Drug and Chemical Toxicology最新文献_第8页

Aflatoxin B₁ and fumonisin B₁ exposure and adverse birth outcomes in HIV-infected and HIV-uninfected women from Harare, Zimbabwe. 津巴布韦哈拉雷感染艾滋病毒和未感染艾滋病毒妇女的黄曲霉毒素B1和伏马菌素B1暴露和不良分娩结局

IF 2.1 4区医学

Drug and Chemical Toxicology Pub Date : 2025-07-01 Epub Date: 2025-01-04 DOI: 10.1080/01480545.2024.2448675

Tatenda Clive Murashiki, Privilege Tendai Munjoma, Rutendo B L Zinyama-Gutsire, Isaac Mutingwende, Lovemore Ronald Mazengera, Kerina Duri

{"title":"Aflatoxin B1 and fumonisin B1 exposure and adverse birth outcomes in HIV-infected and HIV-uninfected women from Harare, Zimbabwe.","authors":"Tatenda Clive Murashiki, Privilege Tendai Munjoma, Rutendo B L Zinyama-Gutsire, Isaac Mutingwende, Lovemore Ronald Mazengera, Kerina Duri","doi":"10.1080/01480545.2024.2448675","DOIUrl":"10.1080/01480545.2024.2448675","url":null,"abstract":"Aflatoxin B1 (AFB1) and fumonisin B1 (FB1) are toxic secondary products of fungi that frequently contaminate staple crops in resource-limited settings. Antenatal AFB1 and FB1 exposure may cause adverse birth outcomes. We conducted a retrospective substudy nested in a case-control cohort of HIV-infected and HIV-uninfected women ≥20 weeks gestation from Harare, Zimbabwe. Urinary aflatoxin M1 (AFM1) and FB1, biomarkers of AFB1 and FB1 exposure, respectively, were quantified in random antenatal urine via ELISA and grouped into tertiles. The adverse birth outcomes considered were low birth weight, preterm birth (PTB), small for gestational age, stillbirth, birth defects, neonatal death, neonatal jaundice and perinatal death (PD). We evaluated any associations between adverse birth outcomes and exposure to AFB1, FB1, or the AFB1-FB1 combination via a multivariable logistic regression controlled for potential confounders. We enrolled 94 HIV-infected and 81 HIV-uninfected women. In HIV-infected, AFM1 was detected in 46/94 (49%), and FB1 was detected in 86/94 (91%). In HIV-uninfected, AFM1 was detected in 48/81 (59%), and FB1 was detected in 74/81 (91%). Among all women, AFM1 tertile 3 was associated with PD (OR: 6.95; 95% CI: 1.21-39.78). In the same population, AFM1 tertiles 2 (OR: 13.46; 95% CI: 1.20-150.11) and 3 (OR: 7.92; 95% CI: 1.08-58.19) were associated with PTB. In HIV-infected, AFM1 tertile 2 was associated with PTB (OR: 64.73; 95% CI: 2.37-177.93). Our results revealed an association between AFB1 exposure and PD and PTB in women, including those infected with HIV. Public health and nutrition measures are necessary to mitigate mycotoxins.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"842-855"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Damage to the sarcoplasmic reticulum by venom of the Mexican black-tailed rattlesnake (Crotalus molossus nigrescens): inhibition of the Ca²⁺-ATPase and membrane lipid disruption. 墨西哥黑尾响尾蛇（Crotalus molossus nigrescens）毒液对肌浆网的损伤：抑制Ca2+- atp酶和膜脂破坏。

IF 2.1 4区医学

Drug and Chemical Toxicology Pub Date : 2025-07-01 Epub Date: 2025-02-10 DOI: 10.1080/01480545.2025.2463369

Luis Fernando Plenge-Tellechea, David Meléndez-Martínez, César Emmanuel Rivas-Valles, Ana Gatica-Colima, Martha Sandra Cruz-Pérez, Jorge A Sierra-Fonseca

