Drug and Chemical Toxicology最新文献_第7页

Hepatoprotective effects of cirsimaritin against CCl₄-induced oxidative stress, inflammation, and apoptosis in rats. 茜草素对ccl4诱导的大鼠氧化应激、炎症和细胞凋亡的保护作用

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-01 Epub Date: 2025-11-12 DOI: 10.1080/01480545.2025.2579542

Yousra Bseiso, Badriyah S Alotaibi, Alaa A A Aljabali, Omar Gammoh, Muna Oqal, Esam Qnais, Abdelrahim Alqudah

{"title":"Hepatoprotective effects of cirsimaritin against CCl4-induced oxidative stress, inflammation, and apoptosis in rats.","authors":"Yousra Bseiso, Badriyah S Alotaibi, Alaa A A Aljabali, Omar Gammoh, Muna Oqal, Esam Qnais, Abdelrahim Alqudah","doi":"10.1080/01480545.2025.2579542","DOIUrl":"10.1080/01480545.2025.2579542","url":null,"abstract":"Background: Carbon tetrachloride (CCl4) induces hepatotoxicity through oxidative stress, inflammation, and apoptosis. Cirsimaritin, a natural flavonoid with antioxidant and anti-inflammatory activity, has not been extensively investigated for hepatoprotection.Methods: Male Wistar rats were allocated into four groups (n = 6): control, cirsimaritin-only (80 mg/kg/day), CCl4-only (1 mL/kg of 1:1 CCl4: olive oil, i.p., twice weekly), and cirsimaritin + CCl4. After four weeks, serum liver function markers, oxidative stress indices, cytokines, apoptotic markers, histology, and hepatic expression of Nrf2, HO-1, and NF-κB p65 were assessed.Results: CCl4 significantly elevated ALT, AST, ALP, bilirubin, MDA, TNF-α, IL-6, caspase-3, and caspase-9, while reducing albumin, total protein, SOD, CAT, GPx, IL-4, and IL-10 (p < 0.05-0.001). Cirsimaritin co-treatment reversed these alterations by normalizing liver enzymes, restoring antioxidant activity, lowering lipid peroxidation and pro-inflammatory cytokines, elevating anti-inflammatory cytokines, and attenuating apoptosis. Histology confirmed preservation of hepatic architecture. qPCR analysis showed that CCl4 downregulated Nrf2/HO-1 and upregulated NF-κB p65, whereas cirsimaritin significantly counteracted these molecular changes.Conclusion: Cirsimaritin protects against CCl4-induced hepatotoxicity by enhancing antioxidant defenses, correcting cytokine imbalance, and inhibiting apoptosis, at least partly via activation of Nrf2/HO-1 and suppression of NF-κB signaling. These findings highlight cirsimaritin as a promising natural hepatoprotective candidate.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1038-1048"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145494961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute and subacute oral toxicity of acetylated Ligubtrum lucidum Ait. polysaccharide in male mice. 乙酰化灵芝的急性和亚急性口服毒性。雄性小鼠中的多糖。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-01 Epub Date: 2025-11-13 DOI: 10.1080/01480545.2025.2574390

Yanli Xi, Mingyang Huo, Rixin Zang, Weijie Du, Haonan Jiang, Hongxia Gao, Meiyao Song, Kunjie Gong, Na Xu

