Drug and Chemical Toxicology最新文献_第6页

Association between dexmedetomidine use and acute kidney injury in critically ill patients treated with amikacin. 右美托咪定与阿米卡星治疗危重患者急性肾损伤的关系。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-21 DOI: 10.1080/01480545.2026.2734920

Murat Kucuk, Ali Necati Gokmen, Bişar Ergün, Yasin Levent Ugur, Cihan Heybeli

{"title":"Association between dexmedetomidine use and acute kidney injury in critically ill patients treated with amikacin.","authors":"Murat Kucuk, Ali Necati Gokmen, Bişar Ergün, Yasin Levent Ugur, Cihan Heybeli","doi":"10.1080/01480545.2026.2734920","DOIUrl":"https://doi.org/10.1080/01480545.2026.2734920","url":null,"abstract":"Amikacin is frequently used in intensive care units (ICUs) for gram-negative infections; however, nephrotoxicity remains a concern. Recent data showed lower odds of acute kidney injury (AKI) in patients who received dexmedetomidine, a selective α2-adrenergic receptor agonist widely used in ICUs for sedation and analgesia. Possible benefits of dexmedetomidine in critical patients who are treated with nephrotoxic therapies have not been studied. We aimed to test this hypothesis in a retrospective cohort study of adult ICU patients treated with amikacin between January 2018 and July 2020. Multivariable logistic regression analysis was performed to assess whether dexmedetomidine exposure was associated with AKI. A total of 149 patients were included. AKI occurred in 52 patients (34.9%), with a median onset of 5 days after amikacin initiation. AKI severity was stage 1 in 25.0%, stage 2 in 28.8%, and stage 3 in 46.2% of cases. Renal replacement therapy was required in 17 patients (11.6%). Dexmedetomidine was administered to 50 patients (33.6%) during amikacin therapy. In multivariable analysis, higher baseline serum creatinine and heart failure were independently associated with higher odds of AKI, whereas dexmedetomidine use was independently associated with lower odds of AKI. In a propensity score-matched analysis, AKI occurred less frequently in the dexmedetomidine group (17.4% vs. 37.0%, p = 0.035). Overall, ICU mortality was 67.8%, and AKI remained an independent predictor of mortality. Dexmedetomidine use was associated with lower odds of AKI in critically ill patients receiving amikacin. Prospective studies are warranted to confirm these findings.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1-9"},"PeriodicalIF":2.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-acetylcysteine modulates peripheral nerve excitability and conduction in a rat Model of chronic organophosphate exposure. n -乙酰半胱氨酸在大鼠慢性有机磷暴露模型中调节周围神经兴奋性和传导。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-21 DOI: 10.1080/01480545.2026.2734923

Seckin Tuncer, Tulay Tuncer Peker, Nizamettin Dalkılıc

{"title":"N-acetylcysteine modulates peripheral nerve excitability and conduction in a rat Model of chronic organophosphate exposure.","authors":"Seckin Tuncer, Tulay Tuncer Peker, Nizamettin Dalkılıc","doi":"10.1080/01480545.2026.2734923","DOIUrl":"https://doi.org/10.1080/01480545.2026.2734923","url":null,"abstract":"Chronic low-dose exposure to organophosphate pesticides has been associated with persistent peripheral neurotoxicity, yet the functional mechanisms underlying axonal dysfunction remain insufficiently defined. We investigated the effects of chronic diazinon exposure on peripheral nerve excitability and conduction properties in rats and evaluated the potential protective role of N-acetylcysteine (NAC). Adult male Wistar rats were allocated to four groups (n = 9 each): control (CON), diazinon (COP), combined treatment (COP+NAC), and NAC alone (NAC) for four weeks. Axonal excitability of the caudal nerve was assessed in vivo using threshold tracking, and sciatic nerve compound action potentials were recorded ex vivo with estimation of conduction velocity distributions. Diazinon exposure reduced rheobase and refractoriness, shortened the relative refractory period, increased superexcitability, and decreased the resting I/V slope, consistent with membrane depolarization and altered sodium channel function. Compound action potential amplitude and area were significantly reduced, accompanied by a shift toward slower-conducting fibers, indicating preferential impairment of fast axons. Concurrent NAC treatment partially normalized excitability parameters and attenuated conduction velocity shifts, while NAC alone produced mild hyperpolarizing changes. These findings indicate that chronic diazinon exposure disrupts axonal membrane properties and selectively affects fast-conducting fibers, and that NAC may mitigate these functional alterations.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1-12"},"PeriodicalIF":2.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytotoxic and cytogenotoxic assessment of hydroquinone using plant and animal bioassays. 对苯二酚的植物毒性和细胞遗传毒性评价，采用植物和动物生物测定法。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-16 DOI: 10.1080/01480545.2026.2731181