{"title":"Damage to the sarcoplasmic reticulum by venom of the Mexican black-tailed rattlesnake (Crotalus molossus nigrescens): inhibition of the Ca2+-ATPase and membrane lipid disruption.","authors":"Luis Fernando Plenge-Tellechea, David Meléndez-Martínez, César Emmanuel Rivas-Valles, Ana Gatica-Colima, Martha Sandra Cruz-Pérez, Jorge A Sierra-Fonseca","doi":"10.1080/01480545.2025.2463369","DOIUrl":"10.1080/01480545.2025.2463369","url":null,"abstract":"Snakebite envenomation is a public health problem in many areas in the world and is a significant cause of disability and death. Crotalid venoms consist of a cocktail of peptides and enzymes that can cause myonecrotoxic lesions, which are associated with irreversible loss of muscle tissue. The sarcoplasmic reticulum Ca2+-ATPase (SERCA) is a transmembrane protein with a critical role in maintaining cellular Ca2+ homeostasis, which is central in facilitating skeletal and cardiac muscle contraction/relaxation. Crotalid venom-induced myotoxicity has been linked to alterations in the intracellular levels of Ca2+. However, the specific mechanisms, including SERCA's involvement, are poorly understood. Thus, we investigated the in vitro toxic effect of crotalid venom on the enzymatic activity of SERCA, using venom of the Mexican black-tailed rattlesnake, Crotalus molossus nigrescens, (vCmn), and SERCA-enriched sarcoplasmic reticulum (SR) microsomes from rabbit skeletal muscle as experimental models. Enzymatic assays revealed significant vCmn-induced decreases in SERCA activity in a time- and dose-dependent manner. Thin layer chromatography and phospholipid hydrolysis measurements showed significant SR membrane damage. The results suggest that vCmn affects SERCA functionality and compromises the integrity of the SR membrane, both of which are critical for skeletal muscle function and could thus be key mediators of vCmn-induced myotoxicity.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"797-805"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 2.1 4区医学

Drug and Chemical Toxicology Pub Date : 2025-07-01 Epub Date: 2025-03-03 DOI: 10.1080/01480545.2025.2473759

引用次数: 0

Kidney damage following a 90-day subchronic inhalation exposure to HTP aerosol in SD rats. SD大鼠亚慢性吸入暴露于HTP气溶胶90天后的肾脏损伤。

IF 2.1 4区医学

Drug and Chemical Toxicology Pub Date : 2025-06-24 DOI: 10.1080/01480545.2025.2513693

Yushan Tian, Hongjuan Wang, Yaning Fu, Wenming Wang, Shuhao Ma, Xiaoxiao Xu, Xianmei Li, Fengjun Lu, Pengxia Feng, Shulei Han, Huan Chen, Hongwei Hou, Qingyuan Hu

{"title":"Kidney damage following a 90-day subchronic inhalation exposure to HTP aerosol in SD rats.","authors":"Yushan Tian, Hongjuan Wang, Yaning Fu, Wenming Wang, Shuhao Ma, Xiaoxiao Xu, Xianmei Li, Fengjun Lu, Pengxia Feng, Shulei Han, Huan Chen, Hongwei Hou, Qingyuan Hu","doi":"10.1080/01480545.2025.2513693","DOIUrl":"https://doi.org/10.1080/01480545.2025.2513693","url":null,"abstract":"Cigarette smoking (CS) was reported to induce the risk of renal diseases. However, heated tobacco product (HTP), a modified risk tobacco product, was claimed to reduce exposure risk, its health risk of kidney was still unclear. In this study, subchronic inhalation toxicity of HTP aerosols for 90 days was performed to assess its health risk of kidney. The nose-only exposure experiments were performed with SD rats. All the rats were randomly divided into sham, HTP (HTP_10, HTP_23, and HTP_50), and CS (Cig_23) groups. After exposure, the blood and kidney were prepared to detect its redox state, biomarkers in the early injury, apoptosis, and histopathology. The results showed that HTP and cigarette smoke both induced the expression of biomarkers including kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, interleukin 18, and oxidative stress. For biochemical markers associated with kidney function, CS induced increased creatinine and urea for female rats and uric acid decreased, while HTP exposure only induced the upregulation of creatinine. Moreover, no obvious apoptosis and pathology of kidney were observed after HTP exposure, which indicated that HTP exposure may induce some biomarkers in the early stage of kidney injury without more serious changes. Overall, these results suggested that HTP with high concentration exposure showed potential slight health risks of kidney.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1-10"},"PeriodicalIF":2.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral acute and subacute toxicity studies as well as safety pharmacology in beagle dogs of total lignans from Arctii Fructus. 牛蒡子总木脂素对小猎犬的急性和亚急性口服毒性及安全药理学研究。

IF 2.1 4区医学

Drug and Chemical Toxicology Pub Date : 2025-06-23 DOI: 10.1080/01480545.2025.2519186

Jieyi Zhang, Xiaobo Li, Wanting Wu, Zhiyong Xu, Haiyang Zhao, Jingyun Zhang, Qin Xu, Zhaohui Xu