{"title":"Acute and subacute oral toxicity of acetylated Ligubtrum lucidum Ait. polysaccharide in male mice.","authors":"Yanli Xi, Mingyang Huo, Rixin Zang, Weijie Du, Haonan Jiang, Hongxia Gao, Meiyao Song, Kunjie Gong, Na Xu","doi":"10.1080/01480545.2025.2574390","DOIUrl":"10.1080/01480545.2025.2574390","url":null,"abstract":"Ligustrum lucidum polysaccharide (FLL-P) is a class of important bioactive macromolecules extracted from the traditional Chinese medicinal herb wine-steamed Ligustrum lucidum Ait. As one of the key active components responsible for the pharmacological effects of this herb, its modern pharmacological value has garnered widespread attention. Research has demonstrated that FLL-P exhibits diverse and significant biological activities, with potential applications that far exceed the traditional scope of Chinese medicine. In recent years, chemical modification has been recognized as an effective strategy for enhancing the biological activity of polysaccharides. Consequently, structural modification of FLL-P is anticipated to further augment its activity and broaden its application prospects. However, current research on the chemical modification of FLL-P remains inadequate, particularly concerning the safety evaluation of modified products, which is still extremely limited. This research comprehensively explores the acetylation modifications of FLL-P, encompassing detailed characterization and toxicity assessments. The optimal product, identified as acetylated FLL-P 12.5 (FLL-PA12.5), was established through analyses of the degree of substitution (DS), FT-IR, and NMR. Toxicity tests, both acute and subacute, were conducted on male mice. The findings indicated that FLL-PA12.5 had a median lethal dose (LD50) exceeding 2000 mg/kg and a no-observed adverse effect level (NOAEL) of 250 mg/kg. Administration of FLL-PA12.5 at doses between 250 and 2000 mg/kg resulted in alterations in various oxidative stress-related parameters in different organs of the mice. These findings indicate that FLL-PA12.5 is a promising therapeutic candidate with an acceptable safety profile, warranting further pharmacological exploration.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1140-1153"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145502868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of glycine against diclofenac-induced toxicity in isolated rat hepatocytes. 甘氨酸对离体大鼠肝细胞双氯芬酸毒性的保护作用。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-01 Epub Date: 2025-10-10 DOI: 10.1080/01480545.2025.2564433

Mostafa G Elkot, Hisham A Nematalla, Ihab T Abdel-Raheem, Asser I Ghoneim

{"title":"Protective effects of glycine against diclofenac-induced toxicity in isolated rat hepatocytes.","authors":"Mostafa G Elkot, Hisham A Nematalla, Ihab T Abdel-Raheem, Asser I Ghoneim","doi":"10.1080/01480545.2025.2564433","DOIUrl":"10.1080/01480545.2025.2564433","url":null,"abstract":"Diclofenac (DIC) is a common cyclo-oxygenase inhibitor that has been linked to liver toxicity. Alternatively, glycine (GLY) has several beneficial actions, including direct cytoprotective, anti-inflammatory, anti-apoptotic, and antioxidant effects. Hence, this study investigated the ability of GLY to protect isolated rat hepatocytes against DIC-induced injury. Hepatocytes were isolated using a modified collagenase-based rat liver perfusion and digestion method. Assessment was conducted on trypan blue (TB) uptake, as well as, reduced glutathione (GSH), lipid peroxidation (LPO), nitric oxide (NO), nuclear factor kappa B (NF-κB), and tumor necrosis factor-alpha (TNF-α) levels. Caspase-3 activity was also measured. Pre-incubation of hepatocytes with GLY (40 mM) for 30 minutes prior to treatment with DIC (200 µM) significantly mitigated hepatocytotoxicity. Additionally, the DIC-depleted GSH level was restored following GLY pretreatment. Moreover, levels of LPO, NO, NF-κB, TNF-α, and caspase-3 activity were normalized and diminished relative to the DIC-intoxicated group. Therefore, GLY prevented DIC-induced hepatocyte toxicity, at least partly, by its cytoprotective, antioxidative, anti-inflammatory, and anti-apoptotic properties. Further research regarding the clinical pharmacologic and toxicologic effects of administering GLY to patients treated with high-dose DIC is thus recommended.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1021-1031"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxytyrosol suppressed the nephrotoxicity of cisplatin while supporting its therapeutic potential in a rat model of hepatocellular carcinoma. 羟基酪醇抑制顺铂的肾毒性，同时支持其在肝细胞癌大鼠模型中的治疗潜力。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-01 Epub Date: 2026-05-13 DOI: 10.1080/01480545.2026.2670721