Andressa Bernardi, Letícia Simon Susin, Paola Reis Freimuth, Vitória Zucco Rizzon, Bárbara de Oliveira Folatre, Juliana Schmitt de Nonohay, Edna Sayuri Suyenaga, Luciano Basso da Silva

{"title":"Phytotoxic and cytogenotoxic assessment of hydroquinone using plant and animal bioassays.","authors":"Andressa Bernardi, Letícia Simon Susin, Paola Reis Freimuth, Vitória Zucco Rizzon, Bárbara de Oliveira Folatre, Juliana Schmitt de Nonohay, Edna Sayuri Suyenaga, Luciano Basso da Silva","doi":"10.1080/01480545.2026.2731181","DOIUrl":"https://doi.org/10.1080/01480545.2026.2731181","url":null,"abstract":"Hydroquinone (HQ) is a phenolic compound widely used in industrial processes and recognized as a priority pollutant. However, information on its ecotoxicological effects on plants and aquatic organisms remains limited. This study evaluated the toxicity of HQ using bioassays with the plant species Allium cepa and Lactuca sativa and the freshwater mussel Limnoperna fortunei. In A. cepa, nine HQ concentrations ranging from 0.125 mg/L to 200 mg/L were tested, and cytogenotoxicity was assessed through the mitotic index (MI), micronucleus (MN) frequency, and chromosomal abnormalities. In L. sativa, phytotoxicity was evaluated by seed germination and root growth at concentrations from 5 mg/L to 200 mg/L. Mussels were exposed to HQ concentrations from 0.0625 mg/L to 0.5 mg/L, and nuclear abnormalities in hemocytes were analyzed. HQ significantly reduced the MI and induced genotoxic effects in A. cepa, and inhibited seed germination and root growth in L. sativa. No significant increase in hemocyte nuclear abnormalities was observed in L. fortunei. These findings indicate that environmentally relevant HQ concentrations did not induce genotoxic effects in mussels, whereas higher concentrations ≥25 mg/L caused phytotoxic and cytogenotoxic effects in plants. This study provides novel in vivo data that address current gaps in the understanding of HQ ecotoxicity.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1-7"},"PeriodicalIF":2.2,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the toxicokinetics and in vivo distribution of benzylpiperazine (BZP) and 1-(3-(trifluoromethyl)phenyl)piperazine (TFMPP) after single and combined administration in Wistar rats. 苯基哌嗪（BZP）和1-（3-（三氟甲基）苯基）哌嗪（TFMPP）在Wistar大鼠体内单独和联合给药的毒性动力学和体内分布研究。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-14 DOI: 10.1080/01480545.2026.2729765