{"title":"Oral acute and subacute toxicity studies as well as safety pharmacology in beagle dogs of total lignans from Arctii Fructus.","authors":"Jieyi Zhang, Xiaobo Li, Wanting Wu, Zhiyong Xu, Haiyang Zhao, Jingyun Zhang, Qin Xu, Zhaohui Xu","doi":"10.1080/01480545.2025.2519186","DOIUrl":"https://doi.org/10.1080/01480545.2025.2519186","url":null,"abstract":"Arctii Fructus is a frequently used Chinese materia medica and the dried ripe fruit of Arctium lappa L. (family Asteraceae). Previous studies discovered that the total lignans from Arctii Fructus (TLAF) could inhibit streptozotocin-induced diabetic retinopathy in addition to having hypoglycemic action on a variety of diabetic animal models. The oral toxicity of TLAF in rats has been reported, but there are no reports on its oral toxicity in beagle dogs. This study evaluated the acute and subacute toxicity of TLAF, as well as its effects on the respiratory and cardiovascular systems in beagle dogs at the first time. The approximate lethal dose of TLAF administered orally to beagle dogs was greater than 5000 mg/kg in the acute oral toxicity testing, and the respiratory and cardiovascular systems of conscious beagle dogs were not significantly affected by the oral administration of TLAF. However, repeated oral administration of TLAF (540 mg/kg) to beagle dogs for 28 days can cause 50% of administered animals to die. The toxic reactions are mainly seen in the digestive system, heart, liver, and kidneys. These results reduce the feasibility of developing TLAF as a clinical drug to treat diabetes and its complications.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1-15"},"PeriodicalIF":2.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rumex hastatus leaves extract alleviates Triclosan-induced reproductive toxicity and improves fertility by modulating oxidative stress. 山楂叶提取物通过调节氧化应激，减轻三氯生诱导的生殖毒性，提高生育能力。

IF 2.1 4区医学

Drug and Chemical Toxicology Pub Date : 2025-06-23 DOI: 10.1080/01480545.2025.2520333

Qurat Ul Ain, Asma Waheed Qureshi, Mehwish David, Moazama Batool

{"title":"Rumex hastatus leaves extract alleviates Triclosan-induced reproductive toxicity and improves fertility by modulating oxidative stress.","authors":"Qurat Ul Ain, Asma Waheed Qureshi, Mehwish David, Moazama Batool","doi":"10.1080/01480545.2025.2520333","DOIUrl":"https://doi.org/10.1080/01480545.2025.2520333","url":null,"abstract":"The current study was designed to determine potential therapeutic role of R. hastatus leaf extract against Triclosan (TCS)-induced testicular toxicity. The methanolic extract of R. hastatus was evaluated for its antioxidant potential, while GC-MS analysis was carried out to identify bioactive components in the extract. For the toxicity study, forty adult male rats were divided into four groups. One group was set as control group whereas, other three groups were given TCS (50 mg/kg), R. hastatus extract (RE, 150 mg/kg) and TCS+RE (50 mg/kg + 150mg/kg) orally for 30 consecutive days. Results showed that TCS exposure caused significant alteration in sperm parameters, and reduced antioxidant enzyme activity while increasing the concentration of oxidative stress markers. Moreover, DNA integrity was compromised along with testicular histopathological damage and lowered levels of reproductive hormones. Fertility test revealed reduced pregnancy outcomes and small litter sizes in females paired with TCS-treated males. RE treatment effectively normalized the attributes of sperm parameters and enzymatic activities of antioxidants. Additionally, co-treatment of RE restored the hormonal levels thus normalizing testicular architecture. Increased pregnancy outcomes and litter size in RE-treated animals were also recorded. So, it is concluded that R. hastatus plant extract has the potential to attenuate TCS-induced reproductive toxicity using antioxidant potential.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1-14"},"PeriodicalIF":2.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of methiopropamine on cognitive function and monoaminergic systems in mice. 甲氧丙胺对小鼠认知功能和单胺能系统的影响。

IF 2.1 4区医学

Drug and Chemical Toxicology Pub Date : 2025-06-17 DOI: 10.1080/01480545.2025.2515128

Mohd Khairulanwar Bunaim, Nor Syafinaz Yaakob, Hanafi Ahmad Damanhuri, Hui-Yin Yow, Fadhlullah Zuhair Japar Sidik, Norizal Mohd Noor, Norazrina Azmi

