in men and women over the study.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"16 2","pages":"372-378"},"PeriodicalIF":1.3,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of oral semaglutide on remnant-like lipoprotein cholesterol in patients with ischemic heart disease receiving statin therapy.","authors":"Shingo Watanabe, Junichi Onuma, Michio Usui","doi":"10.1007/s13340-025-00799-w","DOIUrl":"10.1007/s13340-025-00799-w","url":null,"abstract":"<p><strong>Objectives: </strong>High remnant-like lipoprotein (RLP) cholesterolemia has been reported as a risk factor for cardiovascular events in stable angina patients receiving statin therapy. However, there are no established treatments for lowering RLP cholesterol in patients on statins. Glucagon-Like Peptide-1 (GLP-1) receptor agonists are known to reduce cardiovascular events, but the underlying mechanism is not fully understood. We hypothesized that the lipid profile-improving effects of GLP-1 receptor agonists may also contribute to lowering RLP cholesterol.The purpose of this study was to investigate whether oral semaglutide, a GLP-1 receptor agonist, exerts a cholesterol-lowering effect on RLP cholesterol.</p><p><strong>Methods: </strong>This study was designed as a single-center, single-group, before-and-after comparison trial. The study population consisted of patients with ischemic heart disease who were receiving statin therapy, had initiated oral semaglutide for diabetes, and had an RLP cholesterol level of 3.9 mg/dL or higher before starting semaglutide (<i>N</i> = 41). RLP cholesterol levels were measured in all patients 3 months after initiating semaglutide therapy. RLP cholesterol levels before and after semaglutide treatment were compared.</p><p><strong>Results: </strong>After initiating semaglutide, RLP cholesterol levels were significantly lower compared to baseline levels (before 8.52 ± 3.96 mg/dL After 5.46 ± 2.88 mg/dL, <i>P</i> < 0.001). In 21 patients who switched from DPP-4 inhibitors to semaglutide, RLP cholesterol levels also significantly decreased (7.33 ± 1.03 mg/dL → 6.75 ± 0.95 mg/dL, <i>P</i> < 0.001). Additionally, among 30 patients who were already on SGLT-2 inhibitors, RLP cholesterol levels significantly decreased after starting semaglutide (8.01 ± 3.37 mg/dL → 5.42 ± 2.37 mg/dL, <i>P</i> < 0.001). No correlation was observed between the reduction in RLP cholesterol and weight loss.</p><p><strong>Conclusions: </strong>Oral semaglutide significantly reduced RLP cholesterol levels in patients with ischemic heart disease who were receiving statin therapy.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"16 2","pages":"365-371"},"PeriodicalIF":1.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of online education on thermography-based diabetic foot ulcer prevention for wound care specialists: a single-group quasi-experimental study.","authors":"Muhammad Aminuddin, Sukarni, Haryanto, Suriadi Jais, Amika Yamada, Kanae Mukai, Makoto Oe","doi":"10.1007/s13340-025-00791-4","DOIUrl":"10.1007/s13340-025-00791-4","url":null,"abstract":"<p><strong>Background: </strong>While there is an urgent need worldwide to establish methods that prevent diabetic foot ulcers, the effectiveness of a prevention protocol using thermography has been reported. As the number of diabetic patients in Indonesia is increasing, an online program for wound care specialists was developed to disseminate this protocol. The present study evaluated the impact of an online program on wound care specialists' knowledge of diabetic foot ulcer prevention using thermography.</p><p><strong>Methods: </strong>This single-group quasi-experimental study was conducted in cooperation with the Indonesian Wound Enterostomal Continence Nurses Association with regard to curriculum and content design, and the evaluation methods of online education for thermography-based diabetic foot ulcer prevention using the learning management system. A questionnaire with 50 multiple-choice questions previously validated for content and readability on the knowledge of diabetic foot ulcer prevention using thermography was used for training evaluations.</p><p><strong>Results: </strong>Of 106 Indonesian wound care specialists evaluated, the paired t-test revealed a significant difference between the before and after training questionnaire scores on knowledge (52.0 ± 10.3, 85.2 ± 10.6, respectively, <i>p</i> < 0.001). Repeated measures analysis of variance revealed interactions between time (before and after training) and gender, and between time and type of certificate (<i>p</i> = 0.046, <i>p</i> = 0.014, respectively).</p><p><strong>Conclusions: </strong>An asynchronous e-learning program is an effective method to increase wound care specialists' knowledge of diabetic foot ulcer prevention. These findings suggest that online educational interventions are effective and can be tailored to meet the needs of healthcare professionals, thereby ultimately contributing to better patient care outcomes in preventing DFUs.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"16 2","pages":"356-364"},"PeriodicalIF":1.