Shuo Yang, Jinting Liu, Liying Zhou, Wanting Xie, Yan Shi

{"title":"Study on the toxicokinetics and in vivo distribution of benzylpiperazine (BZP) and 1-(3-(trifluoromethyl)phenyl)piperazine (TFMPP) after single and combined administration in Wistar rats.","authors":"Shuo Yang, Jinting Liu, Liying Zhou, Wanting Xie, Yan Shi","doi":"10.1080/01480545.2026.2729765","DOIUrl":"https://doi.org/10.1080/01480545.2026.2729765","url":null,"abstract":"Benzylpiperazine (BZP) and 1-(3-(trifluoromethyl)phenyl)piperazine (TFMPP) are early‑appearing piperazine‑type new psychoactive substances (NPSs) frequently detected in ecstasy. Their combined use produces cardiovascular stimulation (hypertension and tachycardia) comparable to dextroamphetamine, yet data on their toxicokinetics and tissue distribution are scarce. We investigated the pharmacokinetics and tissue distribution of BZP and TFMPP after intraperitoneal injection (2 mg kg-1) in Wistar rats, both singly and in combination. Compared with single‑drug administration, combined dosing significantly altered t1/2 of BZP, mean residence time (MRT), and apparent volume of distribution (Vz/F), and reduced area under the curve (AUC) of TFMPP (p < 0.05). Apart from peak concentration (Cmax), the two compounds have similar toxicokinetic characteristics in some aspects. BZP and TFMPP were rapidly absorbed (Tmax 0.15-0.70 h). Elimination half‑lives were 0.36 h for BZP and 2.56 h for TFMPP. After a single dose, Cmax (173 ng/mL) of BZP was significantly lower than Cmax (284 ng/mL) of TFMPP. Twenty-four hours after administration, the tissue concentrations of BZP, whether given alone or in combination, ranked as follows: liver > kidney > lung > spleen > brain > heart. For TFMPP, the distribution pattern under combined administration was the same as that of BZP; however, when administered alone, its concentration in the brain was higher than that in the spleen. These findings indicate that co‑exposure to BZP and TFMPP can modify toxicokinetic behavior and tissue distribution, suggesting distinct poisoning dynamics from exposure to either compound alone.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1-8"},"PeriodicalIF":2.2,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148967134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of a cytotoxicity threshold for α-Fe₂O₃ nanoparticles based on an in vitro-in vivo dosimetry model in alveolar epithelial cells. α-Fe2O3纳米颗粒在肺泡上皮细胞中的细胞毒性阈值的测定基于体内外剂量模型。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-07 DOI: 10.1080/01480545.2026.2727999

Athena Rafieepour, Maryam Soleimani Alyar, Masoomeh Vahabi Shekarloo, Saber Moradi Hanifi, Mojtaba Yeganeh, Iraj Alimohammadi

{"title":"Determination of a cytotoxicity threshold for α-Fe2O3 nanoparticles based on an in vitro-in vivo dosimetry model in alveolar epithelial cells.","authors":"Athena Rafieepour, Maryam Soleimani Alyar, Masoomeh Vahabi Shekarloo, Saber Moradi Hanifi, Mojtaba Yeganeh, Iraj Alimohammadi","doi":"10.1080/01480545.2026.2727999","DOIUrl":"https://doi.org/10.1080/01480545.2026.2727999","url":null,"abstract":"This study aimed to extrapolate a cytotoxicity threshold in air using a combined in vitro-in vivo dosimetry model to assess the toxicity of α-Fe2O3 nanoparticles (NPs), innovatively applying this approach to NPs risk assessment. Cultured A549 cells treated with α-Fe2O3 NPs in various concentrations over 24-h and 72-h. Cell survival and mitochondrial membrane permeability were assessed using the MTT and MMP assay, respectively. The dose-response results served for estimating the Benchmark Dose (BMD) and BMDL using the EPA BMD software. BMDLs were extrapolated into equivalent air concentrations using the Combined Dosimetry model (CoDo). A significant loss in cell survival and a rise of mitochondrial membrane permeability, compared to the control group (P-value < 0.05), were observed after 24-h and 72-h, respectively. A time- and concentration-dependent pattern was observed in the toxicity of the A549 cell line. Extrapolated from a BMDL of 1.9 μg/mL, a 0.22 mg/m³ air concentration was found to correspond to the in vitro dose. The predicted cytotoxicity threshold falls below the current occupational exposure limits (OELs) for micro-scale particles. Although further in vivo and epidemiological studies are required to validate its relevance for occupational exposure settings, this modeling approach offers a valuable framework for preliminary risk assessment.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1-9"},"PeriodicalIF":2.2,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-nitrosodimethylamine increased glucose production by promoting hyperglycemia in hepatocyte via AMPK signaling pathway in vivo and in vitro. 在体内和体外实验中，n -亚硝基二甲胺通过AMPK信号通路促进肝细胞高血糖，从而增加葡萄糖的产生。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-01 Epub Date: 2026-01-03 DOI: 10.1080/01480545.2025.2609950