{"title":"Effects of methiopropamine on cognitive function and monoaminergic systems in mice.","authors":"Mohd Khairulanwar Bunaim, Nor Syafinaz Yaakob, Hanafi Ahmad Damanhuri, Hui-Yin Yow, Fadhlullah Zuhair Japar Sidik, Norizal Mohd Noor, Norazrina Azmi","doi":"10.1080/01480545.2025.2515128","DOIUrl":"https://doi.org/10.1080/01480545.2025.2515128","url":null,"abstract":"Methiopropamine (MPA), a novel psychoactive substance (NPS) similar to methamphetamine (METH), warrants investigation into its neurotoxic effects on cognitive function and behaviors due to limited existing research. Therefore, this study aimed to explore the effects of MPA on several behavioral parameters in mice, brain levels of monoamine neurotransmitters, and p-ERK1/2 expression. Mice were randomly divided into four groups (n = 10) which received daily intraperitoneal injections of either saline, 1 or 3 mg/kg of MPA, or 1 mg/kg of METH for 7 days. The novel object recognition test (NORT) revealed a significant decline in recognition memory, particularly evident at a dose of 3 mg/kg of MPA, similar to METH at 1 mg/kg, observed 24 h post-withdrawal. MPA at 3 mg/kg also impaired working and reference memory performance in the 8-arm radial maze (8-ARM) test and exhibited an anxiolytic effect in the open field test (OFT). These cognitive impairments were accompanied by decreased dopaminergic parameters and p-ERK1/2 expression within the prefrontal cortex (PFC). This further suggests that MPA neurotoxicity is targeted at the dopaminergic transmission in the PFC. In conclusion, MPA consumption is associated with memory impairment, which is attributable to dopaminergic deficits and reduced p-ERK1/2 activities in the PFC.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1-11"},"PeriodicalIF":2.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo DMBA induced mouse skin epithelial hypertrophy and associated molecular changes during various intervals within 24-hour of exposure and their prevention by natural agents. 体内DMBA在暴露24小时内不同时间间隔诱导小鼠皮肤上皮细胞肥大及相关分子变化，并通过天然药物进行预防。

IF 2.1 4区医学

Drug and Chemical Toxicology Pub Date : 2025-06-02 DOI: 10.1080/01480545.2025.2513694

Chhaya Pandey, Prakash Tiwari

{"title":"In vivo DMBA induced mouse skin epithelial hypertrophy and associated molecular changes during various intervals within 24-hour of exposure and their prevention by natural agents.","authors":"Chhaya Pandey, Prakash Tiwari","doi":"10.1080/01480545.2025.2513694","DOIUrl":"https://doi.org/10.1080/01480545.2025.2513694","url":null,"abstract":"This in vivo study was conducted to determine the effects of a single exposure to 7,12-dimethylbenzo[a]anthracene (DMBA) on mouse skin at several end points throughout a 24-hour exposure period. The protective effects of calcium glucarate (CAG), butyric acid (BA), and nicotinamide (NA) were also assessed in terms of DNA synthesis, hypertrophy, and cell proliferation markers, including the expression of the inflammation-related gene cyclooxygenase-2 (Cox-2), proliferating cell nuclear antigen (PCNA), cellular myelocytomatosis oncogene (c-Myc), and ornithine decarboxylase (ODC). Briefly, mouse skin was topically treated with DMBA. Additionally, the DMBA-treated area received topical applications of BA, NA, or CAG, either separately or in combination. Mice were sacrificed at the end of 4, 8, 16 and 24 hours after DMBA treatment. To access DNA synthesis, the [methyl-3H] thymidine incorporation test was performed. Reverse transcription-PCR (RT-PCR) and Western blotting were employed to assess gene expression at the mRNA and protein levels. As early as 4 hours after exposure, DMBA caused increased DNA synthesis and consequent hypertrophy, which was followed by overexpression of ODC, c-Myc, PCNA, and Cox-2. It gradually decreases at the end of the 24-hour period following exposure to DMBA, after peaking at the end of the 16-hour period. It was identified that DMBA-induced alterations could be prevented by BA, NA, and CAG, but that their combination worked best. A novel and improved method of managing skin hypertrophy with natural agents is made possible by the combined enhanced preventative effects of BA, NA, and CAG.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of lncRNA H19/Hmox1 axis regulating ferroptosis in anthracycline-induced cardiotoxicity. lncRNA H19/Hmox1轴调控铁凋亡在蒽环类药物诱导的心脏毒性中的作用。

IF 2.1 4区医学

Drug and Chemical Toxicology Pub Date : 2025-05-28 DOI: 10.1080/01480545.2025.2503946

