Diabetology International最新文献

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Impact of prediabetes with a high risk of diabetes stratified by glycated hemoglobin level on the severity of coronavirus disease 2019 during admission. 根据糖化血红蛋白水平分层的糖尿病前期患者对2019年住院期间冠状病毒疾病严重程度的影响。
IF 1.3
Diabetology International Pub Date : 2023-07-01 eCollection Date: 2023-10-01 DOI: 10.1007/s13340-023-00643-z
Seizaburo Masuda, Tetsuya Yamada, Nozomi Hanzawa
{"title":"Impact of prediabetes with a high risk of diabetes stratified by glycated hemoglobin level on the severity of coronavirus disease 2019 during admission.","authors":"Seizaburo Masuda, Tetsuya Yamada, Nozomi Hanzawa","doi":"10.1007/s13340-023-00643-z","DOIUrl":"10.1007/s13340-023-00643-z","url":null,"abstract":"<p><strong>Objective: </strong>Prediabetes with a glycated hemoglobin (HbA1c) level of 5.7 - 6.4% is associated with a poor prognosis of coronavirus disease 2019 (COVID-19), but whether the degree of glycemic control is associated with COVID-19 severity is unknown. The aim of this study was to evaluate the association between the degree of glycemic control and COVID-19 severity in patients with prediabetes.</p><p><strong>Materials and methods: </strong>We reviewed 254 patients with COVID-19 admitted to our hospital between April 2020 and September 2021. Based on their HbA1c level, patients were classified into low (HbA1c level < 5.7%), moderate (HbA1c level, 5.7 - 5.9%), and high risk of diabetes (HbA1c level, 6.0 - 6.4%). The association between risk of diabetes and the worst COVID-19 symptom in terms of severity during admission was evaluated using binary logistic regression analysis.</p><p><strong>Results: </strong>Seventy-one and 88 patients had moderate and high risks of diabetes, respectively. Sixty-three and seven patients presented severe (requiring non-invasive oxygen therapy) or critical (intensive care unit admission or artificial respiratory management) COVID-19. The multivariate logistic regression analysis showed that a high risk of diabetes was correlated with severe COVID-19 (<i>P</i> = 0.01) after adjusting for baseline characteristics, whereas a moderate risk of diabetes was not (<i>P</i> = 0.17).</p><p><strong>Conclusion: </strong>Prediabetes with a high risk of diabetes is associated with the worst COVID-19 symptom in terms of severity during admission. Our findings could aid in more efficient allocation of healthcare resources to a narrower population of prediabetic patients.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13340-023-00643-z.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"14 4","pages":"372-380"},"PeriodicalIF":1.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41108429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lost in translation: assessing the nomenclature change for diabetic kidney disease in Japan. 迷失在翻译中:评估日本糖尿病肾病的命名变化。
IF 1.3
Diabetology International Pub Date : 2023-06-21 eCollection Date: 2023-10-01 DOI: 10.1007/s13340-023-00639-9
Tetsuya Babazono, Tatsumi Moriya
{"title":"Lost in translation: assessing the nomenclature change for diabetic kidney disease in Japan.","authors":"Tetsuya Babazono, Tatsumi Moriya","doi":"10.1007/s13340-023-00639-9","DOIUrl":"10.1007/s13340-023-00639-9","url":null,"abstract":"<p><p>Recently in Japan, the term \"tonyobyo sei jinzobyo\", the Japanese translation of \"diabetic kidney disease\", has been increasingly used in place of the term \"tonyobyo sei jinsho\", the Japanese translation of \"diabetic nephropathy\". Many international diabetes and nephrology guidelines have defined diabetic kidney disease as a condition caused by diabetes, typically presenting with albuminuria, similar to or identical to current and historical definitions for diabetic nephropathy. However, recent guidelines from the Japanese Society of Nephrology propose a broader disease concept for the term diabetic kidney disease, including patients without albuminuria. A rationale for proposing a broader disease concept for diabetic kidney disease may have come from changes in the kidney phenotype of patients with diabetes observed in recent years. Epidemiological studies have shown that an increasing proportion of patients with diabetes have