Tuba Yalçın, Sercan Kaya, Can Ali Ağca, Akın Yiğin, Fatih Demir

{"title":"Hydroxytyrosol suppressed the nephrotoxicity of cisplatin while supporting its therapeutic potential in a rat model of hepatocellular carcinoma.","authors":"Tuba Yalçın, Sercan Kaya, Can Ali Ağca, Akın Yiğin, Fatih Demir","doi":"10.1080/01480545.2026.2670721","DOIUrl":"10.1080/01480545.2026.2670721","url":null,"abstract":"Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. The most important side effect of the chemotherapeutic agent Cisplatin (CIS) is nephrotoxicity. This study aimed to determine how Hydroxytyrosol (HxT), a potent antioxidant, affects the chemotherapeutic effect of CIS against Diethylnitrosamine (DENA)-induced HCC in liver tissue and its effectiveness on the damage caused by CIS in kidney tissues. In the experimental design, 56 male rats were divided into 8 groups (n = 7) for an 8-week experimental period. The rats were randomly assigned to one of the following groups: Control, HCC, HCC+HxT, HCC+CIS, CIS, CIS+HxT, HCC+CIS+HxT, and HxT, in equal numbers (n = 7). The effects of HxT in the HCC and/or CIS groups were examined using biochemical, histopathological, immunohistochemical, real-time PCR, and Western blot techniques. The study found increased liver and kidney function tests, histopathological changes, endoplasmic reticulum stress (ERS) markers, and inflammatory markers in the HCC and/or CIS groups compared to the control group. Furthermore, decreased levels of Phoenixin-14 (PNX-14), an endogenous polypeptide, were observed in the HCC and/or CIS groups compared to the control group. Significantly improved changes resulting from HCC and/or CIS were observed in the HxT-treated groups. Furthermore, cell culture analyses revealed that HxT exhibited cytotoxic effects against the HCC cell line. Conclusively, HxT supplementation demonstrated antioxidant, anti-inflammatory, and anti-apoptotic effects against CIS-induced nephrotoxicity. However, the combination of CIS and HxT may have a more effective anticancer effect against HCC rather than using them separately.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1061-1086"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147927564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A membrane-rupturing protein similar to SIGLEC12 might be involved in sodium arsenite-induced lytic cardiomyocyte death and myocardial necroinflammation. 一种类似SIGLEC12的破膜蛋白可能参与亚砷酸钠诱导的溶性心肌细胞死亡和心肌坏死炎症。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-01 Epub Date: 2026-08-06 DOI: 10.1080/01480545.2026.2711647

Caglar Berkel

引用次数: 0

Xenobiotic modalities impacting the thyroid 3H framework of hormonogenesis, homeostasis, and human health. 影响激素生成、体内平衡和人类健康的甲状腺3H框架的异种生物模式。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-01 Epub Date: 2026-01-08 DOI: 10.1080/01480545.2025.2606102

Abhishek Tater, Bharath Basavapattana Rudresh, Santosh L Gaonkar

{"title":"Xenobiotic modalities impacting the thyroid 3H framework of hormonogenesis, homeostasis, and human health.","authors":"Abhishek Tater, Bharath Basavapattana Rudresh, Santosh L Gaonkar","doi":"10.1080/01480545.2025.2606102","DOIUrl":"10.1080/01480545.2025.2606102","url":null,"abstract":"The thyroid gland is a central endocrine organ regulating growth, metabolism, and energy balance, and is increasingly vulnerable to interference by diverse xenobiotic compounds from pharmaceuticals, environmental pollutants, diet, and consumer products. This review introduces a thyroid '3H' framework - hormonogenesis, homeostasis, and human health - to integrate current understanding of how thyroid endocrine-disrupting chemicals (Thy-EDCs) perturb thyroid physiology and the hypothalamic-pituitary-thyroid axis. A systematic literature search was conducted using PubMed, Scopus, and Web of Science, supplemented by reference screening to ensure comprehensive coverage of mechanistic and toxicological evidence. The synthesis indicates that various exogenous compounds - including tyrosine kinase inhibitors, immune checkpoint inhibitors, heavy metals, industrial endocrine disruptors, and certain dietary phytochemicals - affect thyroid function through multiple molecular initiating events. These include inhibition of thyroperoxidase, disruption of iodine uptake and organification, altered deiodinase activity, modulation of thyroid hormone receptor signaling, and immune-mediated effects on thyroid tissue. Such perturbations lead to abnormalities in hormone synthesis, metabolism, and systemic hormone homeostasis. Emerging structure-activity relationship (SAR) and computational modeling approaches provide further insight into how specific chemical features determine thyroid-disruptive potential, supporting the advancement of predictive toxicology and risk assessment. The novelty of this review lies in its integrated 3H perspective, linking physiological, molecular, immunological, and toxicological dimensions of thyroid disruption. This conceptual framework supports improved diagnosis of thyroid dysfunction, promotes safer chemical and drug design, and informs regulatory strategies aimed at protecting endocrine health.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1247-1265"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of therapeutic effects of royal jelly versus Nigella sativa oil on some brain areas affected by acute methanol poisoning in rats. 蜂王浆与黑油对急性甲醇中毒大鼠部分脑区治疗效果的比较。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-01 Epub Date: 2025-11-17 DOI: 10.1080/01480545.2025.2586135