Wenxin Wang, Shuhua Xi, Yue Wang

{"title":"N-nitrosodimethylamine increased glucose production by promoting hyperglycemia in hepatocyte via AMPK signaling pathway in vivo and in vitro.","authors":"Wenxin Wang, Shuhua Xi, Yue Wang","doi":"10.1080/01480545.2025.2609950","DOIUrl":"10.1080/01480545.2025.2609950","url":null,"abstract":"N-nitrosodimethylamine (NDMA), as a disinfection by-product of drinking water, has been detected in various water. Epidemiological investigations have found that exposure to NDMA can exacerbate the development of diseases related to insulin resistance. In this study, male C57BL/6 mice were exposed to 0.5 and 12.5 mg/L NDMA by drinking water for 12 weeks. The mice in 12.5 mg/L NDMA group appeared fasting blood glucose elevation, and glucose tolerance and insulin sensitivity decreased. NDMA exposure enhanced hepatic gluconeogenesis and suppressed glycolysis of mice, but not affecting glycogen synthesis. In addition, NDMA exposure inhibited the phosphorylation of AMPK and FoxO1 as well as GLUT2 protein expression, and increased PGC-1α protein levels. GLUT2 protein decreasing could reduce glucose uptake of hepatocyte and enhance blood glucose concentration. Dephosphorylated FoxO1 might translocate to the nucleus, binding promoters of gluconeogenesis key enzymes PEPCK and G6Pase to upregulate their expression and promote gluconeogenesis. PGC-1α could also stimulate the expression of PEPCK and G6Pase. Furthermore, human normal liver cells (MIHA) were treated with NDMA for 24 hours. AMPK as a central energy sensor, regulates hepatic glucose production, uptake, and the process of glycolmetabolism. Therefore, AMPK agonist AICAR was used to explore the mechanism of NDMA causing hyperglycemia. AICAR reversed p-FoxO1, PGC-1α, GLUT2, PEPCK and G6Pase proteins expression and improved the glycolysis and glucose uptake capacity in NDMA treated MIHA cells. In conclusion, NDMA in drinking water led to fasting blood glucose enhancing, impairment of glucose tolerance and insulin sensitivity, increasing hepatic gluconeogenesis via AMPK signaling.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1049-1060"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardioprotective effect of apigenin and carvedilol against isoproterenol-induced myocardial infarction in rats. 芹菜素和卡维地洛对异丙肾上腺素所致大鼠心肌梗死的保护作用。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-01 Epub Date: 2025-10-16 DOI: 10.1080/01480545.2025.2565350

Rehnuma Siddiquee, Tarique Mahmood, Vaseem Ahamad Ansari, Farogh Ahsan, Shahzadi Bano, Sana Ahmad, Mohd Masih Uzzaman Khan