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined symptoms of diabetes distress, depression, and anxiety and their association with glycemic control in primary care patients with type 2 diabetes in Egypt.","authors":"Hazem A Sayed Ahmed, Samar F Mohamed, Anwar I Joudeh, Sally Fawzy Elotla, Mona Mostafa, Jaffer Shah, Ahmed Mahmoud Fouad, Samy Abdelrazek Abdelazim","doi":"10.1007/s13340-025-00793-2","DOIUrl":"10.1007/s13340-025-00793-2","url":null,"abstract":"<p><strong>Introduction: </strong>Existing studies mostly focus on the separate impacts of diabetes distress, depression, and anxiety on glycemic control, leaving a gap in understanding their combined influence within primary care settings. This study aims to explore this interaction among patients with type 2 diabetes mellitus (T2DM) in Egyptian primary healthcare.</p><p><strong>Methods: </strong>The study was conducted in rural primary healthcare settings in Egypt from September 2020 to June 2021, included 354 patients with T2DM. Sociodemographic, lifestyle, and clinical characteristics were assessed through patient interviews. Diabetes distress was measured using the 5-item Problem Areas in Diabetes Scale (PAID-5 scale), and symptoms of depression and anxiety were evaluated using the Patient Health Questionnaire 9 (PHQ-9) and the Generalized Anxiety Disorder 7 Scale (GAD-7), respectively. Glycated hemoglobin (HbA1c) measurements indicated glycemic control.</p><p><strong>Results: </strong>Participants experienced varying mental health symptoms: 24.9% had one symptom, 8.2% had two, and 4.5% had all three (diabetes distress, depression, and anxiety symptoms). In multiple linear regression, not working status (β = -0.203, p = 0.015), dyslipidemia (β = 0.258, p = 0.021), increased BMI (β = 0.022, p < 0.001), and more mental health symptoms (β = 0.267, p < 0.001) predicted higher HbA1c levels. Ordinal regression found that higher educational levels (OR = 2.385, p = 0.021), sufficient income (OR = 2.360, p = 0.007), and higher HbA1c (OR = 3.103, p < 0.001) predicted more mental health symptoms.</p><p><strong>Conclusion: </strong>Mental health symptoms were common, and there were reciprocal associations between elevated HbA1c levels and increased mental health symptoms.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13340-025-00793-2.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"16 2","pages":"326-338"},"PeriodicalIF":1.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Job stress evaluated using the brief job stress questionnaire and diabetes mellitus among a Japanese occupational population.","authors":"Hiromitsu Sekizuka, Hirohisa Kato, Toshiya Ishii, Satoko Nagumo","doi":"10.1007/s13340-025-00796-z","DOIUrl":"10.1007/s13340-025-00796-z","url":null,"abstract":"<p><strong>Objective: </strong>Stress and working environments are risk factors for diabetes mellitus. A new occupational health policy called the Stress Check Program was started in Japan in 2015. Therefore, we clarified whether the presence or absence of high job stress (HJS) as determined using the Brief Job Stress Questionnaire (BJSQ) is related to the comorbidity of diabetes.</p><p><strong>Methods: </strong>The results of a single year's BJSQ and medical examinations were investigated for 30,694 Japanese active office workers who were 30 to 59 years old. Presence or absence of HJS was assessed using the BJSQ and investigated using a personal computer in a medical interview. Furthermore, the relationships between HJS and diabetes comorbidity were analyzed.</p><p><strong>Results: </strong>The mean age of the subjects was 43.8 ± 10.5 years old, and the proportion of subjects with HJS was 10%. After adjustment for age and sex, HJS was associated with a risk of diabetes comorbidity (odds ratio, 1.30; 95% confidence interval 1.13-1.49). HJS was not a significant diabetic comorbidity factor when adjusted for lifestyle habits in addition to age and sex.</p><p><strong>Conclusion: </strong>HJS measured using the BJSQ and unhealthy lifestyles synergistically contributed to diabetes comorbidity.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"16 2","pages":"339-347"},"PeriodicalIF":1.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon change rate after glucose load: a potential key for tailoring treatment in gestational diabetes mellitus.","authors":"Sae Joko, Takuya Hashimoto, Miho Yamashita, Daisuke Tsuriya, Masato Maekawa, Moriya Iwaizumi","doi":"10.1007/s13340-025-00797-y","DOIUrl":"10.1007/s13340-025-00797-y","url":null,"abstract":"<p><p>Gestational diabetes mellitus (GDM) is a known risk factor for both maternal and fatal complications. Glycemic control in pregnant women is important for preventing these complications. However, the need for insulin therapy in pregnant women is difficult to determine. This study focuses on glucagon, which provides new prospects due to advancement in the measurement assay method for type 2 diabetes. Investigating the dynamics of glucagon in pregnant women will help in the diagnosis of GDM and in identifying those requiring insulin treatment. A total of 58 pregnant women between 24 and 31 