Bayan Kadeerbieke, Li Wu, Yuan-Ming Zhang

{"title":"The role of lncRNA H19/Hmox1 axis regulating ferroptosis in anthracycline-induced cardiotoxicity.","authors":"Bayan Kadeerbieke, Li Wu, Yuan-Ming Zhang","doi":"10.1080/01480545.2025.2503946","DOIUrl":"https://doi.org/10.1080/01480545.2025.2503946","url":null,"abstract":"This study investigates the molecular mechanisms underlying anthracyclines (ANT)-induced cardiotoxicity, with a specific focus on ferroptosis regulated by the long non-coding RNA (lncRNA) H19/heme oxygenase-1 (Hmox1) signaling axis. A retrospective analysis was performed on 50 breast cancer patients who developed ANT-associated cardiac dysfunction. Clinical assessments included measurements of left ventricular ejection fraction (LVEF) and serum markers, such as cardiac troponin I (cTnI), creatine kinase-MB (CK-MB), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and serum iron levels. Serum analysis revealed a marked downregulation of lncRNA H19 and upregulation of Hmox1, both significantly correlated with impaired cardiac function and disrupted iron homeostasis. To further elucidate the mechanism, an Epirubicin (EPI)-induced injury model in HL-1 cardiomyocytes was established. EPI exposure led to suppression of lncRNA H19, upregulation of Hmox1, and induction of apoptosis and ferroptotic cell death. RNA-seq analysis identified potential downstream targets linking lncRNA H19 to iron metabolism via Hmox1 modulation. Functional assays demonstrated that overexpression of lncRNA H19 mitigated EPI-induced ferroptosis, while enforced expression of Hmox1 reversed these protective effects. Collectively, these findings identify the lncRNA H19/Hmox1 axis as a critical regulator of ferroptosis in ANT-induced cardiotoxicity and suggest it as a potential therapeutic target for mitigating cardiac injury in breast cancer patients undergoing anthracycline chemotherapy.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1-12"},"PeriodicalIF":2.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deferoxamine halt rotenone-induced Parkinson's like symptoms in experimental rats: biochemical, neuroinflammatory, neurotransmitters, and histological evidence. 去铁胺半鱼藤酮诱导的实验大鼠帕金森样症状：生化、神经炎症、神经递质和组织学证据

IF 2.1 4区医学

Drug and Chemical Toxicology Pub Date : 2025-05-26 DOI: 10.1080/01480545.2025.2495361

Anupam Awasthi, G D Gupta, Shamsher Singh

{"title":"Deferoxamine halt rotenone-induced Parkinson's like symptoms in experimental rats: biochemical, neuroinflammatory, neurotransmitters, and histological evidence.","authors":"Anupam Awasthi, G D Gupta, Shamsher Singh","doi":"10.1080/01480545.2025.2495361","DOIUrl":"https://doi.org/10.1080/01480545.2025.2495361","url":null,"abstract":"Rotenone is a pesticide compound that selectively damages dopaminergic neurons in the substantia nigra pars compacta and produces Parkinson's like symptoms in rodents. Deposition of iron and reactive oxygen species (ROS) generation by its oxidation are contributing factors in the etiology of Parkinson's disease. Deferoxamine (DFO) is an iron chelator with high affinity produced by Streptomyces wadayamensis, S. malaysiense, like organisms. The present study provides insight to evaluate the protective effect of DFO in rotenone-induced neurotoxicity in rats. Rotenone (6 μg/2 μl/rat, unilaterally) was injected intranigral on day-1 using a digital stereotaxic apparatus. DFO (50 and 100 mg/kg, intraperitoneally) was given orally daily for 21 days starting from day 8 after the intranigral surgery. On day 28, animals were sacrificed, and the striatum was isolated for oxidative stress parameters (lipid peroxidation, nitrite and reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase), neuroinflammatory cytokines (IL-1β, IL-6, and TNF-α), mitochondrial complexes-I and IV, neurotransmitters (brain catecholamines, gamma-aminobutyric acid, glutamate), and iron level estimation. Unilateral intranigral infusion of rotenone led to significant motor deficits as evidenced by impairments in locomotor activity in open field test, rotarod activity (motor coordination), grip strength, and narrow beam walk performance. DFO administration dose-dependently significantly improved against rotenone-induced behavioral abnormalities in rats, restored the altered level of neurotransmitters in the striatum, and attenuated oxidative stress and inflammatory response in the striatum. These findings indicate that DFO successfully achieved antioxidant and anti-inflammatory properties and protect dopaminergic neurons against rotenone-induced neurotoxicity.","PeriodicalId":11333,"journal":{"name":"Drug and Chemical Toxicology","volume":" ","pages":"1-16"},"PeriodicalIF":2.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0