Yasmien Morsy, Marwa Shahin, Eman Draz, Naglaa Sarhan, Ahmed Hashem

{"title":"Evaluation of therapeutic effects of royal jelly versus Nigella sativa oil on some brain areas affected by acute methanol poisoning in rats.","authors":"Yasmien Morsy, Marwa Shahin, Eman Draz, Naglaa Sarhan, Ahmed Hashem","doi":"10.1080/01480545.2025.2586135","DOIUrl":"10.1080/01480545.2025.2586135","url":null,"abstract":"Methanol (CH3OH) is one of the toxic alcohols that has high morbidity and mortality. It causes lipid peroxidation and oxidative stress. Antioxidants and neuroprotective agents could have therapeutic roles in case of methanol exposure. The aim of this research was to assess the therapeutic impact of royal jelly (RJ) versus Nigella sativa oil (NS) on brain areas affected by acute methanol poisoning in rats. This research was performed on 60 adult male albino rats that were randomly assigned to four groups: the negative control group (I), the positive control group (II), the methanol-intoxicated group (III), and the methanol and adjuvant treatment treated group (IV) which were categorized into two subgroups: the methanol and RJ treated group (IV a) and the methanol and NS treated group (IV b). After two weeks, the blood samples were obtained to determine the total antioxidant capacity (TAC). The frontal cortex, cerebellum, and hippocampus were excised and subjected to histopathological and transmission electron microscopic examination. Acute methanol poisoning induced oxidative stress, indicated by a significant reduction of TAC and marked degenerative changes in nerve cells and nerve fibers. Moreover, the administration of RJ and NS six hours after induction of acute methanol poisoning showed an increase in TAC compared to group III and a non-significant reduction compared to group II, with marked improvement and restoration of the normal brain architecture. Therefore, RJ and NS are effective in reducing the oxidative stress induced by acute methanol poisoning.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1170-1183"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145539612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The phytoestrogen equol protects mice against acetaminophen hepatotoxicity. 植物雌激素雌马酚对小鼠对乙酰氨基酚肝毒性有保护作用。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-01 Epub Date: 2026-03-09 DOI: 10.1080/01480545.2025.2575075

Yasuhiro Masubuchi, Kazuya Tachibana, Nana Niihori

{"title":"The phytoestrogen equol protects mice against acetaminophen hepatotoxicity.","authors":"Yasuhiro Masubuchi, Kazuya Tachibana, Nana Niihori","doi":"10.1080/01480545.2025.2575075","DOIUrl":"10.1080/01480545.2025.2575075","url":null,"abstract":"Female mice have been resistant to acetaminophen (APAP)-induced liver injury, demonstrating that endogenous estrogens provide hepatoprotection, and it is expected that exogenous estrogens may also provide a similar effect. In the present study, we investigated the protective effects of the phytoestrogens equol and genistein against APAP-induced liver injury. Male CD-1 mice were intraperitoneally injected with APAP. Equol or genistein was administered 16 h prior and co-administered with APAP. The blood and liver samples were subjected to evaluation of hepatotoxicity, liver GSH levels and hepatic expression of inflammatory mediators. Phytoestrogen treatment effectively prevented APAP hepatotoxicity. Neither affected the early depletion of hepatic glutathione (GSH) caused by APAP, indicating that they did not affect the generation of N-acetyl-p-benzoquinone imine from APAP. This result was supported by in vitro studies with microsomes, which presented that both phytoestrogens inhibited CYP2E1 and CYP1A2 activities; however, high concentrations of these compounds were required. In contrast, genistein and, to a lesser extent, equol promoted the recovery of GSH after the depletion. Hepatic interleukin-6 expression was increased by after APAP administration, and the increase was suppressed by equol and genistein treatment, potentially contributing to hepatoprotection. The phytoestrogens equol and genistein protect mice from APAP hepatotoxicity, possibly by suppressing liver inflammation through their estrogen-dependent mechanisms.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1032-1037"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid profile, toxicity, and antioxidant potential of flavonoid-rich babassu mesocarp extract after simulated human digestion. 模拟人体消化后富含类黄酮的巴巴苏中果皮提取物的脂质特征、毒性和抗氧化潜力。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-01 Epub Date: 2025-12-16 DOI: 10.1080/01480545.2025.2581706

N Debia, A M Nunes, M L L B do Nascimento, E R S Neta, M S R Rocha, S G Lima, J M C Sousa, P Falagan-Lotsch