weeks of gestation underwent a 75-g glucose tolerance test at our institution between 2013 and 2015. The results showed differences in post-glucose and insulin levels between patients with and without GDM, but not in glucagon levels. However, differences were observed in fasting plasma glucose (79.2 ± 4.2 vs. 85.7 ± 8.5 mg/dL, P = 0.006) and in the glucagon change rates at 15, 30, and 60 min after glucose loading between patients with GDM requiring insulin treatment and those who did not. Using a cutoff value of -0.4566 for the glucagon change rate at 60 min as the predictor for insulin treatment, the sensitivity and specificity were 63.16% and 92.31%, respectively. Overall, the measurement of glucagon during the early post-glucose load period may be useful in predicting insulin therapy requirements in pregnant Asian women with GDM.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13340-025-00797-y.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"16 2","pages":"348-355"},"PeriodicalIF":1.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the type of family history of diabetes and the risk and age at onset of diabetes in the Japanese general population.","authors":"Minoru Iwata, Teruyo Okazawa, Kiyohiro Higuchi, Kazuyuki Tobe","doi":"10.1007/s13340-025-00792-3","DOIUrl":"10.1007/s13340-025-00792-3","url":null,"abstract":"<p><strong>Aim: </strong>The objective of this cross-sectional study was to clarify the relationship between the type of first-degree family history of diabetes (FHD) and the presence and age at onset of diabetes (AOD) in the Japanese general population.</p><p><strong>Material and methods: </strong>Using anonymized processed data collected from community-based health checkups, we classified 10,691 subjects into 5 groups according to the type of FHD as follows: (1) no FHD; (2) diabetes only in a sibling (sFHD); (3) diabetes only in the mother (mFHD); (4) diabetes only in the father (pFHD); and (5) diabetes in ≥ 2 family members, e.g., one parent plus a sibling or both parents (FHD in ≥ 2 family members).</p><p><strong>Result: </strong>Results of multivariate logistic regression analysis performed using the no FHD group as reference revealed a significant association between a positive FHD and the presence of diabetes (odds ratio: sFHD, 3.67; mFHD, 3.70; pFHD, 2.88; FHD in ≥ 2 family members, 6.35; <i>P</i> < 0.0001 for all). Moreover, the AOD was significantly younger in all the four groups with FHD than in the group without FHD (<i>P</i> < 0.01), being the youngest in the group of FHD in ≥ 2 family members.</p><p><strong>Conclusion: </strong>Our results revealed that the degree of associations between a positive FHD and the presence of diabetes and AOD differ according to the type of FHD. In particular, FHD in ≥ 2 family members appears to be especially strongly associated with a high risk of diabetes and a younger AOD.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"16 2","pages":"316-325"},"PeriodicalIF":1.3,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of dietary intake and eating behaviors with glycemic control and body weight under long-term treatment with dapagliflozin: an exploratory prospective study.","authors":"Hisashi Yokomizo, Daiji Kawanami, Noriyuki Sonoda, Yasuhiro Ono, Yasutaka Maeda, Jun Itoh, Takeshi Tohyama, Masayuki Hirose, Hiroko Watanabe, Junji Kishimoto, Yoshihiro Ogawa, Toyoshi Inoguchi","doi":"10.1007/s13340-025-00794-1","DOIUrl":"10.1007/s13340-025-00794-1","url":null,"abstract":"<p><p>Sodium glucose cotransporter-2 (SGLT2) inhibitors improve glycemic control and reduce body weight (BW) in individuals with type 2 diabetes. However, there are still concerns that compensatory hyperphagia may affect their effects. Here, we performed an exploratory prospective study to investigate whether dietary intake and/or eating behaviors affect glycemic control and BW under long-term treatment with dapagliflozin. Fifty-three Japanese individuals with type 2 diabetes received dapagliflozin 5 mg daily for 104 weeks, with frequent assessments of HbA1c, BW, body composition, dietary intake, and eating behaviors. Dietary intake was evaluated using a brief self-administered diet history questionnaire, and eating behavior was evaluated using the Dutch Eating Behavior Questionnaire. The study was registered in the University Hospital Medical Information Network Clinical Trials Registry (UMIN000019192). At 104 weeks, HbA1c decreased by 0.5% and BW decreased by 2.8 kg (both <i>p</i> < 0.001), with a dominant decrease in body fat mass by 2.2 kg (<i>p</i> < 0.001). No significant change was observed in calorie intake or the proportion of carbohydrates, protein, and fat. The change (∆) in HbA1c was significantly correlated with basal HbA1c, basal triglyceride levels, ∆BMI (body mass index), ∆BFP (body fat percentage), and ∆ferritin levels. The ∆BMI was significantly correlated with only the ∆BFP. Neither the ∆HbA1c nor ∆BMI was significantly correlated with dietary intake, any type of eating behavior, or changes in these parameters during this study. In conclusion, dapagliflozin treatment improved glycemic control and reduced BW without being affected by any changes in dietary intake or eating behavior over 104 weeks.