Association between the type of family history of diabetes and the risk and age at onset of diabetes in the Japanese general population.

IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM

Diabetology International Pub Date : 2025-01-25 eCollection Date: 2025-04-01 DOI:10.1007/s13340-025-00792-3

Minoru Iwata, Teruyo Okazawa, Kiyohiro Higuchi, Kazuyuki Tobe

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引用次数: 0

Abstract

Aim: The objective of this cross-sectional study was to clarify the relationship between the type of first-degree family history of diabetes (FHD) and the presence and age at onset of diabetes (AOD) in the Japanese general population.

Material and methods: Using anonymized processed data collected from community-based health checkups, we classified 10,691 subjects into 5 groups according to the type of FHD as follows: (1) no FHD; (2) diabetes only in a sibling (sFHD); (3) diabetes only in the mother (mFHD); (4) diabetes only in the father (pFHD); and (5) diabetes in ≥ 2 family members, e.g., one parent plus a sibling or both parents (FHD in ≥ 2 family members).

Result: Results of multivariate logistic regression analysis performed using the no FHD group as reference revealed a significant association between a positive FHD and the presence of diabetes (odds ratio: sFHD, 3.67; mFHD, 3.70; pFHD, 2.88; FHD in ≥ 2 family members, 6.35; P < 0.0001 for all). Moreover, the AOD was significantly younger in all the four groups with FHD than in the group without FHD (P < 0.01), being the youngest in the group of FHD in ≥ 2 family members.

Conclusion: Our results revealed that the degree of associations between a positive FHD and the presence of diabetes and AOD differ according to the type of FHD. In particular, FHD in ≥ 2 family members appears to be especially strongly associated with a high risk of diabetes and a younger AOD.

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日本普通人群中糖尿病家族史类型与糖尿病发病风险和发病年龄之间的关系

目的：本横断面研究的目的是阐明一级糖尿病家族史（FHD）类型与日本普通人群中糖尿病（AOD）的存在和发病年龄之间的关系。材料与方法：利用社区健康体检中收集的匿名处理数据，将10691名受试者根据FHD类型分为5组：(1)无FHD；(2)兄弟姐妹中有一人患有糖尿病（sFHD）；(3)仅发生于母亲的糖尿病（mFHD）；(4)父亲型糖尿病（pFHD）；(5)糖尿病患者≥2名家庭成员，如父母一方加兄弟姐妹或父母双方（FHD患者≥2名家庭成员）。结果：以无FHD组为参照进行的多因素logistic回归分析结果显示，FHD阳性与糖尿病存在显著相关(优势比：sFHD， 3.67；mFHD 3.70;pFHD 2.88;家族成员中FHD≥2人，6.35；结论：我们的研究结果显示，FHD阳性与糖尿病和AOD存在的关联程度因FHD类型而异。特别是，在≥2个家庭成员中，FHD似乎与糖尿病的高风险和年轻的AOD密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetology International ENDOCRINOLOGY & METABOLISM-

CiteScore

3.90

自引率

4.50%

发文量

期刊介绍： Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.