{"title":"Cardioprotective effect of apigenin and carvedilol against isoproterenol-induced myocardial infarction in rats.","authors":"Rehnuma Siddiquee, Tarique Mahmood, Vaseem Ahamad Ansari, Farogh Ahsan, Shahzadi Bano, Sana Ahmad, Mohd Masih Uzzaman Khan","doi":"10.1080/01480545.2025.2565350","DOIUrl":"10.1080/01480545.2025.2565350","url":null,"abstract":"Myocardial infarction remains one of the leading causes of mortality and morbidity globally. While apigenin (AP), a trihydroxyflavone, and carvedilol, a beta blocker, have both been utilized in the treatment of cardiovascular diseases. There is a notable lack of comprehensive research or limited data regarding their combined cardioprotective activity. This gap emphasizes the need for further investigation into the potential synergistic effects of AP and carvedilol in the context of myocardial infarction. This study aims to evaluate the cardioprotective effect of AP and carvedilol in isoproterenol-induced myocardial infarction in rats. Male Sprague-Dawley rats were used and divided into five groups (n = 6). Isoproterenol (85 mg/kg/s.c.) was administered to induce myocardial infarction. AP (50 mg/kg/day/p.o) and carvedilol (5 mg/kg/day/p.o) were administered to rats for 14 days, along with Isoproterenol on the 15th and 16th days. Various parameters were estimated, including biochemical markers, cardiac markers, oxidative stress markers, antioxidants, and lipid profiles, to observe the effects of flavonoids and drugs. Administration of Isoproterenol showed changes in physical parameters, significantly elevated levels of serum biochemical markers, cardiac markers, oxidative stress markers, lipid profile, and decreased antioxidant enzymes. Treatment with AP and carvedilol diminished these changes very significantly. Histopathological examination of heart tissue in isoproterenol-induced rats showed necrotic lesions, which were reduced by the treatment with test drugs alone and in combination. Our study demonstrated that AP alone and in combination with carvedilol showed cardioprotective activity over isoproterenol-induced myocardial infarction in rats. Further investigations are needed to explore the underlying mechanism.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1087-1103"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute and subacute toxicity evaluation of a polyherbal blend in rats. 复方中草药对大鼠急性和亚急性毒性评价。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-01 Epub Date: 2026-01-11 DOI: 10.1080/01480545.2026.2612974

Prajakta H Murudkar, Akshay M Baheti, Anil T Pawar

{"title":"Acute and subacute toxicity evaluation of a polyherbal blend in rats.","authors":"Prajakta H Murudkar, Akshay M Baheti, Anil T Pawar","doi":"10.1080/01480545.2026.2612974","DOIUrl":"10.1080/01480545.2026.2612974","url":null,"abstract":"Many people often assume the safety of herbs and use them in the form of polyherbal blends to treat various health conditions. The present study aimed to evaluate the acute and subacute oral toxicity profile of a polyherbal blend in Wistar rats. The polyherbal blend was prepared to contain Terminalia chebula Retz., Terminalia bellirica (Gaertn.) Roxb., Phyllanthus emblica L., Curcuma longa L., Tribulus terrestris L., Pterocarpus marsupium Roxb., Tinospora cordifolia (Willd.) Miers, and Cinnamomum verum J. Presl. An acute oral toxicity study of a prepared polyherbal blend was conducted as per OECD guideline 423 and the subacute toxicity study was performed as per OECD 407 guidelines. There was no mortality and signs of toxicity at 2000 mg/kg single oral administration of polyherbal blend, indicating that the oral median lethal dose (LD50) is greater than 2000 mg/kg. The results of the subacute toxicity study indicated no significant changes in body weight, food and water consumption, hematological and biochemical parameters in rats treated with polyherbal blend at 250, 500 and 1000 mg/kg for 28 days when compared to their respective controls. Organ weights and histopathology showed no significant alterations in treated or satellite groups as compared to controls. It is concluded that the polyherbal blend is safe at a single dose of 2000 mg/kg and 28 days repeated dose of 1000 mg/kg by oral route in rats.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1236-1246"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salicylic acid attenuates paclitaxel-induced toxicity by modulating interleukin expression: an in vivo study. 水杨酸通过调节白细胞介素表达减轻紫杉醇诱导的毒性：一项体内研究。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-01 Epub Date: 2026-06-08 DOI: 10.1080/01480545.2025.2593476

Farah Al-Najar, Shahrzad Shahbazi, Somayeh Reiisi, Behnaz Saffar, Elham Moghtadaei Khorasgani