reduced kidney function, while the prevalence of those with albuminuria appears to have decreased. However, these studies also suggested that the more advanced age of patients presenting with diabetes and increased use of renin-angiotensin system blockers may have contributed to this change in disease phenotype. We believe the principal rationale for the nomenclature change from diabetic nephropathy to diabetic kidney disease was to create a more easily understood, lay-language term for English speakers, rather than to create a term to encompass a broader population of diabetes with chronic kidney disease (CKD). Further discussion and international consensus are needed for the definition of diabetic kidney disease, to avoid ambiguity or possible confusion.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"14 4","pages":"319-326"},"PeriodicalIF":1.3,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41115755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vivo relationship between bound and free insulin in patients with diabetes having anti-insulin antibodies. 具有抗胰岛素抗体的糖尿病患者体内结合胰岛素和游离胰岛素之间的关系。
IF 1.3
Diabetology International Pub Date : 2023-06-20 eCollection Date: 2023-10-01 DOI: 10.1007/s13340-023-00641-1
Hiroyuki Asaka, Shigehiro Karashima, Daisuke Chujo, Mitsuhiro Kometani, Mikiya Usukura, Kunimasa Yagi, Ko Aiga, Takashi Yoneda
{"title":"In vivo relationship between bound and free insulin in patients with diabetes having anti-insulin antibodies.","authors":"Hiroyuki Asaka, Shigehiro Karashima, Daisuke Chujo, Mitsuhiro Kometani, Mikiya Usukura, Kunimasa Yagi, Ko Aiga, Takashi Yoneda","doi":"10.1007/s13340-023-00641-1","DOIUrl":"10.1007/s13340-023-00641-1","url":null,"abstract":"<p><strong>Objective: </strong>The Scatchard plot of anti-insulin antibodies is curvilinear, indicating heterogeneity in binding sites. However, the relationship between bound insulin (B) and free insulin (F) in patients with anti-insulin antibodies has not yet been elucidated. This study aimed to determine this relationship.</p><p><strong>Methods: </strong>We studied two insulin-treated patients with diabetes who had high titers of anti-insulin antibodies. The B and F levels were measured using daily blood samples. Assuming that the law of mass action is applicable to the reactions between insulin and anti-insulin antibody forms, we plotted the bound-to-free ratio (B/F) vs. B using patient data. We also performed an equilibrium binding assay in vitro.</p><p><strong>Results: </strong>Some of the B/F vs. B plots of the daily variation showed an approximately linear relationship, while the Scatchard plots of in vitro data became curvilinear.</p><p><strong>Conclusion: </strong>Our study suggests that the one-site (high-affinity site) of anti-insulin antibodies accounts, for the most part, for insulin pharmacokinetics within physiological insulin concentrations.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13340-023-00641-1.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"14 4","pages":"427-433"},"PeriodicalIF":1.3,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41119200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of diabetes medications in adults with T2D and CVD in Japan: secondary analysis of the CAPTURE study. 日本成人T2D和CVD患者糖尿病药物的使用:CAPTURE研究的二次分析。
IF 1.3
Diabetology International Pub Date : 2023-06-15 eCollection Date: 2023-10-01 DOI: 10.1007/s13340-023-00638-w
Yukiko Onishi, Shinichiro Shirabe, Kosei Eguchi, Keiji Nishijima, Toshihiro Sato, Hiroaki Seino
{"title":"Use of diabetes medications in adults with T2D and CVD in Japan: secondary analysis of the CAPTURE study.","authors":"Yukiko Onishi, Shinichiro Shirabe, Kosei Eguchi, Keiji Nishijima, Toshihiro Sato, Hiroaki Seino","doi":"10.1007/s13340-023-00638-w","DOIUrl":"10.1007/s13340-023-00638-w","url":null,"abstract":"<p><strong>Introduction: </strong>The CAPTURE study estimated the global prevalence of established cardiovascular disease (CVD) and characterized the usage of glucose-lowering agents (GLAs) in adults with type 2 diabetes (T2D) across 13 countries. The purpose of this secondary analysis of data from the Japanese sites within CAPTURE (NCT03786406, NCT03811288) was to provide data about medication usage stratified by CVD status among Japanese participants with T2D.