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13340-025-00794-1.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"16 2","pages":"303-315"},"PeriodicalIF":1.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between clustering of hypoglycemic symptoms, psychological traits, and problem-solving abilities in adults with type 1 diabetes: baseline data analysis of the PR-IAH study.","authors":"Naoki Sakane, Ken Kato, Sonyun Hata, Erika Nishimura, Rika Araki, Kunichi Kouyama, Masako Hatao, Yuka Matoba, Yuichi Matsushita, Masayuki Domichi, Akiko Suganuma, Seiko Sakane, Takashi Murata, Fei Ling Wu","doi":"10.1007/s13340-024-00788-5","DOIUrl":"10.1007/s13340-024-00788-5","url":null,"abstract":"<p><strong>Background: </strong>Precision medicine in diabetes care requires a dedicated focus on hypoglycemic symptoms. This study explored the associations between clustering of hypoglycemic symptoms, psychological characteristics, and problem-solving capabilities in adults with type 1 diabetes (T1D).</p><p><strong>Methods: </strong>A total of 251 adults with T1D participated in this survey. Hierarchical clustering was used to analyze 11 hypoglycemic symptoms (Edinburgh scale). The data included diabetic complications, fear of hypoglycemia, depressive symptoms, hypoglycemia problem-solving scale (HPSS), and treatment details. For predicting clusters and identifying feature importance, we utilized a machine learning approach.</p><p><strong>Results: </strong>Three distinct clusters were observed; individuals not sensitive to autonomic or neuroglycopenic symptoms (cluster 1, n = 138), those sensitive to both autonomic and neuroglycopenic symptoms (cluster 2, n = 19), and those sensitive to autonomic but not neuroglycopenic symptoms (cluster 3, n = 94). Compared to cluster 1, individuals from clusters 2 and 3 were of younger age, had higher fear of hypoglycemia, increased depressive symptoms, and greater use of continuous subcutaneous insulin infusion. Cluster 2 displayed enhanced HPSS scores, indicating better detection control and a more proactive approach to seeking preventive strategies than cluster 1. The accuracy for classifying into 3 clusters using machine learning was 88.2%. The feature importance of random forest model indicated that hunger, shaking, palpitation, sweating, and confusion were the top five important factors for predicting clusters.</p><p><strong>Conclusion: </strong>This study identified three distinct clusters of adults with T1D. These findings may provide valuable insights for diabetes professionals seeking to educate these individuals on how to manage hypoglycemia effectively.</p><p><strong>Trial registration: </strong>University Hospital Medical Information Network (UMIN) Center: UMIN000039475); approval date: February 13, 2020.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"16 2","pages":"294-302"},"PeriodicalIF":1.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plantar pressure and shear stress during gait in people with diabetic neuropathy.","authors":"Shunsuke Mima, Yoshiro Abe, Hiroyuki Yamasaki, Mayu Bando, Shinji Nagasaka, Yutaro Yamashita, Kazuhide Mineda, Sumiko Yoshida, Itsuro Endo, Munehide Matsuhisa, Masahiro Takaiwa, Ichiro Hashimoto","doi":"10.1007/s13340-024-00789-4","DOIUrl":"10.1007/s13340-024-00789-4","url":null,"abstract":"<p><strong>Aims: </strong>Diabetic foot ulcers are a leading cause of lower extremity amputations, significantly affecting the quality of life. Excessive plantar surface pressure and shear stress are key factors in ulcer development and aggravation. This study aimed to determine the association of these forces with the progression of diabetic peripheral neuropathy to help in foot-ulcer treatment and prevention.</p><p><strong>Methods: </strong>Participants were categorized into four groups: individuals with no diabetes (NS), people with diabetes without peripheral neuropathy or foot-ulcer history (DM), those with diabetes with peripheral neuropathy but no foot-ulcer history (DPN), and people with diabetes with active or past foot ulcers (DFU). Plantar pressure and shear stress were measured during walking.</p><p><strong>Results: </strong>The study included 47 participants. The DFU group demonstrated significantly higher pressure peak value and plantar pressure time integral value at the fifth metatarsal head compared to the DPN and DM groups. The DPN group exhibited significantly higher shear-stress time integral and shear stress time compared to the NS group.</p><p><strong>Conclusions: </strong>In the DPN group, an increase in shear stress was observed. In the DFU group, an increase in plantar pressure and a tendency for an increase in shear stress were noted. Further research is needed to understand how these changes trigger the onset of foot ulcers.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13340-024-00789-4.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"16 2","pages":"285-293"},"PeriodicalIF":1.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}