{"title":"Lipid profile, toxicity, and antioxidant potential of flavonoid-rich babassu mesocarp extract after simulated human digestion.","authors":"N Debia, A M Nunes, M L L B do Nascimento, E R S Neta, M S R Rocha, S G Lima, J M C Sousa, P Falagan-Lotsch","doi":"10.1080/01480545.2025.2581706","DOIUrl":"10.1080/01480545.2025.2581706","url":null,"abstract":"The babassu (Attalea speciosa Mart. ex Spreng, syn. Orbignya phalerata Mart), native to Brazil, is valued for its medicinal properties. Babassu mesocarp flour has attracted interest for its high flavonoid content. Given the antioxidant effects of flavonoids-and the potential for pro-oxidant or hepatotoxic effects at high doses, and their interactions with other phytochemicals, this study assessed the toxicity and antioxidant activity of a well- characterized hydroethanolic babassu mesocarp extract following in vitro human gastrointestinal digestion to mimic physiological conditions. Additionally, this study offered a physicochemical characterization of the extract's lipid derivatives. Beyond flavonoids, the crude extract exhibited a complex lipid profile, mainly phytosterols. The digested extract (DBME) showed reduced particle size, and it was not cytotoxic to human liver (HepG2) cells. Strong antioxidant effects were observed in HepG2 under oxidative stress conditions, even at low doses. DBME lowered reactive oxygen species (ROS), restored mitochondrial function, and downregulated ROS-induced antioxidant gene expression, highlighting its protective role against oxidative damage and mitochondrial dysfunction. Our findings reinforce the therapeutic potential of babassu mesocarp extracts as antioxidant agents and support their future consideration as an ingredient in functional foods or dietary supplements, based on the potential synergistic action between flavonoids and phytosterols identified within the same food matrix.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1184-1196"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic hepatoprotection by supplementing Saussurea costus (falc.) lipsch and Glycyrrhiza glabra L. in combination against Diethylnitrosamine-induced liver damage in rats. 雪莲、甘草联合对二乙基亚硝胺所致大鼠肝损伤的协同保护作用。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-01 Epub Date: 2025-10-16 DOI: 10.1080/01480545.2025.2564431

Bisen Harsh, Rakesh Kumar, R K Asrani, Joshi Gaurav Santoshrao, Ekta Bisht, Shreya Katoch, Vinesh Sharma, Vikarm Patial, Adarsh Kumar

{"title":"Synergistic hepatoprotection by supplementing Saussurea costus (falc.) lipsch and Glycyrrhiza glabra L. in combination against Diethylnitrosamine-induced liver damage in rats.","authors":"Bisen Harsh, Rakesh Kumar, R K Asrani, Joshi Gaurav Santoshrao, Ekta Bisht, Shreya Katoch, Vinesh Sharma, Vikarm Patial, Adarsh Kumar","doi":"10.1080/01480545.2025.2564431","DOIUrl":"10.1080/01480545.2025.2564431","url":null,"abstract":"This study aims to evaluate the hepatoprotective effects of combined Saussurea costus and Glycyrrhiza glabra extracts against diethylnitrosamine (DEN)-induced hepatic damage in rats. In the present investigation, the in vivo experimental study involved forty-two male Albino Wistar rats allocated into seven groups of six rats in each. Group I served as the vehicle control (10% DMSO) and Group II was administered DEN at a concentration of 0.01% in drinking water. Group III received both DEN and silymarin at 25 mg/kg bw. Groups IV and V were treated with individual extracts of S. costus and G. glabra at 250 mg/kg bw, respectively. Groups VI and VII received combined lower (LDC) and higher doses (HDC) of both plant extracts i.e., 125 mg/kg bw and 250 mg/kg bw, respectively. The ultrasonographic evaluation revealed a significant increase in hepatic echotexture in the positive control group compared to ameliorative groups provided with various plant extract combinations depicting minimal changes comparable to the standard control i.e., rats provided with silymarin. Serum levels of ALT, AST, ALB, creatinine, and LPO indicating liver damage were diminished in the various treatment groups compared to group II receiving DEN only.Therefore, the current study concluded that the higher combined dosage of the root extracts of S. costus and G. glabra i.e., 250 mg/kg bw each, demonstrated the hepatoprotective effect against DEN-induced liver damage in the rat model.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1008-1020"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0