</p><p><strong>Materials and methods: </strong>Data on GLA usage (including those with proven cardiovascular [CV] benefits) in Japanese participants with T2D managed in clinics or hospitals were collected and stratified by CVD subgroups.</p><p><strong>Results: </strong>There were 800 Japanese participants in the CAPTURE study (<i>n</i> = 502 [no CVD group], <i>n</i> = 298 [CVD group], <i>n</i> = 268 [atherosclerotic CVD subgroup]). Oral antidiabetic agents and insulin were used by 88.5% and 23.4%, respectively, of participants overall. Among participants with established CVD, dipeptidyl peptidase-4 inhibitors (65.1%) were most frequently used, followed by biguanides (50.7%) and insulins (26.2%). The pattern was similar among participants with atherosclerotic CVD. A lower proportion of participants in the CVD group used glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT-2is) with proven CV benefits versus the no CVD group (GLP-1 RAs: 7.0% vs. 8.6%; SGLT-2is: 13.4% vs. 19.1%).</p><p><strong>Conclusion: </strong>This analysis of the CAPTURE study provided a comprehensive overview of prescription patterns for the treatment of T2D in Japan. Use of GLAs with proven CV benefit was low, even in participants with established CVD, which was comparable to the findings from the global cohort.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13340-023-00638-w.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"14 4","pages":"363-371"},"PeriodicalIF":1.3,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41102192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucose-lowering effects of semaglutide compared with dulaglutide using professional continuous glucose monitoring in outpatients with type 2 diabetes mellitus: a pilot study. 在门诊2型糖尿病患者中,使用专业连续血糖监测,与杜拉鲁肽相比,赛马鲁肽的血糖降低效果:一项初步研究。
IF 2.2
Diabetology International Pub Date : 2023-06-06 eCollection Date: 2023-10-01 DOI: 10.1007/s13340-023-00640-2
Akira Kurozumi, Yosuke Okada, Momo Saitoh, Yoshiya Tanaka
{"title":"Glucose-lowering effects of semaglutide compared with dulaglutide using professional continuous glucose monitoring in outpatients with type 2 diabetes mellitus: a pilot study.","authors":"Akira Kurozumi, Yosuke Okada, Momo Saitoh, Yoshiya Tanaka","doi":"10.1007/s13340-023-00640-2","DOIUrl":"10.1007/s13340-023-00640-2","url":null,"abstract":"<p><strong>Objective: </strong>Currently, the most frequently prescribed once weekly glucagon-like peptide-1 receptor agonists (GLP-1RA) in Japan are dulaglutide (DG) and semaglutide (SG). However, little is known about the differences between these two compounds in clinical practice in Japan. This study compared the efficacy and safety of DG and SG using professional CGM in 12 patients attending our outpatient with poorly controlled type 2 diabetes mellitus (T2DM) while using GLP-1RA.</p><p><strong>Methods: </strong>The study subjects were 12 T2DM patients with HbA1c ≥ 7.0% on treatment with 0.75 mg/week DG for at least 24 weeks. All patients wore the professional CGM twice, once while receiving DG and once when the SG dose was increased to 0.5 mg/week.</p><p><strong>Results: </strong>Time in range was significantly better with SG than with DG, which was the main outcome measure. Regarding the secondary outcome measures, standard deviation of glucose, average sensor glucose, time above range, maximum sensor glucose, interquartile range, SD of glucose during the nocturnal period (0000-0559), and average nocturnal sensor glucose (0000-0559) were significantly better with SG than DG. In contrast, SG had no effect on the time below range and minimum sensor glucose compared to DG.</p><p><strong>Conclusions: </strong>Switching from 0.75 mg DG to 0.5 mg SG in patients with T2DM improved glycemic variability, mean glycemic index, and daily variability without increasing the hypoglycemic index. The results suggest that switching to SG may be a useful option in patients experiencing inadequate glycemic control with DG.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13340-023-00640-2.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"14 4","pages":"356-362"},"PeriodicalIF":2.2,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41105361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anemia combined with albuminuria increases the risk of cardiovascular and renal events, regardless of a reduced glomerular filtration rate, in patients with type 2 diabetes: a prospective observational study. 2型糖尿病患者无论肾小球滤过率降低,贫血合并蛋白尿都会增加心血管和肾脏事件的风险:一项前瞻性观察性研究。