{"title":"Salicylic acid attenuates paclitaxel-induced toxicity by modulating interleukin expression: an in vivo study.","authors":"Farah Al-Najar, Shahrzad Shahbazi, Somayeh Reiisi, Behnaz Saffar, Elham Moghtadaei Khorasgani","doi":"10.1080/01480545.2025.2593476","DOIUrl":"10.1080/01480545.2025.2593476","url":null,"abstract":"Paclitaxel (PAX) is an effective chemotherapeutic agent for treating various cancers but is associated with side effects such as hepatotoxicity, neurotoxicity, and myelosuppression. To mitigate these toxicities, adjunct therapies like salicylic acid (SA), a plant-derived compound with anti-inflammatory, antioxidant, and cytoprotective properties, have been explored. This study investigates SA's potential to counteract PAX's cytotoxic effects, focusing on hepatic tissue. Thirty-five BALB/cJ mice were treated with PAX and SA, either individually or in combination (low and high doses), for 14 days. Post-treatment, biochemical and histological analyses were performed. ELISA assays measured serum levels of inflammatory markers IL-1β, IL-6, and TNF-α, while caspase-3/7 activity was evaluated to assess apoptosis. qPCR assessed gene expression related to apoptosis (CASP1, CASP3, Bcl-2). Results showed that PAX significantly increased serum levels of inflammatory markers, which were reduced by SA treatment. PAX also elevated caspase-3/7 activity, but co-treatment with SA suppressed this effect. Histological analysis revealed that low-dose SA alleviated PAX-induced necrosis and inflammation in the liver, kidney, and spleen. Moreover, PAX alone significantly upregulated CASP1 and CASP3 expression, while co-treatment with SA significantly downregulated these genes. These findings highlight the protective role of SA in reducing PAX-induced toxicity, particularly in hepatic tissues, suggesting that SA could be a potential adjunct therapy for minimizing chemotherapy-related side effects.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1213-1224"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linagliptin attenuates cisplatin-induced cardiotoxicity in rats via modulation of the SIRT1/AMPK/Nrf2 signaling pathway. 利格列汀通过调节SIRT1/AMPK/Nrf2信号通路减轻顺铂诱导的大鼠心脏毒性。

IF 2.2 4区医学

Drug and Chemical Toxicology Pub Date : 2026-09-01 Epub Date: 2026-08-11 DOI: 10.1080/01480545.2026.2711683

Mahdi H Alsugoor, Naif Al Suhaymi, Bassim M S A Mohamed, Mevidette Elmadani, Alyaa Farouk Hessin, Aya A Shokry, Sherif M Afifi, Reda Ms Korany, Gihan F Asaad, Hany M Fayed

{"title":"Linagliptin attenuates cisplatin-induced cardiotoxicity in rats via modulation of the SIRT1/AMPK/Nrf2 signaling pathway.","authors":"Mahdi H Alsugoor, Naif Al Suhaymi, Bassim M S A Mohamed, Mevidette Elmadani, Alyaa Farouk Hessin, Aya A Shokry, Sherif M Afifi, Reda Ms Korany, Gihan F Asaad, Hany M Fayed","doi":"10.1080/01480545.2026.2711683","DOIUrl":"10.1080/01480545.2026.2711683","url":null,"abstract":"Cisplatin (CP), an effective chemotherapeutic agent, is known to cause cardiotoxicity, limiting its clinical application. This study aimed to investigate the potential cardioprotective effects of linagliptin (LG) against cisplatin-induced cardiac injury and to elucidate its underlying mechanisms. There were four groups of male Wistar rats: control, cisplatin (CP, 8 mg/kg, IP), and two groups with LG treatment (5 mg/kg and 10 mg/kg, orally) and CP. CP significantly increased cardiac injury markers (CK, CK-MB, TNNC1) and oxidative stress (decreased SOD and GSH, increased MDA) compared to controls (p < 0.05). It also elevated inflammatory cytokines (TNF-α, IL-6) and disrupted mitochondrial function (altered ATP level and NADP/NADPH ratios). Furthermore, CP decreased the expression of SIRT1 and Nrf2 and the level of p-AMPK. LG treatment dose-dependently attenuated these changes, with the 10 mg/kg dose showing greater efficacy. Histopathological examination and immunohistochemistry confirmed these biochemical findings, showing improved cardiac structure and increased expression of SIRT1 and Nrf2 with LG treatment. Linagliptin demonstrates potent cardioprotective effects against cisplatin-induced toxicity, primarily through modulation of the SIRT1/AMPK/Nrf2 signaling pathway, thereby resulting in reduced oxidative stress and inflammation. These findings suggest that linagliptin may serve as a potential adjuvant therapy to mitigate cisplatin-induced cardiotoxicity.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1125-1139"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0