IF 2.2
Diabetology International Pub Date : 2023-05-30 eCollection Date: 2023-10-01 DOI: 10.1007/s13340-023-00637-x
Hiroyuki Ito, Suzuko Matsumoto, Hideyuki Inoue, Takuma Izutsu, Eiji Kusano, Shinichi Antoku, Tomoko Yamasaki, Toshiko Mori, Michiko Togane
{"title":"Anemia combined with albuminuria increases the risk of cardiovascular and renal events, regardless of a reduced glomerular filtration rate, in patients with type 2 diabetes: a prospective observational study.","authors":"Hiroyuki Ito, Suzuko Matsumoto, Hideyuki Inoue, Takuma Izutsu, Eiji Kusano, Shinichi Antoku, Tomoko Yamasaki, Toshiko Mori, Michiko Togane","doi":"10.1007/s13340-023-00637-x","DOIUrl":"10.1007/s13340-023-00637-x","url":null,"abstract":"<p><strong>Aim: </strong>The incidence of cardiovascular and renal events was investigated in patients with type 2 diabetes who were classified according to anemia and the components of dialysis-independent chronic kidney disease (CKD) in a prospective observational study.</p><p><strong>Methods: </strong>A population of 778 Japanese patients with type 2 diabetes was prospectively analyzed for 4 years. The outcomes were the incidence of cardiovascular events and renal events.</p><p><strong>Results: </strong>In all subjects, the incidence of cardiovascular and renal events was found to be 5% and 11%, respectively. Even after adjusting for a reduced estimated glomerular filtration rate (eGFR <60 mL/min/1.73 m<sup>2</sup>), the incidence of cardiovascular events was significantly higher (hazard ratio [HR]: 5.73) in patients with anemia and albuminuria than in those without anemia and albuminuria. The incidence of renal events was significantly higher in patients with no anemia and albuminuria (HR: 2.93) and further in those with anemia and albuminuria (HR: 7.56) than in those without anemia and albuminuria even after adjusting for a reduced eGFR.</p><p><strong>Conclusion: </strong>Anemia combined with albuminuria is a risk factor for vascular events in patients with type 2 diabetes, regardless of the eGFR.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13340-023-00637-x.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"14 4","pages":"344-355"},"PeriodicalIF":2.2,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41110692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Role of insulin action in the pathogenesis of diabetic complications. 更正:胰岛素作用在糖尿病并发症发病机制中的作用。
IF 2.2
Diabetology International Pub Date : 2023-05-27 eCollection Date: 2023-07-01 DOI: 10.1007/s13340-023-00636-y
Kyoichiro Tsuchiya
{"title":"Correction to: Role of insulin action in the pathogenesis of diabetic complications.","authors":"Kyoichiro Tsuchiya","doi":"10.1007/s13340-023-00636-y","DOIUrl":"10.1007/s13340-023-00636-y","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1007/s13340-022-00601-1.].</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"14 3","pages":"318"},"PeriodicalIF":2.2,"publicationDate":"2023-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307759/pdf/13340_2023_Article_636.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10123142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determinants of phase angle in Japanese patients with diabetes. 日本糖尿病患者相位角的决定因素。
IF 2.2
Diabetology International Pub Date : 2023-05-25 eCollection Date: 2023-10-01 DOI: 10.1007/s13340-023-00633-1
Naokazu Muramae, Tomokazu Matsuda, Satoshi Inagaki, Hiroaki Takahashi, Kozue Abe, Saki Nakatani, Michiko Takahashi, Kenji Kato, Kazuhiko Sakaguchi, Wataru Ogawa
{"title":"Determinants of phase angle in Japanese patients with diabetes.","authors":"Naokazu Muramae, Tomokazu Matsuda, Satoshi Inagaki, Hiroaki Takahashi, Kozue Abe, Saki Nakatani, Michiko Takahashi, Kenji Kato, Kazuhiko Sakaguchi, Wataru Ogawa","doi":"10.1007/s13340-023-00633-1","DOIUrl":"10.1007/s13340-023-00633-1","url":null,"abstract":"<p><p>Phase angle, obtained using bioelectrical impedance analysis, non-invasively reflects the whole-body cellular condition and nutritional status and may be helpful as a prognostic factor. Patients with diabetes had a smaller phase angle than healthy subjects. However, the clinical significance of phase angle has not yet been elucidated. Therefore, the purpose of this study was to clarify the relationship between phase angle and HbA1c in patients with diabetes and the clinical relevance of phase angle. A retrospective, multicenter, cross-sectional study was conducted with Japanese patients with diabetes. Body composition was determined with bioelectrical impedance analysis, and this was used to obtain phase angle. Phase angle was assessed in relation to clinical parameters, body composition parameters, and HbA1c levels. A total of 655 patients were enrolled (400 men and 255 women, aged 57.1 ± 14.8 years, body mass index 25.6 ± 5.2 kg/m<sup>2</sup>, HbA1c 8.1 ± 1.9%). Even in patients with diabetes, the phase angle was higher in men than in women and did not differ between the types of diabetes. Multiple regression analysis, performed with phase angle as the objective variable, and age, sex, diabetes type, HbA1c, albumin level, and body mass index as explanatory variables, revealed that phase angle was negatively affected by HbA1c (B = - 0.043, 95% Confidence interval: - 0.07 to - 0.02, p < 0.001). HbA1c, age, sex, albumin level, and body mass index were independent determinants of phase angle in participants with diabetes.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"14 4","pages":"339-343"},"PeriodicalIF":2.2,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41113891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concurrent bacterial liver abscess and mild encephalitis/encephalopathy with reversible splenial lesion in a patient with poorly controlled type 2 diabetes. 2型糖尿病患者并发细菌性肝脓肿和轻度脑炎/脑病,伴有可逆性脾脏病变。
IF 2.2
Diabetology International Pub Date : 2023-05-15 eCollection Date: 2023-07-01 DOI: 10.1007/s13340-023-00635-z
Naohiro Sekikawa, Hiroyuki Hirai, Kazuhiro Sugimoto, Yoshiro Kusano
{"title":"Concurrent bacterial liver abscess and mild encephalitis/encephalopathy with reversible splenial lesion in a patient with poorly controlled type 2 diabetes.","authors":"Naohiro Sekikawa, Hiroyuki Hirai, Kazuhiro Sugimoto, Yoshiro Kusano","doi":"10.1007/s13340-023-00635-z","DOIUrl":"10.1007/s13340-023-00635-z","url":null,"abstract":"<p><p>A 34-year-old man with poorly controlled type 2 diabetes was admitted to our hospital because of fever, headache, vomiting, and impaired consciousness. His hemoglobin A1c level was as high as 11.0%. Abdominal computed tomography revealed a bacterial liver abscess, while head magnetic resonance imaging simultaneously showed a high-signal lesion on diffusion-weighted imaging and a low-signal lesion on the apparent diffusion coefficient map of the splenium of the corpus callosum. No significant findings were detected in the cerebrospinal fluid. The latter findings led to a diagnosis of mild encephalitis/encephalopathy with reversible splenial lesions. His impaired consciousness resolved on Day 5 after treatment with ceftriaxone and metronidazole infusion and intensive insulin therapy; magnetic resonance imaging on Day 20 showed that the lesion in the splenium of the corpus callosum had disappeared. We propose that when a person with poorly controlled diabetes develops a bacterial infection and presents with impaired consciousness and headache, clinicians should consider the complications of mild encephalitis/encephalopathy with reversible splenial lesion.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"14 3","pages":"312-317"},"PeriodicalIF":2.2,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10105543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypertriglyceridemia contributes significantly to high prevalence of small dense LDL-cholesterol in patients with type 2 diabetes, even when LDL-C targets are achieved. 在2型糖尿病患者中,即使达到LDL-C目标,高甘油三酯血症也会显著导致低密度脂蛋白胆固醇的高患病率。
IF 2.2
Diabetology International Pub Date : 2023-05-15 eCollection Date: 2023-07-01 DOI: 10.1007/s13340-023-00634-0
Tsutomu Hirano
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